Methods of producing polyketide synthase mutants and compositions and uses thereof

ABSTRACT

The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of producing mutant polyketide synthases, and methods of altering the activity and/or substrate specificity of putative polyketide synthases.

FIELD OF THE INVENTION

[0001] The present invention relates to methods for producing mutant polyketide synthases, and for altering the activity and/or substrate specificity of putative native and mutant polyketide synthases. The present invention further relates to compositions and uses of mutant polyketide synthases.

BACKGROUND

[0002] Advances in molecular biology have allowed the development of biological agents useful in modulating protein or nucleic acid activity or expression, respectively. Many of these advances are based on identifying the primary sequence of the molecule to be modulated. For example, determining the nucleic acid sequence of DNA or RNA allows the development of antisense or ribozyme molecules. Similarly, identifying the primary sequence allows for the identification of sequences that may be useful in creating monoclonal antibodies. However, often the primary sequence of a protein is insufficient to develop therapeutic or diagnostic molecules due to the secondary, tertiary or quartenary structure of the protein from which the primary sequence is obtained. The process of designing potent and specific inhibitors or activators has improved with the arrival of techniques for determining the three-dimensional structure of an enzyme or polypeptide to be modulated.

[0003] The phenylpropanoid synthetic pathway in plants produces a class of compounds know as anthocyanins, which are used for a variety of applications. Anthocyanins are involved in pigmentation and protection against UV photodamage, resynthesis of anti-microbial phytoalexins, and are flavonoid inducers of Rhizobium modulation genes 1-4. As medicinal natural products, the phenylpropanoids exhibit cancer chemopreventive activity, as well as anti-mitotic, estrogenic, anti-malarial, anti-oxidant, and antiasthmatic activities. The benefits of consuming red wine, which contains significant amounts of 3,4′,5-trihydroxystilbene (resveratrol) and other phenylpropanoids, highlight the dietary importance of these compounds. Chalcone synthase (CHS), a polyketide synthase, plays an essential role in the biosynthesis of plant phenylpropanoids.

[0004] An improvement in the understanding of the structure/function of these enzymes would allow for the exploitation of the synthetic capabilities of known enzymes for production of useful new chemical compounds, or allow for the creation of novel non-native enzymes having new synthetic capabilities. A need exists, therefore, for a detailed understanding of the molecular basis of the chemical reactions involved in polyketide synthesis. The present invention addresses this and related needs.

SUMMARY OF THE INVENTION

[0005] In accordance with the present invention there are presented crystalline polyketide synthases and the three-dimensional coordinates derived therefrom. Three-dimensional coordinates have been obtained for an active form of chalcone synthase and several active and inactive mutants thereof, both with and without substrate or substrate analog. Similar results have been obtained for the polyketide synthases stilbene synthase (STS) and pyrone synthase (2-PS).

[0006] One aspect of the present invention that is made possible by results described herein is that the three-dimensional properties of polyketide synthase proteins are determined, in particular the three-dimensional properties of the active site. The invention features specific coordinates of at least fourteen a carbon atoms defined for the active site in three-dimensional space. R-groups attached to said α-carbons are defined such that mutants can be made by changing at least one R-group found in the synthase active site. Such mutants may have unique and useful properties. Thus, in another embodiment of the invention, there are provided isolated non-native (e.g., mutant) synthase(s) having at least fourteen active site α-carbons having the structural coordinates disclosed herein (see, for example Table 1) and one or more R-groups other than those found in native polyketide synthase(s).

[0007] The three-dimensional coordinates disclosed herein can be employed in a variety of methods. The polyketide synthase used in the crystallization studies disclosed herein is a chalcone synthase derived from Medicago sataiva (alfalfa). A large number of proteins have been isolated and sequenced which have primary amino acid sequence similar to that of chalcone synthase, but for which substrate specificity and/or product is unknown. Thus, in another embodiment of the present invention, there are provided methods for altering the activity and/or substrate specificity of a putative polyketide synthase. There are further provided methods for altering the polyketide content of a plant.

[0008] Other aspects, embodiments, advantages, and features of the present invention will become apparent from the following specification.

BRIEF DESCRIPTION OF FIGURES

[0009]FIG. 1 presents the chemical structures of chalcone, naringenin, resveratrol, and cerulenin.

[0010]FIG. 2 presents final SIGMAA-weighted 2Fo-Fc electron density map of the CHS-resveratrol complex in the vicinity of the resveratrol binding site. The map is contoured at 1σ.

[0011]FIG. 3 shows a ribbon representation of the CHS homodimer. The approximate alpha carbon positions of Met 137 from each of the monomers are labeled accordingly. Naringenin completely fills the coumaroyl-binding and cyclization pockets while the CoA binding tunnels are highlighted by black arrows. Produced with MOLSCRIPT and rendered with POV-Ray.

[0012]FIG. 4 shows a comparison of chalcone synthase and 3-ketoacyl-CoA thiolase. Ribbon view of the CHS monomer is oriented perpendicular to the dimer interface. The active site cysteine (Cys 164) and the location of bound CoA are rendered as ball and stick models. In addition, strands β1d and β2d of the cyclization pocket are noted. The reaction catalyzed by CHS is illustrated with the coumaroyl- and malonyl-derived portions of chalcone, respectively. The thiolase monomer is depicted in the same orientation as CHS with the Active site cysteine (Cys 125) modeled and the reaction of thiolase as indicated. Figure prepared with MOLSCRIPT and rendered with POV-Ray.

[0013]FIG. 5 collectively shows structures of CHS-Acyl-CoA complexes. The ribbon diagram in panel FIG. 5A (on the top left) is the same as FIG. 3. The CoA binding region depicted in stereo is bounded by a black box in the upper ribbon diagram. Close-up stereoviews of the C₁₆₄S mutant CoA binding region for the malonyl- and hexanoyl-CoA complexes are depicted in FIGS. 5B and 5C, respectively. This mutant retains decarboxylation activity and an acetyl-CoA complex is observed crystallographically for the malonyl-CoA complex. In each complex, placement of the Met 137 loop originating from the dyad-related molecule spatially defines one wall of the cyclization pocket. Hydrogen bonds are depicted as spheres. Figure prepared with MOLSCRIPT and rendered with POV-Ray.

[0014]FIG. 6A shows the CHS-naringenin complex viewed down the CoA-binding tunnel. The ribbon diagram at the top left has been rotated 90 degrees around the y-axis from the orientation shown in FIG. 3. This view approximates the global orientation of the CHS dimer used for the close-up view of the naringenin binding site depicted in stereo. Again, the black box highlights the region of CHS shown in stereo close-up. Hydrogen bonds are depicted as dashed cylinders. FIG. 6B illustrates a comparison of the CHS apoenzyme, CHS-naringenin, and CHS-resveratrol structures. Protein backbone atoms for the three refined structures (apoenzyme, naringenin, and resveratrol) were superimposed by least squares fit in O. The position of bound naringenin and resveratrol are shown. For reference, a modeled low energy conformation of chalcone is indicated by dashed cylinders. Strands β1d and β2d for each complex are also depicted (see FIG. 4). β2d does not change in all the complexes examined, but β1d moves in the CHS-resveratrol complex. FIG. 6C presents representative sequence alignment of the β1d-β2d region is given with positions 255, 266, and 268 highlighted. The first three sequences follow a CHS-like cyclization pathway, while the last three use the STS-cyclization pathway. Figure prepared with MOLSCRIPT and rendered with POV-Ray.

[0015]FIG. 7 presents the proposed reaction mechanism for chalcone synthesis. The three boxed regions labeled 1, 2, and 3 depict the addition of acetate units derived from malonyl-CoA during the elongation of polyketide intermediates. Box 1 is depicted in expanded fashion to illustrate the mechanistic details governing the decarboxylation, enolization, and condensation phase of ketide elongation. Smaller black arrows depict the flow of electrons. Each acetate unit of the malonyl-CoA thioesters is coded to emphasize the portions of chalcone derived from each of three elongation reactions using malonyl-CoA. Cyclization and aromatization of the enzyme bound tetraketide leads to formation of chalcone. Hydrogen bonds are shown as dashed lines. Coenzyme A is symbolized as a circle.

[0016]FIG. 8 presents a comparison of the active site volumes of CHS from alfalfa and CHS from Gerbera hybrida. The active site volumes available for binding ketide intermediates were calculated with VOID00 for the CHS-COA complex and for a homology model of GCHS2 with CoA. The cavities are shown as a wire mesh. The homology model of GCHS2 was generated using MODELER and the volume calculated and displayed as for CHS. The numbering scheme is for alfalfa CHS homodimer. Figure prepared with MOLSCRIPT and rendered with POV-Ray.

[0017]FIG. 9 shows an example of a computer system in block diagram form.

[0018]FIG. 10 shows the chalcone synthase reaction sequence including initiation, elongation and cyclization.

[0019]FIG. 11 shows an amino acid sequence alignment of P. sylvestris STS and M sativa CHS, along with an evolutionary intermediate, P. sylvestris CHS.

[0020]FIG. 12 shows phenylpropanoid metabolism. From a common linear phenylpropanoid tetraketide intermediate, resveratrol is formed by STS and chalcone is formed by CHS.

[0021]FIG. 13 shows different reaction schemes of CHS and STS. STS forms resveratrol via an intramolecular aldol condensation and CHS utilizes an intramolecular Claisen condensation to produce chalcone.

[0022]FIG. 14 shows an autoradiographic gel following thin layer chromatography. Wild type CHS produces chalcone, which spontaneously converts to naringenin, the position of which is indicated by the arrow on the left. Wild type STS produces resveratrol, the position of which is indicated by the arrow of the right. Function conversion of CHS to STS (i.e., the production of the alternate product from the same intermediate) results in diminished production of naringenin and increased production of resveratrol. Various mutants of CHS produce varying degrees of resveratrol, showing that CHS activity can be altered to STS-like activity to different extents by different mutations.

[0023]FIG. 15 shows the crystalline structure of CHS. Circled areas A1 to A4 represent regions in which mutations result in the conversion of CHS activity to STS-like activity. The 18xCHS mutant contains mutations in these regions.

[0024]FIG. 16 shows the crystalline structure of CHS with area B1, mutated in the 22xCHS mutant circled.

[0025]FIG. 17 shows amino acid sequences of homologous sequences from STS family members.

[0026]FIG. 18 shows the kinetics of the 18xCHS in comparison to the wild type CHS and STS.

[0027]FIG. 19 shows a comparison of the crystal structures of the wild type CHS (alfalfa), two types of STS (pine and peanut) and the 18xCHS mutant. Areas A1 to A4 are as indicated in FIG. 14. A comparison of the amino acid sequence in these areas is also provided. The stars indicated the residues mutated in the 8xCHS mutant.

[0028]FIG. 20 shows that the 8xCHS mutant has activity that is similar to the 18xCHS mutant, i.e. an alteration of the CHS activity to an STS-like activity. The 8xCHS mutant contains five mutations in Area A2 and three additional changes in Areas A1 and A3. The mutations in the 8xCHS are a subset of the mutations in the 18xCHS mutant, eliminating 10 neutral mutations found in the 18xCHS mutant.

[0029]FIG. 21 shows the proposed mechanism of cyclization specificity in STS as compared to CHS, which results in the different end-products. STS elimination of terminal CO₂ favors intramolecular C2 to C7 Aldol Condensation, while CHS causes intramolecullar C6 to C1 Claisen Condensation coupled to thioester cleavage.

[0030]FIG. 22 shows the aldol cyclization switch region as viewed from the CoA-ginding tunnel, involved in the mechanisms depicted in FIG. 21.

DETAILED DESCRIPTION OF THE INVENTION

[0031] The phenylpropanoid synthetic pathway in plants produces a class of compounds know as anthocyanins, which are used for a variety of applications. Anthocyanins are involved in pigmentation and protection against UV photodamage, synthesis of anti-microbial phytoalexins, and are flavonoid inducers of Rhizobium modulation genes 1-4. As medicinal natural products, the phenylpropanoids exhibit cancer chemopreventive activity, as well as anti-mitotic, estrogenic, anti-malarial, anti-oxidant, and antiasthmatic activities. The benefits of consuming red wine, which contains significant amounts of 3,4′,5-trihydroxystilbene (resveratrol) and other phenylpropanoids, highlight the dietary importance of these compounds.

[0032] Polyketides are a large class of compounds and include a broad range of antibiotics, immunosuppressants and anticancer agents which together account for sales of over $5 billion per year. Polyketides are molecules which are an extremely rich source of bioactivities, including antibiotics (e.g., tetracyclines and erythromycin), anti-cancer agents (e.g., daunomycin), immunosuppressants (e.g., FK506 and rapamycin), and veterinary products (e.g., monensin) and the like. Many polyketides (produced by polyketide synthases) are valuable as therapeutic agents. Polyketide synthases are multifunctional enzymes that catalyze the biosynthesis of a huge variety of carbon chains differing in length and patterns of functionality and cyclization.

[0033] Chalcone synthase (CHS), a polyketide synthase, plays an essential role in the biosynthesis of plant phenylpropanoids. CHS supplies 4,2′,4′,6′-tetrahydroxychalcone (chalcone) to downstream enzymes that synthesize a diverse set of flavonoid phytoalexins and anthocyanin pigments. Synthesis of chalcone by CHS involves the sequential condensation of one p-coumaroyl- and three malonyl-Coenzyme-A (CoA) molecules (Kreuzaler and Hahlbrock, Eur. J. Biochem. 56:205-213, 1975). After initial capture of the p-coumaroyl moiety, each subsequent condensation step begins with decarboxylation of malonyl-CoA at the CHS active site; the resulting acetyl-CoA carbanion then serves as the nucleophile for chain elongation.

[0034] Ultimately, these reactions generate a tetraketide intermediate that cyclizes by a Claisen condensation into a hydroxylated aromatic ring system. This mechanism mirrors those of the fatty acid and polyketide synthases but with significant differences. CHS uses CoA-thioesters for shuttling substrates and intermediate polyketides instead of the acyl carrier proteins used by the fatty acid synthases. Also, unlike these enzymes, which function as either multichain or multimodular enzyme complexes catalyzing distinct reactions at different active sites, CHS functions as a unimodular polyketide synthase and carries out a series of decarboxylation, condensation, cyclization, and aromatization reactions at a single active site.

[0035] A number of plant and bacterial polyketide synthases related to CHS by sequence identity, including stilbene synthase (STS), bibenzyl synthase (BBS), and acridone synthase (ACS), share a common chemical mechanism, but differ from CHS in their substrate specificity and/or in the stereochemistry of the polyketide cyclization reaction. For example, STS condenses one coumaroyl- and three malonyl-CoA molecules, like CHS, but synthesizes resveratrol through a structurally distinct cyclization intermediate.

[0036] While the cloning of over 400 CHS-related genes, and characterization of some of these proteins, provides insight into their biological function, it remains unclear how these enzymes perform multiple decarboxylation and condensation reactions and how they dictate the stereochemistry of the final polyketide cyclization reaction. Furthermore, despite significant advances in the biosynthetic manipulation of structurally complex and biologically important natural products, there remains a lack of structural information on polyketide synthases from any source.

[0037] As used herein, “naturally occurring amino acid” and “naturally occurring R-group” includes L-isomers of the twenty amino acids naturally occurring in proteins. Naturally occurring amino acids are glycine, alanine, valine, leucine, isoleucine, serine, methionine, threonine, phenylalanine, tyrosine, tryptophan, cysteine, proline, histidine, aspartic acid, asparagine, glutamic acid, glutamine, arginine, and lysine. Unless specially indicated, all amino acids referred to in this application are in the L-form.

[0038] “Unnatural amino acid” and “unnatural R-group” includes amino acids that are not naturally found in proteins. Examples of unnatural amino acids included herein are racemic mixtures of selenocysteine and selenomethionine. In addition, unnatural amino acids include the D or L forms of, for example, nor-leucine, para-nitrophenylalanine, homophenylalanine, para-fluorophenylalanine, 3-amino-2-benzylpropionic acid, homoarginines, D-phenylalanine, and the like.

[0039] “R-group” refers to the substituent attached to the α-carbon of an amino acid residue. An R-group is an important determinant of the overall chemical character of an amino acid. There are twenty natural R-groups found in proteins, which make up the twenty naturally occurring amino acids.

[0040] “α-carbon” refers to the chiral carbon atom found in an amino acid residue. Typically, four substituents will be covalently bound to said α-carbon including an amine group, a carboxylic acid group, a hydrogen atom, and an R-group. The α-carbon atoms can also be referred to by their crystal structure coordinates as a convenient reference point. Table 1 provides the structural coordinates of α-carbons found in the active site of a polyketide of the present invention. TABLE 1 Active Site-Carbon Number X Position Y Position Z Position Amino Acid 1 25.378 49.320 57.979 Thr 132 2 26.089 45.704 56.981 Ser 133 3 35.423 42.296 66.622 Met 137* 4 25.212 49.977 62.196 Gln 161 5 22.745 44.120 51.193 Thr 194 6 19.022 42.892 54.600 Thr 197 7 13.850 48.144 50.791 Gly 211 8 22.118 48.048 46.357 Gly 216 9 13.001 54.666 59.688 Ile 254 10 16.434 48.819 61.334 Gly 256 11 18.715 43.328 59.526 Leu 263 12 13.943 47.516 57.567 Phe 265 13 9.252 52.715 57.456 Leu 267 14 23.141 53.552 52.148 Ser 338

[0041] “Positively charged amino acid” and “positively charged R-group” includes any naturally occurring or unnatural amino acid having a side chain which is positively charged under normal physiological conditions. Examples of positively charged, naturally occurring amino acids include arginine, lysine, histidine, and the like.

[0042] “Negatively charged amino acid” and “negatively charged R-group” includes any naturally occurring or unnatural amino acid having a side chain which is negatively charged under normal physiological conditions. Examples of negatively charged, naturally occurring amino acids include aspartic acid, glutamic acid, and the like.

[0043] “Hydrophobic amino acid” and “hydrophobic R-group” includes any naturally occurring or unnatural amino acid that is relatively insoluble in water. Examples of naturally occurring hydrophobic amino acids are alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan, methionine, and the like.

[0044] “Hydrophilic amino acid” and “hydrophilic R-group” includes any naturally occurring or unnatural amino acid that is relatively soluble in water. Examples of naturally occurring hydrophilic amino acids include serine, threonine, tyrosine, asparagine, glutamine, cysteine, and the like.

[0045] “Mutant” or “mutated synthase” refers to a polyketide synthase polypeptide containing amino acid residues that have been substituted or modified with respect to a wild type polyketide synthase (for example, the alfalfa CHS having the crystal structure coordinates of Protein Data Bank (PDB)Accession No. 1BI5). Examples of mutant or mutated synthase polypeptides include those having PDB Accession Nos. 1D6F, 1D6L, and 1D6H (the content of which are incorporated by reference herein in their entirety). Further examples of mutant or mutated synthase polypeptides are set forth in a set of crystal structure coordinates in Appendix C, the 18xCHS mutant. Access to the foregoing information in the Protein Data Bank can be found at www.rcsb.org/pdb. The Protein Data Bank is operated by the Research Collaboratory for Structural Bioinformatics (RCSB).

[0046] The R-groups of known isolated polyketide synthases can be readily determined by consulting sequence databases well known in the art, such as, for example, Genbank. Additional R-groups found inside and/or outside of the active site may or may not be the same. R-groups may be a natural R-group, unnatural R-group, hydrophobic R-group, hydrophilic R-group, positively charged R-group, negatively charged R-group, and the like. The term “mutant” refers to the configuration of R-groups within the active site and/or groups involved in second-tier interactions, for example those resulting in the alteration of CHS native activity.

[0047] “Non-native” or “non-native synthase” refers to synthase proteins that are not found in nature, whether isolated or not. A non-native synthase may, for example, be a mutated synthase (see, for example, PDB Accession Nos. 1D6F, 1D6I, 1D6H and Appendix C).

[0048] “Native” or “native synthase” or “wild type synthase” refers to synthase proteins that are produced in nature, e.g., are not mutants (see, for example, PDB Accession Nos. 1BI5 (CHS), 1EE0(2-PS)).

[0049] “Isolated” refers to a protein or nucleic acid that has been identified and separated from its natural environment. Contaminant components of its natural environment may include enzymes, hormones, and other proteinaceous or non-proteinaceous solutes. In one embodiment, the isolated molecule, in the case of a protein, will be purified to a degree sufficient to obtain at least 15 residues of N-terminal or internal amino acid sequence or to homogeneity by SDS-PAGE under reducing or non-reducing conditions using Coomassie blue or silver stain. In the case of a nucleic acid the isolated molecule will preferably be purified to a degree sufficient to obtain a nucleic acid sequence using standard sequencing methods.

[0050] “Degenerate variations thereof” refers to changing a gene sequence using the degenerate nature of the genetic code to encode proteins having the same amino acid sequence yet having a different gene sequence. For example, polyketide synthases of the present invention are based on amino acid sequences. Degenerate gene variations thereof can be made encoding the same protein due to the plasticity of the genetic code, as described herein.

[0051] “Expression” refers to transcription of a gene or nucleic acid sequence, stable accumulation of nucleic acid, and the translation of that nucleic acid to a polypeptide sequence. Expression of genes also involves transcription of the gene to make RNA, processing of RNA into mRNA in eukaryotic systems, and translation of mRNA into proteins. It is not necessary for the genes to integrate into the genome of a cell in order to achieve expression. This definition in no way limits expression to a particular system or to being confined to cells or a particular cell type and is meant to include cellular, transient, in vitro, in vivo, and viral expression systems in both prokaryotic, eukaryotic cells, and the like.

[0052] “Foreign” or “heterologous” genes refers to a gene encoding a protein whose exact amino acid sequence is not normally found in the host cell.

[0053] “Promoter” and “promoter regulatory element”, and the like, refers to a nucleotide sequence element within a nucleic acid fragment or gene that controls the expression of that gene. These can also include expression control sequences. Promoter regulatory elements, and the like, from a variety of sources can be used efficiently to promote gene expression. Promoter regulatory elements are meant to include constitutive, tissue-specific, developmental-specific, inducible, subgenomic promoters, and the like. Promoter regulatory elements may also include certain enhancer elements or silencing elements that improve or regulate transcriptional efficiency. Promoter regulatory elements are recognized by RNA polymerases, promote the binding thereof, and facilitate RNA transcription.

[0054] A polypeptide is a chain of amino acids, regardless of length or post-translational modification (e.g., glycosylation or phosphorylation). A polypeptide or protein refers to a polymer in which the monomers are amino acid residues, which are joined together through amide bonds. When the amino acids are alpha-amino acids, either the L-optical isomer or the D-optical isomer can be used, the L-isomers being typical. A synthase polypeptide of the invention is intended to encompass an amino acid sequence as set forth in SEQ ID NO:1 (see Table 2), or SEQ ID NO:1 having one or more mutations. Mutations include deletions and additions of amino acid residues, and substitutions of one amino acid residue for another. For example substitutions include: D96A (where D at position 96 of a wild type CHS is changed to A), V98L, V99A, V100M, T131S, S133T, G134T, V135P, M137L, Y157V, M158G, M159V, Y160F, C164A, Q165H, D255G, H257K, L258V, H266Q, L268K, K269G, D270A, G273D, H303Q, N336A, mutants, variants and conservative substitutions thereof comprising L- or D-amino acids and include modified sequences such as glycoproteins. TABLE 2 (SEQ ID NO:1) MVSVSEIRKA QRAEGPATIL AIGTANPANC VEQSTYPDFY FKITNSEHKT ELKEKFQRMC DKSMIKRRYM YLTEEILKEN PNVCEYMAPS LDARQDMVVV EVPRLGKEAA VKAIKEWGQP KSKITHLIVC TTSGVDMPGA DYQLTKLLGL RPYVKRYMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEVTAVTFRC PSDTHLDSLV GQALFGDGAA ALIVGSDPVP EIEKPIFEMV WTAQTIAPDS EGAIDGHLRE AGLTFHLLKD VPGIVSKNIT KALVEAFEPL GISDYNSIFW IAHPGGPAIL DQVEQKLALK PEKMNATREV LSEYGNMSSA CVLFILDEMR KKSTQNGLKT TGEGLEWGVL FGFGPGLTIE TVVLRSVAI

[0055] Accordingly, the polypeptides of the invention are intended to cover naturally occurring proteins, as well as those which are recombinantly or synthetically synthesized. Polypeptide or protein fragments are also encompassed by the invention. Fragments can have the same or substantially the same amino acid sequence as the naturally occurring protein. A polypeptide or peptide having substantially the same sequence means that an amino acid sequence is largely, but not entirely, the same, but retains a functional activity of the sequence to which it is related. In general polypeptides of the invention include peptides, or full-length protein, that contains substitutions, deletions, or insertions into the protein backbone, that would still have an approximately 70%/90% homology to the original protein over the corresponding portion. A yet greater degree of departure from homology is allowed if like-amino acids, i.e. conservative amino acid substitutions, do not count as a change in the sequence.

[0056] A polypeptide may be substantially related but for a conservative variation, such polypeptides being encompassed by the invention. A conservative variation denotes the replacement of an amino acid residue by another, biologically similar residue. Examples of conservative variations include the substitution of one hydrophobic residue such as isoleucine, valine, leucine or methionine for another, or the substitution of one polar residue for another, such as the substitution of arginine for lysine, glutamic for aspartic acids, or glutamine for asparagine, and the like. Other illustrative examples of conservative substitutions include the changes of: alanine to serine; arginine to lysine; asparagine to glutamine or histidine; aspartate to glutamate; cysteine to serine; glutamine to asparagine; glutamate to aspartate; glycine to proline; histidine to asparagine or glutamine; isoleucine to leucine or valine; leucine to valine or isoleucine; lysine to arginine, glutamine, or glutamate; methionine to leucine or isoleucine; phenylalanine to tyrosine, leucine or methionine; serine to threonine; threonine to serine; tryptophan to tyrosine; tyrosine to tryptophan or phenylalanine; valine to isoleucine or leucine, and the like. The term “conservative variation” also includes the use of a substituted amino acid in place of an unsubstituted parent amino acid provided that antibodies raised to the substituted polypeptide also immunoreact with the unsubstituted polypeptide.

[0057] Modifications and substitutions are not limited to replacement of amino acids. For a variety of purposes, such as increased stability, solubility, or configuration concerns, one skilled in the art will recognize the need to introduce, (by deletion, replacement, or addition) other modifications. Examples of such other modifications include incorporation of rare amino acids, dextra-amino acids, glycosylation sites, cytosine for specific disulfide bridge formation. The modified peptides can be chemically synthesized, or the isolated gene can be site-directed mutagenized, or a synthetic gene can be synthesized and expressed in bacteria, yeast, baculovirus, tissue culture and so on.

[0058] Chalcone synthase polypeptides of the invention include synthase polypeptides from plants, prokaryotes, eukaryotes, including, for example, invertebrates, mammals and humans and include sequences as set forth in SEQ ID NO:1, as well as sequences that have at least 50% homology, preferably at least 60% homology, more preferably at least 70% homology to the sequence of SEQ ID NO:1, fragments, variants, or conservative substitutions of any of the foregoing sequences.

[0059] The term “variant” refers to polypeptides modified at one or more amino acid residues yet still retain the biological activity of a synthase polypeptide. Variants can be produced by any number of means known in the art, including, for example, methods such as, for example, error-prone PCR, shuffling, oligonucleotide-directed mutagenesis, assembly PCR, sexual PCR mutagenesis, and the like, as well as any combination thereof.

[0060] By “substantially identical” is meant a polypeptide or nucleic acid exhibiting at least 50%, preferably 85%, more preferably 90%, and most preferably 95% homology to a reference amino acid or nucleic acid sequence.

[0061] Sequence homology and identity are often measured using sequence analysis software (e.g., Sequence Analysis Software Package of the Genetics Computer Group, University of Wisconsin Biotechnology Center, 1710 University Avenue, Madison, Wis. 53705). The term “identity” in the context of two or more nucleic acids or polypeptide sequences, refers to two or more sequences or subsequences that are the same or have a specified percentage of amino acid residues or nucleotides that are the same when compared and aligned for maximum correspondence over a comparison window or designated region as measured using any number of sequence comparison algorithms or by manual alignment and visual inspection. The term “homology” in the context of two or more nucleic acids or polypeptide sequences, refers to two or more sequences or subsequences that are homologous or have a specified percentage of amino acid residues or nucleotides that are homologous when compared and aligned for maximum correspondence over a comparison window or designated region as measured using any number of sequence comparison algorithms or by manual alignment and visual inspection. Programs as mentioned above allow for amino acid substitutions with similar amino acids matches by assigning degrees of homology to determine a degree of homology between the sequences being compared.

[0062] For sequence comparison, typically one sequence acts as a reference sequence, to which test sequences are compared. When using a sequence comparison algorithm, test and reference sequences are entered into a computer, subsequence coordinates are designated, if necessary, and sequence algorithm program parameters are designated. Default program parameters can be used, or alternative parameters can be designated. The sequence comparison algorithm then calculates the percent sequence identities for the test sequences relative to the reference sequence, based on the program parameters.

[0063] A “comparison window”, as used herein, includes reference to a segment of any one of the number of contiguous positions selected from the group consisting of from 20 to 600, usually about 50 to about 200, more usually about 100 to about 150 in which a sequence may be compared to a reference sequence of the same number of contiguous positions after the two sequences are optimally aligned. Methods of alignment of sequence for comparison are well-known in the art. Optimal alignment of sequences for comparison can be conducted, e.g., by the local homology algorithm of Smith & Waterman, Adv. Appl. Math. 2:482, 1981, by the homology alignment algorithm of Needleman & Wunsch, J. Mol. Biol 48:443, 1970, by the search for similarity method of Person & Lipman, Proc. Natl. Acad. Sci. USA 85:2444, 1988, by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, Wis.), or by manual alignment and visual inspection. Other algorithms for determining homology or identity include, for example, in addition to a BLAST program (Basic Local Alignment Search Tool at the National Center for Biological Information), ALIGN, AMAS (Analysis of Multiply Aligned Sequences), AMPS (Protein Multiple Sequence Alignment), ASSET (Aligned Segment Statistical Evaluation Tool), BANDS, BESTSCOR, BIOSCAN (Biological Sequence Comparative Analysis Node), BLIMPS (BLocks IMProved Searcher), FASTA, Intervals & Points, BMB, CLUSTAL V, CLUSTAL W, CONSENSUS, LCONSENSUS, WCONSENSUS, Smith-Waterman algorithm, DARWIN, Las Vegas algorithm, FNAT (Forced Nucleotide Alignment Tool), Framealign, Framesearch, DYNAMIC, FILTER, FSAP (Fristensky Sequence Analysis Package), GAP (Global Alignment Program), GENAL, GIBBS, GenQuest, ISSC (Sensitive Sequence Comparison), LALIGN (Local Sequence Alignment), LCP (Local Content Program), MACAW (Multiple Alignment Construction & Analysis Workbench), MAP (Multiple Alignment Program), MBLKP, MBLKN, PMA (Pattern-Induced Multi-sequence Alignment), SAGA (Sequence Alignment by Genetic Algorithm) and WHAT-IF. Such alignment programs can also be used to screen genome databases to identify polynucleotide sequences having substantially identical sequences. A number of genome databases are available, for example, a substantial portion of the human genome is available as part of the Human Genome Sequencing Project (J. Roach, http://weber.u.Washington.edu/˜roach/human_genome_progress 2.html) (Gibbs, 1995). At least twenty-one other genomes have already been sequenced, including, for example, M genitalium (Fraser et al., 1995), M. jannaschii (Bult et al., 1996), H. influenzae (Fleischmann et al., 1995), E. coli (Blattner et al., 1997), and yeast (S. cerevisiae) (Mewes et al., 1997), and D. melanogaster (Adams et al., 2000). Significant progress has also been made in sequencing the genomes of model organism, such as mouse, C. elegans, and Arabadopsis sp. Several databases containing genomic information annotated with some functional information are maintained by different organization, and are accessible via the internet, for example, http://wwwtigr.org/tdb; http://www.genetics.wisc.edu; http://genome-www.stanford.edu/˜ball; http://hivweb.lanl.gov; http://www.ncbi.nlm.nih.gov; http://www.ebi.ac.uk; http://Pasteur.fr/other/biology; and http:H//www.genome.wi.mit.edu.

[0064] One example of a useful algorithm is BLAST and BLAST 2.0 algorithms, which are described in Altschul et al., Nuc. Acids Res. 25:3389-3402, 1977, and Altschul et al., J. Mol. Biol. 215:403-410, 1990, respectively. Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http://www.ncbi.nlm.nih. gov). This algorithm involves first identifying high scoring sequence pairs (HSPs) by identifying short words of length W in the query sequence, which either match or satisfy some positive-valued threshold score T when aligned with a word of the same length in a database sequence. T is referred to as the neighborhood word score threshold (Altschul et al., supra). These initial neighborhood word hits act as seeds for initiating searches to find longer HSPs containing them. The word hits are extended in both directions along each sequence for as far as the cumulative alignment score can be increased. Cumulative scores are calculated using, for nucleotide sequences, the parameters M (reward score for a pair of matching residues; always >0). For amino acid sequences, a scoring matrix is used to calculate the cumulative score. Extension of the word hits in each direction are halted when: the cumulative alignment score falls off by the quantity X from its maximum achieved value; the cumulative score goes to zero or below, due to the accumulation of one or more negative-scoring residue alignments; or the end of either sequence is reached. The BLAST algorithm parameters W, T, and X determine the sensitivity and speed of the alignment. The BLASTN program (for nucleotide sequences) uses as defaults a wordlength (W) of 11, an expectation (E) of 10, M=5, N-4 and a comparison of both strands. For amino acid sequences, the BLASTP program uses as defaults a wordlength of 3, and expectations (E) of 10, and the BLOSUM62 scoring matrix (see Henikoff& Henikoff, Proc. Natl. Acad. Sci. USA 89:10915, 1989) alignments (13) of 50, expectation (E) of 10, M=5, N=4, and a comparison of both strands.

[0065] The BLAST algorithm also performs a statistical analysis of the similarity between two sequences (see, e.g., Karlin & Altschul, Proc. Natl. Acad. Sci. USA 90:5873, 1993). One measure of similarity provided by BLAST algorithm is the smallest sum probability (P(N)), which provides an indication of the probability by which a match between two nucleotide or amino acid sequences would occur by chance. For example, a nucleic acid is considered similar to a references sequence if the smallest sum probability in a comparison of the test nucleic acid to the reference nucleic acid is less than about 0.2, more preferably less than about 0.01, and most preferably less than about 0.001.

[0066] In one embodiment, protein and nucleic acid sequence homologies are evaluated using the Basic Local Alignment Search Tool (“BLAST”) In particular, five specific BLAST programs are used to perform the following task:

[0067] (1) BLASTP and BLAST3 compare an amino acid query sequence against a protein sequence database;

[0068] (2) BLASTN compares a nucleotide query sequence against a nucleotide sequence database;

[0069] (3) BLASTX compares the six-frame conceptual translation products of a query nucleotide sequence (both strands) against a protein sequence database;

[0070] (4) TBLASTN compares a query protein sequence against a nucleotide sequence database translated in all six reading frames (both strands); and

[0071] (5) TBLASTX compares the six-frame translations of a nucleotide query sequence against the six-frame translations of a nucleotide sequence database.

[0072] The BLAST programs identify homologous sequences by identifying similar segments, which are referred to herein as “high-scoring segment pairs,” between a query amino or nucleic acid sequence and a test sequence which is preferably obtained from a protein or nucleic acid sequence database. High-scoring segment pairs are preferably identified (i.e., aligned) by means of a scoring matrix, many of which are known in the art. Preferably, the scoring matrix used is the BLOSUM62 matrix (Gonnet et al., Science 256:1443-1445, 1992; Henikoff and Henikoff, Proteins 17:49-61, 1993). Less preferably, the PAM or PAM250 matrices may also be used (see, e.g., Schwartz and Dayhoff, eds., 1978, Matrices for Detecting Distance Relationships: Atlas of Protein Sequence and Structure, Washington: National Biomedical Research Foundation). BLAST programs are accessible through the U.S. National Library of Medicine, e.g., at www.ncbi.nlm.nih.gov.

[0073] The parameters used with the above algorithms may be adapted depending on the sequence length and degree of homology studied. In some embodiments, the parameters may be the default parameters used by the algorithms in the absence of instructions from the user.

[0074] By a “substantially pure polypeptide” is meant a synthase polypeptide (e.g., a chalcone synthase) which has been separated from components which naturally accompany it. Typically, the polypeptide is substantially pure when it is at least 60%, by weight, free from the proteins and naturally-occurring organic molecules with which it is naturally associated. Preferably, the preparation is at least 75%, more preferably at least 90%, and most preferably at least 99%, by weight, synthase polypeptide. A substantially pure synthase polypeptide may be obtained, for example, by extraction from a natural source; by expression of a recombinant nucleic acid encoding an synthase polypeptide; or by chemically synthesizing the protein. Purity can be measured by any appropriate method (e.g., column chromatography, polyacrylamide gel electrophoresis, or by HPLC analysis).

[0075] One aspect of the invention resides in obtaining crystals of the synthase polypeptide, chalcone synthase, of sufficient quality to determine the three dimensional (tertiary) structure of the protein by X-ray diffraction methods. The knowledge obtained concerning the three-dimensional structure of chalcone synthase can be used in the determination of the three dimensional structure of other synthase polypeptides in the polyketide synthesis pathway. The structural coordinates of chalcone synthase can be used to develop new polyketide synthesis enzymes or synthase inhibitors using various computer models. Based on the structural coordinates of the chalcone synthase polypeptide (e.g., the three dimensional protein structure), as described herein, novel polyketide synthases can be engineered. In addition, small molecules which mimic or are capable of interacting with a functional domain of a synthase molecule, can be designed and synthesized to modulate chalcone synthase, pyrone synthase, and other polyketide synthase biological functions as well as the biological functions of other polyketide synthases. Accordingly, in one embodiment, the invention provides a method of “rational” enzyme or drug design. Another approach to “rational” enzyme or drug design is based on a lead compound that is discovered using high throughput screens; the lead compound is further modified based on a crystal structure of the binding regions of the molecule in question. Accordingly, another aspect of the invention is to provide related protein sequences or material which is a starting material in the rational design of new synthases or drugs which lead to the synthesis of new polyketides or modify the polyketide synthesis pathway.

[0076] “Active Site” refers to a site in a synthase defined by amino acid residues that interact with substrate and facilitate a biosynthetic reaction that allows one or more products to be produced. For example, an active site is comprised of α-carbon atoms that are indirectly linked via peptide bonds and have the structural coordinates disclosed in Table 1 ±2.3 angstroms. Other active site amino acids for chalcone synthase include C164, H303, and N336. The position in three-dimensional space of an α-carbon at the active site of a synthase and of R-groups associated therewith can be determined using techniques such as three-dimensional modeling, X-ray crystallography, and/or techniques associated therewith. Active sites can be specified by a set of amino acid residues. Other residues can play a reole in substrate specificity and enzyme activity by modulating size, shape, charge, and the like of the active site. In addition, second tier residues may also modulate the specificity and/or activity of the enzyme.

[0077] In CHS, at least five areas of primary sequence containing residues that play a role modulating enzyme specificity and/or activity are found. Each area contains a total of about four to about fifteen amino acid residues. Within each area, about three to six, and preferably four or five amino acid residues that interact with substrate are found. Residues may be directly within or lining the active site to modulate specificity and/or activity. Residues may also be involved in second tier interactions that modulate the specificity and/or activity of the active site, without being physically located within the active site. Various mutants of these residues have been prepared to evaluate the role of these residues in CHS function and activity, including substrate specificity and product formation. Table 3 presents some of the mutations of CHS that have been made to affect CHS function. TABLE 3 Mutants of CHS Mutant Mutant Name Code Mutations relative to alfalfa CHS A4 0002 A4 (L268K, K269G, D270A, G273D) 14B 1200 A1 (V98L,) (=6xCHS) A2 (T131S, S133T, G134T, V135P, M137L) 2B 2200 A1 (D96A, V98L, V99A, V100M) A2 (T131S, S133T, G134T, V135P, M137L) 16B 1210 A1 (V98L,) (=8xCHS) A2 (T131S, S133T, G134T, V135P, M137L) A3 (M158G, Y160F) 4B 2211 A1 (D96A, V98L, V99A, V100M) A2 (T131S, S133T, G134T, V135P, M137L) A3 (M158G, Y160F) A4 (K269G) 6B 1220 A1 (V98L,) A2 (T131S, S133T, G134T, V135P, M137L) A3 (Y157V, M158G, M159V, Y160F, Q165H); 18xCHS 2222 A1 (D96A, V98L, V99A, V100M) A2 (T131S, S133T, G134T, V135P, M137L) A3 (Y157V, M158G, M159V, Y160F, Q165H) A4 (L268K, K269G, D270A, G273D) 22xCHS 2222 + A1 (D96A, V98L, V99A, V100M) Area B1 A2 (T131S, S133T, G134T, V135P, M137L) A3 (Y157V, M158G, M159V, Y160F, Q165H) B1 (D255G, H257K, L258V, H266Q) A4 (L268K, K269G, D270A, G273D)

[0078] A polyketide synthase can be divided into regional areas A1-A4 and B 1. Areas A1 and A3 flank area A2, from below and above, respectively (see FIG. 15). Both areas seem to have importance mainly in regards to compensatory steric changes which allow a proline induced kink in area A2 relative to the CHS position. The backbone C-alpha traces of A1 and A3 do not actually vary much from CHS to STS, but length of indicated residues does. In area A1, amino acids involved in the modulation of enzyme specificity and/or activity for chalcone synthase include D96, V98, V99 and V100. In area A3, such amino acids include Y157, M158, M159, Y160 and Q165. Mutations at V98 and V99 in area A1, and at M158 and Y160 in area A3 appear especially important for modifying activity.

[0079] Area A2 appears to be the most important area, and is located at the dimer interface, directly between the active site cavities of each monomer. In area A2 amino acids involved in the modulation of enzyme specificity and/or activity include T131, S133, G134, V135 and M137. Mutations at G134 and V135 appear especially important for modifying activity.

[0080] Area A4 is located on the outside of the protein, near the active site entrance. A4 mutations made to wild type CHS seems to have no effect on cyclization specificity, indicating that this area is not important to the conversion of activity seen in the certain mutants, for example, the 18xCHS mutant. However, this area may be important in the improvements to conversion seen with the addition of four more mutants (at B1, see FIG. 16 and below) in the 22×CHS mutant. In area A4, amino acids involved in the modulation of enzyme specificity and/or activity include L268, K269, D270 and G273.

[0081] Area B1 flanks A4 and bridges the gap between A1-A3 and A4. In area B1, amino acids involved in the modulation of enzyme specificity and/or activity include D255, H257L258 and H266. These mutations are in an area predicted in by Ferrer, et al. and are important for cyclization specificity.

[0082] “Altered substrate specificity” or “altered activity” includes a change in the ability of a mutant synthase to use a particular substrate and/or produce a polyketide product as compared to a non-mutated synthase. Altered substrate specificity may include the ability of a synthase to exhibit different enzymatic parameters relative to a non-mutated synthase (K_(m), V_(max), etc), use different substrates, and/or produce products that are different from those of known synthases.

[0083] “Structure coordinates” refers to Cartesian coordinates (x, y, and z positions) derived from mathematical equations involving Fourier synthesis as determined from patterns obtained via diffraction of a monochromatic beam of X-rays by the atoms (scattering centers) of a polyketide synthase molecule in crystal form. Diffraction data are used to calculate electron density maps of repeating protein units in the crystal (unit cell). Electron density maps are used to establish the positions of individual atoms within a crystal's unit cell. The term “crystal structure coordinates” refers to mathematical coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of X-rays by the atoms (scattering centers) of a synthase polypeptide (e.g., a chalcone synthase protein molecule) in crystal form. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are used to establish the positions of the individual atoms within the unit cell of the crystal. The crystal structure coordinates of a synthase can be obtained from crystals and can also be obtained by means of computational analysis.

[0084] The term “selenomethionine substitution” refers to the method of producing a chemically modified form of the crystal of a synthase (e.g., a chalcone synthase). The synthase protein is expressed by bacteria in media that is depleted in methionine and supplement with selenomethionine. Selenium is thereby incorporated into the crystal in place of methionine sulfurs. The location(s) of selenium are determined by X-ray diffraction analysis of the crystal. This information is used to generate the phase information used to construct a three-dimensional structure of the protein.

[0085] “Heavy atom derivatization” refers to a method of producing a chemically modified form of a synthase crystal. In practice, a crystal is soaked in a solution containing heavy atom salts or organometallic compounds, e.g., lead chloride, gold thiomalate, thirerosal, uranyl acetate, and the like, which can diffuse through the crystal and bind to the protein's surface. Locations of the bound heavy atoms can be determined by X-ray diffraction analysis of the soaked crystal. This information is then used to construct phase information which can then be used to construct three-dimensional structures of the enzyme as described in Blundel, T. L., and Johnson, N. L., Protein Crystallography, Academic Press (1976), which is incorporated by reference herein.

[0086] “Unit cell” refers to a basic parallelepiped shaped block. Regular assembly of such blocks may construct the entire volume of a crystal. Each unit cell comprises a complete representation of the unit pattern, the repetition of which builds up the crystal.

[0087] “Mutagenesis” refers to the changing of one R-group for another as defined herein. This can be most easily performed by changing the coding sequence of the nucleic acid encoding the amino acid residue. In the context of the present invention, mutagenesis does not change the carbon coordinates beyond the limits defined herein.

[0088] “Space Group” refers to the arrangement of symmetry elements within a crystal.

[0089] “Molecular replacement” refers to generating a preliminary model of a polyketide synthase whose structural coordinates are unknown, by orienting and positioning a molecule whose structural coordinates are known within the unit cell of the unknown crystal so as best to account for the observed diffraction pattern of the unknown crystal. Phases can then be calculated from this model and combined with the observed amplitudes to give an approximate Fourier synthesis of the structure whose coordinates are unknown. This in turn can be subject to any of the several forms of refinement to provide a final, accurate structure of the unknown crystal (Lattman, E., 1985, in Methods in Enzymology, 11 5.55-77; Rossmann, M G., ed., “The Molecular Replacement Method” 1972, Int, Sci. Rev. Ser., No. 13, Gordon & Breach, New York). Using structure coordinates of the polyketide synthase provided herein (see e.g., PDB Accession Numbers) molecular replacement may be used to determine the structural coordinates of a crystalline mutant, homologue, or a different crystal form of polyketide synthase.

[0090] A “synthase” or a “polyketide synthase” includes any one of a family of enzymes that catalyze the formation of polyketide compounds. Polyketide synthases are generally homodimers, with each monomer being enzymatically acitve.

[0091] “Substrate” refers to the Coenzyme-A (CoA) thioesters that are acted on by the polyketide synthases and mutants thereof disclosed herein, such as malonyl-CoA, coumaroyl-CoA, hexamoyl-CoA, ACP or NAC thioesters and the like.

[0092] The present invention relates to crystallized polyketide synthases and mutants thereof from which the position of specific α-carbon atoms and R-groups associated therewith comprising the active site can be determined in three-dimensional space. The invention also relates to structural coordinates of said polyketide synthases, use of said structural coordinates to develop structural information related to polyketide synthase homologues, mutants, and the like, and to crystal forms of such synthases. Furthermore, the invention, as disclosed herein, provides a method whereby said α-carbon structural coordinates specifically determined for atoms comprising the active site of said synthase, as shown in Table 1 and including C164, H303, and N336, can be used to develop synthases wherein R-groups associated with active site α-carbon atoms are different from the R-groups found in native CHS, e.g., are mutant synthases. In addition, the present invention provides for production of mutant polyketide synthases based on the structural information of synthases (and provided herein) and for use of said mutant synthases to make a variety of polyketide compounds using a variety of substrates (as described in PCT Application US00/20674, filed Jul. 27, 2000, incorporated by reference in its entirety herein). The present invention also provides methods of producing novel mutant polyketide synthases by comparing the crystal structures of two different polyketide synthases.

[0093] The present invention further provides, for the first time, crystals of several polyketide synthases, as exemplified by chalcone synthase (CHS; PDB Accession No. 1B15), stilbene synthase (STS; Pinus sylvestris, pine—Appendix A; and Arachis hypogaea, peanut—Appendix B), and pyrone synthase (2-PS; PDB Accession No. 1EE0). Also provided are coordinates for crystals which are grown in the presence and absence of substrate, substrate analogues, and products, thus allowing definition of the structural or atomic coordinates associated therewith. Said structural coordinates allow determination of the carbon atoms comprising the active site, R-groups associated therewith, and the interaction of said α-carbons and said R-groups with each other. For example, Table 4 identifies various substrates and products that were grown with chalcone synthase as well as their PDB accession numbers, all of which are incorporated by reference herein in their entirety. TABLE 4 Complex PDB Accession No. CHS-coA complex 1BQ6 CHS-malonyl-CoA complex 1CML CHS-hexanoyl-CoA complex 1CHW CHS-naringenin complex 1CGK CHS-resveratrol complex 1CGZ

[0094] The crystals of the present invention belong to the tetragonal space group. The unit cell dimensions vary by a few angstroms between crystals but on average belong to the space groups with unit cell dimensions as in Table 5. TABLE 5 Crystals of Polyketide Synthases Space Unit Cell Dimensions Crystal Group a (Å) b (Å) c (Å) α (°) β (°) γ (°) CHS P 32 2 1 97.54 97.54 65.52 90.00 90.00 120.00 (alfalfa) STS P2 (1) 57.221 361.291 57.317 90.00 98.39 90.00 (pine) STS P2 (1) 74.348 101.747 113.609 90.00 108.84 90.00 (peanut) 2-PS P 31 2 1 83.41 83.41 240.62 90.00 90.00 120.00 18xCHS P2 (1) 71.638 59.753 82.539 90.00 108.166 90.00

[0095] Crystal structures are preferably obtained at a resolution of about 1.56 angstroms to about 3 angstroms for a polyketide synthase in the presence and in the absence of bound substrate or substrate analog. Coordinates for a polyketide synthase in the absence of a substrate bound in the active site have been deposited at the Protein Data Bank, accession number 1BI5. Those skilled in the art understand that a set of structure coordinates determined by X-ray crystallography is not without standard error. Therefore, for the purpose of this invention, any set of structure coordinates wherein the active site α-carbons of a polyketide synthase, synthase homologue, or mutants thereof, have a root mean square deviation less than ±2.3 angstroms when superimposed using the structural coordinates listed in Table 1 and PDB Accession No. 1BI5, shall be considered identical.

[0096] A schematic representation of the three-dimensional shape of a CHS homodimer is shown in FIG. 2a, which was prepared by MOLSCRIPT (Kraulis, J. Appl. Crystallogr. 24:946-950, 1991). CHS functions as a homodimer of two 42 kDa polypeptides. The structure of CHS reveals that the enzyme forms a symmetric dimer with each monomer related by a 2-fold crystallographic axis. The dimer interface buries approximately 1580 angstroms with interactions occurring along a fairly flat surface. Two distinct structural features delineate the ends of this interface. First, the N-terminal helix of monomer A entwines with the corresponding helix of monomer B. Second, a tight loop containing a cis-peptide bond between Met₁₃₇ and Pro₁₃₈ exposes the methionine sidechain as a knob on the monomer surface. Across the interface, Met₁₃₇ protrudes into a hole found in the surface of the adjoining monomer to form part of the cyclization pocket (discussed below).

[0097] The CHS homodimer contains two functionally independent active sites (Tropf, et al, J. Biol. Chem. 270:7922-7928, 1995). Consistent with this information, bound CoA thioesters and product analogs occupy both active sites of the homodimer in the CHS complex structures. These structures identify the location of the active site at the cleft between the upper and lower domains of each monomer. Each active site consists almost entirely of residues from a single monomer, with Met₁₃₇ from the adjoining monomer being the only exception. A detailed description of the active site structure is presented in the Examples section, below.

[0098] An isolated, polyketide synthase of the invention comprises at least fourteen active site α-carbons having the structural coordinates of Table 1 ±2.3 angstroms. The active site α-carbons of Table 1 generally are not all contiguous, i.e., are not adjacent to one another in the primary amino acid sequence of a polyketide synthase due to intervening amino acid residues between various active site α-carbons. Nevertheless, it should be appreciated that certain active site α-carbons can be adjacent to one another in some instances. Active site α-carbons are numbered in Table 1 for convenience only and may be situated in any suitable order in the primary amino acid sequence that achieves the structural coordinates given in Table 1.

[0099] An appropriate combination of R-groups, linked to active site α-carbons, can facilitate the formation of one or more desired reaction products. The combination of R-groups selected for use in a synthase can be any combination other than the ordered arrangements of R-groups found in known native isolated polyketide synthases. Typically, R-groups found on active site α-carbons are those found in naturally occurring amino acids. In some embodiments, however, R-groups other than those found in naturally occurring amino acids can be used.

[0100] The present invention permits the use of molecular design techniques to design, select, and synthesize mutant polyketide synthases that produce different and/or novel polyketide compounds using the same substrates. Mutant proteins of the present invention and nucleic acids encoding the same can be designed by genetic manipulation based on structural information about polyketide synthases. For example, one or more R-groups associated with the active site α-carbon atoms of CHS can be changed by altering the nucleotide sequence of the corresponding CHS gene, thus making one or more mutant polyketide synthases. Such genetic manipulations can be guided by structural information concerning the R-groups found in the active site α-carbons when substrate is bound to the protein upon crystallization. Alternatively, mutant polyketide syntases can be prepared by standard protocols for polypeptide synthesis as is well known in the art.

[0101] Mutant proteins of the present invention may be prepared in a number of ways available to the skilled artisan. For example, the gene encoding wild-type CHS may be mutated at those sites identified herein as corresponding to amino acid residues identified in the active site by means currently available to the artisan skilled in molecular biology techniques. Said techniques include oligonucleotide-directed mutagenesis, deletion, chemical mutagenesis, and the like. The protein encoded by the mutant gene is then produced by expressing the gene in, for example, a bacterial or plant expression system.

[0102] Alternatively, polyketide synthase mutants may be generated by site specific-replacement of a particular amino acid with an unnaturally occurring amino acid. As such, polyketide synthase mutants may be generated through replacement of an amino acid residue or a particular cysteine or methionine residue with selenocysteine or selenomethionine. This may be achieved by growing a host organism capable of expressing either the wild-type or mutant polypeptide on a growth medium depleted of natural cysteine or methionine or both and growing on medium enriched with either selenocysteine, selenomethionine, or both. These and similar techniques are described in Sambrook et al., (Molecular Cloning, A Laboratory Manual, 2^(nd) Ed. (1989) Cold Spring Harbor Laboratory Press).

[0103] Another suitable method of creating mutant synthases of the present invention is based on a procedure described in Noel and Tsal (1989) J. Cell. Biochem., 40:309-320. In so doing, the nucleic acids encoding said polyketide synthase can be synthetically produced using oligonucleotides having overlapping regions, said oligonucleotides being degenerate at specific bases so that mutations are induced. Alternatively, traditional method of protein or polypeptide synthesis may be used.

[0104] According to the present invention, nucleic acid sequences encoding a mutated polyketide synthase can be produced by the methods described herein, or any alternative methods available to the skilled artisan. In designing the nucleic acid sequence of interest, it may be desirable to reengineer said gene for improved expression in a particular expression system. For example, it has been shown that many bacterially derived genes do not express well in plant systems. In some cases, plant-derived genes do not express well in bacteria. This phenomenon may be due to the non-optimal G+C content and/or A+T content of said gene relative to the expression system being used. For example, the very low G+C content of many bacterial genes results in the generation of sequences minicking or duplicating plant gene control sequences, that are highly A+T rich. The presence of A+T rich sequences within the genes introduced into plants (e.g., TATA box regions normally found in promoters) may result in aberrant transcription of the gene(s). In addition, the presence of other regulatory sequences residing in the transcribed mRNA (e.g. polyadenylation signal sequences (AAUAAA) or sequences complementary to small nuclear RNAs involved in pre-mRNA splicing) may lead to RNA instability. Therefore, one goal in the design of genes is to generate nucleic acid sequences that have a G+C content that affords mRNA stability and translation accuracy for a particular expression system.

[0105] Due to the plasticity afforded by the redundancy of the genetic code (i.e., many amino acids are specified by more than one codon), evolution of the genomes of different organisms or classes of organisms has resulted in differential usage of redundant codons. This “codon bias” is reflected in the mean base composition of protein coding regions. For example, organisms with relatively low G+C contents utilize codons having A or T in the third position of redundant codons, whereas those having higher G+C contents utilize codons having G or C in the third position. Therefore, in reengineering genes for expression, one may wish to determine the codon bias of the organism in which the gene is to be expressed. Looking at the usage of the codons as determined for genes of a particular organism deposited in GenBank can provide this information. After determining the bias thereof, the new gene sequence can be analyzed for restriction enzyme sites as well as other sites that could affect transcription such as exon:intron junctions, polyA addition signals, or RNA polymerase termination signals.

[0106] Genes encoding polyketide synthases can be placed in an appropriate vector, depending on the artisan's interest, and can be expressed using a suitable expression system. An expression vector, as is well known in the art, typically includes elements that permit replication of said vector within the host cell and may contain one or more phenotypic markers for selection of cells containing said gene. The expression vector will typically contain sequences that control expression such as promoter sequences, ribosome binding sites, and translational initiation and termination sequences. Expression vectors may also contain elements such as subgenomic promoters, a repressor gene or various activator genes. The artisan may also choose to include nucleic acid sequences that result in secretion of the gene product, movement of said product to a particular organelle such as a plant plastid (see U.S. Pat. Nos. 4,762,785; 5,451,513 and 5,545,817, which are incorporated by reference herein) or other sequences that increase the ease of peptide purification, such as an affinity tag.

[0107] A wide variety of expression control sequences are useful in expressing the mutated polyketide synthases when operably linked thereto. Such expression control sequences include, for example, the early and late promoters of SV40 for animal cells, the lac system, the trp system, major operator and promoter systems of phage S, and the control regions of coat proteins, particularly those from RNA viruses in plants. In E. coli, a useful transcriptional control sequence is the T7 RNA polymerase binding promoter, which can be incorporated into a pET vector as described by Studier et al., (1990) Methods Enzymology, 185:60-89, which is incorporated by reference herein.

[0108] For expression, a desired gene should be operably linked to the expression control sequence and maintain the appropriate reading frame to permit production of the desired polyketide synthase. Any of a wide variety of well-known expression vectors are of use to the present invention. These include, for example, vectors comprising segments of chromosomal, non-chromosomal and synthetic DNA sequences such as those derived from SV40, bacterial plasmids including those from E. coli such as col E1, pCR1, pBR322 and derivatives thereof, pMB9), wider host range plasmids such as RP4, phage DNA such as phage S, NM989, M13, and other such systems as described by Sambrook et al., (Molecular Cloning, A Laboratory Manual, 2^(nd) Ed. (1989) Cold Spring Harbor Laboratory Press), which is incorporated by reference herein.

[0109] A wide variety of host cells are available for expressing synthase mutants of the present invention. Such host cells include, for example, bacteria such as E. coli, Bacillus and Streptomyces, fungi, yeast, animal cells, plant cells, insect cells, and the like. Preferred embodiments of the present invention include chalcone synthase mutants that are expressed in E. coli or in plant cells. Said plant cells can either be in suspension culture or a transgenic plant as further described herein.

[0110] As stated previously, genes encoding synthases of the present invention can be expressed in transgenic plant cells. In order to produce transgenic plants, vectors containing the nucleic acid construct encoding polyketide synthases and mutants thereof are inserted into the plant genome. Preferably, these recombinant vectors are capable of stable integration into the plant genome. One variable in making a transgenic plant is the choice of a selectable marker. A selectable marker is used to identify transformed cells against a high background of untransformed cells. The preference for a particular marker is at the discretion of the artisan, but any of the selectable markers may be used along with any other gene not listed herein that could function as a selectable marker. Such selectable markers include aminoglycoside phosphotransferase gene of transposon Tn5 (Aph 11) (which encodes resistance to the antibiotics kanamycin), genes encoding resistance to neomycin or G418, as well as those genes which code for resistance or tolerance to glyphosate, hygromycin, methotrexate, phosphinothricin, imidazolinones, sulfonylureas, triazolophyrimidine herbicides, such as chlorosulfuron, bromoxynil, dalapon, and the like. In addition to a selectable marker, it may be desirable to use a reporter gene. In some instances a reporter gene may be used with a selectable marker. Reporter genes allow the detection of transformed cells and may be used at the discretion of the artisan. A list of these reporter genes is provided in K. Wolsing et al., 1988, Ann. Rev. Genetics, 22:421.

[0111] Said genes are expressed either by promoters expressing in all tissues at all times (constitutive promoters), by promoters expressing in specific tissues (tissue-specific promoters), promoters expressing at specific stages of development (developmental promoters), and/or promoter expression in response to a stimulus or stimuli (inducible promoters). The choice of these is at the discretion of the artisan.

[0112] Several techniques exist for introducing foreign genes into plant cells, and for obtaining plants that stably maintain and express the introduced gene. Such techniques include acceleration of genetic material coated on a substrate directly into cells (U.S. Pat. Nos. 4,945,050 to Comell): Plant cells may also be transformed using Agrobacterium technology (see, for example, U.S. Pat. Nos. 5,177,010 to University of Toledo, 5,104,310 to Texas A&M, U.S. Pat. Nos. 5,149,645, 5,469,976, 5,464,763, 4,940,838, and 4,693,976 to Schilperoot, European Patent Applications 116718, 290799, 320500 to Max Planck, European Patent Applications 604662,627752 and U.S. Pat. No. 5,591,616 to Japan Tobacco, European Patent Applications 0267159, 0292435 and U.S. Pat. No. 5,231,019 to Ciba-Geigy, U.S. Pat. Nos. 5,463,174 and 4,762,785 to Calgene, and U.S. Pat. Nos. 5,004,863 and 5,159,135 to Agracetus). Other transformation technologies include whiskers technology (see U.S. Pat. Nos. 5,302,523 and 5,464,765 to Zeneca). Electroporation technology has also been used to transform plants (see WO 87106614 to Boyce Thompson Institute, 5,472,869 and 5,384,253 to Dakalb, and WO 92/09696 and WO 93/21335 to Plant Genetic Systems, all which are incorporated by reference). Viral vector expression systems can also be used such as those described in U.S. Pat. Nos. 5,316,931, 5,589,367, 5,811,653, and 5,866,785 to BioSource, which are incorporated by reference herein.

[0113] In addition to numerous technologies for transforming plants, the type of tissue that is contacted with the genes of interest may vary as well. Suitable tissue includes, for example, embryonic tissue, callus tissue, hypocotyl, meristem, and the like. Almost all plant tissues may be transformed during de-differentiation using the appropriate techniques described herein.

[0114] In addition, it may be desirable to change the polyketide production of a polyketide synthase within a plant. For example, it may be beneficial to increase the production of resveratrol in a plant. Resveratrol, the natural product made by the CHS-related stilbene synthase (STS) enzymes, is an antifungal compound produced in a few families of plants, including pine trees, grapevines, and peanuts. When stilbene synthase is introduced into plants like tobacco or alfalfa, which normally lack this enzyme, the transgenic plant becomes resistant to fungal infection (Mol. Plant Microbe Interact. 13(5):551-62, 2000; and Nature 361(6408):153-6, 1993). Since STS uses the exact same substrates as CHS, which is ubiquitous in higher plants, expression of the STS gene in any of these species should be sufficient to achieve the in vivo biosynthesis of resveratrol.

[0115] Furthermore, resveratrol has also been shown to have a number of beneficial medicinal activities, including copper chelation, anti-oxidant scavenging of free radicals, inhibition of both platelet aggregation and lipid peroxidation, anti-inflammation, vasodilation, anti-cancer (Life Sci. 66(8):663-73, 2000), and the like. These effects of resveratrol contribute to the health benefits of the moderate consumption of red wine, known as “the French paradox”. Red wine has a higher resveratrol content than grape juice or white wine, due to the inclusion of the resveratrol-rich grape skins during the fermentation process.

[0116] Thus, production of resveratrol in plants which lack it is biologically useful for the plant, and medicinally useful for humans who consume the plant. While transgenic introduction of the stilbene synthase gene has proven effective, enzymes are often best-adapted for expression and stability within their own species. The ability to engineer full or partial STS activity into a native CHS of a given species confers the benefits of resveratrol production to that species, while avoiding all of the negative effects of foreign transgene expression.

[0117] The mutants of the present invention show that it is possible to mutate a native CHS to a STS-like activity (see FIG. 14). Furthermore, it is possible to produce the STS product resveratrol to varying degrees with different mutants. Thus, a plant can be manipulated to produce varying levels of resveratrol, without eliminating the production of the chalcone product required for viability.

[0118] Regardless of the transformation system used, a gene encoding a mutant polyketide synthase is preferably incorporated into a gene transfer vector adapted to express said gene in a plant cell by including in the vector an expression control sequence (plant promoter regulatory element). In addition to plant promoter regulatory elements, promoter regulatory elements from a variety of sources can be used efficiently in plant cells to express foreign genes. For example, promoter regulatory elements of bacterial origin, such as the octopine synthase promoter, the nopaline synthase promoter, the mannopine synthase promoter, and the like, may be used. Promoters of viral origin, such as the cauliflower mosaic virus (³⁵S and 198) are also desirable. Plant promoter regulatory elements also include ribulose-1,6-bisphosphate carboxylase small subunit promoter, beta-conglycinin promoter, phaseolin promoter, ADH promoter, heat-shock promoters, tissue specific promoters, and the like. Numerous promoters are available to skilled artisans for use at their discretion.

[0119] It should be understood that not all expression vectors and expression systems function in the same way to express the mutated gene sequences of the present invention. Neither do all host cells function equally well with the same expression system. However, one skilled in the art may make a selection among these vectors, expression control sequences, and host without undue experimentation and without departing from the scope of this invention.

[0120] Once a synthase of the present invention is expressed, the protein obtained therefrom can be purified so that structural analysis, modeling, and/or biochemical analysis can be performed, as exemplified herein. The nature of the protein obtained can be dependent on the expression system used. For example, genes, when expressed in mammalian or other eukaryotic cells, may contain latent signal sequences that may result in glycosylation, phosphorylation, or other post-translational modifications, which may or may not alter function. Therefore, a preferred embodiment of the present invention is the expression of mutant synthase genes in E. coli cells. Once said proteins are expressed, they can be easily purified using techniques common to the person having ordinary skill in the art of protein biochemistry, such as, for example, techniques described in Colligan et al., (1997) Current Protocols in Protein Science, Chanda, V. B., Ed., John Wiley & Sons, Inc., which is incorporated by reference herein. Such techniques often include the use of cation-exchange or anion-exchange chromatography, gel filtration-size exclusion chromatography, and the like. Another technique that may be commonly used is affinity chromatography. Affinity chromatography can include the use of antibodies, substrate analogs, or histidine residues (His-tag technology).

[0121] Once purified, mutants of the present invention may be characterized by any of several different properties. For example, such mutants may have altered active site surface charges of one or more charge units. In addition, said mutants may have altered substrate specificity or product capability relative to a non-mutated polyketide synthase.

[0122] The present invention allows for the characterization of polyketide synthase mutants by crystallization followed by X-ray diffraction. Polypeptide crystallization occurs in solutions where the polypeptide concentration exceeds it solubility maximum (i.e., the polypeptide solution is supersaturated). Such solutions may be restored to equilibrium by reducing the polypeptide concentration, preferably through precipitation of the polypeptide crystals. Often polypeptides may be induced to crystallize from supersaturated solutions by adding agents that alter the polypeptide surface charges or perturb the interaction between the polypeptide and bulk water to promote associations that lead to crystallization.

[0123] Compounds known as “precipitants” are often used to decrease the solubility of the polypeptide in a concentrated solution by forming an energetically unfavorable precipitating layer around the polypeptide molecules (Weber, Advances in Protein Chemistry, 41:1-36, 1991). In addition to precipitants, other materials are sometimes added to the polypeptide crystallization solution. These include buffers to adjust the pH of the solution and salts to reduce the solubility of the polypeptide. Various precipitants are known in the art and include the following: ethanol, 3-ethyl-2-4 pentanediol, and many of the polyglycols, such as polyethylene glycol.

[0124] Commonly used polypeptide crystallization methods include the following techniques: batch, hanging drop, seed initiation, and dialysis. In each of these methods, it is important to promote continued crystallization after nucleation by maintaining a supersaturated solution. In the batch method, polypeptide is mixed with precipitants to achieve supersaturation, the vessel is sealed, and set aside until crystals appear. In the dialysis method, polypeptide is retained in a sealed dialysis membrane that is placed into a solution containing precipitant. Equilibration across the membrane increases the polypeptide and precipitant concentrations thereby causing the polypeptide to reach supersaturation levels.

[0125] In the preferred hanging drop technique (McPherson, J. Biol Chem, 6300-6306, 1976), an initial polypeptide mixture is created by adding a precipitant to a concentrated polypeptide solution. The concentrations of the polypeptide and precipitants are such that in this initial form, the polypeptide does not crystallize. A small drop of this mixture is placed on a glass slide that is inverted and suspended over a reservoir of a second solution. The system is then sealed. Typically, the second solution contains a higher concentration of precipitant or other dehydrating agent. The difference in the precipitant concentrations causes the protein solution to have a higher vapor pressure than the solution. Since the system containing the two solutions is sealed, an equilibrium is established, and water from the polypeptide mixture transfers to the second solution. This equilibrium increases the polypeptide and precipitant concentration in the polypeptide solution. At the critical concentration of polypeptide and precipitant, a crystal of the polypeptide will form.

[0126] Another method of crystallization introduces a nucleation site into a concentrated polypeptide solution. Generally, a concentrated polypeptide solution is prepared and a seed crystal of the polypeptide is introduced into this solution. If the concentration of the polypeptide and any precipitants are correct, the seed crystal will provide a nucleation site around which a larger crystal forms. In preferred embodiments, the crystals of the present invention are formed in hanging drops.

[0127] Some proteins may be recalcitrant to crystallization. However, several techniques are available to the skilled artisan. Quite often the removal of polypeptide segments at the amino or caroxy terminal end of the protein is necessary to produce crystalline protein samples. Said procedures involve either the treatment of the protein with one of several proteases including trypsin, chymotrypsin, substilisin, and the like. This treatment often results in the removal of flexible polypeptide segments that are likely to negatively affect crystallization. Alternatively, the removal of coding sequences from the protein's gene facilitates the recombinant expression of shortened proteins that can be screened for crystallization.

[0128] The crystals so produced have a wide range of uses. For example, high quality crystals are suitable for X-ray or neutron diffraction analysis to determine the three-dimensional structure of a mutant polyketide synthase and to design additional mutants thereof. In addition, crystallization can serve as a further purification method. In some instances, a polypeptide or protein will crystallize from a heterogeneous mixture into crystals. Isolation of such crystals by filtration, centrifugation, etc., followed by redissolving the polypeptide affords a purified solution suitable for use in growing the high-quality crystals needed for diffraction studies. The high-quality crystals may also be dissolved in water and then formulated to provide an aqueous solution having other uses as desired.

[0129] Because synthases may crystallize in more than one crystal form, the structural coordinates of α-carbons of an active site determined from a synthase or portions thereof, as provided by this invention, are particularly useful to solve the structure of other crystal forms of synthases. Said structural coordinates, as provided herein, may also be used to solve the structure of synthases having α-carbons positioned within the active sites in a manner similar to the wild-type, yet having R-groups that may or may not be identical.

[0130] Furthermore, the structural coordinates disclosed herein may be used to determine the structure of the crystalline form of other proteins with significant amino acid or structural homology to any functional domain of a synthase. One method that may be employed for such purpose is molecular replacement. In this method, the unknown crystal structure, whether it is another crystal form of a synthase, a synthase having a mutated active site, or the crystal of some other protein with significant sequence and/or structural homology to a polyketide synthase may be determined using the coordinates given in Table 1. This method provides sufficient structural form for the unknown crystal more efficiently than attempting to determine such information ab initio. In addition, this method can be used to determine whether or not a given polyketide synthase in question falls within the scope of this invention.

[0131] As further disclosed herein, polyketide synthases and mutants thereof may be crystallized in the presence or absence of substrates and substrate analogs. The crystal structures of a series of complexes may then be solved by molecular replacement and compared to that of the wild-type to assist in determination of suitable replacements for R-groups within the active site, thus making synthase mutants according to the present invention.

[0132] All mutants of the present inventions may be modeled using the information disclosed herein without necessarily having to crystallize and solve the structure for each and every mutant. For example, one skilled in the art may use one of several specialized computer programs to assist in the process of designing synthases having mutated active sites relative to the wild-type. Examples of such programs include: GRID (Goodford, 1985, J. Mod. Chem.:28:849-857), MCSS (Miranker and Karplus, 1991, Proteins: Structure, Function and Genetics, 11:29-34); AUTODOCK (Goodsell and Olsen, 1990, Proteins. Structure, Fumtion, and Genetics, 8:195-202); and DOCK (Kuntz et al., 1982, J. Mol Biol:161:269-288), and the like, as well as those discussed in the Examples below. In addition, specific computer programs are also available to evaluate specific substrate-active site interactions and the deformation energies and electrostatic interactions resulting therefrom. MODELLER is a computer program often used for homology or comparative modeling of the three-dimensional structure of a protein. A. Saii & T. L. Blundell. J. Mol. Biol. 234:779-815, 1993. A sequence to be modeled is aligned with one or more known related structures and the MODELLER program is used to calculate a full-atom model, based on optimum satisfaction of spatial restraints. Such restraints can include, inter alia, homologous structures, site-directed mutagenesis, fluorescence spectroscopy, NMR experiments, or atom-atom potentials of mean force.

[0133] The present invention enables polyketide synthase mutants to be made and the crystal structure thereof to be solved. Moreover, by virtue of the present invention, the location of the active site and the interface of substrate therewith permit the identification of desirable R-groups for mutagenesis.

[0134] The three-dimensional coordinates of the polyketide synthase provided herein may additionally be used to predict the activity and or substrate specificity of a protein whose primary amino acid sequence suggests that it may have polyketide synthase activity. The family of CHS-related enzymes is defined, in part, by the presence of four highly conserved amino acid residues, Cys₁₆₄, Phe₂₁₅, His₃₀₃, and Asn₃₃₆. More than 400 enzymes having these conserved residues have been identified to date, including several bacterial proteins. The functions, substrates, and products of many of these enzymes remains unknown. However, by employing the three-dimensional coordinates disclosed herein and computer modeling programs, structural comparisons of CHS can be made with a putative enzyme. Similarities and differences between the two would provide the skilled artisan with information regarding the activity and/or substrate specificity of the putative enzyme. This procedure is demonstrated in the Examples section below.

[0135] Thus, in another embodiment of the invention, there is provided a method of predicting the activity and/or substrate specificity of a putative polyketide synthase comprising (a) generating a three-dimentional representation of a known polyketide synthase using three-dimentional coordinate data, (b) generating a predicted three-dimentional representation of a putative polyketide synthase, and (c) comparing the representation of the known polyketide synthase with the representation of the putative polyketide synthase, wherein the similarities and/or differences between the two representations are predictive of activity and/or substrate specificity of the putative polyketide synthase.

[0136] In a further embodiment of the present invention, there is also provided a method of identifying a potential substrate of a polyketide synthase comprising (a) defining the active site of the polyketide synthase based on the atomic coordinates of said polyketide synthase, (b) identifying a potential substrate that fits the defined active site, and (c) contacting the polyketide synthase with the potential substrate of (b) and determining the activity thereon. Techniques for computer modeling and structural comparisons similar to those described herein for predicting putative polyketide synthase activity and/or substrate specificity can be used to identify novel substrates for polyketide synthases.

[0137] In addition, the structural coordinates and three-dimensional models disclosed herein can be used to design or identify polyketide synthase inhibitors. Using the modeling techniques disclosed herein, potential inhibitor structures can be modeled with the polyketide synthase active site and those that appear to interact therewith can subsequently be tested in activity assays in the presence of substrate.

[0138] Methods of using crystal structure data to design binding agents or substrates are known in the art. Thus, the crystal structure data provided herein can be used in the design of new or improved inhibitors, substrates or binding agents. For example, the synthase polypeptide coordinates can be superimposed onto other available coordinates of similar enzymes to identify modifications in the active sites of the enzymes to create novel products of enzymatic activity or to modulate polyketide synthesis. Alternatively, the synthase polypeptide coordinates can be superimposed onto other available coordinates of similar enzymes which have substrates or inhibitors bound to them to give an approximation of the way these and related substrates or inhibitors might bind to a synthase. Alternatively, computer programs employed in the practice of rational drug design can be used to identify compounds that reproduce interaction characteristics similar to those found between a synthase polypeptide and a co-crystalized substrate. Furthermore, detailed knowledge of the nature of binding site interactions allows for the modification of compounds to alter or improve solubility, pharmacokinetics, etc. without affecting binding activity.

[0139] Computer programs are widely available that are capable of carrying out the activities necessary to design agents using the crystal structure information provided herein. Examples include, but are not limited to, the computer programs listed below:

[0140] Catalyst Databases™—an information retrieval program accessing chemical databases such as BioByte Master File, Derwent WDI and ACD;

[0141] Catalyst/HYPO™—generates models of compounds and hypotheses to explain variations of activity with the structure of drug candidates;

[0142] Ludi™—fits molecules into the active site of a protein by identifying and matching complementary polar and hydrophobic groups;

[0143] Leapfrog™—“grows” new ligands using a genetic algorithm with parameters under the control of the user.

[0144] In addition, various general purpose machines may be used with programs written in accordance with the teachings herein, or it may be more convenient to construct more specialized apparatus to perform the operations. However, preferably the embodiment is implemented in one or more computer programs executing on programmable systems each comprising at least one processor, at least one data storage system (including volatile and non-volatile memory and/or storage elements), at least one input device, and at least one output device. The program is executed on the processor to perform the functions described herein.

[0145] Each such program may be implemented in any desired computer language (including machine, assembly, high level procedural, object oriented programming languages, or the like) to communicate with a computer system. In any case, the language may be a compiled or interpreted language. The computer program will typically be stored on a storage media or device (e.g., ROM, CD-ROM, or magnetic or optical media) readable by a general or special purpose programmable computer, for configuring and operating the computer when the storage media or device is read by the computer to perform the procedures described herein. The system may also be considered to be implemented as a computer-readable storage medium, configured with a computer program, where the storage medium so configured causes a computer to operate in a specific and predefined manner to perform the functions described herein.

[0146] Embodiments of the invention include systems (e.g., internet based systems), particularly computer systems which store and manipulate the coordinate and sequence information described herein. One example of a computer system 100 is illustrated in block diagram form in FIG. 9. As used herein, “a computer system” refers to the hardware components, software components, and data storage components used to analyze the coordinates and sequences as set forth in one or more of Accession Nos. 1BI5, 1D6F, 1D61, 1D6H, 1BQ6, 1CML, 1CHW, 1CGK, 1CGZ, Table 1, and Appendix A. The computer system 100 typically includes a processor for processing, accessing and manipulating the sequence data. The processor 105 can be any well-known type of central processing unit, such as, for example, the Pentium III from Intel Corporation, or similar processor from Sun, Motorola, Compaq, AMD or International Business Machines.

[0147] Typically the computer system 100 is a general purpose system that comprises the processor 105 and one or more internal data storage components 110 for storing data, and one or more data retrieving devices for retrieving the data stored on the data storage components. A skilled artisan can readily appreciate that any one of the currently available computer systems are suitable.

[0148] In one particular embodiment, the computer system 100 includes a processor 105 connected to a bus which is connected to a main memory 115 (preferably implemented as RAM) and one or more internal data storage devices 110, such as a hard drive and/or other computer readable media having data recorded thereon. In some embodiments, the computer system 100 further includes one or more data retrieving device 118 for reading the data stored on the internal data storage devices 110.

[0149] The data retrieving device 118 may represent, for example, a floppy disk drive, a compact disk drive, a magnetic tape drive, or a modem capable of connection to a remote data storage system (e.g., via the internet) etc. In some embodiments, the internal data storage device 110 is a removable computer readable medium such as a floppy disk, a compact disk, a magnetic tape, etc. containing control logic and/or data recorded thereon. The computer system 100 may advantageously include or be programmed by appropriate software for reading the control logic and/or the data from the data storage component once inserted in the data retrieving device.

[0150] The computer system 100 includes a display 120 which is used to display output to a computer user. It should also be noted that the computer system 100 can be linked to other computer systems 125 a-c in a network or wide area network to provide centralized access to the computer system 100.

[0151] Software for accessing and processing the coordinate and sequences described herein, (such as search tools, compare tools, and modeling tools etc.) may reside in main memory 115 during execution.

[0152] For the first time, the present invention permits the use of molecular design techniques to design, select and synthesize novel enzymes, chemical entities and compounds, including inhibitory compounds, capable of binding to a polyketide synthase polypeptide (e.g., a chalcone synthase polypeptide), in whole or in part.

[0153] One approach enabled by this invention, is to use the structure coordinates as set forth in one or more of Accession Nos. 1BI5, 1D6F, 1D6L 1D6H, 1BQ6, 1CML, 1CHW, 1CGK, 1CGZ, 1EE0, Table 1, Appendix A, Appendix B and Appendix C to design new enzymes capable of synthesizing novel and known polyketides. For example, polyketide synthases (PKSs) generate molecular diversity in their products by utilizing different starter molecules and by varying the final size of the polyketide chain. The structural coordinates disclosed herein allow the elucidation of the nature by which PKSs achieve starter molecule selectivity and control polyketide chain length. For example, by comparing the structure of chalcone synthase, which yields a tetraketide product to 2-pyrone synthases which forms a triketide product the invention demonstrated that 2-pyrone synthase maintains a smaller initiation/elongation cavity.

[0154] Accordingly, generation of a chalcone synthase mutant with an active site sterically analogous to 2-pyrone synthase results in the synthesis of a polyketide product of a different size. As discussed more fully below, this invention allows for the strategic development and biosynthesis of more diverse polyketides and demonstrates a structural basis for control of polyketide chain length in other PKss. In addition, the structural coordinates allow for the development of substrates or binding agents that bind to the polypeptide and alter the physical properties of the compounds in different ways, e.g., solubility.

[0155] In another approach a polyketide synthase polypeptide crystal is probed with molecules composed of a variety of different chemical entities to determine optimal sites for interaction between candidate binding molecules (e.g., substrates) and the polyketide synthase (e.g., chalcone synthase).

[0156] In another embodiment, an approach made possible and enabled by this invention, is to screen computationally small molecule data bases for chemical entities or compounds that can bind in whole, or in part, to a polyketide synthase polypeptide or fragment thereof. In this screening, the quality of fit of such entities or compounds to the binding site may be judged either by shape complementarity or by estimated interaction energy. Meng, E. C. et al., J. Comp. Chem., 13:505-524 (1992).

[0157] Because chalcone synthase is a highly representative member of a family of polyketide synthase polypeptides, many of which have similar functional activity, the structure coordinates of chalcone synthase, or portions thereof, as provided by this invention are particularly useful to solve the structure, function or activity of other crystal forms of polyketide synthase molecules. They may also be used to solve the structure of a polyketide synthase or a chalcone synthase mutant.

[0158] One method that may be employed for this purpose is molecular replacement. In this method, the unknown crystal structure, whether it is another polyketide synthase crystal form, a polyketide synthase or chalcone synthase mutant, or a polyketide synthase complexed with a substrate or other molecule, or the crystal of some other protein with significant amino acid sequence homology to any polyketide synthase polypeptide, may be determined using the structure coordinates as provided in one or more of Accession Nos. 1BI5, 1D6F, 1D6L 1D6H, 1BQ6, 1CML, 1CHW, 1CGK, 1CGZ, 1EE0, Table 1, Appendix A, Appendix B or Appendix C. This method will provide an accurate structural form for the unknown crystal more quickly and efficiently than attempting to determine such information ab initio.

[0159] In addition, in accordance with the present invention, a polyketide synthase or chalcone synthase polypeptide mutant maybe crystallized in association or complex with known polyketide synthase binding agents, substrates, products or inhibitors. The crystal structures of a series of such complexes may then be solved by molecular replacement and compared with that of wild-type polyketide synthase molecules. Potential sites for modification within the synthase molecule may thus be identified. This information provides an additional tool for determining the most efficient binding interactions between a polyketide synthase and a chemical entity, substrate, product or compound.

[0160] All of the complexes referred to above may be studied using well-known X-ray diffraction techniques and may be refined to 2-3 Å resolution X-ray data to an R value of about 0.20 or less using computer software, such as X-PLOR (Yale University, 1992, distributed by Molecular Simulations, Inc.). See, e.g., Blundel & Johnson, supra; Methods in Enzymology, vol. 114 and 115, H. W. Wyckoff et al., eds., Academic Press (1985). This information may thus be used to optimize known classes of polyketide synthase substrates or binding agents (e.g., inhibitors), and to design and synthesize novel classes of polyketide synthases, substrates, and binding agents (e.g. inhibitors).

[0161] The design of substrates, compounds or binding agents that bind to or inhibit a polyketide synthase polypeptide according to the invention generally involves consideration of two factors. First, the substrate, compound or binding agent must be capable of physically and structurally associating with a polyketide synthase molecule. Non-covalent molecular interactions important in the association of a polyketide synthase with a substrate include hydrogen bonding, van der Waals and hydrophobic interactions, and the like.

[0162] Second, the substrate, compound or binding agent must be able to assume a conformation that allows it to associate with a polyketide synthase molecule. Although certain portions of the substrate, compound or binding agent will not directly participate in this association, those portions may still influence the overall conformation of the molecule. This, in turn, may have a significant impact on potency. Such conformational requirements include the overall three-dimensional structure and orientation of the chemical entity or compound in relation to all or a portion of the binding site, e.g., active site or accessory binding site of a polyketide synthase (e.g., a chalcone synthase polypeptide), or the spacing between functional groups of a substrate or compound comprising several chemical entities that directly interact with a polyketide synthase.

[0163] The potential binding effect of a substrate or chemical compound on a polyketide synthase or the activity a newly synthesized or mutated polyketide synthase might have on a known substrate may be analyzed prior to its actual synthesis and testing by the use of computer modeling techniques. For example, if the theoretical structure of the given substrate or compound suggests insufficient interaction and association between it and a polyketide synthase, synthesis and testing of the compound may be obviated. However, if computer modeling indicates a strong interaction, the molecule may then be tested for its ability to bind to, initiate catalysis or elongation of a polyketide by a polyketide synthase. Methods of assaying for polyketide synthase activity are known in the art (as identified and discussed herein). Methods for assaying the effect of a newly created polyketide synthase or a potential substrate or binding agent can be performed in the presence of a known binding agent or polyketide synthase. For example, the effect of the potential binding agent can be assayed by measuring the ability of the potential binding agent to compete with a known substrate.

[0164] A mutagenized synthase, novel synthase, substrate or other binding compound of an polyketide synthase may be computationally evaluated and designed by means of a series of steps in which chemical entities or fragments are screened and selected for their ability to associate with binding pockets or other areas of the polyketide synthase.

[0165] One skilled in the art may use one of several methods to screen chemical entities or fragments for their ability to associate with a polyketide synthase and more particularly with the individual binding pockets of a chalcone synthase polypeptide. This process may begin by visual inspection of; for example, the active site on the computer screen based on the coordinates in one or more of Accession Nos. 1BI5, 1D6F, 1D6L 1D6H, 1BQ6, 1CML, 1CHW, 1CGK, 1CGZ 1EE0, Table 1, Appendix A, Appendix B pr Appendix C. Selected fragments or substrates or chemical entities may then be positioned in a variety of orientations, or docked, within an individual binding pocket of a polyketide synthase. Docking may be accomplished using software such as Quanta and Sybyl, followed by energy minimization and molecular dynamics with standard molecular mechanics forcefields, such as CHARMM and AMBER.

[0166] Specialized computer programs may also assist in the process of selecting fragments or chemical entities. These include:

[0167] 1. GRID (Goodford, P. J., “A Computational Procedure for Determining Energetically Favorable Binding Sites on Biologically Important Macromolecules”, J. Med. Chem., 28:849-857 (1985)). GRID is available from Oxford University, Oxford, UK.

[0168] 2. MCSS (Miranker, A. and M. Karplus, “Functionality Maps of Binding Sites: A Multiple Copy Simultaneous Search Method.” Proteins: Structure. Function and Genetics, 11:29-34 (1991)). MCSS is available from Molecular Simulations, Burlington, Mass.

[0169] 3. AUTODOCK (Goodsell, D. S. and A. J. Olsen, “Automated Docking of Substrates to Proteins by Simulated Annealing”, Proteins: Structure. Function, and Genetics, 8:195-202 (1990)). AUTODOCK is available from Scripps Research Institute, La Jolla, Calif

[0170] 4. DOCK (Kuntz, I. D. et al, “A Geometric Approach to Macromolecule-Ligand Interactions”, J. Mol. Biol., 161:269-288 (1982)). DOCK is available from University of California, San Francisco, Calif.

[0171] Once suitable substrates, chemical entities or fragments have been selected, they can be assembled into a single polypeptide, compound or binding agent (e.g. an inhibitor). Assembly may be performed by visual inspection of the relationship of the fragments to each other on the three-dimensional image displayed on a computer screen in relation to the structure coordinates of the molecules as set forth in one or more of Accession Nos. 1BI5, 1D6F, 1D61,1D6H, 1BQ6, 1CML, 1CHW, 1CGK, 1CGZ, 1EE0, Table 1, Appendix A, Appendix B or Appendix C. This would be followed by manual model building using software such as Quanta or Sybyl.

[0172] Useful programs to aid one of skill in the art in connecting the individual chemical entities or fragments include:

[0173] 1. CAVEAT (Bartlett, P. A. et al, “CAVEAT: A Program to Facilitate the Structure-Derived Design of Biologically Active Molecules”. In “Molecular Recognition in Chemical and Biological Problems”, Special Pub., Royal Chem. Soc., 78, pp. 182-196 (1989)). CAVEAT is available from the University of California, Berkeley, Calif.

[0174] 2. 3D Database systems such as MACCS-3D (MDL Information Systems, San Leandro, Calif.). This area is reviewed in Martin, Y. C., “3D Database Searching in Drug Design”, J. Med. Chem., 35:2145-2154 (1992)).

[0175] 3. HOOK (available from Molecular Simulations, Burlington, Mass.).

[0176] In addition to the method of building or identifying novel enzymes or a polyketide synthase substrate or binding agent in a step-wise fashion one fragment or chemical entity at a time as described above, substrates, inhibitors or other polyketide synthase interactions may be designed as a whole or “de novo” using either an empty active site or optionally including some portion(s) of known substrates, binding agents or inhibitors. These methods include:

[0177] 1. LUDI (Bohm, H.-J., “The Computer Program LUDI: A New Method for the De Novo Design of Enzyme Inhibitors”, J. Comp. Aid. Molec. Design, 6:61-78 (1992)). LUDI is available from Biosym Technologies, San Diego, Calif

[0178] 2. LEGEND (Nishibata, Y. and A. Itai, Tetrahedron, 47:8985 (1991)). LEGEND is available from Molecular Simulations, Burlington, Mass.

[0179] 3. LeapFrog (available from Tripos Associates, St. Louis, Mo.).

[0180] Other molecular modeling techniques may also be employed in accordance with this invention. See, e.g., Cohen, N. C. et al., “Molecular Modeling Software and Methods for Medicinal Chemistry”, J. Med. Chem., 33:883-894 (1990). See also, Navia, M. A. and M. A. Murcko, “The Use of Structural Information in Drug Design”, Current Opinions in Structural Biology, 2:202-210 (1992).

[0181] Once a substrate, compound or binding agent has been designed or selected by the above methods, the efficiency with which that substrate, or binding agent may bind to a polyketide synthase may be tested and optimized by computational evaluation.

[0182] A substrate or compound designed or selected as a polyketide binding agent may be further computationally optimized so that in its bound state it would preferably lack repulsive electrostatic interaction with the target site. Such non-complementary (e.g., electrostatic) interactions include repulsive charge-charge, dipole-dipole and charge-dipole interactions. Specifically, the sum of all electrostatic interactions between the binding agent and the polyketide synthase when the binding agent is bound to the synthase, preferably make a neutral or favorable contribution to the enthalpy of binding.

[0183] Specific computer software is available in the art to evaluate compound deformation energy and electrostatic interaction. Examples of programs designed for such uses include: Gaussian 92, revision C (M. J. Frisch, Gaussian, Inc., Pittsburgh, Pa., 1992); AMBER, version 4.0 (P. A. Kollman, University of California at San Francisco, 1994); QUANTA/CHARMM (Molecular Simulations, Inc., Burlington, Mass. 1994); and Insight II/Discover (Biosysm Technologies Inc., San Diego, Calif., 1994). These programs maybe implemented, for example, using a Silicon Graphics workstation, IRIS 4D/35 or IBM RISC/6000 workstation model 550. Other hardware systems and software packages will be known to those skilled in the art of which the speed and capacity are continually modified

[0184] Once a polyketide synthase, polyketide synthase substrate or polyketide synthase binding agent has been selected or designed, as described above, substitutions may then be made in some of its atoms or side groups in order to improve or modify its binding properties. Generally, initial substitutions are conservative, e.g., the replacement group will have approximately the same size, shape, hydrophobicity and charge as the original group. Such substituted chemical compounds may then be analyzed for efficiency of fit to a polyketide synthase substrate or fit of a modified substrate to a polyketide synthase having a structure defined by the coordinates in one or more of Accession Nos. 1BI5, 1D6F, 1D6I, 1D6H, 1BQ6, 1CML, 1CHW, 1CGK, 1CGZ, 1EE0, Table 1, Appendix A, Appendix B, or Appendix C, by the same computer methods described, above.

[0185] Conserved regions of the polyketide family synthases lend themselves to the methods and compositions of the invention. For example, pyrone synthase and chalcone synthase have conserved residues present within their active sites (as described more fully below). Accordingly, modification to the active site of chalcone synthase or a chalcone synthase substrate can be extrapolated to other conserved members of the polyketide family of synthases such as, for example, pyrone synthase.

[0186] Functional fragments of polyketide synthase polypeptides such as, for example, fragments of chalcone synthase can be designed based on the crystal structure and atomic coordinates described herein. Fragments of a chalcone synthase polypeptide and the fragment's corresponding atomic coordinates can be used in the modeling described herein. In addition, such fragments may be used to design novel substrates or modified active sites to create new diverse polyketides.

[0187] In one embodiment of the present invention, the crystal structure and atomic coordinates allow for the design of novel polyketide synthases and novel polyketide synthase substrates. The development of new polyketide synthases will lead to the development a biodiverse repetoir of polyketides for use as antibiotics, anti-cancer agents, anti-fungal agents and other therapeutic agents as described herein or known in the art. In vitro assay systems for production and determination of activity are known in the art. For example, antibiotic activities of novel polyketides can be measured by any number of anti-microbial techniques currently used in hospitals and laboratories. In addition, anticancer activity can be determined by contacting cells having a cell proliferative disorder with a newly synthesized polyketide and measuring the proliferation or apoptosis of the cells before and after contact with the polyketide. Specific examples of apoptosis assays are provided in the following references: Lymphocyte: C. J. Li et al., Science, 268:429-431, 1995; D. Gibellini et al., Br. J. Haematol. 89:24-33, 1995; S. J. Martin et al., J. Immunol. 152:330-42, 1994; C. Terai et al., J. Clin Invest. 87:1710-5, 1991; J. Dhein et al., Nature 373:438441, 1995; P. D. Katsikis et al., J. Exp. Med. 1815:2029-2036, 1995; Michael O. Westendorp et al., Nature 375:497, 1995; DeRossi et ad, Virology 198:234-44, 1994. Fibroblasts: H. Vossbeck et al., Int. J. Cancer 61:92-97, 1995; S. Gomppi et al., Oncogene 9:1537-44, 1994; A. Fernandez et al., Oncogene 9:2009-17, 1994; E. A. Harrington et al., Embo J. 13:3286-3295, 1994; N. Itoh et al., J. Biol. Chem. 268:10932-7, 1993. Neuronal Cells: G. Melino et al., Mol. Cell. Biol. 14:6584-6596, 1994; D. M. Rosenbaum et al., Ann. Neurol. 36:864-870, 1994; N. Sato et al., J. Neurobiol 25:1227-1234, 1994; G. Ferrari et al., J. Neurosci. 1516:2857-2866, 1995; A. K. Talley et al., Mol. Cell Biol. 1585:2359-2366, 1995; A. K. Talley et al., Mol. and Cell. Biol. 15:2359-2366, 1995; G. Walkinshaw et al., J. Clin. Invest. 95:2458-2464, 1995. Insect Cells: R. J. Clem et al., Science 254:1388-90, 1991; N. E. Crook et al., J. Virol. 67:2168-74, 1993; S. Rabizadeh et al., J. Neurochem. 61:2318-21, 1993; M. J. Birnbaum et al., J. Virol 68:2521-8, 1994; R. J. Clem et al., Mol. Cell. Biol. 14:5212-5222, (1994). Other assays are well within the ability of those of skill in the art.

[0188] Product of novel polyketides or polyketide synthases can be carried out in culture. For example, mammalian expression constructs carrying polyketide synthases can be introduced into various cell lines such as CHO, 3T3, HL60, Rat-1, or Jurkart cells, for example. In addition, SF21 insect cells may be used in which case the polyketide synthase gene is expressed using an insect heat shock promotor.

[0189] In another embodiment of the present invention, there is provided a method of designing a mutant polyketide synthese. The method include comparing a crystal structure of a wild type polyketide synthase with the crystal structure of a second polyketide synthase and substituting one or more animo acids with the amino acid residues at homologous positions in the second polyketide synthase. Invention methods can guide the required areas or active sites, and second tier interaction residues for synthase activity. Such areas can be mutated to modify one synthase to resemble another synthase, thereby allowing production of a product not typically synthesized by the wild type enzyme.

[0190] In another embodiment of the present invention, once a novel substrate or binding agent is developed by the computer methodology discussed above, the invention provides a method for determining the ability of the substrate or agent to be acted upon by a polyketide synthase. The method includes contacting components comprising the substrate or agent and a polyketide synthase polypeptide, or a recombinant cell expressing a polyketide synthase polypeptide, under conditions sufficient to allow the substrate or agent to interact and determining the affect of the agent on the activity of the polypeptide. The term “affect”, as used herein, encompasses any means by which protein activity can be modulated, and includes measuring the interaction of the agent with the polyketide synthase molecule by physical means including, for example, fluorescence detection of the binding of an agent to the polypeptide. Such agents can include, for example, polypeptides, peptidomimetics, chemical compounds, small molecules, substrates and biologic agents as described herein. Examples of small molecules include but are not limited to small peptides or peptide-like molecules.

[0191] Contacting or incubating includes conditions which allow contact between the test agent or substrate and a polyketide synthase or modified polyketide synthase polypeptide or a cell expressing a polyketide synthase or modified polyketide synthase polypeptide. Contacting includes in solution and in solid phase. The substrate or test agent may optionally be a combinatorial library for screening a plurality of substrates or test agents. Agents identified in the method of the invention can be further evaluated by chromatography, cloning, sequencing, and the like.

[0192] Although methods and materials similar or equivalent to those described herein can be used to practice the invention, suitable methods and materials are described below. All publications, patent applications, patents and other references mentioned herein are incorporated by reference in their entirety. The invention is described in greater detail by reference to the following non-limiting examples.

EXAMPLES

[0193] Mutagenesis expression and purification Alfalfa CHS2 cDNA (Junghans, H., et al., Plant Mol. Biol. 22:239-253, 1993) was subcloned into pI-HS8 plasmid vector derived from pET-28a(+) (Novagen). PCR-based mutagenesis using the QuikChange system (Stratagene) generated the various mutants including C₁₆₄S, C₁₆₄D, H₃₀₃A, H₃₀₃Q, H₃₀₃D, H₃₀₃T, N₃₃6A, N₃₃₆D, N₃₃₆Q, N₃₃6H, F₂₁₅S, F₂₁₅Y and F₂₁₅W. N-terminal His8-tagged CHS was expressed in BL21 (DE3) E. coli cells. Cells were harvested and lysed by sonication. His-tagged CHS was purified from bacterial sonicates using a NI-NTA (Qiagen) column. Thrombin digest removed the His-tag and the protein was passed over another NI-NTA column and a benzamidine-Sepharose (Pharmacia) column. The final purification step used a Superdex 200 16/60 (Pharmacia) column.

[0194] Crystallization. CHS crystals (wild-type and C₁₆₄S mutant) were grown by vapor diffusion at 4° C. in 2 μl drops containing a 1:1 mixture of 25 mg/ml protein and crystallization buffer (2.2-2.4 M ammonium sulfate and 0.1 M PIPES, pH 6.5) in the presence or absence of 5 mM DTT. Prior to freezing at 1050 K, crystals were stabilized in 40% (v/v) PEG400, 0.1 M PIPES (pH 6.5), and 0.050-0.075 M ammonium sulfate. This cryoprotectant was used for heavy atom soaks. Likewise, all substrate and product analog complexes were obtained by soaking crystals in cryoprotectant containing 10-20 mM of the compound.

[0195] STS from Pinus sylvestris was crystallized using 13-14% PEG 8000, 0.3M ammonium acetate, 0.1M HEPES buffer (pH 7.4) at 4° C. Crystals were soaked for 60 seconds in the same solution plus 10% glycerol.

[0196] STS from Arachis hypogaea was crystallized using 14% PEG 8000, 0.1M MOPSO buffer (pH 7.0), with 3% ethylene glycol at 4° C. Crystals were soaked for 30 seconds in the same solution plus 10% ethylene glycol.

[0197] 18xCHS mutant was crystallized using 21% PEG 8000, 0.3M ammonium acetate, 0.1M HEPES buffer (pH 7.5) at 4° C. Crystals were soaked for 60 seconds in the same solution plus 10% glycerol.

[0198] Data Collection and Processing, X-ray diffraction data were collected at 105° K using a DIP2000 imaging plate system (Mac-Science Corporation, Japan) and CuK radiation produced by a rotating anode operated at 45 kV and 100 mA and equipped with double focusing Pt/Ni coated mirrors. Native CHS crystals belong to space group P3₂21 with unit cell dimensions of a=b=97.54 Å; c=65.52 Å with a single monomer per asymmetric unit. Data were indexed and integrated using DENZO (Otwinowski & Minor, Meth. Enzymol. 276:307-326, 1997) and scaled with SCALEPACK (Otwinowski & Minor, Meth. Enzymol. 276:307-326, 1997). The heavy atom derivative datasets were scaled against the native dataset with SCALEIT (CCP4 Suite: Programs for protein crystallography, Acta Crystallogr. D 50:760-763, 1994).

[0199] Structure determination. MIRAS was used to solve the structure of native CHS using native data set 1 (1.8 Å). Initial phasing was performed with derivative datasets including reflections to 2.3 Å resolution. Heavy atom positions for the Hg(OAc)₂ derivative were estimated by inspection of difference Patterson maps using the program XTALVIEW (McRee, J. Mol. Graph. 10:44-46, 1992) and initially refined with MLPHARE (Otwinowski, Z. in CCP4 Proc. 80-88, Daresbury Laboratory, Warrington, UK, 1991). Heavy atom positions for the additional derivative data sets were determined by difference Fourier analysis using phases calculated from the Hg(OAc)₂ data set and the Hg positions. These sites were confirmed by inspection of difference Patterson maps. Final refinement of heavy atom parameters, identification of minor heavy atom binding sites, and phase-angle calculations were performed with the program SHARP (de La Fortelle, & Bricogne, Meth. Enzymol. 276:472-494, 1997). MIRAS phases were improved and extended to 1.8 Å by solvent flipping using the CCP4 program SOLOMON (Abrahams and Leslie, Acta Crystallogr. D 52:30-42, 1996).

[0200] Model building and refinement The program 0 (Jones, et al., Acta Crystallogr. D 49:148-157, 1993) was used for model building and graphical display of the molecules and electron-density maps. The experimental map for the native 1 dataset at 1.8 Å was of high quality and allowed unambiguous modeling of residues 3 to 389. The model was first refined with REFMAC (Murshudov, et al., Acta Crystallogr. D 53:240-255, 1997) and ARP (Lamzin and Wilson, Acta Crystallogr. D 49:129-147, 1993) against the native 1 dataset. This was followed by manual adjustments using I2F_(o)-F_(c)1 difference maps. Water molecules introduced by ARP were edited using the I2F_(o)-F_(c)1 and IF_(o)-F_(c)1 maps. A second refinement with SHELX-97 (Sheldrick & Schneider, Meth. Enzymol. 277:319-343, 1997) was then carried out against the native 2 data set to 1.56 Å resolution. Structures of CHS complexed with naringenin and resveratrol and the C₁₆₄S mutant complexed with malonyl- and hexanoyl-CoA were obtained using difference Fourier methods and were refined with REFMAC and ARP. All structures were checked with PROCHECK (Laskowski, et al., J. Appl Crystallogr. 26:283-291, 1993). 91.3% of the residues in CHS are in the most favored regions of the Ramachandran plot, 8.4% in the additional allowed region, and 0.3% in the generously allowed region.

[0201] Three Dimensional Structure Determination and Description

[0202] Recombinant alfalfa CHS2 was expressed in E. coli, affinity purified using an N-terminal poly-His linker, and crystallized. The structure of wild-type CHS was determined using multiple isomorphous replacement supplemented with anomalous scattering (MIRAS). The final 1.56 Å resolution apoenzyme model of CHS included 2982 protein atoms and 355 water molecules. In addition, the structures of a series of complexes were obtained by difference Fourier analysis. First, a crystal of a mutant (C₁₆₄S) was soaked with malonyl-CoA. This mutant retains limited catalytic activity, and the resulting acetyl-CoA complex yields insight on the decarboxylation reaction. The same mutant was also complexed with hexanoyl-CoA to mimic the structure of a linear polyketide-CoA reaction intermediate. Finally, two product analogs, naringenin and resveratrol (see FIG. 1) were complexed with CHS to provide information on how the enzyme governs sequential addition of acetates to the coumaroyl moiety and how CHS controls the stereochemistry of the polyketide cyclization reaction. In plants, chalcone isomerase rapidly and stereospecifically converts chalcone to naringenin ((−)(2S)-5,7,4′-trihydroxyflavanone) through an additional ring closure. This reaction also occurs at a slower rate and non-stereospecifically in solution. As such, naringenin provides a suitable mimic of the CHS reaction product. Finally, since STS uses the same substrates as CHS but a different cyclization pathway for the biosynthesis of resveratrol, resveratrol was also soaked into CHS to investigate the structural features governing cyclization of the same substrates into two different products.

[0203] CHS functions as a homodimer of two 42 kDa polypeptides. The structure of CHS revealed that the enzyme forms a symmetric dimer with each monomer related by a 2-fold crystallographic axis (see FIG. 2). The dimer interface buries approximately 1580 Å² with interactions occurring along a fairly flat surface. Two distinct structural features delineate the ends of this interface. First, the N-terminal helix of monomer A entwines with the corresponding helix of monomer B. Second, a tight loop containing a cis-peptide bond between Met₁₃₇ and Pro₁₃₈ exposes the methionine sidechain as a knob on the monomer surface. Across the interface, Met₁₃₇ protrudes into a hole found in the surface of the adjoining monomer to form part of the cyclization pocket.

[0204] Each CHS monomer consists of two structural domains. The upper domain exhibits an xBxBx pseudo-symmetric motif originally observed in thiolase from Saccharomyces cerevisiae (Mathieu, et al, Structure 2:797-808, 1994). The upper domains of CHS and thiolase are superimposeable with a r.m.s. deviation of 3.3 Å for 266 equivalent C-atoms. Both enzymes use a cysteine as a nucleophile and shuttle reaction intermediates via CoA molecules. However, CHS condenses a p-coumaroyl- and three malonyl-CoA molecules through an iterative series of reactions, whereas thiolase generates two acetyl-CoA molecules from acetoacetyl-CoA and free CoA. The drastic structural differences in the lower domain of CHS create a larger active site than that of thiolase and provide space for the polyketide reaction intermediates required for chalcone formation.

[0205] The CHS homodimer contains two functionally independent active sites. Consistent with this information, bound CoA thioesters and product analogs occupy both active sites of the homodimer in the CHS complex structures. These structures identify the location of the active site at the cleft between the upper and lower domains of each monomer. Each active site consists almost entirely of residues from a single monomer with Met₁₃₇ from the adjoining monomer being the only exception. There are remarkably few chemically reactive residues in the active site. Four residues conserved in all the known CHS-related enzymes (Cys₁₆₄, Phe₂₁₅, His₃₀₃, and Asn₃₃₆) define the active site. Cys₁₆₄ apparently serves as the nucleophile and as the attachment site for polyketide intermediates as previously suggested for both CHS and STS (Lanz, et al, J. Biol. Chem. 266:9971-9976, 1991). His₃₀₃ most likely acts as a general base during the generation of a nucleophilic thiolate anion from Cys₁₆₄, since the Nγ of His₃₀₃ is within hydrogen bonding distance of the sulfur of Cys₁₆₄. Phe₂₁₅ and Asn₃₃₆ may function in the decarboxylation reaction, as discussed below. Topologically, three interconnected cavities intersect with these four residues and form the active site architecture of CHS. These cavities include a CoA-binding tunnel, a coumaroyl-binding pocket, and a cyclization pocket.

[0206] The CoA-binding tunnel is 16 angstroms long and links the surrounding solvent with the buried active site. Binding of the CoA moiety in this tunnel positions substrates at the active site, as observed in the C₁₆₄S mutant (described in greater detail below) complexed with malonyl- or hexanoyl-CoA. The conformation of the CoA molecules bound to CHS resembles that observed in other CoA binding enzymes. The adenosine nucleoside is in the 2′-endo conformation with an anti-glycosidic bond torsion angle. At the tunnel entrance, Lys₅₅, Arg₅₈, and Lys₆₂ hydrogen bond with two phosphates of CoA. Apart from these interactions, and an additional hydrogen bond between the backbone amide nitrogen of Ala₃₀₈ and the first carbonyl of the pantetheine moiety, van der Waals contacts dominate the remaining interactions between CHS and CoA. The pantetheine arm of the CoA extends into the enzyme positioning the terminally bound thioester-linked substrates near Cys₁₆₄.

[0207] Both naringenin and resveratrol bind at the active site end of the CoA-binding tunnel. The interactions observed in the naringenin and resveratrol complexes define the coumaroyl-binding and cyclization: pockets. The space to the lower left of the CoA-binding tunnel's end serves as the coumaroyl-binding pocket. Residues of this pocket (Ser₁₃₃, Glu₁₉₂, Thr₁₉₄, Thr₁₉₇, and Ser₃₃₈) surround the coumaroyl-derived portion of the bound naringenin and resveratrol molecules and interact primarily through van der Waals contacts. However, the carbonyl oxygen of Gly₂₁₆ hydrogen bonds to the phenolic oxygen of both naringenin and resveratrol and the hydroxyl of Thr₁₉₇ interacts with the carbonyl of naringenin derived from coumaroyl-CoA. The identity of the residues in this pocket likely contributes to the preference for coumaroyl-CoA as a substrate for parsley CHS over other cinnamoyl-CoA starter molecules, like caffeoyl- or feruloyl-CoA.

[0208] In both the naringenin and resveratrol complexes, the malonyl-derived portion of each molecule occupies a large pocket adjacent to Cys164 suggesting this is where the polyketide reaction intermediate cyclizes into the new ring system and where aromatization of the ring occurs. The six-carbon chain of hexanoyl-CoA also binds in this pocket. Physically, the size of the pocket limits the number of acetate additions to three. Phe₂₆₅ separates the coumaroyl-binding site from the cyclization pocket and may function as a mobile steric gate during successive rounds of polyketide elongation. Although a polyketide possesses a number of hydrogen bond acceptors through which specific interactions could aid in proper folding for the cyclization reaction, the residues of the cyclization pocket, including Thr₁₃₂, Met₁₃₇, Phe₂₁₅, Ile₂₅₄, Gly₂₅₆, Phe₂₆₅, and Pro₃₇₅, provide few potential hydrogen bond donors. As in the coumaroyl-binding pocket, van der Waals contacts dominate the interaction between CHS and both naringenin and resveratrol. Thus, the surface topology of the cyclization pocket dictates how the malonyl-derived portion of the polyketide is folded and how the stereochemistry of the cyclization reaction leading to chalcone formation in CHS and resveratrol formation in STS is controlled.

[0209] Reaction Mechanism

[0210] The position of the CoA thioesters and product analogs in the CHS active site suggest binding modes for substrates and intermediates in the polyketide elongation mechanism that are consistent with the known product specificity of CHS. In addition, the stereochemical features of the substrate and product analog complexes elucidate the roles of Cys₁₆₄, Phe₂₁₅, His₃₀₃, and Asn₃₃₆ in the reaction mechanism. Utilizing structural constraints derived from the available complexes, the following reaction sequence is proposed (see FIG. 6).

[0211] In the mechanism, binding of p-coumaroyl-CoA initiates the CHS reaction. Functional and structural evidence supports a coumaroyl-first mechanism over a malonyl-first one. Cerulenin, a potent irreversible inhibitor of CHS, covalently modifies Cys₁₆₄ in CHS (Lanz, et al., J. Biol. Chem. 266:9971-9976, 1991). Preincubation of CHS with coumaroyl-CoA prevents inactivation by cerulenin, but pre-incubation with malonyl-CoA does not (Preisig-Mueller, et al., Biochemistry 36:8349-8358, 1997). Also, the location of the coumaroyl-derived portion of naringenin and resveratrol in the CHS complexes agrees with a coumaroyl first mechanism, since the presence of a triketide reaction intermediate attached to Cys₁₆₄ would limit access to the coumaroyl-binding pocket.

[0212] After p-coumaroyl-CoA binds to CHS, Cys₁₆₄, activated by His₃₀₃, attacks the thioester linkage, transferring the coumaroyl moiety to Cys₁₆₄ (Monoketide Intermediate). Asn₃₃₆ hydrogen bonds with the carbonyl oxygen of the thioester further stabilizing formation of the tetrahedral reaction intermediate. CoA then dissociates from the enzyme, leaving a coumaroyl-thioester at Cys₁₆₄. Binding of the first malonyl-CoA positions the bridging methylene carbon of the malonyl moiety near the carbonyl carbon of the covalently attached coumaroyl-thioester. Decarboxylation of malonyl-CoA leads to carbanion formation. Resonance between the keto and enol species stabilizes the carbanion. Attack of this carbanion on the coumaroyl-thioester releases the thiolate anion of Cys₁₆₄ and transfers the coumaroyl group to the acetyl moiety of the CoA thioester (Diketide CoA Thioester). Capture of this elongated diketide-CoA by Cys₁₆₄ and release of CoA sets the stage for two additional rounds of elongation resulting in formation of the tetraketide reaction intermediate.

[0213] Asn₃₃₆ appears to play a crucial role in the decarboxylation reaction. Structural evidence shows that the decarboxylation reaction does not require transfer of the malonyl moiety to Cys₁₆₄ as originally indicated by CO₂ exchange assays. Decarboxylation occurs without Cys₁₆₄, since the C₁₆₄S mutant produces acetyl-CoA as determined crystallographically and confirmed by a functional assay. In the hexanoyl-CoA complex, the side chain amide of Asn₃₃₆ provides a hydrogen bond to the carbonyl oxygen of the thioester. This interaction would stabilize the enolate anion resulting from decarboxylation of malonyl-CoA (see FIG. 6). At the same time, the lack of formal positive charge at Asn₃₃₆ may preserve the partial carbanion character of this resonance-stabilized anion, and thus the nucleophilicity of the carbanion form.

[0214] The role of Phe₂₁₅ in the catalytic mechanism is subtler than that of Asn₃₃₆. Its position in both CoA complexes suggests that it provide van der Waals interactions for substrate binding. However, its conservation in bacterial enzymes related to CHS that do not make flavonoids or stilbenes may indicate a more general catalytic role for Phe₂₁₅. Its position near the acetyl moiety of the malonyl-CoA complex suggests that it participates in decarboxylation by favoring conversion of the negatively charged carboxyl group to a neutral carbon dioxide molecule.

[0215]FIG. 7A depicts the addition of the third malonyl-CoA molecule as a three-dimensional model. The position of the coumaroyl ring in the modeled triketide intermediate is as observed in the naringenin and resveratrol complexes. The coumaroyl-binding pocket locks this moiety in position, while the acetate units added in subsequent chain extension steps bend to fill the cyclization pocket. The backbone of bound hexanoyl-CoA provides a guide for modeling the triketide reaction intermediate attached to Cys₁₆₄. Based on the observed acetyl-CoA complex, a rotation of the acetyl group would place the terminal methylene of the decarboxylated malonyl-CoA in position for nucleophilic attack on the triketide thioester linkage resulting in formation of a tetraketide CoA thioester.

[0216] The cyclization reaction catalyzed by CHS is an intramolecular Claisen condensation encompassing the three acetate units derived from three malonyl-CoAs. During cyclization, the nucleophilic methylene group nearest the coumaroyl moiety attacks the carbonyl carbon of the thioester linked to Cys₁₆₄. Ring closure proceeds through an internal proton transfer from the nucleophilic carbon to the carbonyl oxygen. Modeling of the tetraketide intermediate in a conformation leading to chalcone formation places one of the acidic protons of the nucleophilic carbon (C6) proximal to the target carbonyl (C1) (see FIG. 7B). Since there is no base capable of proton abstraction from the tetraketide, it is proposed that the intermediate itself provides the driving force for carbanion formation. Protonation of the carbonyl oxygen would also stabilize the negative charge on the tetrahedral intermediate. Breakdown of this tetrahedral intermediate expels the newly cyclized ring system from Cys₁₆₄. Subsequent aromatization of the trione ring through a second series of facile internal proton transfers yields chalcone.

[0217] Although the cyclization reaction has been modeled as occurring via a polyketide intermediate attached to Cys₁₆₄, it is possible that the reaction proceeds when the polyketide is attached to CoA. The rate of cyclization versus the rate of reattachment to Cys₁₆₄ would dictate which of the two cyclization alternatives is mechanistically preferred.

[0218] An important question in the biosynthesis of chalcones concerns the exchangeability of the polyketide reaction intermediates. In the presence of chalcone reductase (CHR), CHS produces 6-deoxychalcone (Welle & Grisebach, FEBS Lett. 236:22-225, 1988). Mechanistically, CHR must reduce a ketone on the polyketide intermediate before cyclization occurs. Based on the CHS structure, any polyketide attached to Cys₁₆₄ would be inaccessible to CHR unless a drastic structural change occurs in CHS upon interaction with CHR. While this conformational change is possible, such a change is difficult to imagine given the buried nature of the CHS active site. This would argue for the presence of moderately exchangeable polyketide-CoA reaction intermediates. Consistent with this idea, a recently identified CHS-like enzyme from Pinus strobus involved in the biosynthesis of C-methylated chalcones is active only with a starter molecule that is sterically analogous to the diketide-CoA intermediate postulated to be formed after the first condensation reaction in CHS30. These results suggest that the enzymes involved in the biosynthesis of plant polyketides may require specific localization in the plant cell to allow efficient channeling of intermediates from one enzyme to another during the production of particular products.

[0219] Cyclization Specificity of CHS and STS

[0220] Elucidation of the structure of CHS provided mechanistic insight and active site configuration for CHS reaction. Homology modeling and sequence alignments suggested evolutionary functional divergence of CHS superfamily (type In PKSs) occurs via the the preservation of catalytic residues while using steric variation of other active site residues. Elucidation of the structure of 2-PS confirms the above ‘steric modulation’ model, by revealing substrate and product specificity differences achieved by only three active site mutations, as suggested by homology model of 2-PS based upon CHS 3D structure.

[0221] However, with these structures alone, the structural cause/determinants of the alternate cyclization seen in the stilbene synthase (STS) subfamily of CHS-like enzymes remained unknown. STS makes the same tetraketide intermediate as CHS, but cyclizes it differently (C2->C7 attack instead of C6->C1). STS evolved from CHS independently at least three times, with no clear STS consensus sequence.

[0222] Elucidation of the structure of pine (Pinus sylvestris) STS according to the present invention reveals a similar active site configuration, with minor differences. Furthermore, an 18xCHS mutant encompassing observed STS structural backbone differences proves to have activity and kinetics similar to STS (see FIG. 18), confirming that observed structural differences between CHS and STS are relevant to mechanistic differences.

[0223] It was further determined that ten of the eighteen mutations in 18xCHS prove to be neutral (not related to functional conversion, i.e. an alteration in CHS activity), and an 8xCHS mutant with similar STS-like activity is made. All of the 8xCHS changes are clustered in a single area, although encoded on three different stretches of primary sequence (see FIG. 19). This area is thus implicated as important for STS-like versus CHS-like cyclization.

[0224] Elucidation of the structure of peanut (Arachis hypogaea) STS, as well as of the 18xCHS engineered STS, show similar three-dimensional conformational changes in the area implicated by the 8xCHS mutagenic conversion of CHS to STS (see FIG. 20). This implies that a single 3D solution to the CHS to STS conversion problem has been found by all three STS subfamilies, despite variation in primary sequence. A compensatory increase in bulkiness at CHS residue 98 seems to be involved in all three families of STS.

[0225] A closer look at where the altered region meets the active site (see FIG. 22) reveals a consistent change in STS-like enzymes that suggests a cyclization switch mechanism (see FIG. 21), involving movement of Thr132 to allow a hydrogen-bond chain to transfer an electron from Glu192, through Thr132 and a water (bonded to Ser 338). This electron is proposed to encourage hydrolysis of the tetraketide intermediate off of the catalytic cysteine, where decarboxylation of the terminal carboxyl group drives the STS reaction toward a C2->C7 cyclization. In CHS, this hydrolysis does not occur, and so the C6->C1 cyclization is encouraged, as it serves to break the thioester bond to cysteine.

[0226] To test this proposed mechanism, various mutations were made in the 18xCHS engineered STS enzyme, in an attempt to revert the product specificity back to that of CHS, without reversing the other structural changes. Single mutations designed to disrupt only the hydrogen-bonding character in the relevant region succeeded in reverting 18CHS's activity from STS-like to CHS-like. A few of these mutants produce almost equal amounts of resveratrol and chalcone, which might be useful when engineered into a plant. This way, the beneficial resveratrol antifungal natural product could be made, without completely abrogating the vital CHS-like activity necessary in plants.

[0227] The residue implicated as the crucial base for STS-like behavior (Glu192) is not altered in STS. Instead, the adjacent Thr132 changes positions. As a further test of the proposed aldol mechanism, the residue equivalent to CHS Glu192 was mutated to Gln in both the pine and peanut STS wild type enzymes. As predicted, both of these single mutants made more chalcone and less resveratrol than the wild type STS enzymes. The ratio of products supports the proposed mechanism. The decrease in overall activity of these mutants is due to the fact that Glu192 is also important for folding and/or stability, apart from its role in cyclization specificity.

[0228] Structural Basis for Functionally Novel CHS-Like Enzymes

[0229] Absolute conservation of Cys₁₆₄, Phe₂₁₅, His₃₀₃, and Asn₃₃₆ occurs in CHS-like sequences, including several bacterial proteins possessing very low (typically 20-30%) amino acid sequence identity. Moreover, all CHS-like proteins exhibit strong conservation of residues shaping the geometry of the active site. Although the functions of the bacterial CHS-like proteins remain unknown, these enzymes likely form polyketides or polyketide-CoA thioesters in a manner resembling CHS. However, steric differences resulting from sequence variation in both the coumaroyl-binding pocket and the cyclization pocket strongly suggest alternate substrate and product specificity in the bacterial enzymes.

[0230] The sequence databases include approximately 150 plant enzyme sequences classified as CHS like proteins. The substrate and product specificity of a majority of these sequences remains to be determined. In addition, the high sequence similarity of all plant sequences complicates classification of these sequences as authentic CHS, STS, ACS, or BBS enzymes. The information provided by the three-dimensional structure of CHS should make new substrate and product specificity more readily discernible from sequence information.

[0231] To illustrate the usefulness of structural information in identifying potentially new activities, a CHS-related sequence from Gerbera hybrids (GCHS2)₃₂ that is 74% identical with alfalfa CHS2 was examined. Modeling the active site architecture of GCHS2 using the structure of alfalfa CHS2 as a template indicates that GCHS2 will not catalyze either the CHS-like or STS-like reaction (see FIG. 8). This variation in reaction specificity results from striking steric differences in the coumaroyl binding and cyclization pockets that substantially reduce the volume of both pockets from 923 Å³ in CHS to 269 Å³ in GCHS2. Side chain variation at positions 197 and 338 alter the coumaroyl binding pocket, while the identity of residue 256 dictates major steric changes in the cychzation pocket. The reduced size of these pockets in GCHS2 suggests that fewer than three acetate additions will occur, and that a CoA thioester with an acyl moiety smaller than p-coumaroyl initiates the reaction. Recent functional characterization of GCHS2 confirms this prediction and demonstrates that this enzyme uses acetyl-CoA or benzoyl-CoA and two condensation reactions with malonyl-CoA to form pyrone products (Eckermann, et al., Nature 396:397-396, 1998).

[0232] Crystallization of Additional Polyketide Synthases

[0233] Stilbene synthase from Pinus sylvestris was overexpressed in E. coli as an octahistidyl N-terminal fusion protein, purified to >90% homogeneity by metal affinity and gel filtration chromatography, and crystallized in the preparation lacking the N-terminal polyhistidine tag (removed by thrombin cleavage) from 13% (w/v) polyethylene glycol (PEG8000), 0.05 M MOPSO, 0.3 M ammonium acetate at pH 7.0. This STS is 396 amino acids in length and, like alfalfa CHS exists as a homodimer in solution. The structural coordinates of this pine STS are presented in Appendix A. STS from Arachis hypogaea was similarly expressed and crystallized. The structural coordinates of this peanut STS are presented in Appendix B.

[0234] 2-Pyrone synthase (2-PS) from Gerbera hybrida was expressed and purified from E. coli in a similar manner to CHS and STS. Crystals were obtained from 1.5 M ammonium sulfate, 011 M Na⁺-succinate, 0.002 M DTT at pH 5.5.

[0235] 2-Pyrone synthase (2-PS) from Gerbera hybrida forms a triketide from an acetyl-CoA initiator and two acetyl-CoA α-carbanions derived from decarboxylation of two malonyl-CoAs that cyclizes into the 6-methyl-4-hydroxy-2-pyrone. In comparison, alfalfa chalcone synthase 2 (CHS2; 74% amino acid sequence identity to 2-PS), condenses p-coumaroyl-CoA and three acetyl-CoA α-carbanions derived from decarboxylation of three malonyl-CoAs into a tetraketide that cyclizes into chalcone. A homology model of 2-PS based on the structure of CHS suggested that the 2-PS initiation/elongation cavity is smaller than that of CHS. A smaller cavity would account for the terminal formation of a triketide intermediate prior to cyclization by 2-PS.

[0236] Expression. Purification and Crystallization of 2-PS.

[0237] 2-PS was expressed in E. coli, purified and crystallized as described above. Gerbera hybrida 2-PS was expressed in E. coli using the pIHS8 vector and was purified as described for CHS. 2-PS crystals grew at 4° C. in hanging-drops containing a 1:1 mixture of 25 mg ml⁻¹ protein and crystallization buffer (1.5 M ammonium sulfate, 50 mM succinic acid (pH 5.5), and 5 mM DTT). Before freezing at 105° K, crystals (P3121; unit cell dimensions a=82.15 Å, c=241.33 Å; one 2-PS dimer per asymmetric unit) were stepped through stabilizer (50 mM succinic acid (pH 5.5), 50 mM ammonium sulfate, and S mM DTT) containing 5 mM acetoacetyl-CoA and increasing concentrations of glycerol (30% (v/v) final). Diffraction data were collected using a DIP2030 imaging plate system and CuK radiation produced by a rotating anode (wavelength 1.54 Å). All images were processed with DENZO/SCALEPACK (Z. Otwinowski, W. Minor, Methods Enzymol. 276:307 (1997)). A total of 179,623 reflections were merged to give 60,824 unique reflections (98.2% complete overall to 2.05 Å and 98.1% complete in the highest resolution shell) with an R_(sym)=0.042 (0.206 in the highest resolution shell) and an α/_ of 21.7 (4.5 in the highest resolution shell). The structure of 2-PS complexed with acetoacetyl-CoA was determined by molecular replacement using CHS as a search model and was refined to 2.05 Å resolution. The overall fold of 2-PS is the apapa motif found in CHS and β-ketoacyl synthase II (KAS II). In addition, the positions of the catalytic residues of 2-PS (Cys16₉, His₃₀₈, and Asn₃₄₁), CHS (Cys₁₆₃, His₃₀₃, Asn₃₃₆), and KAS II (Cys₁₆₃, His₃₀₃, and His₃₄₀) are structurally analogous. As expected from sequence homology, the structures of 2-PS and CHS are nearly identical and superimpose with a r.m.s. deviation of 0.64 Å for the two proteins' α-carbon atoms. Similar to CHS, the 2-PS dimerization surface buries 1805 Å² of surface area per monomer and a loop containing a cis-peptide bond between Met₁₄₂ and Pro₁₄₃ allows the methionine of one monomer to protrude into the adjoining monomer's active site. Thus, dimerization allows formation of the complete 2-PS active site.

[0238] Acetoacetyl-CoA is a reaction intermediate of 2-PS. Electron density for the ligand is well defined in the 2-PS active site and shows that the acetoacetyl moiety extends from the CoA pantetheine arm into a large internal cavity. The electron density also reveals oxidation of the catalytic cysteine's (Cys₁₆₉) sulfhydryl to sulfinic acid (—SO₂H). This oxidation state prevents formation of a covalent acetoacetyl-enzyme complex but allows trapping of the bound acetoacetyl-CoA intermediate. Extensive protein-ligand contacts position CoA at the entrance to the active site and orient the acetoacetyl moiety at the end of a 15 Å long tunnel that opens into a cavity that defines the initiation and elongation steps of polyketide formation.

[0239] The 2-PS active site cavity consists of twenty-seven residues from one monomer and Met₁₄₂ from the adjoining monomer. Phe₂₂₀ and Phe₂₇₀ mark the boundary between the CoA binding site and the initiation/elongation cavity. Near the CoA thioester, Cys₁₆₉, His₃₀₈, and Asn₃₄₁ form the catalytic center of 2-PS. These residues are conserved in all homodimeric iterative PKSs. Based on this, catalytic roles were proposed for each residue that are analogous to the corresponding residues in CHS. Cys₁₆₉ acts as the nucleophile in the reaction and as the attachment site for the elongating polyketide chain. Interaction between His₃₀₈ and Cys₁₆₉ maintains the thiolate required for condensation of the starter molecule. His₃₀₈ and Asn₃₄₁ catalyze malonyl-CoA decarboxylation and stabilize the transition states during the condensation steps by forming an oxyanion hole that accommodates the negatively charged tetravalent transition state. Following the first condensation reaction, a diketide remains attached to Cys₁₆₉. The second malonyl-CoA then binds, undergoes decarboxylation, and the resulting nucleophilic acetyl-coA α-carbanion performs a second condensation reaction with the enzyme bound diketide, ultimately generating the triketide that cyclizes into methylpyrone.

[0240] Comparison of the initiation/elongation cavities of 2-PS and CHS reveal four amino acid differences. In 2-PS, Leu₂₀₂, Met₂₅₉, Leu₂₆₁, and Ile₃₄₃ replace Thr₁₉₇, Ile₂₅₄, Gly₂₅₆, and Ser₃₃₈, respectively, of CHS. These four substitutions reduce cavity volume from 923 Å³ in CHS to 274 Å³ in 2-PS. A model of methylpyrone in the 2-PS cavity, based on the position of acetoacetyl-CoA, emphasizes the volume change compared to the CHS-naringerin complex (Accession No. 1CGK). Leu₂₀₂ and Ile₃₄₃ occlude the portion of the 2-PS cavity corresponding to the coumaroyl-binding site of CHS. Replacement of Gly₂₅₆ in CHS by Leu₂₆₁ in 2-PS severely reduces the size of the active site cavity. Substitution of Met₂₅₉ in 2-PS for Ile₂₅₄ in CHS produces a modest alteration in cavity volume. To examine the functional importance of these amino acid differences, the initiation/elongation cavity of CHS was altered by mutagenesis to resemble that of 2-PS. The resulting mutant proteins were screened for activity using either p-coumaroyl-CoA or acetyl-CoA as starter molecules. Activities of 2-PS, CHS, and the CHS mutants were determined by monitoring product formation using a TLC-based radiometric assay. Assay conditions were 100 mM Hepes (pH 7.0), 30 μM starter-CoA (either p-coumaroyl-CoA or acetyl-CoA), and 60 μM [¹⁴C]-malonyl-CoA (50,000 cpm) in 100 μl at 25° C. Reactions were quenched with 5% acetic acid, extracted with ethyl acetate, and applied to TLC plates and developed. Due to the spontaneous cyclization of chalcone into the flavanone naringenin, activities of CHS are referenced to naringenin formation.

[0241] The x-ray crystal structures of 2-PS and CHS imply that the size of the active site cavity limits polyketide length and modulates folding of the polyketide chain. Wild-type CHS generates the tetraketide chalcone and 2-PS produces the triketide methylpyrone. Likewise, the CHS I254M mutant also yields chalcone. Interestingly, the T197L, G256L, and S3381 mutants do not form chalcone. Crystallographic analysis of the G256L and S338I mutants demonstrates that the substituted side-chains adopt conformations similar to the corresponding residues in 2-PS without altering the position of the protein backbone. Since the T197L, G256L, and S338I mutants altered product formation, a CHS triple mutant was generated. Consistent with the proposal that cavity volume dictates polyketide length, the T197L/G256L/S3381 mutant produces only methylpyrone, as confirmed by liquid chromatography/mass spectroscopy (LC/MS). LC/MS/MS analysis was performed by the Mass Spectroscopy facility of the Scripps Research Institute. Scaled-up assays (2 ml reaction volume) with the CHS T197L/G256L/S338I mutant and 2-PS were performed. Extracts were analyzed on a Hewlett-Packard HP1100 MSD single quadrupole mass spectrometer coupled to a Zorbax SB-C₁₈ column (5 μm, 2.1 mm×150 mm). HPLC conditions were as follows: gradient system from 0 to 100% methanol in water (each containing 0.2% acetic acid) within 10 min; flow rate 0.25 ml min⁻¹. LC/MS/MS data from both reactions were identical: 6-methyl-4-hydroxy-2-pyrone, R_(t)=5.068 min; [M−H]⁻ 125; [M−H—CO₂]⁻ 81. The numbers show m/z values with relative intensities in parenthesis. The observed fragmentation matches previously published data.

[0242] In addition, the size of the cavity in 2-PS and CHS confers starter molecule specificity. 2-PS accepts acetyl-CoA but does not use p-coumaroyl-CoA. Structurally, the constricted 2-PS active site excludes the bulky coumaroyl group. As such, incubation of 2-PS in the presence of coumaroyl-CoA and malonyl-CoA yields methylpyrone produced from three malonyl-CoA molecules. In comparison, the larger initiation/elongation cavity of CHS allows for different sized aliphatic and aromatic starter molecules to be used in vitro with varying efficiencies. CHS exhibits a 230-fold preference for p-coumaroyl-CoA versus acetyl-CoA. Alterations in the active site cavity of CHS, affect starter molecule preference. The CHS I254M mutant is functionally comparable to wild-type enzyme with a modest reduction in specific activity. The T197L and S338I mutants exhibit 10-fold and 3-fold preferences, respectively, for coumaroyl-CoA. Moreover, both form a distinct product using coumaroyl-CoA as a starter molecule. In contrast, the G256L mutant favors acetyl-CoA 3-fold. Like 2-PS, the CHS T197L/G256L/S3381 (3×) mutant only accepts acetyl-CoA (or malonyl-CoA) as the starter molecule.

[0243] Functional diversity among other homodimeric iterative PKSs, like p-coumaroyltriacetic acid synthase (CTAS), acridone synthase (ACS), and the rppA protein from Streptomyces griseus, likely results from variations of residues lining the initiation/elongation cavity. As demonstrated, positions 197,256, and 338 distinguish between tetraketide products derived from a final Claisen condensation in wild-type CHS and triketide products derived from an enolate-directed condensation in the CHS triple mutant. Although CHS, CTAS, and ACS generate tetraketides, each enzyme differs in either the cyclization reaction or in the identity of the starter molecule. CTAS forms the same enzyme-bound tetraketide as CHS but does not catalyze the final cyclization reaction. Comparison of these two enzymes reveals that substitution of Thr 197 in CHS with an asparagine in CTAS may prevent the covalently-bound tetraketide intermediate from undergoing cyclization into chalcone. ACS uses N-methylanthranoyl-CoA as a starting substrate to produce the alkaloid acridone. Three differences between CHS (Thr₁₃₂, Ser₁₃₃, and Phe₂₆₅) and ACS (Ser₁₃₂, Ala₁₃₃, and Val₂₆₅) may alter starter molecule specificity. In ACS, these changes likely widen the portion of the cavity corresponding to the p-coumaroyl-binding site in CHS to accommodate N-methylanthranoyl-CoA binding. Comparative changes in the active site cavity allow formation of longer polyketides. The rppA protein forms a pentaketide from five acetates derived from malonyl-CoA decarboxylation. Thr₁₃₇, Ala₁₃₈, Thr₁₉₉, Leu₂₀₂, Met₂₅₉, Leu₂₆₁, Leu₂₆₈, Pro₃₀₄, and Ile₃₄₃ of 2-PS are replaced by Cys₁₀₆, Thr₁₀₇, Cys₁₆₈, Cys₁₇₁, Ile₂₂₈, Tyr₂₃₀, Phe₂₃₇, Ala₂₆₁, and Ala₂₉₅, respectively, in the rppA protein. Models of the rppA protein based on the 2-PS and CHS structures show that cavity volume is 1145 Å³ in the rppA protein versus 274 Å³ in 2-PS (or 923 Å in CHS). Manipulation of the active site through amino acid substitutions offers a strategy for increasing the molecular diversity of polyketide formation through both the choice of starter molecule and the number of subsequent condensation steps.

[0244] The reaction mechanism for polyketide formation and the structural basis for controlling polyketide length described here may be shared with other more complex iterative (e.g., actinorhodin (act) PKS and tetracenomycin (tcm) PKS) and modular PKSs (e.g., 6-deoxyerythronolide B synthase (DEBS)). The structural similarity of the 2-PS, CHS, and KAS II active sites, the sequence homology of KAS II and the ketosynthases of act PKS, tcm PKS, and DEBS, and mutagenesis studies of CHS and act PKS demonstrating similar roles for the catalytic residues of each protein indicate that a conserved active site architecture catalyzes similar reactions in these enzymes.

[0245] As in 2-PS and CHS, the volume of the active site cavities in other PKSs likely limits the size of the final polyketide. For example, act PKS and tcm PKS generate octaketide and decaketide products, respectively, at a single active site. This suggests that the active site cavities of these PKSs differ in size, and are larger than those of 2-PS or CHS. Similarly, the ketosynthases of different DEBS modules accept polyketide intermediates ranging in length from five to twelve carbons. Modular PKSs, like DEBS, use an assembly-line system in which an individual module catalyzes one elongation reaction and passes the growing polyketide to the next module. Although the ketosynthase domains of DEBS are functionally permissive, modulation of active site volume in each module's ketosynthase would provide selectivity for the proper sized intermediate at each elongation step. Structural differences among PKSs alter the volume of the initiation/elongation cavity to allow discrimination between starter molecules and to vary the number of elongation steps to ultimately direct the nature and length of the polyketide product.

[0246] Functional Conversion of Chalcone Synthase to Stilbene Synthase

[0247] All CHS-like enzymes utilize a small number of absolutely conserved catalytic residues within a single active site to catalyze the iterative addition of acetate units to a starter molecule. A chalcone synthase reaction sequence starts with initiation, is followed by elongation, and ends with cyclization (see FIG. 10). CHS family members differ in their choice of starter molecule, number of acetyl additions and cyclization pathway of the resulting polyketide. Structural and functional characterization of CHS from M. sativa suggested that substrate specificity is modulated in the chalcone synthase superfamily by steric constraints. Such constraints are provided by a set of variable residues lining the active site. Functional conversion through mutagenesis of alfalfa CHS to a pyrone synthase, and the structural characterization of pyrone synthase (PS) from G. hybrida (daisy) support this model. Thus, homology modeling is a valid approach to gain insight into the specificity's of chalcone synthase superfamily members, including members that are identified and/or characterized as well as those still to be identified and characterized.

[0248] Stilbene synthase (STS) is related to CHS, and is thought to have arisen from CHS on at least three independent occasions. An amino acid sequence alignment of P. sylvestris STS and M sativa CHS, along with an evolutionary intermediate, P. sylvestris CHS shows amino acid sequence homology (FIG. 11). Both CHS and STS form the same linear phenylpropanoid tetraketide intermediate via the sequential condensation of three acetyl units derived from decarboxylation of malonyl-CoA with one coumaroyl-CoA starter (FIG. 12). STS forms resveratrol via an intramolecular aldol condensation. In contrast, CHS utilizes an intramolecular Claisen condensation to produce chalcone (FIG. 13).

[0249] Function conversion is achieved by mutations of CHS. Mutation of M. sativa (alfalfa) CHS confers wild type STS activity resulting in an STS-like product profile from mutant CHS activity. Specifically, alfalfa wild type CHS activity results in the production of the plant polyketide synthase product, naringenin, a flavanone product resulting from spontaneous ring closure of chalcone product. Mutant CHS activity results in the production of resveratrol, an expected product of wild type STS activity, and a decrease in the production of naringenin (see FIG. 14).

[0250] Based on the structural information, a variety of mutant CHS molecules can be designed. Mutant CHS enzymes can vary with respect to starter preference, activity, product formation, and the like. Various CHS mutants as shown in Table 3 above were designed by invention methods and prepared, and were tested for activity.

[0251] Mutant CHS has altered activity based on assays conducted with ¹⁴ Cmalonyl-CoA. Products were extracted with ethyl acetate and analyzed by silica gel thin layer chromatography (TLC) and visualized by autoradiography. Mutants 14B and 2B showed reduced amounts of naringenin compared to wild type CHS and little or no resveratrol. Mutants 16B, 4B, 6B, 18x and 22x showed reduced amounts of naringenin compared to wild type CHS and various amounts of resveratrol. Mutants 18xCHS and 22xCHS showed the lowest naringenin amounts and the highest resveratrol amounts, in fact, in 22x the naringenin:resveratrol ratio is similar to that seen with wild type STS from P. sylvestris.

[0252] Specific mutations in 18xCHS by area are as follows. with areas underlined showing residue changes especially important for altering activity: A1: D96A, V98L. V99A, V100M; A2: T131S, S133T, G134T, V135P, M137L; A3: Y157V, M158G. M159V, Y160F, Q165H; A4: L268K, K269G, D270A, G273D.

[0253] The 22x mutant consists of 18xCHS plus four additional mutations in area B1, which flanks A4, and bridges the gap between A1-A3 and A4 (see FIG. 16). The 22xCHS has decreased naringenin production (relative to 18xCHS), matching identically the product profile of wild type STS. These mutations are in an area predicted to be important for cyclization specificity, due to changes seen here in comparing the CHS/resveratrol complex structure to apo and other complexes of CHS. Note that final mutation is only two residues before the first change in A4 region.

[0254] Specific mutations in 22xCHS by area are as follows. with areas underlined showing residue changes especially important for altering activity: A1: D96A, V98L. V99A, V100M; A2: T131S, S133T, G134T V135P M137L; A3: Y157V, M158G. M159V, Y160F, Q165H; A4: L268K, K269G, D270A, G273D; B1: D255G, H257K, L258V, H266Q.

[0255] The crystal structural coordinates of the 18xCHS mutant are presented in Appendix C. Table 6 shows the relative active site α-carbon coordinates of the 18xCHS mutant possessing STS-like activity. TABLE 6 Active Site α- Carbon Number X Position Y Position Z Position Amino Acid 1 3.754 −8.620 58.411 Thr 132 2 0.541 −10.075 59.960 Thr 133 3 0.228 −9.423 49.613 Met 137* 4 0.230 −7.076 55.634 Gln 161 5 9.260 −15.931 61.148 Thr 194 6 6.542 −18.097 57.263 Thr 197 7 13.288 −17.295 51.888 Gly 211 8 15.195 −13.751 60.585 Gly 216 9 6.827 −10.404 45.169 Ile 254 10 2.304 −13.379 49.664 Gly 256 11 1.944 −17.210 54.954 Leu 263 12 5.520 −16.124 49.059 Phe 265 13 8.197 −14.531 42.889 Leu 267 14 11.540 −7.480 56.987 Ser 338 15 8.611 −9.306 62.954 Glu 192

[0256] Table

[0257] Table 7 shows the wild type CHS active site positions that differ from the coordinates listed in Table 6. The unlisted positions are equivalent for both CHS-like Claissen and STS-like aldol cyclization specificity. TABLE 7 Active Site α- Carbon Number X Position Y Position Z Position Amino Acid 1 4.033  −8.884 58.744 Thr 132 2 3.656 −11.697 61.297 Ser 133

[0258] Table 8 shows various amino acid positions where mutations thereof can enable or enhance STS-like activity in CHS mutants. The α-carbon positions are those observed in the 18xCHS crystal sturcture. The comparison of crystal structure may identify further positions that produce similar results. TABLE 8 Enabling α- X Y Z Location Carbon Number Position Position Position Mutation Designation 1 2.452 −14.634 67.063 V98L A1 2 −0.144 −13.492 69.602 V99A A1 3 2.537 −13.818 72.285 V100M A1 4 4.117 −6.516 61.579 S131T A2 5 0.541 −10.075 59.960 T133S A2 6 −1.599 −9.886 63.127 G134T A2 7 −3.665 −12.840 64.483 V135P A2 8 0.228 −9.423 49.613 M137L* A2 9 −1.725 −0.801 63.145 M158G A3 10 −0.401 −5.049 58.793 Y160F A3 11 3.525 −11.762 46.471 D255G B1 12 −0.844 −15.289 50.586 H257K B1 13 −2.269 −15.735 54.104 L258V B1 14 5.803 −16.354 45.249 H266Q B1 15 8.069 −13.510 39.218 L268K A4 16 10.985 −12.040 37.288 K269G A4 17 14.223 −10.808 38.865 D270A A4

[0259] These results show that a function conversion of CHS to STS can be achieved by designing mutations in the CHS sequence based on CHS structural information.

ADDITIONAL REFERENCES CITED

[0260] Schroeder, J. (1999) The Chalcone/Stilbene Synthase-type Family of Condensing Enzymes in Comprehensive Natural Products Chemistry Barton, D. & Nakanishi, K. (ed.) 1 (Elsevier Science Ltd., Amsterdam 1999).

[0261] Ferrer, J.-L., Jez, J. M., Bowman, M. E., Dixon, R. A., and Noel, J. P. (1999) Structure of Chalcone Synthase and the Molecular Basis of Plant Polyketide Biosynthesis. Nature Structural Biology, 6: 775-783.

[0262] Jez, J. M., Ferrer, J.-L., Bowman, M. E., Dixon, R. A., and Noel, J. P. (2000) Dissection of malonyl-CoA decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry, 39: 890-902.

[0263] Jez, J. M. & Noel, J. P. (2000) Mechanism of chalcone synthase: pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase. J. Biol. Chem. 2000 Sep 26 [epub ahead of print—in press].

[0264] Jez, J. M., Austin, M. B., Ferrer, J.-L., Bowman, M. E., Schroder, J., and Noel, J. P. (2000) Structural control of polyketide formation in plant-specific polyketide synthases. Chemistry & Biology 7(12):919-930.

[0265] Tropf S, Lanz T, Rensing S A, Schroder J, Schroder G Evidence that stilbene synthases have developed from chalcone synthases several times in the course of evolution J Mol Evol 1994 June;38(6):610-8.

[0266] Suh D Y, Fukuma K, Kagami J, Yamazaki Y, Shibuya M, Ebizuka Y, Sankawa U Identification of amino acid residues important in the cyclization reactions of chalcone and stilbene synthases Biochem J 2000 Aug. 15;350(Pt 1):229-235.

[0267] While the foregoing has been presented with reference to particular embodiments of the invention, it will be appreciated by those skilled in the art that changes in these embodiments may be made without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims. APPENDIX A Pinus sylvestris STS ATOM # TYPE RES X Y Z OCC B ATOM 1 CB ASP A 5 15.478 −29.459 49.168 1.00 67.43 A ATOM 2 CG ASP A 5 16.008 −30.062 47.877 1.00 68.10 A ATOM 3 OD1 ASP A 5 17.184 −30.480 47.850 1.00 68.26 A ATOM 4 OD2 ASP A 5 15.247 −30.116 46.890 1.00 68.59 A ATOM 5 C ASP A 5 16.056 −27.113 48.532 1.00 65.16 A ATOM 6 O ASP A 5 17.024 −26.582 47.995 1.00 64.39 A ATOM 7 N ASP A 5 15.729 −27.703 50.902 1.00 67.43 A ATOM 8 CA ASP A 5 16.237 −28.193 49.588 1.00 66.83 A ATOM 9 N PHE A 6 14.800 −26.782 48.261 1.00 64.20 A ATOM 10 CA PHE A 6 14.453 −25.779 47.266 1.00 63.13 A ATOM 11 CB PHE A 6 12.938 −25.783 47.053 1.00 63.60 A ATOM 12 CG PHE A 6 12.353 −27.157 46.885 1.00 64.51 A ATOM 13 CD1 PHE A 6 11.522 −27.695 47.866 1.00 66.17 A ATOM 14 CD2 PHE A 6 12.642 −27.923 45.760 1.00 63.90 A ATOM 15 CE1 PHE A 6 10.987 −28.976 47.729 1.00 65.63 A ATOM 16 CE2 PHE A 6 12.113 −29.206 45.613 1.00 63.56 A ATOM 17 CZ PHE A 6 11.285 −29.734 46.598 1.00 64.57 A ATOM 18 C PHE A 6 14.926 −24.360 47.606 1.00 62.05 A ATOM 19 O PHE A 6 15.234 −23.577 46.707 1.00 61.61 A ATOM 20 N GLU A 7 14.982 −24.029 48.895 1.00 61.34 A ATOM 21 CA GLU A 7 15.416 −22.699 49.317 1.00 59.88 A ATOM 22 CB GLU A 7 15.345 −22.556 50.845 1.00 61.69 A ATOM 23 CG GLU A 7 15.802 −21.182 51.365 1.00 63.25 A ATOM 24 CD GLU A 7 15.466 −20.956 52.840 1.00 64.35 A ATOM 25 OE1 GLU A 7 14.263 −20.904 53.183 1.00 64.96 A ATOM 26 OE2 GLU A 7 16.401 −20.823 53.661 1.00 64.20 A ATOM 27 C GLU A 7 16.832 −22.421 48.838 1.00 57.91 A ATOM 28 O GLU A 7 17.322 −21.298 48.950 1.00 58.52 A ATOM 29 N GLY A 8 17.487 −23.455 48.315 1.00 56.11 A ATOM 30 CA GLY A 8 18.839 −23.312 47.796 1.00 52.75 A ATOM 31 C GLY A 8 18.787 −23.324 46.277 1.00 50.24 A ATOM 32 O GLY A 8 19.523 −22.595 45.601 1.00 49.08 A ATOM 33 N PHE A 9 17.899 −24.163 45.748 1.00 47.36 A ATOM 34 CA PHE A 9 17.696 −24.287 44.312 1.00 45.44 A ATOM 35 CB PHE A 9 16.631 −25.347 44.028 1.00 46.27 A ATOM 36 CG PHE A 9 16.463 −25.670 42.569 1.00 46.38 A ATOM 37 CD1 PHE A 9 17.453 −26.362 41.878 1.00 45.31 A ATOM 38 CD2 PHE A 9 15.308 −25.296 41.889 1.00 46.41 A ATOM 39 CE1 PHE A 9 17.294 −26.678 40.532 1.00 46.87 A ATOM 40 CE2 PHE A 9 15.139 −25.608 40.540 1.00 46.26 A ATOM 41 CZ PHE A 9 16.131 −26.299 39.862 1.00 46.36 A ATOM 42 C PHE A 9 17.219 −22.938 43.779 1.00 43.88 A ATOM 43 O PHE A 9 17.610 −22.503 42.695 1.00 42.95 A ATOM 44 N ARG A 10 16.369 −22.285 44.559 1.00 42.46 A ATOM 45 CA ARG A 10 15.820 −20.988 44.199 1.00 41.78 A ATOM 46 CB ARG A 10 14.759 −20.587 45.227 1.00 42.76 A ATOM 47 CG ARG A 10 13.336 −20.513 44.699 1.00 45.24 A ATOM 48 CD ARG A 10 13.108 −19.253 43.870 1.00 46.91 A ATOM 49 NE ARG A 10 13.803 −19.267 42.582 1.00 47.12 A ATOM 50 CZ ARG A 10 13.848 −18.226 41.753 1.00 47.04 A ATOM 51 NH1 ARG A 10 13.243 −17.092 42.083 1.00 46.16 A ATOM 52 NH2 ARG A 10 14.490 −18.316 40.599 1.00 45.13 A ATOM 53 C ARG A 10 16.912 −19.923 44.145 1.00 41.81 A ATOM 54 O ARG A 10 17.039 −19.191 43.158 1.00 40.31 A ATOM 55 N LYS A 11 17.704 −19.848 45.211 1.00 41.51 A ATOM 56 CA LYS A 11 18.771 −18.859 45.306 1.00 42.45 A ATOM 57 CB LYS A 11 19.441 −18.946 46.679 1.00 44.35 A ATOM 58 CG LYS A 11 18.520 −18.561 47.831 1.00 47.24 A ATOM 59 CD LYS A 11 19.157 −18.828 49.194 1.00 47.39 A ATOM 60 CE LYS A 11 18.222 −18.392 50.321 1.00 48.83 A ATOM 61 NZ LYS A 11 18.760 −18.701 51.673 1.00 49.79 A ATOM 62 C LYS A 11 19.819 −18.981 44.214 1.00 41.73 A ATOM 63 O LYS A 11 20.409 −17.980 43.801 1.00 41.36 A ATOM 64 N LEU A 12 20.048 −20.206 43.749 1.00 41.94 A ATOM 65 CA LEU A 12 21.042 −20.465 42.705 1.00 41.33 A ATOM 66 CB LEU A 12 21.631 −21.869 42.864 1.00 41.99 A ATOM 67 CG LEU A 12 23.057 −21.952 43.411 1.00 42.59 A ATOM 68 CD1 LEU A 12 23.449 −23.403 43.608 1.00 44.32 A ATOM 69 CD2 LEU A 12 24.010 −21.276 42.445 1.00 42.25 A ATOM 70 C LEU A 12 20.483 −20.321 41.299 1.00 40.77 A ATOM 71 O LEU A 12 21.224 −20.037 40.357 1.00 41.09 A ATOM 72 N GLN A 13 19.175 −20.520 41.167 1.00 39.79 A ATOM 73 CA GLN A 13 18.490 −20.431 39.884 1.00 38.24 A ATOM 74 CB GLN A 13 17.119 −21.113 39.996 1.00 38.10 A ATOM 75 CG GLN A 13 16.185 −20.943 38.793 1.00 38.78 A ATOM 76 CD GLN A 13 14.899 −21.761 38.934 1.00 39.17 A ATOM 77 OE1 GLN A 13 14.231 −21.723 39.975 1.00 35.94 A ATOM 78 NE2 GLN A 13 14.549 −22.500 37.884 1.00 36.91 A ATOM 79 C GLN A 13 18.329 −18.996 39.395 1.00 38.22 A ATOM 80 O GLN A 13 18.228 −18.764 38.195 1.00 39.15 A ATOM 81 N ARG A 14 18.328 −18.040 40.322 1.00 37.88 A ATOM 82 CA ARG A 14 18.149 −16.628 39.990 1.00 37.89 A ATOM 83 CB ARG A 14 17.136 −16.013 40.950 1.00 40.76 A ATOM 84 CG ARG A 14 17.583 −16.012 42.406 1.00 44.03 A ATOM 85 CD ARG A 14 16.477 −15.471 43.280 1.00 46.98 A ATOM 86 NE ARG A 14 16.898 −15.263 44.661 1.00 49.61 A ATOM 87 CZ ARG A 14 16.112 −14.748 45.600 1.00 50.12 A ATOM 88 NH1 ARG A 14 14.868 −14.394 45.298 1.00 51.87 A ATOM 89 NH2 ARG A 14 16.567 −14.577 46.833 1.00 49.78 A ATOM 90 C ARG A 14 19.431 −15.796 40.010 1.00 37.27 A ATOM 91 O ARG A 14 20.383 −16.128 40.708 1.00 37.71 A ATOM 92 N ALA A 15 19.434 −14.702 39.250 1.00 36.59 A ATOM 93 CA ALA A 15 20.592 −13.811 39.144 1.00 36.04 A ATOM 94 CB ALA A 15 20.561 −13.083 37.805 1.00 35.74 A ATOM 95 C ALA A 15 20.675 −12.797 40.285 1.00 36.64 A ATOM 96 O ALA A 15 19.668 −12.470 40.906 1.00 36.28 A ATOM 97 N ASP A 16 21.877 −12.284 40.540 1.00 36.70 A ATOM 98 CA ASP A 16 22.093 −11.331 41.626 1.00 37.04 A ATOM 99 CB ASP A 16 23.517 −11.467 42.181 1.00 37.71 A ATOM 100 CG ASP A 16 23.864 −12.885 42.578 1.00 39.12 A ATOM 101 OD1 ASP A 16 23.005 −13.579 43.161 1.00 41.62 A ATOM 102 OD2 ASP A 16 25.010 −13.301 42.319 1.00 39.23 A ATOM 103 C ASP A 16 21.871 −9.857 41.292 1.00 37.37 A ATOM 104 O ASP A 16 21.127 −9.152 41.978 1.00 38.64 A ATOM 105 N GLY A 17 22.523 −9.387 40.240 1.00 35.60 A ATOM 106 CA GLY A 17 22.422 −7.984 39.903 1.00 35.63 A ATOM 107 C GLY A 17 21.159 −7.453 39.272 1.00 35.92 A ATOM 108 O GLY A 17 20.077 −8.023 39.380 1.00 35.96 A ATOM 109 N PHE A 18 21.329 −6.318 38.607 1.00 36.31 A ATOM 110 CA PHE A 18 20.253 −5.636 37.923 1.00 34.75 A ATOM 111 CB PHE A 18 20.466 −4.126 38.012 1.00 37.21 A ATOM 112 CG PHE A 18 19.578 −3.441 39.004 1.00 39.74 A ATOM 113 CD1 PHE A 18 20.048 −2.351 39.732 1.00 39.87 A ATOM 114 CD2 PHE A 18 18.262 −3.862 39.195 1.00 40.31 A ATOM 115 CE1 PHE A 18 19.223 −1.690 40.637 1.00 40.82 A ATOM 116 CE2 PHE A 18 17.426 −3.204 40.101 1.00 40.34 A ATOM 117 CZ PHE A 18 17.910 −2.119 40.823 1.00 41.49 A ATOM 118 C PHE A 18 20.257 −6.048 36.469 1.00 33.11 A ATOM 119 O PHE A 18 21.321 −6.251 35.886 1.00 30.89 A ATOM 120 N ALA A 19 19.066 −6.184 35.895 1.00 32.19 A ATOM 121 CA ALA A 19 18.932 −6.528 34.488 1.00 32.21 A ATOM 122 CB ALA A 19 17.458 −6.639 34.106 1.00 32.97 A ATOM 123 C ALA A 19 19.593 −5.362 33.746 1.00 32.44 A ATOM 124 O ALA A 19 19.319 −4.187 34.039 1.00 30.18 A ATOM 125 N SER A 20 20.464 −5.673 32.792 1.00 30.51 A ATOM 126 CA SER A 20 21.158 −4.611 32.095 1.00 29.55 A ATOM 127 CB SER A 20 22.575 −4.502 32.646 1.00 29.41 A ATOM 128 OG SER A 20 22.544 −4.494 34.062 1.00 31.94 A ATOM 129 C SER A 20 21.210 −4.779 30.598 1.00 29.71 A ATOM 130 O SER A 20 21.222 −5.897 30.083 1.00 31.07 A ATOM 131 N ILE A 21 21.231 −3.651 29.900 1.00 28.89 A ATOM 132 CA ILE A 21 21.324 −3.651 28.454 1.00 29.32 A ATOM 133 CB ILE A 21 20.827 −2.328 27.862 1.00 29.06 A ATOM 134 CG2 ILE A 21 20.864 −2.401 26.358 1.00 29.04 A ATOM 135 CG1 ILE A 21 19.403 −2.033 28.344 1.00 30.26 A ATOM 136 CD1 ILE A 21 18.400 −3.115 28.026 1.00 33.08 A ATOM 137 C ILE A 21 22.817 −3.802 28.185 1.00 30.88 A ATOM 138 O ILE A 21 23.619 −2.964 28.602 1.00 30.81 A ATOM 139 N LEU A 22 23.194 −4.872 27.500 1.00 30.73 A ATOM 140 CA LEU A 22 24.600 −5.121 27.240 1.00 29.37 A ATOM 141 CB LEU A 22 24.926 −6.563 27.606 1.00 27.95 A ATOM 142 CG LEU A 22 24.496 −6.947 29.019 1.00 26.37 A ATOM 143 CD1 LEU A 22 24.854 −8.404 29.301 1.00 26.97 A ATOM 144 CD2 LEU A 22 25.178 −6.019 30.006 1.00 27.73 A ATOM 145 C LEU A 22 25.000 −4.843 25.801 1.00 30.57 A ATOM 146 O LEU A 22 26.190 −4.902 25.457 1.00 30.82 A ATOM 147 N ALA A 23 24.007 −4.537 24.966 1.00 29.20 A ATOM 148 CA ALA A 23 24.255 −4.240 23.556 1.00 27.79 A ATOM 149 CB ALA A 23 24.867 −5.449 22.865 1.00 24.35 A ATOM 150 C ALA A 23 22.989 −3.804 22.825 1.00 27.34 A ATOM 151 O ALA A 23 21.877 −4.233 23.150 1.00 25.25 A ATOM 152 N ILE A 24 23.169 −2.934 21.837 1.00 27.98 A ATOM 153 CA ILE A 24 22.048 −2.444 21.054 1.00 27.20 A ATOM 154 CB ILE A 24 21.643 −1.002 21.444 1.00 26.17 A ATOM 155 CG2 ILE A 24 20.398 −.596 20.665 1.00 26.40 A ATOM 156 CG1 ILE A 24 21.361 −.895 22.945 1.00 26.96 A ATOM 157 CD1 ILE A 24 20.943 .540 23.399 1.00 22.86 A ATOM 158 C ILE A 24 22.409 −2.437 19.572 1.00 27.82 A ATOM 159 O ILE A 24 23.418 −1.859 19.165 1.00 27.57 A ATOM 160 N GLY A 25 21.568 −3.098 18.782 1.00 28.16 A ATOM 161 CA GLY A 25 21.746 −3.166 17.347 1.00 26.42 A ATOM 162 C GLY A 25 20.512 −2.563 16.685 1.00 28.50 A ATOM 163 O GLY A 25 19.409 −2.612 17.241 1.00 26.10 A ATOM 164 N THR A 26 20.699 −2.012 15.490 1.00 28.50 A ATOM 165 CA THR A 26 19.621 −1.377 14.741 1.00 30.82 A ATOM 166 CB THR A 26 19.708 .168 14.908 1.00 32.46 A ATOM 167 OG1 THR A 26 18.878 .576 16.003 1.00 32.28 A ATOM 168 CG2 THR A 26 19.302 .894 13.629 1.00 34.07 A ATOM 169 C THR A 26 19.691 −1.746 13.258 1.00 30.38 A ATOM 170 O THR A 26 20.776 −1.870 12.694 1.00 30.95 A ATOM 171 N ALA A 27 18.533 −1.914 12.630 1.00 28.84 A ATOM 172 CA ALA A 27 18.495 −2.263 11.220 1.00 27.36 A ATOM 173 CB ALA A 27 18.361 −3.753 11.075 1.00 26.92 A ATOM 174 C ALA A 27 17.346 −1.564 10.506 1.00 26.05 A ATOM 175 O ALA A 27 16.306 −1.337 11.089 1.00 23.77 A ATOM 176 N ASN A 28 17.536 −1.231 9.235 1.00 28.03 A ATOM 177 CA ASN A 28 16.490 −.573 8.457 1.00 28.64 A ATOM 178 CB ASN A 28 16.646 .948 8.528 1.00 27.80 A ATOM 179 CG ASN A 28 16.309 1.503 9.893 1.00 29.20 A ATOM 180 OD1 ASN A 28 17.197 1.766 10.715 1.00 28.54 A ATOM 181 ND2 ASN A 28 15.013 1.675 10.152 1.00 26.02 A ATOM 182 C ASN A 28 16.481 −1.001 6.989 1.00 28.59 A ATOM 183 O ASN A 28 17.525 −1.282 6.420 1.00 28.02 A ATOM 184 N PRO A 29 15.292 −1.034 6.356 1.00 29.65 A ATOM 185 CD PRO A 29 13.967 −.696 6.908 1.00 28.87 A ATOM 186 CA PRO A 29 15.179 −1.425 4.947 1.00 29.12 A ATOM 187 CB PRO A 29 13.671 −1.388 4.686 1.00 30.72 A ATOM 188 CG PRO A 29 13.061 −1.530 6.048 1.00 32.13 A ATOM 189 C PRO A 29 15.932 −.409 4.083 1.00 31.07 A ATOM 190 O PRO A 29 16.037 .768 4.444 1.00 29.67 A ATOM 191 N PRO A 30 16.452 −.853 2.927 1.00 32.61 A ATOM 192 CD PRO A 30 16.229 −2.205 2.388 1.00 33.12 A ATOM 193 CA PRO A 30 17.210 −.045 1.966 1.00 33.75 A ATOM 194 CB PRO A 30 17.300 −.956 .748 1.00 33.69 A ATOM 195 CG PRO A 30 17.308 −2.305 1.351 1.00 34.85 A ATOM 196 C PRO A 30 16.553 1.276 1.618 1.00 34.72 A ATOM 197 O PRO A 30 17.123 2.352 1.826 1.00 33.78 A ATOM 198 N ASN A 31 15.342 1.172 1.084 1.00 36.47 A ATOM 199 CA ASN A 31 14.577 2.332 .656 1.00 35.87 A ATOM 200 CB ASN A 31 13.179 1.898 .222 1.00 37.58 A ATOM 201 CG ASN A 31 12.379 3.033 −.377 1.00 38.77 A ATOM 202 OD1 ASN A 31 12.852 3.738 −1.267 1.00 42.91 A ATOM 203 ND2 ASN A 31 11.158 3.208 .097 1.00 38.97 A ATOM 204 C ASN A 31 14.466 3.444 1.682 1.00 36.12 A ATOM 205 O ASN A 31 13.752 3.330 2.678 1.00 35.66 A ATOM 206 N ALA A 32 15.190 4.526 1.431 1.00 35.45 A ATOM 207 CA ALA A 32 15.139 5.680 2.300 1.00 35.87 A ATOM 208 CB ALA A 32 16.501 6.300 2.428 1.00 34.90 A ATOM 209 C ALA A 32 14.186 6.633 1.603 1.00 36.32 A ATOM 210 O ALA A 32 14.450 7.062 .481 1.00 36.89 A ATOM 211 N VAL A 33 13.066 6.935 2.254 1.00 37.11 A ATOM 212 CA VAL A 33 12.072 7.838 1.687 1.00 38.65 A ATOM 213 CB VAL A 33 10.628 7.294 1.858 1.00 39.24 A ATOM 214 CG1 VAL A 33 10.507 5.921 1.248 1.00 38.32 A ATOM 215 CG2 VAL A 33 10.255 7.256 3.337 1.00 39.28 A ATOM 216 C VAL A 33 12.135 9.195 2.371 1.00 40.05 A ATOM 217 O VAL A 33 12.190 9.281 3.597 1.00 40.74 A ATOM 218 N ASP A 34 12.120 10.259 1.579 1.00 41.52 A ATOM 219 CA ASP A 34 12.159 11.601 2.140 1.00 42.79 A ATOM 220 CB ASP A 34 12.984 12.526 1.239 1.00 45.56 A ATOM 221 CG ASP A 34 14.476 12.234 1.316 1.00 47.51 A ATOM 222 OD1 ASP A 34 15.219 12.722 .439 1.00 49.63 A ATOM 223 OD2 ASP A 34 14.905 11.524 2.258 1.00 48.98 A ATOM 224 C ASP A 34 10.735 12.120 2.287 1.00 42.33 A ATOM 225 O ASP A 34 9.951 12.093 1.338 1.00 42.08 A ATOM 226 N GLN A 35 10.407 12.582 3.490 1.00 41.73 A ATOM 227 CA GLN A 35 9.076 13.098 3.787 1.00 41.81 A ATOM 228 CB GLN A 35 9.020 13.584 5.243 1.00 40.69 A ATOM 229 CG GLN A 35 7.627 13.923 5.764 1.00 40.17 A ATOM 230 CD GLN A 35 6.798 12.688 6.067 1.00 40.34 A ATOM 231 OE1 GLN A 35 6.692 11.785 5.244 1.00 39.84 A ATOM 232 NE2 GLN A 35 6.200 12.649 7.252 1.00 39.72 A ATOM 233 C GLN A 35 8.686 14.241 2.843 1.00 42.93 A ATOM 234 O GLN A 35 7.504 14.483 2.613 1.00 44.31 A ATOM 235 N SER A 36 9.677 14.940 2.294 1.00 43.00 A ATOM 236 CA SER A 36 9.404 16.056 1.391 1.00 42.43 A ATOM 237 CB SER A 36 10.701 16.798 1.060 1.00 42.98 A ATOM 238 OG SER A 36 11.126 17.582 2.162 1.00 44.09 A ATOM 239 C SER A 36 8.705 15.666 .092 1.00 41.13 A ATOM 240 O SER A 36 7.772 16.339 −.345 1.00 39.36 A ATOM 241 N THR A 37 9.155 14.579 −.522 1.00 39.75 A ATOM 242 CA THR A 37 8.575 14.134 −1.783 1.00 39.31 A ATOM 243 CB THR A 37 9.686 13.652 −2.762 1.00 39.54 A ATOM 244 OG1 THR A 37 10.694 14.666 −2.877 1.00 39.51 A ATOM 245 CG2 THR A 37 9.107 13.383 −4.151 1.00 40.15 A ATOM 246 C THR A 37 7.557 13.010 −1.590 1.00 38.36 A ATOM 247 O THR A 37 7.066 12.434 −2.564 1.00 38.53 A ATOM 248 N TYR A 38 7.225 12.697 −.342 1.00 36.06 A ATOM 249 CA TYR A 38 6.274 11.625 −.124 1.00 36.72 A ATOM 250 CB TYR A 38 6.232 11.187 1.335 1.00 35.69 A ATOM 251 CG TYR A 38 5.647 9.801 1.479 1.00 35.07 A ATOM 252 CD1 TYR A 38 6.260 8.704 .873 1.00 35.39 A ATOM 253 CE1 TYR A 38 5.724 7.420 .983 1.00 34.19 A ATOM 254 CD2 TYR A 38 4.476 9.585 2.201 1.00 35.84 A ATOM 255 CE2 TYR A 38 3.930 8.308 2.320 1.00 34.78 A ATOM 256 CZ TYR A 38 4.561 7.229 1.710 1.00 33.22 A ATOM 257 OH TYR A 38 4.037 5.967 1.840 1.00 30.24 A ATOM 258 C TYR A 38 4.875 12.002 −.572 1.00 37.11 A ATOM 259 O TYR A 38 4.125 11.151 −1.057 1.00 36.68 A ATOM 260 N PRO A 39 4.495 13.279 −.407 1.00 36.61 A ATOM 261 CD PRO A 39 5.087 14.349 .413 1.00 35.84 A ATOM 262 CA PRO A 39 3.151 13.648 −.841 1.00 36.96 A ATOM 263 CB PRO A 39 3.068 15.118 −.459 1.00 37.53 A ATOM 264 CG PRO A 39 3.869 15.155 .811 1.00 37.43 A ATOM 265 C PRO A 39 2.917 13.399 −2.330 1.00 36.68 A ATOM 266 O PRO A 39 1.939 12.749 −2.700 1.00 37.75 A ATOM 267 N ASP A 40 3.803 13.901 −3.187 1.00 35.67 A ATOM 268 CA ASP A 40 3.626 13.681 −4.617 1.00 37.12 A ATOM 269 CB ASP A 40 4.714 14.387 −5.438 1.00 38.06 A ATOM 270 CG ASP A 40 4.556 15.905 −5.457 1.00 41.46 A ATOM 271 OD1 ASP A 40 3.426 16.411 −5.246 1.00 41.34 A ATOM 272 OD2 ASP A 40 5.570 16.595 −5.709 1.00 43.90 A ATOM 273 C ASP A 40 3.663 12.187 −4.913 1.00 36.95 A ATOM 274 O ASP A 40 2.752 11.654 −5.547 1.00 38.21 A ATOM 275 N PHE A 41 4.715 11.521 −4.439 1.00 35.19 A ATOM 276 CA PHE A 41 4.907 10.090 −4.637 1.00 35.05 A ATOM 277 CB PHE A 41 6.236 9.647 −4.021 1.00 35.93 A ATOM 278 CG PHE A 41 6.379 8.155 −3.916 1.00 34.85 A ATOM 279 CD1 PHE A 41 6.487 7.375 −5.051 1.00 36.28 A ATOM 280 CD2 PHE A 41 6.354 7.527 −2.681 1.00 36.32 A ATOM 281 CE1 PHE A 41 6.566 5.982 −4.960 1.00 36.91 A ATOM 282 CE2 PHE A 41 6.431 6.138 −2.579 1.00 35.53 A ATOM 283 CZ PHE A 41 6.536 5.365 −3.724 1.00 35.23 A ATOM 284 C PHE A 41 3.792 9.203 −4.071 1.00 34.73 A ATOM 285 O PHE A 41 3.370 8.253 −4.724 1.00 32.31 A ATOM 286 N TYR A 42 3.347 9.501 −2.848 1.00 35.03 A ATOM 287 CA TYR A 42 2.283 8.734 −2.189 1.00 36.12 A ATOM 288 CB TYR A 42 2.042 9.251 −.761 1.00 37.39 A ATOM 289 CG TYR A 42 .882 8.580 −.041 1.00 39.07 A ATOM 290 CD1 TYR A 42 .912 7.220 .270 1.00 38.88 A ATOM 291 CE1 TYR A 42 −.164 6.599 .908 1.00 40.03 A ATOM 292 CD2 TYR A 42 −.256 9.306 .311 1.00 41.58 A ATOM 293 CE2 TYR A 42 −1.339 8.695 .950 1.00 42.57 A ATOM 294 CZ TYR A 42 −1.286 7.340 1.242 1.00 42.03 A ATOM 295 OH TYR A 42 −2.371 6.730 1.837 1.00 42.82 A ATOM 296 C TYR A 42 .972 8.797 −2.966 1.00 35.76 A ATOM 297 O TYR A 42 .263 7.794 −3.067 1.00 35.92 A ATOM 298 N PHE A 43 .657 9.973 −3.511 1.00 35.17 A ATOM 299 CA PHE A 43 −.570 10.157 −4.275 1.00 35.00 A ATOM 300 CB PHE A 43 −1.008 11.621 −4.227 1.00 34.32 A ATOM 301 CG PHE A 43 −1.821 11.946 −3.019 1.00 35.42 A ATOM 302 CD1 PHE A 43 −1.258 11.874 −1.749 1.00 36.46 A ATOM 303 CD2 PHE A 43 −3.182 12.209 −3.131 1.00 36.17 A ATOM 304 CE1 PHE A 43 −2.043 12.050 −.605 1.00 36.76 A ATOM 305 CE2 PHE A 43 −3.973 12.385 −1.995 1.00 36.73 A ATOM 306 CZ PHE A 43 −3.402 12.303 −.733 1.00 36.01 A ATOM 307 C PHE A 43 −.466 9.674 −5.711 1.00 34.97 A ATOM 308 O PHE A 43 −1.464 9.296 −6.324 1.00 35.50 A ATOM 309 N ARG A 44 .749 9.670 −6.238 1.00 35.11 A ATOM 310 CA ARG A 44 .978 9.213 −7.594 1.00 36.10 A ATOM 311 CB ARG A 44 2.377 9.628 −8.067 1.00 35.40 A ATOM 312 CG ARG A 44 2.664 9.344 −9.535 1.00 35.13 A ATOM 313 CD ARG A 44 4.163 9.339 −9.811 1.00 35.91 A ATOM 314 NE ARG A 44 4.677 7.973 −9.832 1.00 37.90 A ATOM 315 CZ ARG A 44 5.852 7.593 −9.347 1.00 36.82 A ATOM 316 NH1 ARG A 44 6.669 8.472 −8.787 1.00 35.87 A ATOM 317 NH2 ARG A 44 6.203 6.319 −9.420 1.00 35.52 A ATOM 318 C ARG A 44 .875 7.692 −7.596 1.00 36.32 A ATOM 319 O ARG A 44 .045 7.116 −8.289 1.00 37.41 A ATOM 320 N ILE A 45 1.724 7.051 −6.801 1.00 36.73 A ATOM 321 CA ILE A 45 1.761 5.597 −6.709 1.00 36.73 A ATOM 322 CB ILE A 45 2.832 5.150 −5.657 1.00 37.01 A ATOM 323 CG2 ILE A 45 2.165 4.717 −4.354 1.00 36.42 A ATOM 324 CG1 ILE A 45 3.705 4.028 −6.238 1.00 36.57 A ATOM 325 CD1 ILE A 45 2.967 2.746 −6.571 1.00 38.47 A ATOM 326 C ILE A 45 .391 4.990 −6.379 1.00 36.30 A ATOM 327 O ILE A 45 .153 3.810 −6.621 1.00 34.20 A ATOM 328 N THR A 46 −.515 5.801 −5.838 1.00 38.01 A ATOM 329 CA THR A 46 −1.850 5.310 −5.493 1.00 37.39 A ATOM 330 CB THR A 46 −2.252 5.740 −4.074 1.00 36.17 A ATOM 331 OG1 THR A 46 −1.982 7.136 −3.893 1.00 33.06 A ATOM 332 CG2 THR A 46 −1.479 4.926 −3.048 1.00 37.56 A ATOM 333 C THR A 46 −2.958 5.728 −6.457 1.00 38.51 A ATOM 334 O THR A 46 −4.132 5.436 −6.219 1.00 37.81 A ATOM 335 N GLY A 47 −2.584 6.408 −7.540 1.00 39.96 A ATOM 336 CA GLY A 47 −3.565 6.846 −8.521 1.00 42.56 A ATOM 337 C GLY A 47 −4.502 7.909 −7.984 1.00 44.81 A ATOM 338 O GLY A 47 −5.650 8.022 −8.420 1.00 43.82 A ATOM 339 N ASN A 48 −4.005 8.694 −7.035 1.00 46.78 A ATOM 340 CA ASN A 48 −4.797 9.746 −6.421 1.00 49.83 A ATOM 341 CB ASN A 48 −4.906 9.495 −4.911 1.00 49.33 A ATOM 342 CG ASN A 48 −5.900 8.388 −4.562 1.00 49.27 A ATOM 343 OD1 ASN A 48 −7.092 8.641 −4.364 1.00 47.01 A ATOM 344 ND2 ASN A 48 −5.410 7.156 −4.494 1.00 47.58 A ATOM 345 C ASN A 48 −4.222 11.141 −6.674 1.00 52.04 A ATOM 346 O ASN A 48 −4.160 11.965 −5.765 1.00 51.94 A ATOM 347 N GLU A 49 −3.800 11.407 −7.906 1.00 54.73 A ATOM 348 CA GLU A 49 −3.246 12.720 −8.234 1.00 57.69 A ATOM 349 CB GLU A 49 −2.369 12.637 −9.485 1.00 59.73 A ATOM 350 CG GLU A 49 −.879 12.518 −9.183 1.00 63.54 A ATOM 351 CD GLU A 49 −.007 12.726 −10.417 1.00 66.25 A ATOM 352 OE1 GLU A 49 −.282 13.681 −11.186 1.00 65.49 A ATOM 353 OE2 GLU A 49 .959 11.945 −10.605 1.00 66.00 A ATOM 354 C GLU A 49 −4.329 13.776 −8.446 1.00 58.31 A ATOM 355 O GLU A 49 −4.185 14.927 −8.035 1.00 59.07 A ATOM 356 N HIS A 50 −5.418 13.371 −9.084 1.00 58.62 A ATOM 357 CA HIS A 50 −6.527 14.268 −9.374 1.00 59.61 A ATOM 358 CB HIS A 50 −7.610 13.497 −10.121 1.00 60.54 A ATOM 359 CG HIS A 50 −8.106 12.301 −9.376 1.00 61.50 A ATOM 360 CD2 HIS A 50 −7.982 10.977 −9.629 1.00 62.11 A ATOM 361 ND1 HIS A 50 −8.800 12.402 −8.190 1.00 62.16 A ATOM 362 CE1 HIS A 50 −9.084 11.191 −7.744 1.00 62.79 A ATOM 363 NE2 HIS A 50 −8.599 10.309 −8.599 1.00 62.52 A ATOM 364 C HIS A 50 −7.149 14.957 −8.153 1.00 59.88 A ATOM 365 O HIS A 50 −7.651 16.080 −8.270 1.00 60.59 A ATOM 366 N ASN A 51 −7.128 14.296 −6.995 1.00 58.82 A ATOM 367 CA ASN A 51 −7.719 14.870 −5.781 1.00 56.81 A ATOM 368 CB ASN A 51 −8.203 13.767 −4.843 1.00 56.29 A ATOM 369 CG ASN A 51 −9.152 14.286 −3.790 1.00 56.26 A ATOM 370 OD1 ASN A 51 −8.874 15.284 −3.123 1.00 56.98 A ATOM 371 ND2 ASN A 51 −10.282 13.614 −3.632 1.00 56.27 A ATOM 372 C ASN A 51 −6.760 15.785 −5.028 1.00 56.35 A ATOM 373 O ASN A 51 −6.394 15.529 −3.877 1.00 55.87 A ATOM 374 N THR A 52 −6.376 16.860 −5.705 1.00 55.80 A ATOM 375 CA THR A 52 −5.463 17.865 −5.188 1.00 54.81 A ATOM 376 CB THR A 52 −5.459 19.087 −6.111 1.00 55.61 A ATOM 377 OG1 THR A 52 −6.814 19.464 −6.398 1.00 54.96 A ATOM 378 CG2 THR A 52 −4.736 18.764 −7.417 1.00 55.96 A ATOM 379 C THR A 52 −5.750 18.336 −3.767 1.00 53.99 A ATOM 380 O THR A 52 −4.838 18.786 −3.071 1.00 53.61 A ATOM 381 N GLU A 53 −7.007 18.241 −3.339 1.00 53.25 A ATOM 382 CA GLU A 53 −7.384 18.670 −1.991 1.00 52.66 A ATOM 383 CB GLU A 53 −8.908 18.712 −1.848 1.00 53.87 A ATOM 384 CG GLU A 53 −9.545 19.936 −2.469 1.00 56.65 A ATOM 385 CD GLU A 53 −9.077 21.226 −1.809 1.00 58.56 A ATOM 386 OE1 GLU A 53 −9.448 21.471 −.638 1.00 59.21 A ATOM 387 OE2 GLU A 53 −8.331 21.990 −2.460 1.00 59.26 A ATOM 388 C GLU A 53 −6.795 17.774 −.902 1.00 51.50 A ATOM 389 O GLU A 53 −6.097 18.248 −.001 1.00 50.48 A ATOM 390 N LEU A 54 −7.084 16.479 −.986 1.00 50.21 A ATOM 391 CA LEU A 54 −6.580 15.524 −.006 1.00 49.09 A ATOM 392 CB LEU A 54 −7.098 14.123 −.324 1.00 46.64 A ATOM 393 CG LEU A 54 −6.867 13.107 .787 1.00 45.40 A ATOM 394 CD1 LEU A 54 −7.488 13.628 2.071 1.00 43.87 A ATOM 395 CD2 LEU A 54 −7.464 11.766 .393 1.00 44.37 A ATOM 396 C LEU A 54 −5.057 15.524 −.019 1.00 49.00 A ATOM 397 O LEU A 54 −4.411 15.498 1.033 1.00 47.49 A ATOM 398 N LYS A 55 −4.497 15.556 −1.226 1.00 48.68 A ATOM 399 CA LYS A 55 −3.055 15.572 −1.408 1.00 47.72 A ATOM 400 CB LYS A 55 −2.729 15.647 −2.901 1.00 48.44 A ATOM 401 CG LYS A 55 −1.262 15.406 −3.270 1.00 50.21 A ATOM 402 CD LYS A 55 −1.057 15.477 −4.794 1.00 50.11 A ATOM 403 CE LYS A 55 .398 15.232 −5.188 1.00 51.15 A ATOM 404 NZ LYS A 55 .637 15.423 −6.646 1.00 51.72 A ATOM 405 C LYS A 55 −2.465 16.773 −.667 1.00 46.95 A ATOM 406 O LYS A 55 −1.555 16.624 .148 1.00 45.99 A ATOM 407 N ASP A 56 −2.993 17.962 −.938 1.00 47.40 A ATOM 408 CA ASP A 56 −2.487 19.158 −.277 1.00 48.44 A ATOM 409 CB ASP A 56 −3.171 20.423 −.811 1.00 50.05 A ATOM 410 CG ASP A 56 −2.567 21.706 −.233 1.00 52.26 A ATOM 411 OD1 ASP A 56 −1.327 21.769 −.059 1.00 52.72 A ATOM 412 OD2 ASP A 56 −3.332 22.656 .038 1.00 53.74 A ATOM 413 C ASP A 56 −2.716 19.027 1.217 1.00 47.51 A ATOM 414 O ASP A 56 −1.932 19.538 2.026 1.00 47.63 A ATOM 415 N LYS A 57 −3.793 18.337 1.582 1.00 46.00 A ATOM 416 CA LYS A 57 −4.098 18.115 2.988 1.00 45.09 A ATOM 417 CB LYS A 57 −5.500 17.525 3.150 1.00 46.26 A ATOM 418 CG LYS A 57 −5.753 16.920 4.524 1.00 47.34 A ATOM 419 CD LYS A 57 −7.006 17.481 5.180 1.00 48.29 A ATOM 420 CE LYS A 57 −8.282 17.064 4.462 1.00 46.87 A ATOM 421 NZ LYS A 57 −9.480 17.627 5.149 1.00 46.62 A ATOM 422 C LYS A 57 −3.068 17.164 3.593 1.00 42.98 A ATOM 423 O LYS A 57 −2.712 17.280 4.762 1.00 41.90 A ATOM 424 N PHE A 58 −2.587 16.229 2.786 1.00 41.09 A ATOM 425 CA PHE A 58 −1.606 15.270 3.261 1.00 40.95 A ATOM 426 CB PHE A 58 −1.620 14.033 2.371 1.00 40.96 A ATOM 427 CG PHE A 58 −.646 12.975 2.786 1.00 42.12 A ATOM 428 CD1 PHE A 58 .574 12.838 2.128 1.00 42.03 A ATOM 429 CD2 PHE A 58 −.957 12.093 3.815 1.00 41.57 A ATOM 430 CE1 PHE A 58 1.470 11.834 2.484 1.00 42.26 A ATOM 431 CE2 PHE A 58 −.064 11.085 4.181 1.00 42.43 A ATOM 432 CZ PHE A 58 1.150 10.955 3.512 1.00 40.79 A ATOM 433 C PHE A 58 −.219 15.888 3.300 1.00 41.74 A ATOM 434 O PHE A 58 .610 15.528 4.141 1.00 40.63 A ATOM 435 N LYS A 59 .034 16.823 2.389 1.00 42.14 A ATOM 436 CA LYS A 59 1.327 17.496 2.363 1.00 42.84 A ATOM 437 CB LYS A 59 1.445 18.441 1.158 1.00 44.84 A ATOM 438 CG LYS A 59 1.444 17.756 −.206 1.00 47.75 A ATOM 439 CD LYS A 59 1.788 18.739 −1.329 1.00 49.41 A ATOM 440 CE LYS A 59 1.789 18.050 −2.697 1.00 51.02 A ATOM 441 NZ LYS A 59 2.057 18.999 −3.823 1.00 51.85 A ATOM 442 C LYS A 59 1.403 18.307 3.639 1.00 41.25 A ATOM 443 O LYS A 59 2.446 18.388 4.278 1.00 40.75 A ATOM 444 N ARG A 60 .274 18.898 4.005 1.00 40.74 A ATOM 445 CA ARG A 60 .198 19.713 5.205 1.00 42.28 A ATOM 446 CB ARG A 60 −1.133 20.473 5.239 1.00 46.48 A ATOM 447 CG ARG A 60 −1.243 21.564 4.174 1.00 51.56 A ATOM 448 CD ARG A 60 −.227 22.673 4.426 1.00 56.26 A ATOM 449 NE ARG A 60 −.197 23.681 3.364 1.00 60.76 A ATOM 450 CZ ARG A 60 .504 24.812 3.426 1.00 62.22 A ATOM 451 NH1 ARG A 60 1.233 25.084 4.501 1.00 62.02 A ATOM 452 NH2 ARG A 60 .486 25.670 2.412 1.00 62.68 A ATOM 453 C ARG A 60 .374 18.885 6.475 1.00 40.66 A ATOM 454 O ARG A 60 .823 19.402 7.496 1.00 41.04 A ATOM 455 N ILE A 61 .024 17.603 6.421 1.00 38.03 A ATOM 456 CA ILE A 61 .192 16.746 7.590 1.00 34.21 A ATOM 457 CB ILE A 61 −.631 15.456 7.497 1.00 32.45 A ATOM 458 CG2 ILE A 61 −.228 14.520 8.638 1.00 29.47 A ATOM 459 CG1 ILE A 61 −2.127 15.776 7.548 1.00 31.31 A ATOM 460 CD1 ILE A 61 −3.010 14.567 7.320 1.00 30.86 A ATOM 461 C ILE A 61 1.654 16.344 7.689 1.00 33.40 A ATOM 462 O ILE A 61 2.230 16.326 8.773 1.00 30.59 A ATOM 463 N CYS A 62 2.235 16.012 6.539 1.00 34.39 A ATOM 464 CA CYS A 62 3.630 15.605 6.469 1.00 36.39 A ATOM 465 CB CYS A 62 4.009 15.211 5.035 1.00 35.67 A ATOM 466 SG CYS A 62 3.392 13.621 4.435 1.00 36.68 A ATOM 467 C CYS A 62 4.543 16.736 6.937 1.00 37.23 A ATOM 468 O CYS A 62 5.539 16.498 7.615 1.00 36.14 A ATOM 469 N GLU A 63 4.190 17.968 6.585 1.00 38.33 A ATOM 470 CA GLU A 63 4.996 19.124 6.961 1.00 39.37 A ATOM 471 CB GLU A 63 4.608 20.325 6.097 1.00 41.87 A ATOM 472 CG GLU A 63 5.008 20.131 4.637 1.00 44.04 A ATOM 473 CD GLU A 63 4.621 21.296 3.752 1.00 45.93 A ATOM 474 OE1 GLU A 63 3.407 21.593 3.652 1.00 47.07 A ATOM 475 OE2 GLU A 63 5.533 21.909 3.152 1.00 46.35 A ATOM 476 C GLU A 63 4.957 19.483 8.442 1.00 37.95 A ATOM 477 O GLU A 63 5.798 20.250 8.915 1.00 37.13 A ATOM 478 N ARG A 64 3.986 18.934 9.166 1.00 36.39 A ATOM 479 CA ARG A 64 3.886 19.163 10.608 1.00 37.43 A ATOM 480 CB ARG A 64 2.428 19.371 11.037 1.00 37.43 A ATOM 481 CG ARG A 64 1.829 20.731 10.710 1.00 40.40 A ATOM 482 CD ARG A 64 .612 20.995 11.592 1.00 42.29 A ATOM 483 NE ARG A 64 −.415 19.974 11.406 1.00 43.14 A ATOM 484 CZ ARG A 64 −1.196 19.897 10.335 1.00 44.35 A ATOM 485 NH1 ARG A 64 −1.065 20.785 9.360 1.00 44.07 A ATOM 486 NH2 ARG A 64 −2.103 18.933 10.234 1.00 44.06 A ATOM 487 C ARG A 64 4.454 17.952 11.377 1.00 37.08 A ATOM 488 O ARG A 64 4.840 18.067 12.539 1.00 38.38 A ATOM 489 N SER A 65 4.506 16.801 10.714 1.00 36.12 A ATOM 490 CA SER A 65 4.997 15.570 11.314 1.00 35.70 A ATOM 491 CB SER A 65 5.048 14.464 10.265 1.00 35.60 A ATOM 492 OG SER A 65 6.067 14.711 9.310 1.00 34.83 A ATOM 493 C SER A 65 6.364 15.665 11.982 1.00 36.13 A ATOM 494 O SER A 65 6.655 14.899 12.890 1.00 36.64 A ATOM 495 N ALA A 66 7.207 16.593 11.540 1.00 36.59 A ATOM 496 CA ALA A 66 8.544 16.736 12.115 1.00 34.73 A ATOM 497 CB ALA A 66 8.451 16.912 13.624 1.00 34.03 A ATOM 498 C ALA A 66 9.372 15.497 11.780 1.00 35.37 A ATOM 499 O ALA A 66 10.364 15.199 12.444 1.00 37.03 A ATOM 500 N ILE A 67 8.947 14.765 10.753 1.00 34.92 A ATOM 501 CA ILE A 67 9.651 13.566 10.312 1.00 33.47 A ATOM 502 CB ILE A 67 8.673 12.386 10.079 1.00 30.76 A ATOM 503 CG2 ILE A 67 9.438 11.146 9.666 1.00 29.23 A ATOM 504 CG1 ILE A 67 7.872 12.108 11.348 1.00 28.84 A ATOM 505 CD1 ILE A 67 6.788 11.067 11.151 1.00 28.29 A ATOM 506 C ILE A 67 10.312 13.925 8.989 1.00 34.28 A ATOM 507 O ILE A 67 9.624 14.239 8.017 1.00 36.16 A ATOM 508 N LYS A 68 11.638 13.873 8.943 1.00 34.27 A ATOM 509 CA LYS A 68 12.352 14.235 7.724 1.00 34.52 A ATOM 510 CB LYS A 68 13.688 14.891 8.090 1.00 35.42 A ATOM 511 CG LYS A 68 13.505 16.015 9.091 1.00 41.45 A ATOM 512 CD LYS A 68 14.753 16.865 9.328 1.00 44.25 A ATOM 513 CE LYS A 68 14.409 18.006 10.300 1.00 45.99 A ATOM 514 NZ LYS A 68 15.554 18.899 10.677 1.00 46.24 A ATOM 515 C LYS A 68 12.569 13.077 6.760 1.00 33.29 A ATOM 516 O LYS A 68 12.737 13.287 5.555 1.00 33.72 A ATOM 517 N GLN A 69 12.560 11.854 7.283 1.00 31.93 A ATOM 518 CA GLN A 69 12.756 10.679 6.441 1.00 30.12 A ATOM 519 CB GLN A 69 14.211 10.591 5.963 1.00 32.01 A ATOM 520 CG GLN A 69 15.208 10.263 7.060 1.00 34.66 A ATOM 521 CD GLN A 69 15.994 8.989 6.779 1.00 37.65 A ATOM 522 OE1 GLN A 69 15.416 7.908 6.627 1.00 42.24 A ATOM 523 NE2 GLN A 69 17.317 9.108 6.717 1.00 35.40 A ATOM 524 C GLN A 69 12.410 9.400 7.174 1.00 27.55 A ATOM 525 O GLN A 69 12.518 9.318 8.389 1.00 26.69 A ATOM 526 N ARG A 70 12.009 8.396 6.414 1.00 26.61 A ATOM 527 CA ARG A 70 11.648 7.110 6.973 1.00 28.66 A ATOM 528 CB ARG A 70 10.129 6.982 7.054 1.00 29.52 A ATOM 529 CG ARG A 70 9.441 7.999 7.946 1.00 31.27 A ATOM 530 CD ARG A 70 7.912 7.856 7.848 1.00 32.64 A ATOM 531 NE ARG A 70 7.373 8.476 6.636 1.00 31.85 A ATOM 532 CZ ARG A 70 6.126 8.330 6.190 1.00 33.49 A ATOM 533 NH1 ARG A 70 5.253 7.571 6.844 1.00 33.87 A ATOM 534 NH2 ARG A 70 5.746 8.952 5.083 1.00 33.20 A ATOM 535 C ARG A 70 12.202 6.021 6.065 1.00 28.42 A ATOM 536 O ARG A 70 12.528 6.280 4.908 1.00 26.75 A ATOM 537 N TYR A 71 12.322 4.809 6.596 1.00 28.10 A ATOM 538 CA TYR A 71 12.811 3.683 5.814 1.00 28.19 A ATOM 539 CB TYR A 71 13.940 2.958 6.556 1.00 28.62 A ATOM 540 CG TYR A 71 15.224 3.761 6.650 1.00 29.33 A ATOM 541 CD1 TYR A 71 15.475 4.597 7.735 1.00 29.31 A ATOM 542 CE1 TYR A 71 16.651 5.341 7.812 1.00 31.09 A ATOM 543 CD2 TYR A 71 16.180 3.690 5.643 1.00 28.03 A ATOM 544 CE2 TYR A 71 17.350 4.426 5.710 1.00 30.76 A ATOM 545 CZ TYR A 71 17.581 5.248 6.794 1.00 30.97 A ATOM 546 OH TYR A 71 18.748 5.974 6.847 1.00 34.98 A ATOM 547 C TYR A 71 11.637 2.740 5.558 1.00 29.16 A ATOM 548 O TYR A 71 11.068 2.161 6.486 1.00 26.84 A ATOM 549 N MET A 72 11.275 2.599 4.288 1.00 28.94 A ATOM 550 CA MET A 72 10.147 1.773 3.907 1.00 27.84 A ATOM 551 CB MET A 72 9.169 2.600 3.062 1.00 27.20 A ATOM 552 CG MET A 72 8.753 3.911 3.706 1.00 27.56 A ATOM 553 SD MET A 72 7.148 4.518 3.144 1.00 22.93 A ATOM 554 CE MET A 72 6.139 3.616 4.227 1.00 26.94 A ATOM 555 C MET A 72 10.528 .516 3.151 1.00 26.70 A ATOM 556 O MET A 72 11.360 .551 2.241 1.00 25.56 A ATOM 557 N TYR A 73 9.918 −.597 3.549 1.00 24.06 A ATOM 558 CA TYR A 73 10.147 −1.876 2.895 1.00 23.85 A ATOM 559 CB TYR A 73 9.463 −3.014 3.658 1.00 24.18 A ATOM 560 CG TYR A 73 9.171 −4.217 2.779 1.00 24.55 A ATOM 561 CD1 TYR A 73 10.193 −5.055 2.348 1.00 21.59 A ATOM 562 CE1 TYR A 73 9.928 −6.136 1.525 1.00 27.28 A ATOM 563 CD2 TYR A 73 7.869 −4.495 2.357 1.00 26.09 A ATOM 564 CE2 TYR A 73 7.594 −5.581 1.531 1.00 26.05 A ATOM 565 CZ TYR A 73 8.630 −6.395 1.125 1.00 26.65 A ATOM 566 OH TYR A 73 8.371 −7.483 .340 1.00 30.63 A ATOM 567 C TYR A 73 9.501 −1.756 1.531 1.00 24.72 A ATOM 568 O TYR A 73 10.066 −2.153 .516 1.00 25.42 A ATOM 569 N LEU A 74 8.291 −1.220 1.529 1.00 24.58 A ATOM 570 CA LEU A 74 7.547 −1.023 .297 1.00 27.00 A ATOM 571 CB LEU A 74 6.134 −.524 .597 1.00 26.63 A ATOM 572 CG LEU A 74 5.223 −1.486 1.347 1.00 23.99 A ATOM 573 CD1 LEU A 74 4.071 −.711 1.932 1.00 24.50 A ATOM 574 CD2 LEU A 74 4.749 −2.579 .420 1.00 23.90 A ATOM 575 C LEU A 74 8.242 .004 −.576 1.00 27.44 A ATOM 576 O LEU A 74 8.339 1.174 −.211 1.00 26.38 A ATOM 577 N THR A 75 8.733 −.447 −1.724 1.00 29.33 A ATOM 578 CA THR A 75 9.385 .427 −2.685 1.00 28.26 A ATOM 579 CB THR A 75 10.624 −.258 −3.316 1.00 27.99 A ATOM 580 OG1 THR A 75 10.243 −1.499 −3.918 1.00 27.29 A ATOM 581 CG2 THR A 75 11.671 −.542 −2.260 1.00 30.37 A ATOM 582 C THR A 75 8.331 .701 −3.764 1.00 29.52 A ATOM 583 O THR A 75 7.188 .229 −3.664 1.00 25.85 A ATOM 584 N GLU A 76 8.699 1.464 −4.788 1.00 30.38 A ATOM 585 CA GLU A 76 7.758 1.758 −5.853 1.00 31.86 A ATOM 586 CB GLU A 76 8.277 2.888 −6.730 1.00 34.29 A ATOM 587 CG GLU A 76 7.227 3.361 −7.709 1.00 37.84 A ATOM 588 CD GLU A 76 7.774 4.305 −8.738 1.00 40.62 A ATOM 589 OE1 GLU A 76 8.541 5.215 −8.359 1.00 41.20 A ATOM 590 OE2 GLU A 76 7.422 4.144 −9.926 1.00 44.13 A ATOM 591 C GLU A 76 7.562 .511 −6.707 1.00 32.06 A ATOM 592 O GLU A 76 6.453 .199 −7.154 1.00 31.57 A ATOM 593 N GLU A 77 8.662 −.192 −6.936 1.00 30.45 A ATOM 594 CA GLU A 77 8.656 −1.412 −7.720 1.00 32.97 A ATOM 595 CB GLU A 77 10.080 −1.949 −7.790 1.00 35.54 A ATOM 596 CG GLU A 77 10.284 −3.126 −8.705 1.00 43.11 A ATOM 597 CD GLU A 77 11.767 −3.446 −8.885 1.00 46.08 A ATOM 598 OE1 GLU A 77 12.485 −2.654 −9.543 1.00 47.40 A ATOM 599 OE2 GLU A 77 12.218 −4.484 −8.358 1.00 47.34 A ATOM 600 C GLU A 77 7.727 −2.445 −7.089 1.00 33.13 A ATOM 601 O GLU A 77 7.005 −3.150 −7.789 1.00 33.97 A ATOM 602 N ILE A 78 7.737 −2.525 −5.761 1.00 32.98 A ATOM 603 CA ILE A 78 6.890 −3.482 −5.045 1.00 33.29 A ATOM 604 CB ILE A 78 7.368 −3.668 −3.584 1.00 32.97 A ATOM 605 CG2 ILE A 78 6.397 −4.556 −2.814 1.00 34.53 A ATOM 606 CG1 ILE A 78 8.745 −4.330 −3.571 1.00 31.63 A ATOM 607 CD1 ILE A 78 9.382 −4.396 −2.195 1.00 33.04 A ATOM 608 C ILE A 78 5.419 −3.066 −5.051 1.00 34.05 A ATOM 609 O ILE A 78 4.544 −3.902 −5.262 1.00 32.38 A ATOM 610 N LEU A 79 5.145 −1.782 −4.813 1.00 35.12 A ATOM 611 CA LEU A 79 3.770 −1.297 −4.834 1.00 36.98 A ATOM 612 CB LEU A 79 3.698 .167 −4.389 1.00 37.47 A ATOM 613 CG LEU A 79 3.811 .411 −2.887 1.00 37.60 A ATOM 614 CD1 LEU A 79 3.898 1.899 −2.597 1.00 36.08 A ATOM 615 CD2 LEU A 79 2.611 −.216 −2.202 1.00 35.79 A ATOM 616 C LEU A 79 3.191 −1.433 −6.243 1.00 38.11 A ATOM 617 O LEU A 79 2.002 −1.705 −6.405 1.00 39.23 A ATOM 618 N LYS A 80 4.038 −1.262 −7.257 1.00 39.10 A ATOM 619 CA LYS A 80 3.600 −1.368 −8.649 1.00 40.27 A ATOM 620 CB LYS A 80 4.706 −.885 −9.589 1.00 42.10 A ATOM 621 CG LYS A 80 4.913 .627 −9.598 1.00 43.49 A ATOM 622 CD LYS A 80 4.325 1.294 −10.844 1.00 44.07 A ATOM 623 CE LYS A 80 2.802 1.242 −10.867 1.00 46.55 A ATOM 624 NZ LYS A 80 2.232 2.001 −12.020 1.00 47.24 A ATOM 625 C LYS A 80 3.171 −2.787 −9.043 1.00 39.71 A ATOM 626 O LYS A 80 2.313 −2.958 −9.910 1.00 39.42 A ATOM 627 N LYS A 81 3.777 −3.799 −8.425 1.00 39.39 A ATOM 628 CA LYS A 81 3.420 −5.188 −8.709 1.00 39.36 A ATOM 629 CB LYS A 81 4.599 −6.129 −8.454 1.00 40.38 A ATOM 630 CG LYS A 81 5.848 −5.880 −9.269 1.00 42.46 A ATOM 631 CD LYS A 81 6.940 −6.882 −8.883 1.00 44.35 A ATOM 632 CE LYS A 81 6.480 −8.334 −9.111 1.00 45.75 A ATOM 633 NZ LYS A 81 7.512 −9.371 −8.780 1.00 43.48 A ATOM 634 C LYS A 81 2.289 −5.598 −7.772 1.00 38.94 A ATOM 635 O LYS A 81 1.782 −6.711 −7.850 1.00 40.01 A ATOM 636 N ASN A 82 1.897 −4.693 −6.884 1.00 39.20 A ATOM 637 CA ASN A 82 .849 −4.992 −5.918 1.00 38.88 A ATOM 638 CB ASN A 82 1.475 −5.246 −4.543 1.00 38.01 A ATOM 639 CG ASN A 82 2.231 −6.562 −4.482 1.00 36.74 A ATOM 640 OD1 ASN A 82 1.639 −7.619 −4.291 1.00 35.51 A ATOM 641 ND2 ASN A 82 3.541 −6.500 −4.663 1.00 34.42 A ATOM 642 C ASN A 82 −.193 −3.890 −5.807 1.00 38.13 A ATOM 643 O ASN A 82 −.275 −3.195 −4.788 1.00 39.26 A ATOM 644 N PRO A 83 −1.017 −3.724 −6.851 1.00 36.98 A ATOM 645 CD PRO A 83 −1.086 −4.574 −8.051 1.00 34.43 A ATOM 646 CA PRO A 83 −2.069 −2.698 −6.867 1.00 37.02 A ATOM 647 CB PRO A 83 −2.780 −2.957 −8.195 1.00 36.28 A ATOM 648 CG PRO A 83 −2.530 −4.442 −8.435 1.00 34.63 A ATOM 649 C PRO A 83 −3.042 −2.735 −5.673 1.00 37.05 A ATOM 650 O PRO A 83 −3.478 −1.686 −5.192 1.00 39.34 A ATOM 651 N ASP A 84 −3.367 −3.930 −5.185 1.00 35.56 A ATOM 652 CA ASP A 84 −4.308 −4.062 −4.078 1.00 33.46 A ATOM 653 CB ASP A 84 −4.649 −5.530 −3.853 1.00 34.51 A ATOM 654 CG ASP A 84 −5.314 −6.158 −5.061 1.00 35.83 A ATOM 655 OD1 ASP A 84 −6.199 −5.499 −5.646 1.00 37.72 A ATOM 656 OD2 ASP A 84 −4.961 −7.308 −5.420 1.00 37.56 A ATOM 657 C ASP A 84 −3.845 −3.426 −2.774 1.00 33.39 A ATOM 658 O ASP A 84 −4.665 −2.968 −1.982 1.00 31.87 A ATOM 659 N VAL A 85 −2.534 −3.411 −2.547 1.00 31.84 A ATOM 660 CA VAL A 85 −1.970 −2.804 −1.349 1.00 29.40 A ATOM 661 CB VAL A 85 −.464 −3.168 −1.201 1.00 31.38 A ATOM 662 CG1 VAL A 85 .244 −2.216 −.222 1.00 32.10 A ATOM 663 CG2 VAL A 85. −.336 −4.600 −.718 1.00 29.20 A ATOM 664 C VAL A 85 −2.134 −1.282 −1.449 1.00 29.43 A ATOM 665 O VAL A 85 −2.082 −.574 −.445 1.00 26.13 A ATOM 666 N CYS A 86 −2.344 −.791 −2.670 1.00 29.46 A ATOM 667 CA CYS A 86 −2.524 .638 −2.904 1.00 29.39 A ATOM 668 CB CYS A 86 −2.097 1.001 −4.328 1.00 30.74 A ATOM 669 SG CYS A 86 −.317 .843 −4.599 1.00 36.69 A ATOM 670 C CYS A 86 −3.953 1.107 −2.664 1.00 29.64 A ATOM 671 O CYS A 86 −4.179 2.262 −2.306 1.00 30.15 A ATOM 672 N ALA A 87 −4.925 .228 −2.864 1.00 26.40 A ATOM 673 CA ALA A 87 −6.295 .642 −2.636 1.00 28.82 A ATOM 674 CB ALA A 87 −7.256 −.483 −2.988 1.00 25.62 A ATOM 675 C ALA A 87 −6.429 1.031 −1.161 1.00 29.47 A ATOM 676 O ALA A 87 −5.489 .881 −.385 1.00 29.21 A ATOM 677 N PHE A 88 −7.591 1.548 −.779 1.00 30.50 A ATOM 678 CA PHE A 88 −7.817 1.946 .604 1.00 31.87 A ATOM 679 CB PHE A 88 −8.753 3.157 .667 1.00 31.60 A ATOM 680 CG PHE A 88 −9.116 3.567 2.064 1.00 31.92 A ATOM 681 CD1 PHE A 88 −8.127 3.926 2.979 1.00 32.89 A ATOM 682 CD2 PHE A 88 −10.443 3.592 2.471 1.00 30.33 A ATOM 683 CE1 PHE A 88 −8.463 4.303 4.271 1.00 31.78 A ATOM 684 CE2 PHE A 88 −10.786 3.967 3.761 1.00 30.31 A ATOM 685 CZ PHE A 88 −9.798 4.323 4.663 1.00 30.55 A ATOM 686 C PHE A 88 −8.432 .775 1.352 1.00 32.46 A ATOM 687 O PHE A 88 −7.846 .258 2.297 1.00 33.36 A ATOM 688 N VAL A 89 −9.614 .358 .907 1.00 31.48 A ATOM 689 CA VAL A 89 −10.315 −.759 1.518 1.00 31.02 A ATOM 690 CB VAL A 89 −11.000 −.330 2.835 1.00 32.10 A ATOM 691 CG1 VAL A 89 −12.350 .336 2.543 1.00 30.78 A ATOM 692 CG2 VAL A 89 −11.183 −1.527 3.737 1.00 33.25 A ATOM 693 C VAL A 89 −11.377 −1.316 .563 1.00 30.23 A ATOM 694 O VAL A 89 −12.263 −2.036 .997 1.00 26.54 A ATOM 695 N GLU A 90 −11.284 −.980 −.729 1.00 32.29 A ATOM 696 CA GLU A 90 −12.246 −1.465 −1.729 1.00 32.87 A ATOM 697 CB GLU A 90 −12.260 −.598 −2.989 1.00 35.11 A ATOM 698 CG GLU A 90 −12.132 .884 −2.780 1.00 39.52 A ATOM 699 CD GLU A 90 −10.703 1.296 −2.502 1.00 40.81 A ATOM 700 OE1 GLU A 90 −10.391 1.564 −1.326 1.00 44.46 A ATOM 701 OE2 GLU A 90 −9.893 1.341 −3.457 1.00 42.34 A ATOM 702 C GLU A 90 −11.945 −2.885 −2.166 1.00 32.49 A ATOM 703 O GLU A 90 −12.815 −3.577 −2.663 1.00 32.58 A ATOM 704 N VAL A 91 −10.696 −3.311 −2.019 1.00 34.49 A ATOM 705 CA VAL A 91 −10.318 −4.673 −2.384 1.00 34.27 A ATOM 706 CB VAL A 91 −9.548 −4.719 −3.734 1.00 34.98 A ATOM 707 CG1 VAL A 91 −10.522 −4.597 −4.887 1.00 36.02 A ATOM 708 CG2 VAL A 91 −8.528 −3.595 −3.805 1.00 34.63 A ATOM 709 C VAL A 91 −9.450 −5.265 −1.282 1.00 34.25 A ATOM 710 O VAL A 91 −8.662 −4.553 −.650 1.00 36.76 A ATOM 711 N PRO A 92 −9.587 −6.573 −1.022 1.00 32.30 A ATOM 712 CD PRO A 92 −10.508 −7.541 −1.637 1.00 31.68 A ATOM 713 CA PRO A 92 −8.783 −7.210 .027 1.00 31.47 A ATOM 714 CB PRO A 92 −9.387 −8.608 .120 1.00 28.44 A ATOM 715 CG PRO A 92 −9.877 −8.851 −1.263 1.00 30.17 A ATOM 716 C PRO A 92 −7.282 −7.223 −.286 1.00 30.77 A ATOM 717 O PRO A 92 −6.888 −7.231 −1.457 1.00 31.24 A ATOM 718 N SER A 93 −6.450 −7.213 .756 1.00 29.04 A ATOM 719 CA SER A 93 −5.000 −7.212 .560 1.00 28.86 A ATOM 720 CB SER A 93 −4.488 −5.774 .406 1.00 27.99 A ATOM 721 OG SER A 93 −4.609 −5.050 1.615 1.00 24.98 A ATOM 722 C SER A 93 −4.222 −7.900 1.679 1.00 28.57 A ATOM 723 O SER A 93 −2.994 −7.841 1.710 1.00 30.63 A ATOM 724 N LEU A 94 −4.934 −8.567 2.584 1.00 27.50 A ATOM 725 CA LEU A 94 −4.311 −9.263 3.712 1.00 24.56 A ATOM 726 CB LEU A 94 −5.394 −9.949 4.558 1.00 22.81 A ATOM 727 CG LEU A 94 −5.266 −10.012 6.088 1.00 24.83 A ATOM 728 CD1 LEU A 94 −5.765 −11.375 6.568 1.00 20.33 A ATOM 729 CD2 LEU A 94 −3.824 −9.778 6.536 1.00 21.99 A ATOM 730 C LEU A 94 −3.260 −10.310 3.295 1.00 23.22 A ATOM 731 O LEU A 94 −2.144 −10.312 3.799 1.00 21.73 A ATOM 732 N ASP A 95 −3.631 −11.198 2.381 1.00 22.41 A ATOM 733 CA ASP A 95 −2.733 −12.253 1.923 1.00 24.20 A ATOM 734 CB ASP A 95 −3.446 −13.139 .896 1.00 25.44 A ATOM 735 CG ASP A 95 −4.614 −13.932 1.507 1.00 29.88 A ATOM 736 OD1 ASP A 95 −5.294 −14.653 .749 1.00 34.47 A ATOM 737 OD2 ASP A 95 −4.851 −13.849 2.737 1.00 29.62 A ATOM 738 C ASP A 95 −1.426 −11.727 1.356 1.00 24.33 A ATOM 739 O ASP A 95 −.349 −12.190 1.731 1.00 24.02 A ATOM 740 N ALA A 96 −1.515 −10.759 .451 1.00 24.12 A ATOM 741 CA ALA A 96 −.318 −10.173 −.124 1.00 23.91 A ATOM 742 CB ALA A 96 −.685 −9.090 −1.113 1.00 24.59 A ATOM 743 C ALA A 96 .550 −9.585 .975 1.00 25.17 A ATOM 744 O ALA A 96 1.776 −9.679 .906 1.00 28.05 A ATOM 745 N ARG A 97 −.076 −8.981 1.987 1.00 22.01 A ATOM 746 CA ARG A 97 .679 −8.381 3.084 1.00 21.90 A ATOM 747 CB ARG A 97 −.208 −7.447 3.911 1.00 20.08 A ATOM 748 CG ARG A 97 −.695 −6.199 3.155 1.00 21.02 A ATOM 749 CD ARG A 97 −1.827 −5.559 3.909 1.00 19.89 A ATOM 750 NE ARG A 97 −2.538 −4.543 3.141 1.00 24.71 A ATOM 751 CZ ARG A 97 −2.095 −3.307 2.938 1.00 23.62 A ATOM 752 NH1 ARG A 97 −.931 −2.931 3.443 1.00 23.02 A ATOM 753 NH2 ARG A 97 −2.832 −2.440 2.254 1.00 25.63 A ATOM 754 C ARG A 97 1.315 −9.415 4.008 1.00 23.99 A ATOM 755 O ARG A 97 2.438 −9.221 4.495 1.00 25.02 A ATOM 756 N GLN A 98 .603 −10.510 4.255 1.00 22.43 A ATOM 757 CA GLN A 98 1.124 −11.538 5.125 1.00 22.91 A ATOM 758 CB GLN A 98 .081 −12.645 5.340 1.00 21.13 A ATOM 759 CG GLN A 98 −1.261 −12.154 5.938 1.00 20.57 A ATOM 760 CD GLN A 98 −1.161 −11.687 7.391 1.00 19.43 A ATOM 761 OE1 GLN A 98 −1.797 −12.254 8.283 1.00 19.15 A ATOM 762 NE2 GLN A 98 −.366 −10.654 7.630 1.00 15.68 A ATOM 763 C GLN A 98 2.400 −12.097 4.504 1.00 24.91 A ATOM 764 O GLN A 98 3.366 −12.364 5.218 1.00 24.11 A ATOM 765 N ALA A 99 2.410 −12.238 3.174 1.00 26.86 A ATOM 766 CA ALA A 99 3.580 −12.766 2.455 1.00 28.83 A ATOM 767 CB ALA A 99 3.268 −12.934 .961 1.00 28.35 A ATOM 768 C ALA A 99 4.764 −11.825 2.640 1.00 27.98 A ATOM 769 O ALA A 99 5.875 −12.258 2.955 1.00 29.15 A ATOM 770 N MET A 100 4.515 −10.535 2.438 1.00 27.72 A ATOM 771 CA MET A 100 5.537 −9.507 2.599 1.00 26.42 A ATOM 772 CB MET A 100 4.941 −8.106 2.390 1.00 24.11 A ATOM 773 CG MET A 100 4.634 −7.739 .940 1.00 24.57 A ATOM 774 SD MET A 100 3.735 −6.165 .749 1.00 18.38 A ATOM 775 CE MET A 100 2.752 −6.545 −.586 1.00 21.64 A ATOM 776 C MET A 100 6.096 −9.597 4.005 1.00 25.75 A ATOM 777 O MET A 100 7.305 −9.547 4.203 1.00 24.42 A ATOM 778 N LEU A 101 5.194 −9.742 4.971 1.00 26.33 A ATOM 779 CA LEU A 101 5.540 −9.819 6.388 1.00 27.46 A ATOM 780 CB LEU A 101 4.262 −9.777 7.225 1.00 26.83 A ATOM 781 CG LEU A 101 4.012 −8.510 8.029 1.00 29.59 A ATOM 782 CD1 LEU A 101 4.229 −7.300 7.144 1.00 30.34 A ATOM 783 CD2 LEU A 101 2.600 −8.536 8.587 1.00 28.87 A ATOM 784 C LEU A 101 6.349 −11.050 6.785 1.00 27.33 A ATOM 785 O LEU A 101 7.377 −10.944 7.457 1.00 28.56 A ATOM 786 N ALA A 102 5.881 −12.218 6.371 1.00 25.00 A ATOM 787 CA ALA A 102 6.560 −13.457 6.716 1.00 27.48 A ATOM 788 CB ALA A 102 5.894 −14.627 5.994 1.00 23.71 A ATOM 789 C ALA A 102 8.056 −13.395 6.381 1.00 28.69 A ATOM 790 O ALA A 102 8.870 −13.987 7.084 1.00 29.73 A ATOM 791 N MET A 103 8.415 −12.661 5.329 1.00 29.35 A ATOM 792 CA MET A 103 9.818 −12.560 4.924 1.00 32.04 A ATOM 793 CB MET A 103 9.941 −12.662 3.401 1.00 34.43 A ATOM 794 CG MET A 103 9.850 −14.076 2.841 1.00 38.55 A ATOM 795 SD MET A 103 11.158 −15.155 3.475 1.00 44.76 A ATOM 796 CE MET A 103 10.276 −16.041 4.747 1.00 39.47 A ATOM 797 C MET A 103 10.568 −11.314 5.387 1.00 31.24 A ATOM 798 O MET A 103 11.695 −11.402 5.864 1.00 31.61 A ATOM 799 N GLU A 104 9.951 −10.153 5.257 1.00 31.59 A ATOM 800 CA GLU A 104 10.626 −8.915 5.630 1.00 31.31 A ATOM 801 CB GLU A 104 9.865 −7.731 5.045 1.00 30.05 A ATOM 802 CG GLU A 104 10.553 −6.406 5.240 1.00 32.44 A ATOM 803 CD GLU A 104 11.995 −6.407 4.762 1.00 33.01 A ATOM 804 OE1 GLU A 104 12.390 −7.309 3.989 1.00 33.54 A ATOM 805 OE2 GLU A 104 12.735 −5.485 5.158 1.00 33.64 A ATOM 806 C GLU A 104 10.900 −8.671 7.118 1.00 30.88 A ATOM 807 O GLU A 104 11.992 −8.211 7.482 1.00 29.95 A ATOM 808 N VAL A 105 9.926 −8.974 7.976 1.00 30.76 A ATOM 809 CA VAL A 105 10.085 −8.749 9.417 1.00 29.41 A ATOM 810 CB VAL A 105 8.766 −8.996 10.161 1.00 28.39 A ATOM 811 CG1 VAL A 105 8.985 −8.867 11.646 1.00 28.65 A ATOM 812 CG2 VAL A 105 7.715 −8.003 9.688 1.00 27.81 A ATOM 813 C VAL A 105 11.199 −9.569 10.062 1.00 28.24 A ATOM 814 O VAL A 105 11.977 −9.046 10.858 1.00 28.68 A ATOM 815 N PRO A 106 11.264 −10.877 9.762 1.00 28.43 A ATOM 816 CD PRO A 106 10.166 −11.740 9.283 1.00 28.16 A ATOM 817 CA PRO A 106 12.336 −11.688 10.357 1.00 25.95 A ATOM 818 CB PRO A 106 11.905 −13.120 10.035 1.00 25.33 A ATOM 819 CG PRO A 106 10.418 −13.032 10.058 1.00 27.25 A ATOM 820 C PRO A 106 13.703 −11.332 9.742 1.00 24.31 A ATOM 821 O PRO A 106 14.732 −11.423 10.400 1.00 20.89 A ATOM 822 N ARG A 107 13.695 −10.934 8.473 1.00 24.37 A ATOM 823 CA ARG A 107 14.920 −10.556 7.785 1.00 29.22 A ATOM 824 CB ARG A 107 14.641 −10.194 6.330 1.00 32.72 A ATOM 825 CG ARG A 107 15.902 −9.914 5.510 1.00 36.87 A ATOM 826 CD ARG A 107 15.684 −8.778 4.525 1.00 40.02 A ATOM 827 NE ARG A 107 15.873 −7.473 5.164 1.00 45.13 A ATOM 828 CZ ARG A 107 15.466 −6.313 4.653 1.00 47.15 A ATOM 829 NH1 ARG A 107 14.832 −6.282 3.488 1.00 50.56 A ATOM 830 NH2 ARG A 107 15.702 −5.181 5.304 1.00 47.09 A ATOM 831 C ARG A 107 15.504 −9.341 8.485 1.00 28.90 A ATOM 832 O ARG A 107 16.661 −9.357 8.908 1.00 29.13 A ATOM 833 N LEU A 108 14.695 −8.289 8.616 1.00 28.98 A ATOM 834 CA LEU A 108 15.142 −7.067 9.280 1.00 28.70 A ATOM 835 CB LEU A 108 14.043 −6.000 9.261 1.00 30.81 A ATOM 836 CG LEU A 108 14.376 −4.716 8.483 1.00 34.16 A ATOM 837 CD1 LEU A 108 13.264 −3.690 8.653 1.00 33.94 A ATOM 838 CD2 LEU A 108 15.694 −4.138 8.981 1.00 33.48 A ATOM 839 C LEU A 108 15.558 −7.350 10.716 1.00 26.96 A ATOM 840 O LEU A 108 16.597 −6.879 11.170 1.00 27.32 A ATOM 841 N ALA A 109 14.748 −8.124 11.429 1.00 25.77 A ATOM 842 CA ALA A 109 15.052 −8.471 12.816 1.00 24.84 A ATOM 843 CB ALA A 109 13.973 −9.388 13.379 1.00 26.69 A ATOM 844 C ALA A 109 16.409 −9.161 12.914 1.00 25.54 A ATOM 845 O ALA A 109 17.164 −8.924 13.855 1.00 23.26 A ATOM 846 N LYS A 110 16.710 −10.008 11.934 1.00 25.63 A ATOM 847 CA LYS A 110 17.966 −10.745 11.917 1.00 27.86 A ATOM 848 CB LYS A 110 17.955 −11.805 10.811 1.00 29.07 A ATOM 849 CG LYS A 110 19.306 −12.492 10.620 1.00 28.94 A ATOM 850 CD LYS A 110 19.309 −13.385 9.389 1.00 30.99 A ATOM 851 CE LYS A 110 20.569 −14.242 9.321 1.00 31.04 A ATOM 852 NZ LYS A 110 21.804 −13.436 9.126 1.00 31.14 A ATOM 853 C LYS A 110 19.166 −9.831 11.716 1.00 28.05 A ATOM 854 O LYS A 110 20.223 −10.049 12.296 1.00 28.69 A ATOM 855 N GLU A 111 19.011 −8.821 10.873 1.00 27.50 A ATOM 856 CA GLU A 111 20.100 −7.897 10.622 1.00 28.58 A ATOM 857 CB GLU A 111 19.718 −6.956 9.487 1.00 33.09 A ATOM 858 CG GLU A 111 20.666 −5.789 9.264 1.00 37.76 A ATOM 859 CD GLU A 111 20.122 −4.809 8.231 1.00 41.62 A ATOM 860 OE1 GLU A 111 19.723 −5.269 7.138 1.00 42.07 A ATOM 861 OE2 GLU A 111 20.094 −3.586 8.512 1.00 45.45 A ATOM 862 C GLU A 111 20.407 −7.097 11.886 1.00 28.49 A ATOM 863 O GLU A 111 21.571 −6.841 12.205 1.00 27.38 A ATOM 864 N ALA A 112 19.359 −6.720 12.612 1.00 26.03 A ATOM 865 CA ALA A 112 19.512 −5.944 13.833 1.00 26.94 A ATOM 866 CB ALA A 112 18.143 −5.504 14.354 1.00 28.28 A ATOM 867 C ALA A 112 20.241 −6.715 14.918 1.00 27.67 A ATOM 868 O ALA A 112 21.086 −6.161 15.616 1.00 25.90 A ATOM 869 N ASP A 113 19.918 −7.995 15.066 1.00 28.66 A ATOM 870 CA ASP A 113 20.551 −8.775 16.109 1.00 29.69 A ATOM 871 CB ASP A 113 19.677 −9.961 16.490 1.00 36.80 A ATOM 872 CG ASP A 113 18.955 −10.548 15.311 1.00 42.93 A ATOM 873 OD1 ASP A 113 19.629 −10.976 14.352 1.00 47.19 A ATOM 874 OD2 ASP A 113 17.707 −10.583 15.346 1.00 49.00 A ATOM 875 C ASP A 113 21.951 −9.231 15.791 1.00 27.88 A ATOM 876 O ASP A 113 22.744 −9.424 16.696 1.00 29.10 A ATOM 877 N GLU A 114 22.270 −9.411 14.520 1.00 27.42 A ATOM 878 CA GLU A 114 23.629 −9.802 14.181 1.00 29.07 A ATOM 879 CB GLU A 114 23.759 −10.072 12.679 1.00 32.21 A ATOM 880 CG GLU A 114 23.033 −11.347 12.216 1.00 36.51 A ATOM 881 CD GLU A 114 23.752 −12.637 12.619 1.00 37.69 A ATOM 882 OE1 GLU A 114 24.350 −12.673 13.715 1.00 38.62 A ATOM 883 OE2 GLU A 114 23.710 −13.621 11.842 1.00 39.78 A ATOM 884 C GLU A 114 24.514 −8.632 14.616 1.00 28.69 A ATOM 885 O GLU A 114 25.608 −8.834 15.156 1.00 26.64 A ATOM 886 N LYS A 115 24.030 −7.409 14.394 1.00 28.82 A ATOM 887 CA LYS A 115 24.757 −6.213 14.815 1.00 29.61 A ATOM 888 CB LYS A 115 24.007 −4.929 14.448 1.00 31.35 A ATOM 889 CG LYS A 115 24.182 −4.438 13.028 1.00 33.87 A ATOM 890 CD LYS A 115 23.587 −3.040 12.893 1.00 37.24 A ATOM 891 CE LYS A 115 23.869 −2.444 11.530 1.00 38.63 A ATOM 892 NZ LYS A 115 23.370 −3.328 10.448 1.00 40.84 A ATOM 893 C LYS A 115 24.863 −6.276 16.324 1.00 28.63 A ATOM 894 O LYS A 115 25.950 −6.214 16.888 1.00 29.75 A ATOM 895 N ALA A 116 23.711 −6.412 16.971 1.00 28.40 A ATOM 896 CA ALA A 116 23.637 −6.497 18.427 1.00 28.89 A ATOM 897 CB ALA A 116 22.187 −6.743 18.864 1.00 29.26 A ATOM 898 C ALA A 116 24.538 −7.605 18.976 1.00 28.49 A ATOM 899 O ALA A 116 25.285 −7.391 19.931 1.00 29.43 A ATOM 900 N ILE A 117 24.462 −8.782 18.374 1.00 28.53 A ATOM 901 CA ILE A 117 25.265 −9.910 18.829 1.00 31.21 A ATOM 902 CB ILE A 117 25.027 −11.179 17.971 1.00 29.88 A ATOM 903 CG2 ILE A 117 25.823 −12.339 18.538 1.00 28.55 A ATOM 904 CG1 ILE A 117 23.549 −11.577 17.997 1.00 32.55 A ATOM 905 CD1 ILE A 117 23.062 −12.008 19.351 1.00 33.54 A ATOM 906 C ILE A 117 26.738 −9.563 18.766 1.00 32.35 A ATOM 907 O ILE A 117 27.474 −9.769 19.732 1.00 30.97 A ATOM 908 N GLN A 118 27.152 −9.024 17.625 1.00 34.54 A ATOM 909 CA GLN A 118 28.544 −8.646 17.402 1.00 37.18 A ATOM 910 CB GLN A 118 28.690 −7.981 16.039 1.00 40.03 A ATOM 911 CG GLN A 118 30.113 −7.648 15.668 1.00 44.57 A ATOM 912 CD GLN A 118 30.200 −7.018 14.300 1.00 47.69 A ATOM 913 OE1 GLN A 118 29.776 −7.611 13.302 1.00 49.39 A ATOM 914 NE2 GLN A 118 30.748 −5.807 14.239 1.00 49.45 A ATOM 915 C GLN A 118 29.112 −7.727 18.478 1.00 37.04 A ATOM 916 O GLN A 118 30.203 −7.977 18.988 1.00 37.17 A ATOM 917 N GLU A 119 28.380 −6.666 18.820 1.00 36.89 A ATOM 918 CA GLU A 119 28.828 −5.715 19.846 1.00 36.40 A ATOM 919 CB GLU A 119 27.773 −4.638 20.082 1.00 36.37 A ATOM 920 CG GLU A 119 28.216 −3.559 21.045 1.00 36.77 A ATOM 921 CD GLU A 119 27.063 −2.710 21.534 1.00 38.45 A ATOM 922 OE1 GLU A 119 26.097 −2.525 20.768 1.00 38.88 A ATOM 923 OE2 GLU A 119 27.132 −2.213 22.677 1.00 38.52 A ATOM 924 C GLU A 119 29.071 −6.444 21.161 1.00 35.77 A ATOM 925 O GLU A 119 30.134 −6.340 21.778 1.00 36.48 A ATOM 926 N TRP A 120 28.054 −7.177 21.580 1.00 35.05 A ATOM 927 CA TRP A 120 28.097 −7.950 22.805 1.00 34.32 A ATOM 928 CB TRP A 120 26.802 −8.747 22.903 1.00 31.27 A ATOM 929 CG TRP A 120 26.695 −9.670 24.050 1.00 29.64 A ATOM 930 CD2 TRP A 120 26.228 −11.019 24.001 1.00 28.18 A ATOM 931 CE2 TRP A 120 26.168 −11.486 25.328 1.00 28.95 A ATOM 932 CE3 TRP A 120 25.849 −11.879 22.960 1.00 28.14 A ATOM 933 CD1 TRP A 120 26.903 −9.380 25.365 1.00 27.98 A ATOM 934 NE1 TRP A 120 26.583 −10.464 26.141 1.00 28.05 A ATOM 935 CZ2 TRP A 120 25.742 −12.788 25.647 1.00 30.03 A ATOM 936 CZ3 TRP A 120 25.425 −13.172 23.278 1.00 30.61 A ATOM 937 CH2 TRP A 120 25.378 −13.612 24.611 1.00 27.55 A ATOM 938 C TRP A 120 29.309 −8.863 22.735 1.00 34.10 A ATOM 939 O TRP A 120 29.861 −9.269 23.757 1.00 36.05 A ATOM 940 N GLY A 121 29.711 −9.178 21.510 1.00 34.61 A ATOM 941 CA GLY A 121 30.864 −10.028 21.283 1.00 35.14 A ATOM 942 C GLY A 121 30.900 −11.386 21.961 1.00 35.69 A ATOM 943 O GLY A 121 31.983 −11.912 22.194 1.00 36.76 A ATOM 944 N GLN A 122 29.743 −11.960 22.273 1.00 35.13 A ATOM 945 CA GLN A 122 29.683 −13.276 22.910 1.00 35.20 A ATOM 946 CB GLN A 122 28.897 −13.209 24.224 1.00 35.80 A ATOM 947 CG GLN A 122 29.639 −12.555 25.362 1.00 38.25 A ATOM 948 CD GLN A 122 30.903 −13.313 25.745 1.00 40.71 A ATOM 949 OE1 GLN A 122 30.849 −14.458 26.210 1.00 41.52 A ATOM 950 NE2 GLN A 122 32.050 −12.678 25.549 1.00 40.42 A ATOM 951 C GLN A 122 29.022 −14.291 21.977 1.00 34.64 A ATOM 952 O GLN A 122 28.359 −13.922 21.009 1.00 34.92 A ATOM 953 N SER A 123 29.205 −15.571 22.268 1.00 33.07 A ATOM 954 CA SER A 123 28.622 −16.626 21.449 1.00 33.33 A ATOM 955 CB SER A 123 28.974 −17.989 22.045 1.00 31.42 A ATOM 956 OG SER A 123 28.341 −19.041 21.349 1.00 29.57 A ATOM 957 C SER A 123 27.103 −16.487 21.352 1.00 34.17 A ATOM 958 O SER A 123 26.471 −15.885 22.220 1.00 35.47 A ATOM 959 N LYS A 124 26.529 −17.018 20.276 1.00 35.18 A ATOM 960 CA LYS A 124 25.083 −16.992 20.093 1.00 33.65 A ATOM 961 CB LYS A 124 24.689 −17.401 18.674 1.00 33.98 A ATOM 962 CG LYS A 124 24.815 −16.325 17.623 1.00 36.96 A ATOM 963 CD LYS A 124 24.322 −16.850 16.280 1.00 37.21 A ATOM 964 CE LYS A 124 24.557 −15.840 15.171 1.00 40.53 A ATOM 965 NZ LYS A 124 24.053 −14.487 15.527 1.00 40.81 A ATOM 966 C LYS A 124 24.527 −18.021 21.060 1.00 32.99 A ATOM 967 O LYS A 124 23.502 −17.791 21.707 1.00 31.91 A ATOM 968 N SER A 125 25.224 −19.154 21.157 1.00 30.09 A ATOM 969 CA SER A 125 24.813 −20.243 22.037 1.00 31.14 A ATOM 970 CB SER A 125 25.904 −21.328 22.104 1.00 30.57 A ATOM 971 OG SER A 125 27.056 −20.885 22.806 1.00 29.74 A ATOM 972 C SER A 125 24.503 −19.733 23.438 1.00 29.64 A ATOM 973 O SER A 125 23.612 −20.245 24.109 1.00 30.79 A ATOM 974 N GLY A 126 25.236 −18.712 23.867 1.00 29.37 A ATOM 975 CA GLY A 126 25.018 −18.154 25.192 1.00 29.53 A ATOM 976 C GLY A 126 23.653 −17.512 25.375 1.00 27.71 A ATOM 977 O GLY A 126 23.261 −17.163 26.489 1.00 25.74 A ATOM 978 N ILE A 127 22.938 −17.344 24.268 1.00 26.99 A ATOM 979 CA ILE A 127 21.605 −16.751 24.287 1.00 25.17 A ATOM 980 CB ILE A 127 21.237 −16.221 22.886 1.00 22.05 A ATOM 981 CG2 ILE A 127 19.752 −15.896 22.811 1.00 22.05 A ATOM 982 CG1 ILE A 127 22.106 −15.001 22.577 1.00 18.84 A ATOM 983 CD1 ILE A 127 21.862 −14.406 21.238 1.00 17.66 A ATOM 984 C ILE A 127 20.610 −17.810 24.754 1.00 24.70 A ATOM 985 O ILE A 127 20.363 −18.790 24.060 1.00 26.26 A ATOM 986 N THR A 128 20.047 −17.594 25.939 1.00 25.26 A ATOM 987 CA THR A 128 19.101 −18.526 26.555 1.00 25.26 A ATOM 988 CB THR A 128 19.418 −18.698 28.053 1.00 27.22 A ATOM 989 OG1 THR A 128 19.208 −17.446 28.731 1.00 27.55 A ATOM 990 CG2 THR A 128 20.866 −19.134 28.245 1.00 27.17 A ATOM 991 C THR A 128 17.646 −18.090 26.454 1.00 25.40 A ATOM 992 O THR A 128 16.730 −18.854 26.798 1.00 24.68 A ATOM 993 N HIS A 129 17.435 −16.857 26.007 1.00 22.77 A ATOM 994 CA HIS A 129 16.097 −16.303 25.892 1.00 20.64 A ATOM 995 CB HIS A 129 15.762 −15.456 27.122 1.00 18.09 A ATOM 996 CG HIS A 129 15.565 −16.245 28.378 1.00 21.09 A ATOM 997 CD2 HIS A 129 14.433 −16.640 29.013 1.00 19.20 A ATOM 998 ND1 HIS A 129 16.615 −16.724 29.130 1.00 18.25 A ATOM 999 CE1 HIS A 129 16.137 −17.379 30.175 1.00 18.16 A ATOM 1000 NE2 HIS A 129 14.817 −17.342 30.128 1.00 17.69 A ATOM 1001 C HIS A 129 15.975 −15.408 24.673 1.00 22.13 A ATOM 1002 O HIS A 129 16.953 −14.800 24.243 1.00 21.06 A ATOM 1003 N LEU A 130 14.762 −15.336 24.129 1.00 22.34 A ATOM 1004 CA LEU A 130 14.463 −14.477 22.993 1.00 22.64 A ATOM 1005 CB LEU A 130 14.471 −15.241 21.672 1.00 24.24 A ATOM 1006 CG LEU A 130 13.867 −14.417 20.522 1.00 22.91 A ATOM 1007 CD1 LEU A 130 14.786 −13.246 20.200 1.00 24.49 A ATOM 1008 CD2 LEU A 130 13.647 −15.289 19.303 1.00 21.22 A ATOM 1009 C LEU A 130 13.071 −13.894 23.199 1.00 24.28 A ATOM 1010 O LEU A 130 12.117 −14.611 23.505 1.00 22.97 A ATOM 1011 N ILE A 131 12.978 −12.580 23.051 1.00 23.85 A ATOM 1012 CA ILE A 131 11.718 −11.867 23.177 1.00 22.17 A ATOM 1013 CB ILE A 131 11.752 −10.834 24.320 1.00 19.17 A ATOM 1014 CG2 ILE A 131 10.523 −9.914 24.219 1.00 17.23 A ATOM 1015 CG1 ILE A 131 11.822 −11.557 25.666 1.00 15.59 A ATOM 1016 CD1 ILE A 131 11.885 −10.632 26.867 1.00 16.20 A ATOM 1017 C ILE A 131 11.572 −11.139 21.856 1.00 22.74 A ATOM 1018 O ILE A 131 12.378 −10.260 21.537 1.00 24.68 A ATOM 1019 N PHE A 132 10.571 −11.522 21.075 1.00 21.87 A ATOM 1020 CA PHE A 132 10.364 −10.896 19.788 1.00 22.84 A ATOM 1021 CB PHE A 132 10.407 −11.935 18.658 1.00 25.22 A ATOM 1022 CG PHE A 132 10.347 −11.327 17.282 1.00 26.03 A ATOM 1023 CD1 PHE A 132 9.126 −11.002 16.699 1.00 27.91 A ATOM 1024 CD2 PHE A 132 11.516 −11.014 16.596 1.00 26.87 A ATOM 1025 CE1 PHE A 132 9.074 −10.370 15.456 1.00 27.98 A ATOM 1026 CE2 PHE A 132 11.469 −10.383 15.356 1.00 26.12 A ATOM 1027 CZ PHE A 132 10.249 −10.061 14.787 1.00 27.33 A ATOM 1028 C PHE A 132 9.054 −10.142 19.757 1.00 23.78 A ATOM 1029 O PHE A 132 8.020 −10.636 20.235 1.00 25.01 A ATOM 1030 N CYS A 133 9.108 −8.948 19.176 1.00 21.79 A ATOM 1031 CA CYS A 133 7.951 −8.082 19.076 1.00 22.75 A ATOM 1032 CB CYS A 133 8.129 −6.891 20.026 1.00 25.53 A ATOM 1033 SG CYS A 133 6.991 −5.537 19.732 1.00 27.54 A ATOM 1034 C CYS A 133 7.676 −7.562 17.669 1.00 21.50 A ATOM 1035 O CYS A 133 8.592 −7.180 16.940 1.00 22.97 A ATOM 1036 N SER A 134 6.399 −7.533 17.309 1.00 21.18 A ATOM 1037 CA SER A 134 5.954 −7.031 16.009 1.00 22.43 A ATOM 1038 CB SER A 134 6.173 −8.095 14.925 1.00 22.07 A ATOM 1039 OG SER A 134 6.351 −7.508 13.641 1.00 21.45 A ATOM 1040 C SER A 134 4.464 −6.733 16.168 1.00 24.43 A ATOM 1041 O SER A 134 3.756 −7.503 16.838 1.00 24.55 A ATOM 1042 N THR A 135 3.977 −5.637 15.580 1.00 24.20 A ATOM 1043 CA THR A 135 2.555 −5.313 15.716 1.00 26.34 A ATOM 1044 CB THR A 135 2.107 −4.107 14.846 1.00 26.54 A ATOM 1045 OG1 THR A 135 1.786 −4.562 13.530 1.00 28.93 A ATOM 1046 CG2 THR A 135 3.199 −3.045 14.786 1.00 25.74 A ATOM 1047 C THR A 135 1.712 −6.537 15.349 1.00 25.69 A ATOM 1048 O THR A 135 .660 −6.749 15.929 1.00 26.52 A ATOM 1049 N THR A 136 2.168 −7.329 14.379 1.00 25.88 A ATOM 1050 CA THR A 136 1.479 −8.567 14.007 1.00 25.55 A ATOM 1051 CB THR A 136 .460 −8.402 12.834 1.00 24.45 A ATOM 1052 OG1 THR A 136 1.149 −8.006 11.648 1.00 22.72 A ATOM 1053 CG2 THR A 136 −.625 −7.396 13.173 1.00 25.44 A ATOM 1054 C THR A 136 2.497 −9.623 13.558 1.00 25.00 A ATOM 1055 O THR A 136 3.692 −9.343 13.416 1.00 23.29 A ATOM 1056 N THR A 137 2.004 −10.839 13.360 1.00 24.15 A ATOM 1057 CA THR A 137 2.808 −11.957 12.875 1.00 24.60 A ATOM 1058 CB THR A 137 3.378 −12.819 14.045 1.00 23.38 A ATOM 1059 OG1 THR A 137 4.548 −13.503 13.580 1.00 25.80 A ATOM 1060 CG2 THR A 137 2.370 −13.837 14.543 1.00 20.20 A ATOM 1061 C THR A 137 1.814 −12.724 11.997 1.00 23.38 A ATOM 1062 O THR A 137 .676 −12.959 12.393 1.00 21.68 A ATOM 1063 N PRO A 138 2.225 −13.099 10.781 1.00 24.14 A ATOM 1064 CD PRO A 138 3.545 −12.846 10.175 1.00 23.44 A ATOM 1065 CA PRO A 138 1.347 −13.816 9.851 1.00 24.04 A ATOM 1066 CB PRO A 138 2.069 −13.657 8.523 1.00 24.17 A ATOM 1067 CG PRO A 138 3.504 −13.700 8.930 1.00 23.06 A ATOM 1068 C PRO A 138 .927 −15.259 10.100 1.00 24.49 A ATOM 1069 O PRO A 138 −.168 −15.662 9.699 1.00 24.01 A ATOM 1070 N ASP A 139 1.765 −16.043 10.757 1.00 24.32 A ATOM 1071 CA ASP A 139 1.427 −17.443 10.959 1.00 26.63 A ATOM 1072 CB ASP A 139 2.227 −18.311 9.970 1.00 30.30 A ATOM 1073 CG ASP A 139 2.354 −17.683 8.582 1.00 34.13 A ATOM 1074 OD1 ASP A 139 3.341 −17.999 7.875 1.00 38.40 A ATOM 1075 OD2 ASP A 139 1.474 −16.893 8.179 1.00 34.14 A ATOM 1076 C ASP A 139 1.741 −17.938 12.358 1.00 26.12 A ATOM 1077 O ASP A 139 2.041 −17.175 13.270 1.00 25.57 A ATOM 1078 N LEU A 140 1.654 −19.253 12.499 1.00 27.76 A ATOM 1079 CA LEU A 140 2.002 −19.949 13.731 1.00 26.83 A ATOM 1080 CB LEU A 140 .778 −20.555 14.399 1.00 28.40 A ATOM 1081 CG LEU A 140 −.177 −19.538 15.008 1.00 30.52 A ATOM 1082 CD1 LEU A 140 −.928 −18.799 13.904 1.00 32.48 A ATOM 1083 CD2 LEU A 140 −1.132 −20.254 15.923 1.00 30.95 A ATOM 1084 C LEU A 140 2.929 −21.052 13.244 1.00 27.18 A ATOM 1085 O LEU A 140 2.548 −21.853 12.388 1.00 28.82 A ATOM 1086 N PRO A 141 4.160 −21.104 13.766 1.00 25.78 A ATOM 1087 CD PRO A 141 5.159 −22.037 13.216 1.00 25.32 A ATOM 1088 CA PRO A 141 4.766 −20.228 14.775 1.00 24.99 A ATOM 1089 CB PRO A 141 6.107 −20.898 15.025 1.00 26.03 A ATOM 1090 CG PRO A 141 6.459 −21.422 13.661 1.00 26.03 A ATOM 1091 C PRO A 141 4.924 −18.763 14.344 1.00 24.56 A ATOM 1092 O PRO A 141 4.825 −18.427 13.162 1.00 23.75 A ATOM 1093 N GLY A 142 5.177 −17.894 15.313 1.00 24.62 A ATOM 1094 CA GLY A 142 5.349 −16.490 15.009 1.00 23.80 A ATOM 1095 C GLY A 142 6.792 −16.180 14.679 1.00 26.14 A ATOM 1096 O GLY A 142 7.660 −17.059 14.729 1.00 25.21 A ATOM 1097 N ALA A 143 7.041 −14.917 14.352 1.00 25.92 A ATOM 1098 CA ALA A 143 8.363 −14.426 13.999 1.00 26.94 A ATOM 1099 CB ALA A 143 8.299 −12.909 13.760 1.00 25.13 A ATOM 1100 C ALA A 143 9.471 −14.756 15.008 1.00 26.98 A ATOM 1101 O ALA A 143 10.650 −14.690 14.665 1.00 29.10 A ATOM 1102 N ASP A 144 9.112 −15.085 16.248 1.00 27.97 A ATOM 1103 CA ASP A 144 10.130 −15.435 17.241 1.00 28.11 A ATOM 1104 CB ASP A 144 9.513 −15.650 18.643 1.00 28.84 A ATOM 1105 CG ASP A 144 8.364 −16.668 18.662 1.00 29.51 A ATOM 1106 OD1 ASP A 144 7.340 −16.426 17.994 1.00 27.31 A ATOM 1107 OD2 ASP A 144 8.480 −17.703 19.364 1.00 30.81 A ATOM 1108 C ASP A 144 10.862 −16.697 16.784 1.00 27.99 A ATOM 1109 O ASP A 144 12.100 −16.747 16.763 1.00 26.30 A ATOM 1110 N PHE A 145 10.086 −17.711 16.406 1.00 26.99 A ATOM 1111 CA PHE A 145 10.648 −18.968 15.930 1.00 27.15 A ATOM 1112 CB PHE A 145 9.536 −19.933 15.544 1.00 27.87 A ATOM 1113 CG PHE A 145 10.027 −21.173 14.858 1.00 28.08 A ATOM 1114 CD1 PHE A 145 10.427 −22.280 15.594 1.00 29.08 A ATOM 1115 CD2 PHE A 145 10.108 −21.226 13.475 1.00 27.17 A ATOM 1116 CE1 PHE A 145 10.902 −23.430 14.960 1.00 28.55 A ATOM 1117 CE2 PHE A 145 10.580 −22.362 12.828 1.00 29.72 A ATOM 1118 CZ PHE A 145 10.979 −23.472 13.575 1.00 27.75 A ATOM 1119 C PHE A 145 11.520 −18.711 14.710 1.00 27.78 A ATOM 1120 O PHE A 145 12.690 −19.107 14.663 1.00 25.37 A ATOM 1121 N GLU A 146 10.937 −18.041 13.723 1.00 28.13 A ATOM 1122 CA GLU A 146 11.652 −17.746 12.504 1.00 28.43 A ATOM 1123 CB GLU A 146 10.763 −16.982 11.538 1.00 32.67 A ATOM 1124 CG GLU A 146 10.552 −17.733 10.237 1.00 39.15 A ATOM 1125 CD GLU A 146 10.033 −19.152 10.462 1.00 42.85 A ATOM 1126 OE1 GLU A 146 8.847 −19.299 10.847 1.00 43.22 A ATOM 1127 OE2 GLU A 146 10.816 −20.113 10.259 1.00 43.47 A ATOM 1128 C GLU A 146 12.932 −16.983 12.730 1.00 27.87 A ATOM 1129 O GLU A 146 13.941 −17.282 12.104 1.00 28.61 A ATOM 1130 N VAL A 147 12.900 −16.004 13.626 1.00 26.97 A ATOM 1131 CA VAL A 147 14.087 −15.210 13.902 1.00 27.33 A ATOM 1132 CB VAL A 147 13.757 −14.038 14.848 1.00 28.53 A ATOM 1133 CG1 VAL A 147 15.024 −13.382 15.340 1.00 27.78 A ATOM 1134 CG2 VAL A 147 12.912 −13.009 14.102 1.00 28.86 A ATOM 1135 C VAL A 147 15.154 −16.108 14.509 1.00 27.76 A ATOM 1136 O VAL A 147 16.338 −15.976 14.199 1.00 26.81 A ATOM 1137 N ALA A 148 14.721 −17.030 15.365 1.00 27.35 A ATOM 1138 CA ALA A 148 15.630 −17.973 16.001 1.00 27.81 A ATOM 1139 CB ALA A 148 14.878 −18.841 17.011 1.00 26.38 A ATOM 1140 C ALA A 148 16.252 −18.849 14.923 1.00 28.55 A ATOM 1141 O ALA A 148 17.464 −19.061 14.895 1.00 27.16 A ATOM 1142 N LYS A 149 15.409 −19.344 14.028 1.00 28.27 A ATOM 1143 CA LYS A 149 15.865 −20.192 12.940 1.00 30.54 A ATOM 1144 CB LYS A 149 14.655 −20.672 12.125 1.00 30.34 A ATOM 1145 CG LYS A 149 14.879 −21.959 11.344 1.00 33.21 A ATOM 1146 CD LYS A 149 15.675 −21.726 10.077 1.00 35.22 A ATOM 1147 CE LYS A 149 14.855 −20.955 9.054 1.00 36.29 A ATOM 1148 NZ LYS A 149 15.631 −20.646 7.821 1.00 34.92 A ATOM 1149 C LYS A 149 16.885 −19.453 12.052 1.00 31.84 A ATOM 1150 O LYS A 149 17.946 −20.000 11.752 1.00 33.57 A ATOM 1151 N LEU A 150 16.588 −18.223 11.638 1.00 30.97 A ATOM 1152 CA LEU A 150 17.540 −17.480 10.804 1.00 31.42 A ATOM 1153 CB LEU A 150 16.949 −16.151 10.311 1.00 33.16 A ATOM 1154 CG LEU A 150 16.023 −16.098 9.091 1.00 34.92 A ATOM 1155 CD1 LEU A 150 14.652 −16.632 9.434 1.00 36.29 A ATOM 1156 CD2 LEU A 150 15.904 −14.657 8.623 1.00 36.72 A ATOM 1157 C LEU A 150 18.811 −17.166 11.578 1.00 30.60 A ATOM 1158 O LEU A 150 19.903 −17.155 11.020 1.00 31.87 A ATOM 1159 N LEU A 151 18.665 −16.893 12.866 1.00 29.87 A ATOM 1160 CA LEU A 151 19.809 −16.557 13.698 1.00 29.41 A ATOM 1161 CB LEU A 151 19.340 −15.867 14.980 1.00 27.66 A ATOM 1162 CG LEU A 151 19.013 −14.378 14.886 1.00 29.11 A ATOM 1163 CD1 LEU A 151 18.489 −13.880 16.225 1.00 26.30 A ATOM 1164 CD2 LEU A 151 20.272 −13.620 14.468 1.00 28.44 A ATOM 1165 C LEU A 151 20.669 −17.763 14.061 1.00 29.68 A ATOM 1166 O LEU A 151 21.799 −17.619 14.539 1.00 29.22 A ATOM 1167 N GLY A 152 20.140 −18.955 13.826 1.00 29.85 A ATOM 1168 CA GLY A 152 20.886 −20.145 14.176 1.00 29.71 A ATOM 1169 C GLY A 152 21.021 −20.159 15.687 1.00 29.47 A ATOM 1170 O GLY A 152 22.076 −20.485 16.231 1.00 31.09 A ATOM 1171 N LEU A 153 19.950 −19.766 16.367 1.00 26.59 A ATOM 1172 CA LEU A 153 19.947 −19.743 17.814 1.00 24.43 A ATOM 1173 CB LEU A 153 18.747 −18.947 18.326 1.00 25.57 A ATOM 1174 CG LEU A 153 19.004 −17.578 18.956 1.00 26.97 A ATOM 1175 CD1 LEU A 153 19.894 −16.771 18.055 1.00 26.84 A ATOM 1176 CD2 LEU A 153 17.682 −16.865 19.210 1.00 25.05 A ATOM 1177 C LEU A 153 19.844 −21.190 18.241 1.00 23.58 A ATOM 1178 O LEU A 153 19.525 −22.051 17.426 1.00 24.50 A ATOM 1179 N HIS A 154 20.124 −21.458 19.512 1.00 25.47 A ATOM 1180 CA HIS A 154 20.063 −22.818 20.063 1.00 23.90 A ATOM 1181 CB HIS A 154 20.640 −22.827 21.488 1.00 22.82 A ATOM 1182 CG HIS A 154 20.888 −24.199 22.031 1.00 24.68 A ATOM 1183 CD2 HIS A 154 20.084 −25.041 22.723 1.00 26.57 A ATOM 1184 ND1 HIS A 154 22.080 −24.869 21.855 1.00 25.52 A ATOM 1185 CE1 HIS A 154 22.001 −26.064 22.414 1.00 26.84 A ATOM 1186 NE2 HIS A 154 20.800 −26.194 22.949 1.00 28.28 A ATOM 1187 C HIS A 154 18.612 −23.318 20.081 1.00 23.62 A ATOM 1188 O HIS A 154 17.693 −22.576 20.407 1.00 21.68 A ATOM 1189 N PRO A 155 18.391 −24.590 19.740 1.00 24.80 A ATOM 1190 CD PRO A 155 19.359 −25.673 19.505 1.00 25.17 A ATOM 1191 CA PRO A 155 17.023 −25.109 19.739 1.00 25.08 A ATOM 1192 CB PRO A 155 17.215 −26.578 19.371 1.00 25.18 A ATOM 1193 CG PRO A 155 18.576 −26.880 19.928 1.00 27.56 A ATOM 1194 C PRO A 155 16.277 −24.932 21.058 1.00 26.29 A ATOM 1195 O PRO A 155 15.053 −24.979 21.088 1.00 26.00 A ATOM 1196 N SER A 156 17.016 −24.729 22.143 1.00 25.49 A ATOM 1197 CA SER A 156 16.392 −24.565 23.452 1.00 23.23 A ATOM 1198 CB SER A 156 17.114 −25.424 24.500 1.00 24.30 A ATOM 1199 OG SER A 156 16.916 −26.801 24.255 1.00 24.44 A ATOM 1200 C SER A 156 16.314 −23.133 23.956 1.00 21.04 A ATOM 1201 O SER A 156 16.185 −22.911 25.147 1.00 19.96 A ATOM 1202 N VAL A 157 16.429 −22.161 23.061 1.00 21.07 A ATOM 1203 CA VAL A 157 16.314 −20.779 23.481 1.00 20.46 A ATOM 1204 CB VAL A 157 16.499 −19.753 22.308 1.00 18.81 A ATOM 1205 CG1 VAL A 157 16.244 −18.331 22.828 1.00 19.92 A ATOM 1206 CG2 VAL A 157 17.899 −19.826 21.737 1.00 22.14 A ATOM 1207 C VAL A 157 14.875 −20.662 23.963 1.00 21.14 A ATOM 1208 O VAL A 157 13.962 −21.152 23.312 1.00 19.78 A ATOM 1209 N LYS A 158 14.673 −20.035 25.110 1.00 20.85 A ATOM 1210 CA LYS A 158 13.328 −19.855 25.622 1.00 22.35 A ATOM 1211 CB LYS A 158 13.373 −19.711 27.141 1.00 23.13 A ATOM 1212 CG LYS A 158 13.667 −21.030 27.858 1.00 25.41 A ATOM 1213 CD LYS A 158 13.697 −20.828 29.357 1.00 24.19 A ATOM 1214 CE LYS A 158 15.117 −20.708 29.873 1.00 26.45 A ATOM 1215 NZ LYS A 158 15.823 −22.024 29.939 1.00 25.92 A ATOM 1216 C LYS A 158 12.798 −18.596 24.939 1.00 23.09 A ATOM 1217 O LYS A 158 13.164 −17.480 25.291 1.00 21.21 A ATOM 1218 N ARG A 159 11.929 −18.799 23.956 1.00 24.01 A ATOM 1219 CA ARG A 159 11.380 −17.710 23.155 1.00 24.63 A ATOM 1220 CB ARG A 159 11.358 −18.128 21.676 1.00 25.38 A ATOM 1221 CG ARG A 159 12.174 −19.388 21.376 1.00 27.28 A ATOM 1222 CD ARG A 159 12.021 −19.830 19.935 1.00 29.70 A ATOM 1223 NE ARG A 159 10.669 −20.293 19.622 1.00 29.95 A ATOM 1224 CZ ARG A 159 10.282 −21.565 19.619 1.00 29.82 A ATOM 1225 NH1 ARG A 159 11.139 −22.533 19.916 1.00 30.94 A ATOM 1226 NH2 ARG A 159 9.028 −21.868 19.313 1.00 33.57 A ATOM 1227 C ARG A 159 9.982 −17.289 23.561 1.00 23.52 A ATOM 1228 O ARG A 159 9.217 −18.080 24.097 1.00 25.02 A ATOM 1229 N VAL A 160 9.665 −16.024 23.311 1.00 22.32 A ATOM 1230 CA VAL A 160 8.345 −15.474 23.595 1.00 21.08 A ATOM 1231 CB VAL A 160 8.244 −14.796 24.984 1.00 22.06 A ATOM 1232 CG1 VAL A 160 9.252 −13.676 25.105 1.00 21.67 A ATOM 1233 CG2 VAL A 160 6.838 −14.249 25.175 1.00 19.10 A ATOM 1234 C VAL A 160 8.035 −14.433 22.540 1.00 21.72 A ATOM 1235 O VAL A 160 8.852 −13.562 22.231 1.00 20.95 A ATOM 1236 N GLY A 161 6.847 −14.528 21.976 1.00 21.41 A ATOM 1237 CA GLY A 161 6.478 −13.560 20.967 1.00 22.25 A ATOM 1238 C GLY A 161 5.433 −12.613 21.509 1.00 20.28 A ATOM 1239 O GLY A 161 4.449 −13.044 22.117 1.00 20.06 A ATOM 1240 N VAL A 162 5.655 −11.322 21.309 1.00 20.58 A ATOM 1241 CA VAL A 162 4.706 −10.314 21.769 1.00 22.29 A ATOM 1242 CB VAL A 162 5.397 −9.253 22.691 1.00 21.30 A ATOM 1243 CG1 VAL A 162 6.693 −8.821 22.104 1.00 24.10 A ATOM 1244 CG2 VAL A 162 4.501 −8.056 22.885 1.00 21.27 A ATOM 1245 C VAL A 162 4.125 −9.656 20.530 1.00 21.88 A ATOM 1246 O VAL A 162 4.769 −8.818 19.899 1.00 22.52 A ATOM 1247 N PHE A 163 2.904 −10.050 20.179 1.00 21.80 A ATOM 1248 CA PHE A 163 2.258 −9.516 18.989 1.00 20.47 A ATOM 1249 CB PHE A 163 2.004 −10.663 18.012 1.00 21.66 A ATOM 1250 CG PHE A 163 3.212 −11.550 17.792 1.00 22.63 A ATOM 1251 CD1 PHE A 163 4.364 −11.052 17.174 1.00 25.88 A ATOM 1252 CD2 PHE A 163 3.206 −12.875 18.210 1.00 22.78 A ATOM 1253 CE1 PHE A 163 5.495 −11.865 16.975 1.00 24.44 A ATOM 1254 CE2 PHE A 163 4.329 −13.695 18.017 1.00 24.67 A ATOM 1255 CZ PHE A 163 5.472 −13.187 17.398 1.00 21.69 A ATOM 1256 C PHE A 163 .960 −8.743 19.261 1.00 20.46 A ATOM 1257 O PHE A 163 .251 −9.001 20.231 1.00 20.17 A ATOM 1258 N GLN A 164 .662 −7.787 18.390 1.00 19.59 A ATOM 1259 CA GLN A 164 −.538 −6.954 18.500 1.00 21.23 A ATOM 1260 CB GLN A 164 −1.798 −7.767 18.156 1.00 20.31 A ATOM 1261 CG GLN A 164 −1.650 −8.597 16.882 1.00 21.02 A ATOM 1262 CD GLN A 164 −2.973 −8.990 16.228 1.00 23.06 A ATOM 1263 OE1 GLN A 164 −2.985 −9.831 15.322 1.00 21.66 A ATOM 1264 NE2 GLN A 164 −4.085 −8.380 16.666 1.00 19.73 A ATOM 1265 C GLN A 164 −.699 −6.258 19.858 1.00 22.09 A ATOM 1266 O GLN A 164 −1.791 −6.189 20.425 1.00 22.31 A ATOM 1267 N HIS A 165 .405 −5.748 20.382 1.00 22.18 A ATOM 1268 CA HIS A 165 .354 −5.022 21.635 1.00 24.10 A ATOM 1269 CB HIS A 165 1.592 −5.307 22.483 1.00 21.91 A ATOM 1270 CG HIS A 165 1.517 −6.596 23.241 1.00 17.46 A ATOM 1271 CD2 HIS A 165 1.334 −6.842 24.559 1.00 15.97 A ATOM 1272 ND1 HIS A 165 1.557 −7.827 22.623 1.00 16.67 A ATOM 1273 CE1 HIS A 165 1.395 −8.776 23.527 1.00 17.09 A ATOM 1274 NE2 HIS A 165 1.255 −8.206 24.710 1.00 15.95 A ATOM 1275 C HIS A 165 .292 −3.556 21.215 1.00 27.28 A ATOM 1276 O HIS A 165 −.587 −2.812 21.642 1.00 26.92 A ATOM 1277 N GLY A 166 1.211 −3.155 20.348 1.00 29.59 A ATOM 1278 CA GLY A 166 1.189 −1.787 19.877 1.00 33.81 A ATOM 1279 C GLY A 166 2.466 −1.002 20.046 1.00 34.98 A ATOM 1280 O GLY A 166 3.506 −1.539 20.436 1.00 36.81 A ATOM 1281 N CYS A 167 2.370 .287 19.748 1.00 35.13 A ATOM 1282 CA CYS A 167 3.490 1.200 19.847 1.00 34.95 A ATOM 1283 CB CYS A 167 3.049 2.604 19.435 1.00 36.37 A ATOM 1284 SG CYS A 167 2.675 2.790 17.682 1.00 38.64 A ATOM 1285 C CYS A 167 4.102 1.257 21.238 1.00 34.59 A ATOM 1286 O CYS A 167 5.198 1.782 21.402 1.00 36.85 A ATOM 1287 N PHE A 168 3.407 .729 22.240 1.00 32.51 A ATOM 1288 CA PHE A 168 3.936 .761 23.603 1.00 31.87 A ATOM 1289 CB PHE A 168 2.781 .885 24.613 1.00 30.03 A ATOM 1290 CG PHE A 168 1.954 −.362 24.758 1.00 30.47 A ATOM 1291 CD1 PHE A 168 2.428 −1.451 25.477 1.00 29.65 A ATOM 1292 CD2 PHE A 168 .700 −.454 24.165 1.00 30.86 A ATOM 1293 CE1 PHE A 168 1.662 −2.619 25.604 1.00 28.73 A ATOM 1294 CE2 PHE A 168 −.073 −1.618 24.286 1.00 29.81 A ATOM 1295 CZ PHE A 168 .413 −2.698 25.008 1.00 28.11 A ATOM 1296 C PHE A 168 4.803 −.462 23.932 1.00 31.42 A ATOM 1297 O PHE A 168 5.464 −.502 24.966 1.00 31.40 A ATOM 1298 N ALA A 169 4.797 −1.449 23.039 1.00 29.90 A ATOM 1299 CA ALA A 169 5.554 −2.685 23.227 1.00 27.01 A ATOM 1300 CB ALA A 169 5.299 −3.607 22.053 1.00 26.41 A ATOM 1301 C ALA A 169 7.067 −2.512 23.444 1.00 26.73 A ATOM 1302 O ALA A 169 7.720 −3.369 24.062 1.00 25.79 A ATOM 1303 N GLY A 170 7.623 −1.414 22.941 1.00 24.59 A ATOM 1304 CA GLY A 170 9.047 −1.176 23.100 1.00 24.21 A ATOM 1305 C GLY A 170 9.454 −1.313 24.551 1.00 25.87 A ATOM 1306 O GLY A 170 10.559 −1.776 24.871 1.00 25.12 A ATOM 1307 N GLY A 171 8.540 −.918 25.433 1.00 25.08 A ATOM 1308 CA GLY A 171 8.792 −1.002 26.852 1.00 25.49 A ATOM 1309 C GLY A 171 8.347 −2.307 27.489 1.00 25.76 A ATOM 1310 O GLY A 171 9.017 −2.805 28.390 1.00 24.97 A ATOM 1311 N THR A 172 7.222 −2.869 27.054 1.00 26.67 A ATOM 1312 CA THR A 172 6.768 −4.120 27.666 1.00 26.43 A ATOM 1313 CB THR A 172 5.403 −4.619 27.094 1.00 25.00 A ATOM 1314 OG1 THR A 172 5.588 −5.868 26.421 1.00 25.54 A ATOM 1315 CG2 THR A 172 4.819 −3.626 26.142 1.00 22.87 A ATOM 1316 C THR A 172 7.841 −5.198 27.459 1.00 27.23 A ATOM 1317 O THR A 172 8.014 −6.091 28.290 1.00 26.37 A ATOM 1318 N VAL A 173 8.580 −5.106 26.360 1.00 27.56 A ATOM 1319 CA VAL A 173 9.623 −6.088 26.122 1.00 29.17 A ATOM 1320 CB VAL A 173 10.179 −5.996 24.693 1.00 29.87 A ATOM 1321 CG1 VAL A 173 11.413 −6.834 24.591 1.00 33.23 A ATOM 1322 CG2 VAL A 173 9.142 −6.501 23.696 1.00 28.54 A ATOM 1323 C VAL A 173 10.760 −5.914 27.136 1.00 29.10 A ATOM 1324 O VAL A 173 11.349 −6.908 27.581 1.00 29.94 A ATOM 1325 N LEU A 174 11.062 −4.668 27.508 1.00 26.46 A ATOM 1326 CA LEU A 174 12.107 −4.416 28.504 1.00 25.15 A ATOM 1327 CB LEU A 174 12.472 −2.931 28.557 1.00 23.15 A ATOM 1328 CG LEU A 174 13.226 −2.342 27.361 1.00 22.33 A ATOM 1329 CD1 LEU A 174 13.316 −.839 27.523 1.00 22.43 A ATOM 1330 CD2 LEU A 174 14.612 −2.955 27.254 1.00 23.94 A ATOM 1331 C LEU A 174 11.594 −4.874 29.872 1.00 25.36 A ATOM 1332 O LEU A 174 12.360 −5.370 30.716 1.00 23.86 A ATOM 1333 N ARG A 175 10.288 −4.713 30.071 1.00 23.61 A ATOM 1334 CA ARG A 175 9.635 −5.115 31.304 1.00 26.33 A ATOM 1335 CB ARG A 175 8.184 −4.608 31.310 1.00 26.51 A ATOM 1336 CG ARG A 175 7.329 −5.182 32.409 1.00 29.10 A ATOM 1337 CD ARG A 175 6.139 −4.287 32.726 1.00 31.57 A ATOM 1338 NE ARG A 175 5.198 −4.159 31.620 1.00 34.18 A ATOM 1339 CZ ARG A 175 4.398 −5.132 31.196 1.00 35.28 A ATOM 1340 NH1 ARG A 175 4.422 −6.323 31.783 1.00 37.05 A ATOM 1341 NH2 ARG A 175 3.554 −4.907 30.198 1.00 35.45 A ATOM 1342 C ARG A 175 9.690 −6.646 31.394 1.00 26.56 A ATOM 1343 O ARG A 175 9.846 −7.222 32.481 1.00 27.45 A ATOM 1344 N MET A 176 9.584 −7.303 30.242 1.00 27.50 A ATOM 1345 CA MET A 176 9.644 −8.764 30.193 1.00 27.64 A ATOM 1346 CB MET A 176 9.029 −9.278 28.879 1.00 26.71 A ATOM 1347 CG MET A 176 7.521 −9.034 28.775 1.00 28.23 A ATOM 1348 SD MET A 176 6.800 −9.487 27.195 1.00 23.55 A ATOM 1349 CE MET A 176 7.101 −8.102 26.259 1.00 28.45 A ATOM 1350 C MET A 176 11.096 −9.221 30.323 1.00 27.94 A ATOM 1351 O MET A 176 11.403 −10.166 31.052 1.00 30.27 A ATOM 1352 N ALA A 177 11.987 −8.532 29.628 1.00 28.25 A ATOM 1353 CA ALA A 177 13.403 −8.868 29.672 1.00 29.84 A ATOM 1354 CB ALA A 177 14.200 −7.954 28.738 1.00 29.86 A ATOM 1355 C ALA A 177 13.961 −8.767 31.075 1.00 30.68 A ATOM 1356 O ALA A 177 14.790 −9.592 31.469 1.00 32.02 A ATOM 1357 N LYS A 178 13.528 −7.759 31.830 1.00 30.79 A ATOM 1358 CA LYS A 178 14.038 −7.588 33.188 1.00 31.72 A ATOM 1359 CB LYS A 178 13.477 −6.310 33.830 1.00 31.12 A ATOM 1360 CG LYS A 178 13.749 −6.197 35.345 1.00 29.02 A ATOM 1361 CD LYS A 178 13.189 −4.903 35.918 1.00 29.04 A ATOM 1362 CE LYS A 178 13.136 −4.914 37.449 1.00 27.26 A ATOM 1363 NZ LYS A 178 14.480 −4.807 38.065 1.00 28.61 A ATOM 1364 C LYS A 178 13.706 −8.795 34.067 1.00 31.60 A ATOM 1365 O LYS A 178 14.581 −9.355 34.733 1.00 31.68 A ATOM 1366 N ASP A 179 12.441 −9.200 34.062 1.00 31.22 A ATOM 1367 CA ASP A 179 12.033 −10.329 34.880 1.00 30.84 A ATOM 1368 CB ASP A 179 10.517 −10.497 34.829 1.00 31.04 A ATOM 1369 CG ASP A 179 9.797 −9.640 35.859 1.00 35.44 A ATOM 1370 OD1 ASP A 179 10.435 −8.734 36.452 1.00 30.14 A ATOM 1371 OD2 ASP A 179 8.581 −9.875 36.070 1.00 37.43 A ATOM 1372 C ASP A 179 12.733 −11.607 34.446 1.00 29.75 A ATOM 1373 O ASP A 179 13.051 −12.450 35.273 1.00 28.93 A ATOM 1374 N LEU A 180 12.986 −11.744 33.151 1.00 28.74 A ATOM 1375 CA LEU A 180 13.661 −12.936 32.651 1.00 28.44 A ATOM 1376 CB LEU A 180 13.561 −13.009 31.132 1.00 25.80 A ATOM 1377 CG LEU A 180 12.197 −13.379 30.563 1.00 25.86 A ATOM 1378 CD1 LEU A 180 12.387 −13.863 29.142 1.00 26.09 A ATOM 1379 CD2 LEU A 180 11.575 −14.493 31.379 1.00 26.77 A ATOM 1380 C LEU A 180 15.126 −12.981 33.060 1.00 29.17 A ATOM 1381 O LEU A 180 15.590 −13.971 33.624 1.00 29.96 A ATOM 1382 N ALA A 181 15.852 −11.901 32.787 1.00 29.52 A ATOM 1383 CA ALA A 181 17.273 −11.843 33.116 1.00 28.81 A ATOM 1384 CB ALA A 181 17.909 −10.617 32.473 1.00 27.02 A ATOM 1385 C ALA A 181 17.571 −11.850 34.614 1.00 29.43 A ATOM 1386 O ALA A 181 18.621 −12.323 35.037 1.00 29.28 A ATOM 1387 N GLU A 182 16.654 −11.334 35.418 1.00 28.32 A ATOM 1388 CA GLU A 182 16.903 −11.283 36.845 1.00 28.42 A ATOM 1389 CB GLU A 182 16.206 −10.057 37.446 1.00 28.31 A ATOM 1390 CG GLU A 182 17.074 −8.799 37.425 1.00 28.39 A ATOM 1391 CD GLU A 182 16.286 −7.505 37.641 1.00 30.17 A ATOM 1392 OE1 GLU A 182 15.276 −7.535 38.378 1.00 31.81 A ATOM 1393 OE2 GLU A 182 16.683 −6.455 37.079 1.00 26.98 A ATOM 1394 C GLU A 182 16.533 −12.545 37.612 1.00 29.49 A ATOM 1395 O GLU A 182 17.124 −12.827 38.657 1.00 29.42 A ATOM 1396 N ASN A 183 15.587 −13.318 37.085 1.00 27.48 A ATOM 1397 CA ASN A 183 15.139 −14.531 37.747 1.00 26.14 A ATOM 1398 CB ASN A 183 13.626 −14.682 37.571 1.00 28.22 A ATOM 1399 CG ASN A 183 13.022 −15.678 38.538 1.00 27.66 A ATOM 1400 OD1 ASN A 183 13.287 −15.633 39.740 1.00 26.28 A ATOM 1401 ND2 ASN A 183 12.190 −16.571 38.023 1.00 29.55 A ATOM 1402 C ASN A 183 15.844 −15.781 37.236 1.00 26.45 A ATOM 1403 O ASN A 183 15.562 −16.896 37.690 1.00 25.91 A ATOM 1404 N ASN A 184 16.755 −15.595 36.288 1.00 26.39 A ATOM 1405 CA ASN A 184 17.507 −16.710 35.715 1.00 25.21 A ATOM 1406 CB ASN A 184 17.006 −17.015 34.305 1.00 23.95 A ATOM 1407 CG ASN A 184 15.540 −17.407 34.285 1.00 26.13 A ATOM 1408 OD1 ASN A 184 15.150 −18.407 34.888 1.00 27.10 A ATOM 1409 ND2 ASN A 184 14.719 −16.618 33.595 1.00 24.91 A ATOM 1410 C ASN A 184 18.979 −16.346 35.685 1.00 24.51 A ATOM 1411 O ASN A 184 19.439 −15.657 34.774 1.00 22.61 A ATOM 1412 N ARG A 185 19.713 −16.793 36.701 1.00 25.18 A ATOM 1413 CA ARG A 185 21.135 −16.489 36.792 1.00 26.91 A ATOM 1414 CB ARG A 185 21.757 −17.152 38.027 1.00 27.36 A ATOM 1415 CG ARG A 185 23.194 −16.712 38.326 1.00 27.62 A ATOM 1416 CD ARG A 185 23.915 −17.698 39.265 1.00 29.15 A ATOM 1417 NE ARG A 185 23.236 −17.834 40.554 1.00 32.65 A ATOM 1418 CZ ARG A 185 23.199 −16.886 41.491 1.00 32.73 A ATOM 1419 NH1 ARG A 185 23.808 −15.718 41.298 1.00 34.52 A ATOM 1420 NH2 ARG A 185 22.543 −17.102 42.623 1.00 32.17 A ATOM 1421 C ARG A 185 21.805 −17.000 35.534 1.00 27.64 A ATOM 1422 O ARG A 185 21.583 −18.142 35.124 1.00 26.90 A ATOM 1423 N GLY A 186 22.593 −16.131 34.907 1.00 29.73 A ATOM 1424 CA GLY A 186 23.301 −16.500 33.694 1.00 29.72 A ATOM 1425 C GLY A 186 22.517 −16.302 32.408 1.00 28.96 A ATOM 1426 O GLY A 186 23.035 −16.517 31.314 1.00 28.86 A ATOM 1427 N ALA A 187 21.267 −15.884 32.533 1.00 27.00 A ATOM 1428 CA ALA A 187 20.423 −15.676 31.369 1.00 27.51 A ATOM 1429 CB ALA A 187 18.968 −15.538 31.800 1.00 27.04 A ATOM 1430 C ALA A 187 20.817 −14.463 30.547 1.00 28.01 A ATOM 1431 O ALA A 187 21.187 −13.416 31.082 1.00 28.40 A ATOM 1432 N ARG A 188 20.724 −14.624 29.236 1.00 27.77 A ATOM 1433 CA ARG A 188 21.006 −13.551 28.300 1.00 27.68 A ATOM 1434 CB ARG A 188 22.331 −13.810 27.581 1.00 26.99 A ATOM 1435 CG ARG A 188 23.572 −13.728 28.492 1.00 27.67 A ATOM 1436 CD ARG A 188 23.868 −12.276 28.890 1.00 31.52 A ATOM 1437 NE ARG A 188 24.994 −12.151 29.820 1.00 30.38 A ATOM 1438 CZ ARG A 188 24.909 −12.292 31.143 1.00 31.58 A ATOM 1439 NH1 ARG A 188 23.741 −12.562 31.722 1.00 24.80 A ATOM 1440 NH2 ARG A 188 26.002 −12.165 31.891 1.00 31.53 A ATOM 1441 C ARG A 188 19.809 −13.538 27.321 1.00 28.85 A ATOM 1442 O ARG A 188 19.605 −14.459 26.515 1.00 27.23 A ATOM 1443 N VAL A 189 18.993 −12.499 27.436 1.00 27.60 A ATOM 1444 CA VAL A 189 17.819 −12.367 26.597 1.00 26.30 A ATOM 1445 CB VAL A 189 16.676 −11.696 27.375 1.00 25.85 A ATOM 1446 CG1 VAL A 189 15.384 −11.786 26.597 1.00 24.31 A ATOM 1447 CG2 VAL A 189 16.519 −12.363 28.719 1.00 28.18 A ATOM 1448 C VAL A 189 18.122 −11.539 25.360 1.00 25.71 A ATOM 1449 O VAL A 189 18.738 −10.485 25.438 1.00 25.75 A ATOM 1450 N LEU A 190 17.723 −12.052 24.206 1.00 27.67 A ATOM 1451 CA LEU A 190 17.889 −11.319 22.961 1.00 27.51 A ATOM 1452 CB LEU A 190 18.196 −12.259 21.793 1.00 26.13 A ATOM 1453 CG LEU A 190 18.194 −11.660 20.379 1.00 24.00 A ATOM 1454 CD1 LEU A 190 19.134 −10.440 20.284 1.00 16.10 A ATOM 1455 CD2 LEU A 190 18.579 −12.758 19.394 1.00 20.62 A ATOM 1456 C LEU A 190 16.519 −10.687 22.781 1.00 27.57 A ATOM 1457 O LEU A 190 15.505 −11.383 22.709 1.00 29.76 A ATOM 1458 N VAL A 191 16.491 −9.365 22.758 1.00 27.48 A ATOM 1459 CA VAL A 191 15.252 −8.632 22.614 1.00 25.21 A ATOM 1460 CB VAL A 191 15.171 −7.544 23.696 1.00 26.45 A ATOM 1461 CG1 VAL A 191 14.054 −6.574 23.376 1.00 26.55 A ATOM 1462 CG2 VAL A 191 14.953 −8.198 25.072 1.00 23.22 A ATOM 1463 C VAL A 191 15.188 −8.022 21.218 1.00 25.89 A ATOM 1464 O VAL A 191 16.056 −7.243 20.829 1.00 25.61 A ATOM 1465 N ILE A 192 14.162 −8.390 20.460 1.00 25.32 A ATOM 1466 CA ILE A 192 14.026 −7.891 19.102 1.00 25.33 A ATOM 1467 CB ILE A 192 14.340 −9.019 18.074 1.00 23.22 A ATOM 1468 CG2 ILE A 192 14.375 −8.447 16.664 1.00 24.09 A ATOM 1469 CG1 ILE A 192 15.700 −9.648 18.399 1.00 23.39 A ATOM 1470 CD1 ILE A 192 16.041 −10.889 17.601 1.00 21.13 A ATOM 1471 C ILE A 192 12.654 −7.286 18.792 1.00 27.03 A ATOM 1472 O ILE A 192 11.616 −7.857 19.117 1.00 28.27 A ATOM 1473 N CYS A 193 12.676 −6.110 18.176 1.00 27.44 A ATOM 1474 CA CYS A 193 11.459 −5.410 17.777 1.00 29.84 A ATOM 1475 CB CYS A 193 11.286 −4.079 18.524 1.00 29.24 A ATOM 1476 SG CYS A 193 10.748 −4.211 20.241 1.00 33.41 A ATOM 1477 C CYS A 193 11.616 −5.107 16.307 1.00 28.84 A ATOM 1478 O CYS A 193 12.470 −4.301 15.939 1.00 27.97 A ATOM 1479 N SER A 194 10.803 −5.761 15.476 1.00 28.80 A ATOM 1480 CA SER A 194 10.844 −5.541 14.036 1.00 28.93 A ATOM 1481 CB SER A 194 11.290 −6.816 13.304 1.00 28.77 A ATOM 1482 OG SER A 194 11.556 −6.556 11.932 1.00 27.02 A ATOM 1483 C SER A 194 9.462 −5.111 13.552 1.00 28.93 A ATOM 1484 O SER A 194 8.457 −5.766 13.833 1.00 26.74 A ATOM 1485 N GLU A 195 9.425 −4.005 12.816 1.00 29.64 A ATOM 1486 CA GLU A 195 8.172 −3.468 12.311 1.00 30.24 A ATOM 1487 CB GLU A 195 7.737 −2.305 13.200 1.00 31.77 A ATOM 1488 CG GLU A 195 7.727 −2.645 14.686 1.00 36.82 A ATOM 1489 CD GLU A 195 6.410 −3.250 15.148 1.00 39.92 A ATOM 1490 OE1 GLU A 195 5.813 −4.031 14.374 1.00 39.88 A ATOM 1491 OE2 GLU A 195 5.981 −2.948 16.290 1.00 40.67 A ATOM 1492 C GLU A 195 8.278 −2.994 10.864 1.00 29.61 A ATOM 1493 O GLU A 195 9.326 −2.519 10.426 1.00 28.59 A ATOM 1494 N THR A 196 7.188 −3.141 10.118 1.00 28.84 A ATOM 1495 CA THR A 196 7.151 −2.688 8.733 1.00 28.59 A ATOM 1496 CB THR A 196 7.561 −3.802 7.732 1.00 29.67 A ATOM 1497 OG1 THR A 196 7.608 −3.250 6.412 1.00 27.60 A ATOM 1498 CG2 THR A 196 6.558 −4.942 7.749 1.00 27.62 A ATOM 1499 C THR A 196 5.741 −2.204 8.394 1.00 28.47 A ATOM 1500 O THR A 196 4.750 −2.732 8.902 1.00 29.71 A ATOM 1501 N THR A 197 5.661 −1.194 7.536 1.00 26.20 A ATOM 1502 CA THR A 197 4.390 −.632 7.139 1.00 23.42 A ATOM 1503 CB THR A 197 4.580 .788 6.587 1.00 24.48 A ATOM 1504 OG1 THR A 197 5.705 .797 5.713 1.00 24.80 A ATOM 1505 CG2 THR A 197 4.824 1.780 7.713 1.00 22.95 A ATOM 1506 C THR A 197 3.666 −1.475 6.099 1.00 24.32 A ATOM 1507 O THR A 197 2.504 −1.209 5.791 1.00 21.28 A ATOM 1508 N ALA A 198 4.341 −2.490 5.561 1.00 23.32 A ATOM 1509 CA ALA A 198 3.731 −3.347 4.546 1.00 24.83 A ATOM 1510 CB ALA A 198 4.631 −4.554 4.259 1.00 22.22 A ATOM 1511 C ALA A 198 2.327 −3.827 4.944 1.00 27.02 A ATOM 1512 O ALA A 198 1.436 −3.939 4.099 1.00 29.39 A ATOM 1513 N VAL A 199 2.129 −4.110 6.225 1.00 25.63 A ATOM 1514 CA VAL A 199 .834 −4.581 6.697 1.00 25.98 A ATOM 1515 CB VAL A 199 1.001 −5.406 7.999 1.00 27.15 A ATOM 1516 CG1 VAL A 199 1.506 −4.512 9.124 1.00 26.01 A ATOM 1517 CG2 VAL A 199 −.319 −6.058 8.381 1.00 25.90 A ATOM 1518 C VAL A 199 −.198 −3.459 6.943 1.00 27.11 A ATOM 1519 O VAL A 199 −1.385 −3.736 7.171 1.00 24.23 A ATOM 1520 N THR A 200 .243 −2.203 6.872 1.00 26.28 A ATOM 1521 CA THR A 200 −.649 −1.072 7.127 1.00 28.77 A ATOM 1522 CB THR A 200 −.207 −.306 8.375 1.00 28.69 A ATOM 1523 OG1 THR A 200 −1.236 .617 8.745 1.00 34.92 A ATOM 1524 CG2 THR A 200 1.082 .468 8.100 1.00 29.34 A ATOM 1525 C THR A 200 −.812 −.046 6.003 1.00 29.04 A ATOM 1526 O THR A 200 −1.803 .686 5.966 1.00 29.83 A ATOM 1527 N PHE A 201 .154 .013 5.093 1.00 29.37 A ATOM 1528 CA PHE A 201 .099 .967 3.993 1.00 27.14 A ATOM 1529 CB PHE A 201 1.390 .900 3.164 1.00 26.36 A ATOM 1530 CG PHE A 201 1.328 1.654 1.853 1.00 23.85 A ATOM 1531 CD1 PHE A 201 .634 1.131 .762 1.00 24.10 A ATOM 1532 CD2 PHE A 201 1.959 2.889 1.713 1.00 24.80 A ATOM 1533 CE1 PHE A 201 .567 1.831 −.447 1.00 24.95 A ATOM 1534 CE2 PHE A 201 1.901 3.597 .513 1.00 21.90 A ATOM 1535 CZ PHE A 201 1.205 3.072 −.569 1.00 24.52 A ATOM 1536 C PHE A 201 −1.095 .748 3.089 1.00 26.41 A ATOM 1537 O PHE A 201 −1.278 −.325 2.531 1.00 24.36 A ATOM 1538 N ARG A 202 −1.900 1.789 2.941 1.00 24.97 A ATOM 1539 CA ARG A 202 −3.063 1.730 2.075 1.00 24.55 A ATOM 1540 CB ARG A 202 −4.299 1.327 2.883 1.00 20.28 A ATOM 1541 CG ARG A 202 −4.532 2.183 4.108 1.00 20.71 A ATOM 1542 CD ARG A 202 −5.718 1.693 4.931 1.00 23.12 A ATOM 1543 NE ARG A 202 −5.454 .417 5.588 1.00 24.02 A ATOM 1544 CZ ARG A 202 −5.566 −.771 4.999 1.00 23.58 A ATOM 1545 NH1 ARG A 202 −5.942 −.855 3.736 1.00 23.59 A ATOM 1546 NH2 ARG A 202 −5.305 −1.883 5.680 1.00 24.60 A ATOM 1547 C ARG A 202 −3.251 3.116 1.448 1.00 24.73 A ATOM 1548 O ARG A 202 −2.648 4.091 1.895 1.00 23.81 A ATOM 1549 N GLY A 203 −4.079 3.192 .411 1.00 26.77 A ATOM 1550 CA GLY A 203 −4.339 4.458 −.251 1.00 27.86 A ATOM 1551 C GLY A 203 −5.000 5.470 .666 1.00 29.95 A ATOM 1552 O GLY A 203 −5.455 5.128 1.757 1.00 30.65 A ATOM 1553 N PRO A 204 −5.086 6.730 .238 1.00 31.00 A ATOM 1554 CD PRO A 204 −4.681 7.238 −1.085 1.00 31.27 A ATOM 1555 CA PRO A 204 −5.693 7.799 1.034 1.00 33.93 A ATOM 1556 CB PRO A 204 −5.127 9.047 .388 1.00 33.92 A ATOM 1557 CG PRO A 204 −5.221 8.670 −1.069 1.00 33.17 A ATOM 1558 C PRO A 204 −7.207 7.780 .961 1.00 35.37 A ATOM 1559 O PRO A 204 −7.784 7.238 .028 1.00 38.01 A ATOM 1560 N SER A 205 −7.846 8.387 1.945 1.00 37.66 A ATOM 1561 CA SER A 205 −9.295 8.452 1.975 1.00 39.54 A ATOM 1562 CB SER A 205 −9.858 7.242 2.722 1.00 40.11 A ATOM 1563 OG SER A 205 −11.271 7.211 2.638 1.00 45.37 A ATOM 1564 C SER A 205 −9.694 9.746 2.675 1.00 39.76 A ATOM 1565 O SER A 205 −9.102 10.119 3.687 1.00 40.03 A ATOM 1566 N GLU A 206 −10.685 10.438 2.129 1.00 41.11 A ATOM 1567 CA GLU A 206 −11.138 11.690 2.723 1.00 43.15 A ATOM 1568 CB GLU A 206 −11.788 12.585 1.660 1.00 44.15 A ATOM 1569 CG GLU A 206 −12.678 11.861 .666 1.00 47.17 A ATOM 1570 CD GLU A 206 −11.906 11.275 −.512 1.00 50.55 A ATOM 1571 OE1 GLU A 206 −11.174 10.273 −.332 1.00 50.11 A ATOM 1572 OE2 GLU A 206 −12.031 11.830 −1.628 1.00 51.91 A ATOM 1573 C GLU A 206 −12.100 11.481 3.895 1.00 43.15 A ATOM 1574 O GLU A 206 −12.333 12.392 4.690 1.00 44.07 A ATOM 1575 N THR A 207 −12.651 10.281 4.012 1.00 43.47 A ATOM 1576 CA THR A 207 −13.559 9.998 5.109 1.00 43.94 A ATOM 1577 CB THR A 207 −14.742 9.123 4.639 1.00 46.32 A ATOM 1578 OG1 THR A 207 −14.258 7.858 4.172 1.00 50.01 A ATOM 1579 CG2 THR A 207 −15.494 9.814 3.511 1.00 47.66 A ATOM 1580 C THR A 207 −12.831 9.297 6.260 1.00 42.70 A ATOM 1581 O THR A 207 −13.456 8.884 7.232 1.00 42.48 A ATOM 1582 N HIS A 208 −11.509 9.183 6.155 1.00 41.66 A ATOM 1583 CA HIS A 208 −10.709 8.520 7.185 1.00 40.56 A ATOM 1584 CB HIS A 208 −10.471 7.071 6.761 1.00 40.63 A ATOM 1585 CG HIS A 208 −11.728 6.272 6.641 1.00 41.45 A ATOM 1586 CD2 HIS A 208 −12.552 6.060 5.588 1.00 41.71 A ATOM 1587 ND1 HIS A 208 −12.306 5.629 7.714 1.00 43.34 A ATOM 1588 CE1 HIS A 208 −13.432 5.056 7.327 1.00 42.20 A ATOM 1589 NE2 HIS A 208 −13.605 5.303 6.041 1.00 40.79 A ATOM 1590 C HIS A 208 −9.366 9.216 7.468 1.00 40.72 A ATOM 1591 O HIS A 208 −8.305 8.578 7.455 1.00 36.97 A ATOM 1592 N LEU A 209 −9.428 10.519 7.744 1.00 41.16 A ATOM 1593 CA LEU A 209 −8.240 11.328 8.013 1.00 42.25 A ATOM 1594 CB LEU A 209 −8.648 12.766 8.322 1.00 44.19 A ATOM 1595 CG LEU A 209 −9.250 13.521 7.130 1.00 45.60 A ATOM 1596 CD1 LEU A 209 −9.688 14.911 7.553 1.00 45.32 A ATOM 1597 CD2 LEU A 209 −8.214 13.608 6.016 1.00 45.26 A ATOM 1598 C LEU A 209 −7.326 10.806 9.117 1.00 43.63 A ATOM 1599 O LEU A 209 −6.117 11.059 9.100 1.00 43.18 A ATOM 1600 N ASP A 210 −7.885 10.077 10.077 1.00 44.10 A ATOM 1601 CA ASP A 210 −7.054 9.538 11.144 1.00 43.86 A ATOM 1602 CB ASP A 210 −7.921 8.879 12.224 1.00 44.72 A ATOM 1603 CG ASP A 210 −8.520 7.567 11.781 1.00 46.10 A ATOM 1604 OD1 ASP A 210 −8.932 7.454 10.606 1.00 45.79 A ATOM 1605 OD2 ASP A 210 −8.595 6.649 12.626 1.00 48.31 A ATOM 1606 C ASP A 210 −6.087 8.539 10.506 1.00 44.25 A ATOM 1607 O ASP A 210 −4.962 8.352 10.985 1.00 44.96 A ATOM 1608 N SER A 211 −6.521 7.928 9.402 1.00 42.15 A ATOM 1609 CA SER A 211 −5.700 6.970 8.671 1.00 40.33 A ATOM 1610 CB SER A 211 −6.570 6.078 7.776 1.00 41.73 A ATOM 1611 OG SER A 211 −5.763 5.245 6.948 1.00 40.95 A ATOM 1612 C SER A 211 −4.659 7.679 7.808 1.00 39.17 A ATOM 1613 O SER A 211 −3.592 7.128 7.550 1.00 37.98 A ATOM 1614 N LEU A 212 −4.979 8.892 7.355 1.00 38.41 A ATOM 1615 CA LEU A 212 −4.049 9.668 6.533 1.00 35.56 A ATOM 1616 CB LEU A 212 −4.622 11.048 6.201 1.00 34.77 A ATOM 1617 CG LEU A 212 −5.091 11.392 4.787 1.00 33.15 A ATOM 1618 CD1 LEU A 212 −5.182 12.915 4.668 1.00 32.90 A ATOM 1619 CD2 LEU A 212 −4.125 10.855 3.754 1.00 31.17 A ATOM 1620 C LEU A 212 −2.792 9.857 7.358 1.00 35.22 A ATOM 1621 O LEU A 212 −1.701 9.450 6.961 1.00 36.22 A ATOM 1622 N VAL A 213 −2.962 10.499 8.510 1.00 33.04 A ATOM 1623 CA VAL A 213 −1.864 10.745 9.430 1.00 32.51 A ATOM 1624 CB VAL A 213 −2.414 10.985 10.857 1.00 31.66 A ATOM 1625 CG1 VAL A 213 −1.275 11.153 11.843 1.00 31.63 A ATOM 1626 CG2 VAL A 213 −3.307 12.211 10.860 1.00 29.64 A ATOM 1627 C VAL A 213 −.911 9.539 9.439 1.00 32.48 A ATOM 1628 O VAL A 213 .271 9.660 9.104 1.00 32.59 A ATOM 1629 N GLY A 214 −1.449 8.378 9.809 1.00 31.64 A ATOM 1630 CA GLY A 214 −.666 7.158 9.864 1.00 31.10 A ATOM 1631 C GLY A 214 .185 6.885 8.638 1.00 31.81 A ATOM 1632 O GLY A 214 1.283 6.339 8.760 1.00 31.87 A ATOM 1633 N GLN A 215 −.303 7.249 7.454 1.00 30.01 A ATOM 1634 CA GLN A 215 .470 7.016 6.239 1.00 29.39 A ATOM 1635 CB GLN A 215 −.383 7.249 4.990 1.00 29.12 A ATOM 1636 CG GLN A 215 −1.456 6.213 4.805 1.00 28.36 A ATOM 1637 CD GLN A 215 −.938 4.825 5.120 1.00 29.65 A ATOM 1638 OE1 GLN A 215 −1.545 4.095 5.899 1.00 27.40 A ATOM 1639 NE2 GLN A 215 .195 4.458 4.523 1.00 29.22 A ATOM 1640 C GLN A 215 1.697 7.908 6.181 1.00 29.72 A ATOM 1641 O GLN A 215 2.644 7.619 5.452 1.00 29.34 A ATOM 1642 N ALA A 216 1.673 8.988 6.957 1.00 29.06 A ATOM 1643 CA ALA A 216 2.781 9.928 6.977 1.00 29.34 A ATOM 1644 CB ALA A 216 2.250 11.358 6.959 1.00 28.98 A ATOM 1645 C ALA A 216 3.711 9.744 8.167 1.00 28.44 A ATOM 1646 O ALA A 216 4.859 10.171 8.119 1.00 28.77 A ATOM 1647 N LEU A 217 3.226 9.105 9.225 1.00 26.41 A ATOM 1648 CA LEU A 217 4.037 8.934 10.417 1.00 26.85 A ATOM 1649 CB LEU A 217 3.159 9.022 11.660 1.00 27.43 A ATOM 1650 CG LEU A 217 2.419 10.340 11.889 1.00 27.77 A ATOM 1651 CD1 LEU A 217 1.602 10.236 13.167 1.00 27.93 A ATOM 1652 CD2 LEU A 217 3.411 11.495 11.970 1.00 28.42 A ATOM 1653 C LEU A 217 4.860 7.660 10.489 1.00 28.52 A ATOM 1654 O LEU A 217 6.070 7.707 10.703 1.00 29.49 A ATOM 1655 N PHE A 218 4.196 6.524 10.324 1.00 28.61 A ATOM 1656 CA PHE A 218 4.853 5.229 10.409 1.00 28.75 A ATOM 1657 CB PHE A 218 3.794 4.127 10.391 1.00 31.22 A ATOM 1658 CG PHE A 218 2.703 4.324 11.403 1.00 34.00 A ATOM 1659 CD1 PHE A 218 3.008 4.645 12.719 1.00 36.79 A ATOM 1660 CD2 PHE A 218 1.370 4.170 11.046 1.00 36.49 A ATOM 1661 CE1 PHE A 218 2.002 4.811 13.674 1.00 36.73 A ATOM 1662 CE2 PHE A 218 .347 4.333 11.993 1.00 38.04 A ATOM 1663 CZ PHE A 218 .667 4.654 13.310 1.00 37.72 A ATOM 1664 C PHE A 218 5.933 4.916 9.368 1.00 27.22 A ATOM 1665 O PHE A 218 5.798 5.219 8.181 1.00 25.21 A ATOM 1666 N GLY A 219 7.011 4.300 9.851 1.00 28.13 A ATOM 1667 CA GLY A 219 8.125 3.894 9.007 1.00 27.30 A ATOM 1668 C GLY A 219 8.561 2.497 9.424 1.00 27.92 A ATOM 1669 O GLY A 219 7.950 1.909 10.311 1.00 27.50 A ATOM 1670 N ASP A 220 9.615 1.968 8.805 1.00 28.69 A ATOM 1671 CA ASP A 220 10.100 .626 9.123 1.00 27.97 A ATOM 1672 CB ASP A 220 10.161 −.243 7.860 1.00 27.48 A ATOM 1673 CG ASP A 220 8.833 −.326 7.138 1.00 28.81 A ATOM 1674 OD1 ASP A 220 7.811 .115 7.706 1.00 28.94 A ATOM 1675 OD2 ASP A 220 8.810 −.848 6.003 1.00 30.23 A ATOM 1676 C ASP A 220 11.470 .591 9.792 1.00 29.31 A ATOM 1677 O ASP A 220 12.346 1.412 9.503 1.00 28.92 A ATOM 1678 N GLY A 221 11.648 −.388 10.678 1.00 29.62 A ATOM 1679 CA GLY A 221 12.911 −.556 11.378 1.00 27.70 A ATOM 1680 C GLY A 221 12.920 −1.746 12.328 1.00 26.08 A ATOM 1681 O GLY A 221 11.876 −2.273 12.703 1.00 24.58 A ATOM 1682 N ALA A 222 14.114 −2.173 12.711 1.00 26.01 A ATOM 1683 CA ALA A 222 14.270 −3.283 13.634 1.00 25.76 A ATOM 1684 CB ALA A 222 14.657 −4.564 12.885 1.00 23.29 A ATOM 1685 C ALA A 222 15.343 −2.915 14.644 1.00 27.10 A ATOM 1686 O ALA A 222 16.394 −2.365 14.292 1.00 25.67 A ATOM 1687 N CYS A 223 15.071 −3.214 15.906 1.00 27.08 A ATOM 1688 CA CYS A 223 16.016 −2.917 16.960 1.00 28.62 A ATOM 1689 CB CYS A 223 15.413 −1.939 17.942 1.00 33.80 A ATOM 1690 SG CYS A 223 14.226 −2.768 18.964 1.00 42.48 A ATOM 1691 C CYS A 223 16.282 −4.210 17.684 1.00 26.75 A ATOM 1692 O CYS A 223 15.392 −5.058 17.783 1.00 25.04 A ATOM 1693 N ALA A 224 17.494 −4.347 18.212 1.00 24.80 A ATOM 1694 CA ALA A 224 17.872 −5.560 18.923 1.00 26.10 A ATOM 1695 CB ALA A 224 18.578 −6.529 17.975 1.00 21.48 A ATOM 1696 C ALA A 224 18.752 −5.261 20.129 1.00 26.20 A ATOM 1697 O ALA A 224 19.707 −4.487 20.057 1.00 23.62 A ATOM 1698 N LEU A 225 18.408 −5.901 21.240 1.00 28.73 A ATOM 1699 CA LEU A 225 19.117 −5.738 22.499 1.00 29.59 A ATOM 1700 CB LEU A 225 18.213 −5.087 23.547 1.00 28.37 A ATOM 1701 CG LEU A 225 17.447 −3.834 23.171 1.00 30.11 A ATOM 1702 CD1 LEU A 225 16.636 −3.373 24.360 1.00 33.00 A ATOM 1703 CD2 LEU A 225 18.417 −2.757 22.733 1.00 30.82 A ATOM 1704 C LEU A 225 19.541 −7.077 23.070 1.00 28.64 A ATOM 1705 O LEU A 225 18.892 −8.099 22.837 1.00 26.77 A ATOM 1706 N ILE A 226 20.629 −7.036 23.834 1.00 27.61 A ATOM 1707 CA ILE A 226 21.143 −8.187 24.552 1.00 27.04 A ATOM 1708 CB ILE A 226 22.659 −8.443 24.267 1.00 25.88 A ATOM 1709 CG2 ILE A 226 23.243 −9.389 25.305 1.00 27.04 A ATOM 1710 CG1 ILE A 226 22.836 −9.095 22.899 1.00 25.32 A ATOM 1711 CD1 ILE A 226 22.257 −10.490 22.817 1.00 24.29 A ATOM 1712 C ILE A 226 20.932 −7.744 26.008 1.00 27.60 A ATOM 1713 O ILE A 226 21.506 −6.746 26.463 1.00 26.23 A ATOM 1714 N VAL A 227 20.064 −8.455 26.718 1.00 27.92 A ATOM 1715 CA VAL A 227 19.790 −8.127 28.109 1.00 29.45 A ATOM 1716 CB VAL A 227 18.280 −7.875 28.355 1.00 29.44 A ATOM 1717 CG1 VAL A 227 17.995 −7.745 29.851 1.00 27.14 A ATOM 1718 CG2 VAL A 227 17.856 −6.602 27.647 1.00 27.64 A ATOM 1719 C VAL A 227 20.274 −9.260 29.004 1.00 30.44 A ATOM 1720 O VAL A 227 20.119 −10.441 28.677 1.00 30.38 A ATOM 1721 N GLY A 228 20.878 −8.891 30.129 1.00 30.00 A ATOM 1722 CA GLY A 228 21.381 −9.893 31.039 1.00 30.18 A ATOM 1723 C GLY A 228 21.795 −9.294 32.354 1.00 31.31 A ATOM 1724 O GLY A 228 22.112 −8.109 32.433 1.00 31.60 A ATOM 1725 N ALA A 229 21.774 −10.126 33.390 1.00 32.55 A ATOM 1726 CA ALA A 229 22.160 −9.710 34.724 1.00 33.95 A ATOM 1727 CB ALA A 229 21.252 −10.367 35.764 1.00 34.17 A ATOM 1728 C ALA A 229 23.619 −10.111 34.961 1.00 35.33 A ATOM 1729 O ALA A 229 24.164 −10.972 34.256 1.00 33.08 A ATOM 1730 N ASP A 230 24.248 −9.465 35.942 1.00 36.86 A ATOM 1731 CA ASP A 230 25.640 −9.740 36.300 1.00 39.56 A ATOM 1732 CB ASP A 230 25.757 −11.083 37.044 1.00 41.40 A ATOM 1733 CG ASP A 230 24.520 −11.413 37.868 1.00 43.35 A ATOM 1734 OD1 ASP A 230 24.054 −10.532 38.623 1.00 44.48 A ATOM 1735 OD2 ASP A 230 24.022 −12.560 37.767 1.00 44.89 A ATOM 1736 C ASP A 230 26.532 −9.793 35.066 1.00 39.71 A ATOM 1737 O ASP A 230 26.951 −10.873 34.651 1.00 39.33 A ATOM 1738 N PRO A 231 26.831 −8.633 34.456 1.00 39.86 A ATOM 1739 CD PRO A 231 26.381 −7.252 34.717 1.00 40.12 A ATOM 1740 CA PRO A 231 27.692 −8.692 33.271 1.00 40.52 A ATOM 1741 CB PRO A 231 27.573 −7.280 32.687 1.00 39.25 A ATOM 1742 CG PRO A 231 27.353 −6.433 33.884 1.00 38.53 A ATOM 1743 C PRO A 231 29.136 −9.073 33.629 1.00 41.54 A ATOM 1744 O PRO A 231 29.692 −8.570 34.605 1.00 43.36 A ATOM 1745 N ILE A 232 29.723 −9.977 32.850 1.00 41.13 A ATOM 1746 CA ILE A 232 31.099 −10.420 33.062 1.00 40.68 A ATOM 1747 CB ILE A 232 31.474 −11.530 32.070 1.00 40.34 A ATOM 1748 CG2 ILE A 232 32.886 −11.998 32.333 1.00 38.27 A ATOM 1749 CG1 ILE A 232 30.465 −12.675 32.178 1.00 39.77 A ATOM 1750 CD1 ILE A 232 30.197 −13.355 30.861 1.00 41.07 A ATOM 1751 C ILE A 232 32.046 −9.236 32.843 1.00 40.67 A ATOM 1752 O ILE A 232 32.089 −8.660 31.751 1.00 39.36 A ATOM 1753 N PRO A 233 32.836 −8.882 33.872 1.00 41.83 A ATOM 1754 CD PRO A 233 33.100 −9.709 35.064 1.00 41.56 A ATOM 1755 CA PRO A 233 33.782 −7.762 33.803 1.00 42.38 A ATOM 1756 CB PRO A 233 34.560 −7.888 35.108 1.00 42.80 A ATOM 1757 CG PRO A 233 34.539 −9.368 35.365 1.00 42.88 A ATOM 1758 C PRO A 233 34.681 −7.788 32.589 1.00 42.20 A ATOM 1759 O PRO A 233 35.137 −8.844 32.172 1.00 42.50 A ATOM 1760 N GLN A 234 34.914 −6.606 32.032 1.00 43.76 A ATOM 1761 CA GLN A 234 35.764 −6.406 30.860 1.00 45.45 A ATOM 1762 CB GLN A 234 37.245 −6.416 31.262 1.00 46.00 A ATOM 1763 CG GLN A 234 37.726 −7.729 31.838 1.00 48.56 A ATOM 1764 CD GLN A 234 39.175 −7.678 32.263 1.00 49.12 A ATOM 1765 OE1 GLN A 234 39.553 −6.892 33.128 1.00 50.98 A ATOM 1766 NE2 GLN A 234 39.997 −8.520 31.656 1.00 49.92 A ATOM 1767 C GLN A 234 35.544 −7.394 29.726 1.00 44.87 A ATOM 1768 O GLN A 234 36.397 −7.549 28.849 1.00 45.60 A ATOM 1769 N VAL A 235 34.404 −8.071 29.756 1.00 44.58 A ATOM 1770 CA VAL A 235 34.039 −9.028 28.720 1.00 43.67 A ATOM 1771 CB VAL A 235 33.805 −10.440 29.299 1.00 44.91 A ATOM 1772 CG1 VAL A 235 33.227 −11.353 28.218 1.00 45.45 A ATOM 1773 CG2 VAL A 235 35.115 −11.010 29.822 1.00 45.12 A ATOM 1774 C VAL A 235 32.743 −8.524 28.108 1.00 42.68 A ATOM 1775 O VAL A 235 32.571 −8.547 26.889 1.00 42.55 A ATOM 1776 N GLU A 236 31.835 −8.076 28.975 1.00 40.47 A ATOM 1777 CA GLU A 236 30.547 −7.527 28.551 1.00 39.21 A ATOM 1778 CB GLU A 236 29.380 −8.321 29.133 1.00 35.88 A ATOM 1779 CG GLU A 236 29.437 −9.787 28.844 1.00 34.44 A ATOM 1780 CD GLU A 236 28.341 −10.545 29.544 1.00 29.35 A ATOM 1781 OE1 GLU A 236 28.117 −10.279 30.740 1.00 28.34 A ATOM 1782 OE2 GLU A 236 27.718 −11.406 28.900 1.00 29.13 A ATOM 1783 C GLU A 236 30.475 −6.112 29.082 1.00 39.21 A ATOM 1784 O GLU A 236 30.804 −5.863 30.240 1.00 39.77 A ATOM 1785 N LYS A 237 30.041 −5.188 28.236 1.00 40.00 A ATOM 1786 CA LYS A 237 29.946 −3.792 28.630 1.00 38.96 A ATOM 1787 CB LYS A 237 30.721 −2.934 27.631 1.00 38.86 A ATOM 1788 CG LYS A 237 30.876 −1.475 28.023 1.00 41.75 A ATOM 1789 CD LYS A 237 31.777 −.743 27.024 1.00 44.57 A ATOM 1790 CE LYS A 237 31.936 .730 27.385 1.00 45.75 A ATOM 1791 NZ LYS A 237 32.833 1.455 26.432 1.00 46.22 A ATOM 1792 C LYS A 237 28.480 −3.377 28.676 1.00 38.35 A ATOM 1793 O LYS A 237 27.786 −3.403 27.659 1.00 36.98 A ATOM 1794 N ALA A 238 28.006 −3.019 29.865 1.00 37.12 A ATOM 1795 CA ALA A 238 26.625 −2.598 30.031 1.00 35.90 A ATOM 1796 CB ALA A 238 26.131 −2.956 31.421 1.00 34.13 A ATOM 1797 C ALA A 238 26.549 −1.094 29.811 1.00 36.34 A ATOM 1798 O ALA A 238 27.546 −.386 29.977 1.00 37.36 A ATOM 1799 N CYS A 239 25.375 −.608 29.415 1.00 35.65 A ATOM 1800 CA CYS A 239 25.179 .824 29.179 1.00 34.67 A ATOM 1801 CB CYS A 239 25.042 1.096 27.682 1.00 34.03 A ATOM 1802 SG CYS A 239 23.884 .011 26.852 1.00 39.50 A ATOM 1803 C CYS A 239 23.952 1.345 29.928 1.00 32.01 A ATOM 1804 O CYS A 239 23.922 2.488 30.384 1.00 29.97 A ATOM 1805 N PHE A 240 22.952 .489 30.073 1.00 30.69 A ATOM 1806 CA PHE A 240 21.731 .864 30.772 1.00 29.43 A ATOM 1807 CB PHE A 240 20.651 1.222 29.753 1.00 27.09 A ATOM 1808 CG PHE A 240 21.002 2.399 28.886 1.00 26.17 A ATOM 1809 CD1 PHE A 240 21.036 3.686 29.415 1.00 25.93 A ATOM 1810 CD2 PHE A 240 21.323 2.223 27.544 1.00 28.55 A ATOM 1811 CE1 PHE A 240 21.384 4.772 28.623 1.00 25.72 A ATOM 1812 CE2 PHE A 240 21.673 3.314 26.743 1.00 23.97 A ATOM 1813 CZ PHE A 240 21.703 4.583 27.285 1.00 23.90 A ATOM 1814 C PHE A 240 21.251 −.288 31.643 1.00 30.74 A ATOM 1815 O PHE A 240 21.413 −1.447 31.277 1.00 32.77 A ATOM 1816 N GLU A 241 20.677 .021 32.802 1.00 31.99 A ATOM 1817 CA GLU A 241 20.147 −1.025 33.678 1.00 34.57 A ATOM 1818 CB GLU A 241 20.852 −1.023 35.046 1.00 35.81 A ATOM 1819 CG GLU A 241 22.360 −1.271 34.997 1.00 37.93 A ATOM 1820 CD GLU A 241 23.006 −1.280 36.381 1.00 40.79 A ATOM 1821 OE1 GLU A 241 22.690 −.392 37.211 1.00 42.12 A ATOM 1822 OE2 GLU A 241 23.845 −2.170 36.638 1.00 42.83 A ATOM 1823 C GLU A 241 18.648 −.771 33.867 1.00 34.22 A ATOM 1824 O GLU A 241 18.200 .382 33.877 1.00 34.52 A ATOM 1825 N ILE A 242 17.877 −1.846 34.004 1.00 34.06 A ATOM 1826 CA ILE A 242 16.434 −1.733 34.196 1.00 32.84 A ATOM 1827 CB ILE A 242 15.670 −2.830 33.421 1.00 32.65 A ATOM 1828 CG2 ILE A 242 14.229 −2.383 33.165 1.00 31.59 A ATOM 1829 CG1 ILE A 242 16.359 −3.113 32.089 1.00 32.73 A ATOM 1830 CD1 ILE A 242 16.466 −1.903 31.191 1.00 33.02 A ATOM 1831 C ILE A 242 16.124 −1.891 35.683 1.00 32.33 A ATOM 1832 O ILE A 242 16.073 −3.009 36.199 1.00 34.81 A ATOM 1833 N VAL A 243 15.903 −.770 36.362 1.00 30.43 A ATOM 1834 CA VAL A 243 15.624 −.761 37.795 1.00 27.37 A ATOM 1835 CB VAL A 243 16.016 .621 38.394 1.00 28.23 A ATOM 1836 CG1 VAL A 243 15.188 .923 39.626 1.00 22.92 A ATOM 1837 CG2 VAL A 243 17.499 .632 38.740 1.00 29.02 A ATOM 1838 C VAL A 243 14.196 −1.094 38.247 1.00 26.31 A ATOM 1839 O VAL A 243 14.000 −1.938 39.119 1.00 25.11 A ATOM 1840 N TRP A 244 13.213 −.416 37.659 1.00 26.80 A ATOM 1841 CA TRP A 244 11.806 −.578 38.033 1.00 25.99 A ATOM 1842 CB TRP A 244 11.459 .445 39.123 1.00 24.69 A ATOM 1843 CG TRP A 244 10.085 .344 39.686 1.00 26.65 A ATOM 1844 CD2 TRP A 244 8.923 1.064 39.252 1.00 26.94 A ATOM 1845 CE2 TRP A 244 7.851 .655 40.071 1.00 28.19 A ATOM 1846 CE3 TRP A 244 8.684 2.012 38.249 1.00 30.14 A ATOM 1847 CD1 TRP A 244 9.681 −.448 40.715 1.00 27.61 A ATOM 1848 NE1 TRP A 244 8.342 −.269 40.956 1.00 27.74 A ATOM 1849 CZ2 TRP A 244 6.554 1.163 39.923 1.00 29.62 A ATOM 1850 CZ3 TRP A 244 7.387 2.517 38.100 1.00 31.77 A ATOM 1851 CH2 TRP A 244 6.344 2.089 38.935 1.00 30.68 A ATOM 1852 C TRP A 244 10.930 −.360 36.803 1.00 25.64 A ATOM 1853 O TRP A 244 11.230 .499 35.968 1.00 24.94 A ATOM 1854 N THR A 245 9.837 −1.117 36.712 1.00 25.35 A ATOM 1855 CA THR A 245 8.946 −1.064 35.554 1.00 25.32 A ATOM 1856 CB THR A 245 9.110 −2.349 34.743 1.00 26.48 A ATOM 1857 OG1 THR A 245 8.406 −2.238 33.509 1.00 28.56 A ATOM 1858 CG2 THR A 245 8.551 −3.538 35.532 1.00 25.04 A ATOM 1859 C THR A 245 7.455 −.904 35.888 1.00 25.82 A ATOM 1860 O THR A 245 7.029 −1.132 37.024 1.00 24.99 A ATOM 1861 N ALA A 246 6.665 −.524 34.885 1.00 24.85 A ATOM 1862 CA ALA A 246 5.228 −.346 35.067 1.00 23.46 A ATOM 1863 CB ALA A 246 4.957 .788 36.061 1.00 26.77 A ATOM 1864 C ALA A 246 4.493 −.073 33.757 1.00 23.79 A ATOM 1865 O ALA A 246 5.073 .412 32.783 1.00 22.48 A ATOM 1866 N GLN A 247 3.205 −.394 33.754 1.00 23.39 A ATOM 1867 CA GLN A 247 2.326 −.210 32.601 1.00 25.65 A ATOM 1868 CB GLN A 247 2.155 −1.531 31.835 1.00 24.53 A ATOM 1869 CG GLN A 247 1.151 −1.473 30.682 1.00 24.31 A ATOM 1870 CD GLN A 247 .838 −2.843 30.074 1.00 22.11 A ATOM 1871 OE1 GLN A 247 .257 −3.709 30.726 1.00 23.16 A ATOM 1872 NE2 GLN A 247 1.224 −3.036 28.825 1.00 20.77 A ATOM 1873 C GLN A 247 .984 .220 33.170 1.00 27.26 A ATOM 1874 O GLN A 247 .569 −.263 34.222 1.00 28.63 A ATOM 1875 N THR A 248 .295 1.125 32.494 1.00 28.56 A ATOM 1876 CA THR A 248 −.988 1.567 33.017 1.00 28.92 A ATOM 1877 CB THR A 248 −.797 2.755 33.987 1.00 30.79 A ATOM 1878 OG1 THR A 248 −1.944 2.862 34.842 1.00 35.24 A ATOM 1879 CG2 THR A 248 −.615 4.060 33.211 1.00 31.01 A ATOM 1880 C THR A 248 −1.953 1.977 31.916 1.00 27.53 A ATOM 1881 O THR A 248 −1.539 2.318 30.812 1.00 25.84 A ATOM 1882 N VAL A 249 −3.241 1.925 32.226 1.00 25.93 A ATOM 1883 CA VAL A 249 −4.272 2.318 31.279 1.00 27.96 A ATOM 1884 CB VAL A 249 −5.407 1.288 31.251 1.00 28.05 A ATOM 1885 CG1 VAL A 249 −6.550 1.797 30.397 1.00 27.80 A ATOM 1886 CG2 VAL A 249 −4.884 −.038 30.713 1.00 28.94 A ATOM 1887 C VAL A 249 −4.825 3.679 31.713 1.00 27.45 A ATOM 1888 O VAL A 249 −5.378 3.810 32.805 1.00 26.81 A ATOM 1889 N VAL A 250 −4.652 4.700 30.880 1.00 27.86 A ATOM 1890 CA VAL A 250 −5.153 6.018 31.254 1.00 28.83 A ATOM 1891 CB VAL A 250 −4.656 7.129 30.318 1.00 28.90 A ATOM 1892 CG1 VAL A 250 −3.192 7.416 30.593 1.00 29.74 A ATOM 1893 CG2 VAL A 250 −4.834 6.717 28.889 1.00 30.61 A ATOM 1894 C VAL A 250 −6.670 5.968 31.235 1.00 28.87 A ATOM 1895 O VAL A 250 −7.274 5.444 30.301 1.00 27.18 A ATOM 1896 N PRO A 251 −7.302 6.513 32.283 1.00 28.95 A ATOM 1897 CD PRO A 251 −6.680 7.371 33.302 1.00 27.77 A ATOM 1898 CA PRO A 251 −8.760 6.530 32.405 1.00 30.93 A ATOM 1899 CB PRO A 251 −8.991 7.390 33.643 1.00 28.74 A ATOM 1900 CG PRO A 251 −7.799 8.286 33.662 1.00 30.42 A ATOM 1901 C PRO A 251 −9.479 7.053 31.168 1.00 33.62 A ATOM 1902 O PRO A 251 −8.942 7.863 30.409 1.00 34.58 A ATOM 1903 N ASN A 252 −10.692 6.550 30.970 1.00 36.56 A ATOM 1904 CA ASN A 252 −11.546 6.917 29.851 1.00 38.78 A ATOM 1905 CB ASN A 252 −12.471 8.052 30.291 1.00 40.73 A ATOM 1906 CG ASN A 252 −13.412 8.486 29.198 1.00 44.33 A ATOM 1907 OD1 ASN A 252 −13.037 9.262 28.321 1.00 46.53 A ATOM 1908 ND2 ASN A 252 −14.642 7.978 29.232 1.00 45.05 A ATOM 1909 C ASN A 252 −10.776 7.295 28.579 1.00 38.09 A ATOM 1910 O ASN A 252 −10.867 8.427 28.106 1.00 38.27 A ATOM 1911 N SER A 253 −10.044 6.331 28.016 1.00 36.57 A ATOM 1912 CA SER A 253 −9.236 6.568 26.816 1.00 36.26 A ATOM 1913 CB SER A 253 −7.775 6.719 27.216 1.00 34.68 A ATOM 1914 OG SER A 253 −7.312 5.503 27.778 1.00 32.19 A ATOM 1915 C SER A 253 −9.329 5.455 25.761 1.00 36.96 A ATOM 1916 O SER A 253 −8.391 5.232 24.998 1.00 36.84 A ATOM 1917 N GLU A 254 −10.455 4.762 25.719 1.00 37.92 A ATOM 1918 CA GLU A 254 −10.658 3.678 24.766 1.00 38.18 A ATOM 1919 CB GLU A 254 −11.874 2.865 25.196 1.00 40.81 A ATOM 1920 CG GLU A 254 −11.709 1.362 25.110 1.00 44.37 A ATOM 1921 CD GLU A 254 −12.993 .637 25.461 1.00 44.94 A ATOM 1922 OE1 GLU A 254 −13.494 .833 26.591 1.00 46.54 A ATOM 1923 OE2 GLU A 254 −13.507 −.118 24.607 1.00 45.46 A ATOM 1924 C GLU A 254 −10.872 4.196 23.342 1.00 37.96 A ATOM 1925 O GLU A 254 −11.532 5.217 23.127 1.00 34.76 A ATOM 1926 N GLY A 255 −10.319 3.479 22.368 1.00 35.90 A ATOM 1927 CA GLY A 255 −10.487 3.881 20.985 1.00 34.05 A ATOM 1928 C GLY A 255 −9.532 4.966 20.536 1.00 33.62 A ATOM 1929 O GLY A 255 −9.456 5.283 19.348 1.00 34.14 A ATOM 1930 N ALA A 256 −8.806 5.549 21.482 1.00 32.67 A ATOM 1931 CA ALA A 256 −7.844 6.588 21.145 1.00 31.58 A ATOM 1932 CB ALA A 256 −7.138 7.081 22.399 1.00 30.56 A ATOM 1933 C ALA A 256 −6.840 6.001 20.169 1.00 30.51 A ATOM 1934 O ALA A 256 −6.523 6.610 19.155 1.00 32.75 A ATOM 1935 N ILE A 257 −6.348 4.808 20.482 1.00 29.54 A ATOM 1936 CA ILE A 257 −5.383 4.115 19.635 1.00 28.79 A ATOM 1937 CB ILE A 257 −3.971 4.131 20.255 1.00 28.12 A ATOM 1938 CG2 ILE A 257 −2.973 3.501 19.300 1.00 28.32 A ATOM 1939 CG1 ILE A 257 −3.553 5.567 20.566 1.00 26.99 A ATOM 1940 CD1 ILE A 257 −2.172 5.686 21.172 1.00 22.94 A ATOM 1941 C ILE A 257 −5.829 2.662 19.477 1.00 29.98 A ATOM 1942 O ILE A 257 −6.128 1.976 20.457 1.00 31.42 A ATOM 1943 N GLY A 258 −5.882 2.193 18.239 1.00 31.11 A ATOM 1944 CA GLY A 258 −6.300 .826 18.003 1.00 27.25 A ATOM 1945 C GLY A 258 −6.105 .422 16.561 1.00 27.85 A ATOM 1946 O GLY A 258 −5.851 1.259 15.682 1.00 24.88 A ATOM 1947 N GLY A 259 −6.223 −.879 16.324 1.00 26.06 A ATOM 1948 CA GLY A 259 −6.054 −1.401 14.987 1.00 24.94 A ATOM 1949 C GLY A 259 −6.788 −2.709 14.848 1.00 25.74 A ATOM 1950 O GLY A 259 −6.904 −3.474 15.804 1.00 27.81 A ATOM 1951 N LYS A 260 −7.280 −2.972 13.648 1.00 24.91 A ATOM 1952 CA LYS A 260 −8.022 −4.191 13.392 1.00 24.18 A ATOM 1953 CB LYS A 260 −9.468 −3.834 13.058 1.00 23.37 A ATOM 1954 CG LYS A 260 −10.120 −2.976 14.105 1.00 21.02 A ATOM 1955 CD LYS A 260 −11.477 −2.506 13.624 1.00 27.51 A ATOM 1956 CE LYS A 260 −12.267 −1.873 14.757 1.00 27.39 A ATOM 1957 NZ LYS A 260 −12.506 −2.874 15.835 1.00 30.72 A ATOM 1958 C LYS A 260 −7.402 −4.988 12.256 1.00 23.16 A ATOM 1959 O LYS A 260 −7.139 −4.452 11.185 1.00 26.09 A ATOM 1960 N VAL A 261 −7.152 −6.265 12.496 1.00 22.53 A ATOM 1961 CA VAL A 261 −6.581 −7.112 11.458 1.00 22.47 A ATOM 1962 CB VAL A 261 −5.764 −8.275 12.056 1.00 22.44 A ATOM 1963 CG1 VAL A 261 −5.339 −9.236 10.954 1.00 24.43 A ATOM 1964 CG2 VAL A 261 −4.526 −7.728 12.759 1.00 23.17 A ATOM 1965 C VAL A 261 −7.748 −7.640 10.645 1.00 21.55 A ATOM 1966 O VAL A 261 −8.525 −8.473 11.109 1.00 20.82 A ATOM 1967 N ARG A 262 −7.880 −7.126 9.428 1.00 21.55 A ATOM 1968 CA ARG A 262 −8.982 −7.514 8.564 1.00 22.38 A ATOM 1969 CB ARG A 262 −9.961 −6.344 8.452 1.00 21.69 A ATOM 1970 CG ARG A 262 −10.631 −5.983 9.766 1.00 21.51 A ATOM 1971 CD ARG A 262 −11.517 −7.128 10.288 1.00 22.91 A ATOM 1972 NE ARG A 262 −12.241 −6.748 11.501 1.00 23.25 A ATOM 1973 CZ ARG A 262 −11.766 −6.836 12.740 1.00 24.30 A ATOM 1974 NH1 ARG A 262 −10.547 −7.315 12.972 1.00 21.08 A ATOM 1975 NH2 ARG A 262 −12.502 −6.398 13.753 1.00 24.59 A ATOM 1976 C ARG A 262 −8.555 −7.997 7.178 1.00 22.47 A ATOM 1977 O ARG A 262 −7.366 −8.019 6.852 1.00 22.56 A ATOM 1978 N GLU A 263 −9.525 −8.392 6.364 1.00 21.88 A ATOM 1979 CA GLU A 263 −9.207 −8.888 5.035 1.00 22.36 A ATOM 1980 CB GLU A 263 −10.481 −9.388 4.355 1.00 22.82 A ATOM 1981 CG GLU A 263 −11.010 −10.653 5.037 1.00 28.67 A ATOM 1982 CD GLU A 263 −12.505 −10.893 4.844 1.00 33.40 A ATOM 1983 OE1 GLU A 263 −13.067 −11.739 5.577 1.00 32.78 A ATOM 1984 OE2 GLU A 263 −13.120 −10.249 3.961 1.00 37.42 A ATOM 1985 C GLU A 263 −8.486 −7.831 4.203 1.00 22.25 A ATOM 1986 O GLU A 263 −7.881 −8.145 3.173 1.00 18.80 A ATOM 1987 N VAL A 264 −8.530 −6.579 4.661 1.00 21.62 A ATOM 1988 CA VAL A 264 −7.835 −5.508 3.955 1.00 21.09 A ATOM 1989 CB VAL A 264 −8.650 −4.211 3.935 1.00 22.68 A ATOM 1990 CG1 VAL A 264 −9.941 −4.419 3.158 1.00 23.99 A ATOM 1991 CG2 VAL A 264 −8.929 −3.758 5.355 1.00 21.59 A ATOM 1992 C VAL A 264 −6.500 −5.222 4.630 1.00 20.86 A ATOM 1993 O VAL A 264 −5.816 −4.249 4.292 1.00 19.04 A ATOM 1994 N GLY A 265 −6.135 −6.077 5.583 1.00 20.38 A ATOM 1995 CA GLY A 265 −4.896 −5.897 6.314 1.00 22.57 A ATOM 1996 C GLY A 265 −5.141 −5.198 7.641 1.00 24.13 A ATOM 1997 O GLY A 265 −6.258 −5.210 8.154 1.00 24.25 A ATOM 1998 N LEU A 266 −4.109 −4.575 8.195 1.00 24.55 A ATOM 1999 CA LEU A 266 −4.257 −3.900 9.476 1.00 27.01 A ATOM 2000 CB LEU A 266 −2.935 −3.923 10.259 1.00 26.32 A ATOM 2001 CG LEU A 266 −2.987 −4.172 11.779 1.00 28.57 A ATOM 2002 CD1 LEU A 266 −1.872 −3.374 12.425 1.00 25.69 A ATOM 2003 CD2 LEU A 266 −4.335 −3.764 12.389 1.00 25.63 A ATOM 2004 C LEU A 266 −4.712 −2.457 9.301 1.00 28.29 A ATOM 2005 O LEU A 266 −3.964 −1.618 8.809 1.00 27.00 A ATOM 2006 N THR A 267 −5.951 −2.182 9.689 1.00 29.50 A ATOM 2007 CA THR A 267 −6.485 −.836 9.608 1.00 30.44 A ATOM 2008 CB THR A 267 −8.022 −.825 9.574 1.00 29.41 A ATOM 2009 OG1 THR A 267 −8.541 −1.701 10.579 1.00 28.88 A ATOM 2010 CG2 THR A 267 −8.512 −1.271 8.220 1.00 31.59 A ATOM 2011 C THR A 267 −5.990 −.143 10.861 1.00 32.37 A ATOM 2012 O THR A 267 −5.475 −.790 11.762 1.00 32.42 A ATOM 2013 N PHE A 268 −6.153 1.168 10.931 1.00 34.52 A ATOM 2014 CA PHE A 268 −5.646 1.909 12.076 1.00 37.28 A ATOM 2015 CB PHE A 268 −4.208 2.318 11.770 1.00 35.84 A ATOM 2016 CG PHE A 268 −3.713 3.443 12.595 1.00 36.17 A ATOM 2017 CD1 PHE A 268 −3.373 3.249 13.927 1.00 38.58 A ATOM 2018 CD2 PHE A 268 −3.576 4.709 12.039 1.00 36.83 A ATOM 2019 CE1 PHE A 268 −2.895 4.309 14.700 1.00 39.39 A ATOM 2020 CE2 PHE A 268 −3.104 5.771 12.798 1.00 37.60 A ATOM 2021 CZ PHE A 268 −2.762 5.573 14.129 1.00 38.49 A ATOM 2022 C PHE A 268 −6.479 3.137 12.430 1.00 38.24 A ATOM 2023 O PHE A 268 −6.645 4.041 11.613 1.00 38.90 A ATOM 2024 N GLN A 269 −7.000 3.157 13.655 1.00 39.85 A ATOM 2025 CA GLN A 269 −7.805 4.274 14.138 1.00 40.66 A ATOM 2026 CB GLN A 269 −9.084 3.760 14.815 1.00 40.42 A ATOM 2027 CG GLN A 269 −8.836 2.678 15.859 1.00 43.55 A ATOM 2028 CD GLN A 269 −8.868 1.271 15.277 1.00 45.56 A ATOM 2029 OE1 GLN A 269 −8.456 1.043 14.135 1.00 43.46 A ATOM 2030 NE2 GLN A 269 −9.349 .316 16.069 1.00 44.36 A ATOM 2031 C GLN A 269 −6.957 5.068 15.130 1.00 41.21 A ATOM 2032 O GLN A 269 −6.235 4.482 15.938 1.00 41.66 A ATOM 2033 N LEU A 270 −7.041 6.396 15.061 1.00 41.43 A ATOM 2034 CA LEU A 270 −6.263 7.264 15.944 1.00 41.35 A ATOM 2035 CB LEU A 270 −4.927 7.598 15.273 1.00 40.81 A ATOM 2036 CG LEU A 270 −3.927 8.500 15.991 1.00 42.32 A ATOM 2037 CD1 LEU A 270 −3.581 7.908 17.338 1.00 43.04 A ATOM 2038 CD2 LEU A 270 −2.675 8.642 15.142 1.00 41.53 A ATOM 2039 C LEU A 270 −7.007 8.555 16.283 1.00 41.06 A ATOM 2040 O LEU A 270 −6.881 9.554 15.575 1.00 44.11 A ATOM 2041 N LYS A 271 −7.786 8.540 17.358 1.00 38.77 A ATOM 2042 CA LYS A 271 −8.537 9.730 17.762 1.00 37.60 A ATOM 2043 CB LYS A 271 −9.392 9.420 18.999 1.00 36.95 A ATOM 2044 CG LYS A 271 −10.504 8.407 18.714 1.00 38.43 A ATOM 2045 CD LYS A 271 −11.337 8.048 19.940 1.00 37.75 A ATOM 2046 CE LYS A 271 −12.440 7.055 19.555 1.00 40.27 A ATOM 2047 NZ LYS A 271 −13.165 6.457 20.723 1.00 42.36 A ATOM 2048 C LYS A 271 −7.577 10.888 18.053 1.00 35.81 A ATOM 2049 O LYS A 271 −6.477 10.682 18.557 1.00 34.82 A ATOM 2050 N GLY A 272 −7.998 12.105 17.724 1.00 34.36 A ATOM 2051 CA GLY A 272 −7.159 13.269 17.955 1.00 32.41 A ATOM 2052 C GLY A 272 −6.859 13.596 19.412 1.00 31.39 A ATOM 2053 O GLY A 272 −5.909 14.324 19.701 1.00 30.50 A ATOM 2054 N ALA A 273 −7.646 13.053 20.335 1.00 30.16 A ATOM 2055 CA ALA A 273 −7.442 13.316 21.758 1.00 30.25 A ATOM 2056 CB ALA A 273 −8.680 12.896 22.527 1.00 28.04 A ATOM 2057 C ALA A 273 −6.193 12.667 22.391 1.00 30.52 A ATOM 2058 O ALA A 273 −5.906 12.886 23.572 1.00 31.69 A ATOM 2059 N VAL A 274 −5.449 11.888 21.613 1.00 29.09 A ATOM 2060 CA VAL A 274 −4.255 11.197 22.124 1.00 30.02 A ATOM 2061 CB VAL A 274 −3.574 10.349 20.994 1.00 29.02 A ATOM 2062 CG1 VAL A 274 −2.120 10.066 21.328 1.00 26.26 A ATOM 2063 CG2 VAL A 274 −4.324 9.029 20.829 1.00 28.14 A ATOM 2064 C VAL A 274 −3.185 12.040 22.832 1.00 29.91 A ATOM 2065 O VAL A 274 −2.706 11.667 23.908 1.00 31.11 A ATOM 2066 N PRO A 275 −2.785 13.174 22.246 1.00 29.31 A ATOM 2067 CD PRO A 275 −3.039 13.717 20.903 1.00 28.93 A ATOM 2068 CA PRO A 275 −1.759 13.959 22.943 1.00 29.97 A ATOM 2069 CB PRO A 275 −1.536 15.141 22.009 1.00 29.08 A ATOM 2070 CG PRO A 275 −1.794 14.543 20.662 1.00 30.30 A ATOM 2071 C PRO A 275 −2.170 14.391 24.348 1.00 30.48 A ATOM 2072 O PRO A 275 −1.355 14.376 25.271 1.00 31.35 A ATOM 2073 N ASP A 276 −3.439 14.752 24.514 1.00 31.00 A ATOM 2074 CA ASP A 276 −3.931 15.197 25.810 1.00 31.59 A ATOM 2075 CB ASP A 276 −5.286 15.885 25.661 1.00 34.05 A ATOM 2076 CG ASP A 276 −5.849 16.327 26.993 1.00 35.35 A ATOM 2077 OD1 ASP A 276 −5.196 17.162 27.658 1.00 36.13 A ATOM 2078 OD2 ASP A 276 −6.927 15.829 27.384 1.00 36.47 A ATOM 2079 C ASP A 276 −4.060 14.089 26.838 1.00 31.20 A ATOM 2080 O ASP A 276 −3.790 14.299 28.016 1.00 31.91 A ATOM 2081 N LEU A 277 −4.492 12.913 26.400 1.00 32.16 A ATOM 2082 CA LEU A 277 −4.646 11.777 27.303 1.00 31.43 A ATOM 2083 CB LEU A 277 −5.261 10.598 26.547 1.00 30.50 A ATOM 2084 CG LEU A 277 −6.689 10.892 26.089 1.00 30.10 A ATOM 2085 CD1 LEU A 277 −7.184 9.828 25.132 1.00 30.66 A ATOM 2086 CD2 LEU A 277 −7.582 10.971 27.310 1.00 30.85 A ATOM 2087 C LEU A 277 −3.298 11.381 27.903 1.00 31.68 A ATOM 2088 O LEU A 277 −3.166 11.214 29.114 1.00 31.00 A ATOM 2089 N ILE A 278 −2.294 11.243 27.048 1.00 32.33 A ATOM 2090 CA ILE A 278 −.962 10.887 27.502 1.00 32.96 A ATOM 2091 CB ILE A 278 −.013 10.649 26.300 1.00 30.68 A ATOM 2092 CG2 ILE A 278 1.422 10.523 26.777 1.00 28.01 A ATOM 2093 CG1 ILE A 278 −.456 9.391 25.547 1.00 29.23 A ATOM 2094 CD1 ILE A 278 .283 9.139 24.250 1.00 29.89 A ATOM 2095 C ILE A 278 −.378 11.966 28.406 1.00 34.32 A ATOM 2096 O ILE A 278 .168 11.657 29.455 1.00 34.80 A ATOM 2097 N SER A 279 −.517 13.229 28.011 1.00 36.66 A ATOM 2098 CA SER A 279 .025 14.351 28.790 1.00 37.98 A ATOM 2099 CB SER A 279 −.114 15.663 28.002 1.00 40.15 A ATOM 2100 OG SER A 279 .917 15.792 27.031 1.00 41.42 A ATOM 2101 C SER A 279 −.550 14.562 30.186 1.00 37.84 A ATOM 2102 O SER A 279 .193 14.762 31.151 1.00 38.76 A ATOM 2103 N ALA A 280 −1.870 14.527 30.294 1.00 36.55 A ATOM 2104 CA ALA A 280 −2.530 14.749 31.572 1.00 34.53 A ATOM 2105 CB ALA A 280 −3.977 15.142 31.335 1.00 34.08 A ATOM 2106 C ALA A 280 −2.471 13.547 32.490 1.00 35.22 A ATOM 2107 O ALA A 280 −3.258 13.450 33.432 1.00 35.65 A ATOM 2108 N ASN A 281 −1.551 12.626 32.220 1.00 34.56 A ATOM 2109 CA ASN A 281 −1.418 11.437 33.045 1.00 33.77 A ATOM 2110 CB ASN A 281 −2.257 10.309 32.459 1.00 35.68 A ATOM 2111 CG ASN A 281 −3.730 10.602 32.520 1.00 36.67 A ATOM 2112 OD1 ASN A 281 −4.386 10.347 33.529 1.00 37.02 A ATOM 2113 ND2 ASN A 281 −4.258 11.169 31.447 1.00 37.77 A ATOM 2114 C ASN A 281 .017 10.963 33.187 1.00 34.57 A ATOM 2115 O ASN A 281 .323 10.141 34.057 1.00 33.59 A ATOM 2116 N ILE A 282 .900 11.476 32.339 1.00 34.05 A ATOM 2117 CA ILE A 282 2.291 11.057 32.383 1.00 36.36 A ATOM 2118 CB ILE A 282 3.060 11.550 31.128 1.00 36.30 A ATOM 2119 CG2 ILE A 282 3.278 13.054 31.197 1.00 35.15 A ATOM 2120 CG1 ILE A 282 4.388 10.803 31.010 1.00 36.39 A ATOM 2121 CD1 ILE A 282 5.063 10.962 29.679 1.00 35.07 A ATOM 2122 C ILE A 282 2.976 11.540 33.661 1.00 39.22 A ATOM 2123 O ILE A 282 3.876 10.874 34.183 1.00 40.83 A ATOM 2124 N GLU A 283 2.534 12.687 34.172 1.00 38.71 A ATOM 2125 CA GLU A 283 3.095 13.251 35.395 1.00 38.20 A ATOM 2126 CB GLU A 283 2.403 14.586 35.710 1.00 39.81 A ATOM 2127 CG GLU A 283 2.918 15.313 36.936 1.00 41.71 A ATOM 2128 CD GLU A 283 4.340 15.821 36.761 1.00 46.24 A ATOM 2129 OE1 GLU A 283 4.717 16.782 37.472 1.00 45.68 A ATOM 2130 OE2 GLU A 283 5.079 15.260 35.915 1.00 46.93 A ATOM 2131 C GLU A 283 2.868 12.260 36.535 1.00 37.62 A ATOM 2132 O GLU A 283 3.760 11.988 37.340 1.00 37.84 A ATOM 2133 N ASN A 284 1.654 11.726 36.579 1.00 37.45 A ATOM 2134 CA ASN A 284 1.237 10.757 37.584 1.00 36.64 A ATOM 2135 CB ASN A 284 −.211 10.353 37.300 1.00 38.10 A ATOM 2136 CG ASN A 284 −.766 9.388 38.322 1.00 40.96 A ATOM 2137 OD1 ASN A 284 −1.919 8.971 38.219 1.00 43.35 A ATOM 2138 ND2 ASN A 284 .042 9.028 39.316 1.00 41.64 A ATOM 2139 C ASN A 284 2.138 9.522 37.567 1.00 36.15 A ATOM 2140 O ASN A 284 2.421 8.932 38.606 1.00 34.35 A ATOM 2141 N CYS A 285 2.582 9.136 36.377 1.00 35.52 A ATOM 2142 CA CYS A 285 3.449 7.977 36.232 1.00 37.87 A ATOM 2143 CB CYS A 285 3.511 7.556 34.764 1.00 39.05 A ATOM 2144 SG CYS A 285 1.908 7.052 34.114 1.00 43.04 A ATOM 2145 C CYS A 285 4.858 8.242 36.761 1.00 36.43 A ATOM 2146 O CYS A 285 5.515 7.339 37.268 1.00 36.47 A ATOM 2147 N MET A 286 5.309 9.486 36.649 1.00 35.56 A ATOM 2148 CA MET A 286 6.639 9.860 37.118 1.00 34.53 A ATOM 2149 CB MET A 286 7.033 11.227 36.566 1.00 29.51 A ATOM 2150 CG MET A 286 7.148 11.285 35.060 1.00 27.11 A ATOM 2151 SD MET A 286 8.518 10.331 34.419 1.00 17.52 A ATOM 2152 CE MET A 286 9.910 11.357 34.834 1.00 24.72 A ATOM 2153 C MET A 286 6.725 9.892 38.641 1.00 34.62 A ATOM 2154 O MET A 286 7.770 9.561 39.206 1.00 34.71 A ATOM 2155 N VAL A 287 5.639 10.292 39.305 1.00 34.59 A ATOM 2156 CA VAL A 287 5.648 10.352 40.764 1.00 34.53 A ATOM 2157 CB VAL A 287 4.551 11.294 41.337 1.00 33.53 A ATOM 2158 CG1 VAL A 287 4.518 12.594 40.551 1.00 32.05 A ATOM 2159 CG2 VAL A 287 3.198 10.602 41.339 1.00 33.56 A ATOM 2160 C VAL A 287 5.448 8.964 41.348 1.00 36.11 A ATOM 2161 O VAL A 287 5.612 8.764 42.551 1.00 38.82 A ATOM 2162 N GLU A 288 5.087 8.011 40.490 1.00 37.10 A ATOM 2163 CA GLU A 288 4.879 6.630 40.912 1.00 36.49 A ATOM 2164 CB GLU A 288 3.735 5.994 40.121 1.00 37.81 A ATOM 2165 CG GLU A 288 2.351 6.394 40.608 1.00 41.70 A ATOM 2166 CD GLU A 288 1.246 5.589 39.945 1.00 43.46 A ATOM 2167 OE1 GLU A 288 .071 5.752 40.335 1.00 42.08 A ATOM 2168 OE2 GLU A 288 1.555 4.791 39.032 1.00 45.61 A ATOM 2169 C GLU A 288 6.154 5.812 40.724 1.00 34.02 A ATOM 2170 O GLU A 288 6.383 4.826 41.417 1.00 35.06 A ATOM 2171 N ALA A 289 6.988 6.243 39.792 1.00 32.31 A ATOM 2172 CA ALA A 289 8.229 5.553 39.504 1.00 34.35 A ATOM 2173 CB ALA A 289 8.374 5.370 38.005 1.00 32.96 A ATOM 2174 C ALA A 289 9.464 6.259 40.043 1.00 35.81 A ATOM 2175 O ALA A 289 10.570 5.746 39.895 1.00 36.21 A ATOM 2176 N PHE A 290 9.303 7.422 40.672 1.00 37.04 A ATOM 2177 CA PHE A 290 10.480 8.126 41.163 1.00 38.53 A ATOM 2178 CB PHE A 290 10.824 9.258 40.196 1.00 37.84 A ATOM 2179 CG PHE A 290 11.510 8.785 38.945 1.00 37.15 A ATOM 2180 CD1 PHE A 290 12.854 8.420 38.971 1.00 35.74 A ATOM 2181 CD2 PHE A 290 10.808 8.675 37.746 1.00 36.63 A ATOM 2182 CE1 PHE A 290 13.488 7.950 37.822 1.00 35.20 A ATOM 2183 CE2 PHE A 290 11.431 8.207 36.592 1.00 34.21 A ATOM 2184 CZ PHE A 290 12.772 7.843 36.631 1.00 35.84 A ATOM 2185 C PHE A 290 10.510 8.643 42.600 1.00 39.68 A ATOM 2186 O PHE A 290 11.593 8.932 43.129 1.00 38.64 A ATOM 2187 N SER A 291 9.352 8.768 43.238 1.00 40.39 A ATOM 2188 CA SER A 291 9.340 9.240 44.615 1.00 41.28 A ATOM 2189 CB SER A 291 7.902 9.336 45.138 1.00 41.61 A ATOM 2190 OG SER A 291 7.321 8.052 45.305 1.00 42.21 A ATOM 2191 C SER A 291 10.153 8.248 45.461 1.00 41.72 A ATOM 2192 O SER A 291 10.838 8.634 46.411 1.00 41.43 A ATOM 2193 N GLN A 292 10.078 6.970 45.088 1.00 41.71 A ATOM 2194 CA GLN A 292 10.798 5.899 45.776 1.00 41.58 A ATOM 2195 CB GLN A 292 10.393 4.537 45.198 1.00 41.30 A ATOM 2196 CG GLN A 292 10.805 4.334 43.744 1.00 43.26 A ATOM 2197 CD GLN A 292 10.166 3.102 43.106 1.00 43.82 A ATOM 2198 OE1 GLN A 292 10.242 1.992 43.644 1.00 44.70 A ATOM 2199 NE2 GLN A 292 9.538 3.295 41.943 1.00 43.31 A ATOM 2200 C GLN A 292 12.312 6.090 45.642 1.00 41.07 A ATOM 2201 O GLN A 292 13.095 5.469 46.365 1.00 40.68 A ATOM 2202 N PHE A 293 12.717 6.944 44.708 1.00 40.42 A ATOM 2203 CA PHE A 293 14.129 7.232 44.498 1.00 40.51 A ATOM 2204 CB PHE A 293 14.511 7.016 43.033 1.00 39.74 A ATOM 2205 CG PHE A 293 14.218 5.639 42.543 1.00 39.95 A ATOM 2206 CD1 PHE A 293 14.845 4.543 43.113 1.00 38.79 A ATOM 2207 CD2 PHE A 293 13.273 5.429 41.548 1.00 40.76 A ATOM 2208 CE1 PHE A 293 14.533 3.258 42.702 1.00 40.38 A ATOM 2209 CE2 PHE A 293 12.955 4.146 41.131 1.00 38.84 A ATOM 2210 CZ PHE A 293 13.584 3.061 41.710 1.00 39.21 A ATOM 2211 C PHE A 293 14.369 8.676 44.900 1.00 40.43 A ATOM 2212 O PHE A 293 15.233 9.353 44.351 1.00 41.10 A ATOM 2213 N LYS A 294 13.589 9.126 45.876 1.00 41.39 A ATOM 2214 CA LYS A 294 13.673 10.482 46.396 1.00 42.03 A ATOM 2215 CB LYS A 294 14.806 10.593 47.425 1.00 42.52 A ATOM 2216 CG LYS A 294 16.217 10.478 46.856 1.00 44.37 A ATOM 2217 CD LYS A 294 17.124 11.572 47.438 1.00 46.80 A ATOM 2218 CE LYS A 294 18.469 11.658 46.725 1.00 46.23 A ATOM 2219 NZ LYS A 294 19.268 12.839 47.195 1.00 46.98 A ATOM 2220 C LYS A 294 13.893 11.502 45.285 1.00 42.25 A ATOM 2221 O LYS A 294 14.693 12.423 45.435 1.00 42.94 A ATOM 2222 N ILE A 295 13.182 11.345 44.171 1.00 42.75 A ATOM 2223 CA ILE A 295 13.318 12.281 43.058 1.00 43.31 A ATOM 2224 CB ILE A 295 13.915 11.616 41.814 1.00 42.40 A ATOM 2225 CG2 ILE A 295 13.899 12.598 40.657 1.00 42.02 A ATOM 2226 CG1 ILE A 295 15.351 11.165 42.092 1.00 42.85 A ATOM 2227 CD1 ILE A 295 16.017 10.483 40.918 1.00 42.43 A ATOM 2228 C ILE A 295 11.995 12.902 42.660 1.00 44.46 A ATOM 2229 O ILE A 295 11.004 12.201 42.444 1.00 44.51 A ATOM 2230 N SER A 296 11.995 14.228 42.564 1.00 46.30 A ATOM 2231 CA SER A 296 10.801 14.978 42.192 1.00 47.21 A ATOM 2232 CB SER A 296 10.308 15.827 43.369 1.00 48.70 A ATOM 2233 OG SER A 296 9.921 15.012 44.463 1.00 52.02 A ATOM 2234 C SER A 296 11.048 15.877 40.989 1.00 46.34 A ATOM 2235 O SER A 296 10.104 16.280 40.314 1.00 47.29 A ATOM 2236 N ASP A 297 12.309 16.203 40.720 1.00 45.60 A ATOM 2237 CA ASP A 297 12.613 17.048 39.574 1.00 44.42 A ATOM 2238 CB ASP A 297 13.785 17.981 39.878 1.00 46.17 A ATOM 2239 CG ASP A 297 14.192 18.825 38.666 1.00 47.06 A ATOM 2240 OD1 ASP A 297 13.296 19.317 37.948 1.00 47.00 A ATOM 2241 OD2 ASP A 297 15.407 19.000 38.436 1.00 47.36 A ATOM 2242 C ASP A 297 12.920 16.219 38.329 1.00 44.32 A ATOM 2243 O ASP A 297 14.036 15.727 38.135 1.00 44.05 A ATOM 2244 N TRP A 298 11.905 16.079 37.488 1.00 42.80 A ATOM 2245 CA TRP A 298 12.001 15.327 36.253 1.00 40.26 A ATOM 2246 CB TRP A 298 10.742 15.587 35.438 1.00 38.68 A ATOM 2247 CG TRP A 298 9.506 15.431 36.245 1.00 35.51 A ATOM 2248 CD2 TRP A 298 9.313 14.553 37.363 1.00 35.36 A ATOM 2249 CE2 TRP A 298 7.985 14.735 37.812 1.00 33.05 A ATOM 2250 CE3 TRP A 298 10.133 13.631 38.028 1.00 32.97 A ATOM 2251 CD1 TRP A 298 8.326 16.087 36.065 1.00 36.11 A ATOM 2252 NE1 TRP A 298 7.408 15.675 37.003 1.00 34.29 A ATOM 2253 CZ2 TRP A 298 7.456 14.029 38.896 1.00 32.55 A ATOM 2254 CZ3 TRP A 298 9.607 12.929 39.105 1.00 33.62 A ATOM 2255 CH2 TRP A 298 8.278 13.133 39.529 1.00 33.12 A ATOM 2256 C TRP A 298 13.239 15.674 35.438 1.00 39.63 A ATOM 2257 O TRP A 298 13.873 14.797 34.862 1.00 36.85 A ATOM 2258 N ASN A 299 13.584 16.956 35.399 1.00 40.40 A ATOM 2259 CA ASN A 299 14.744 17.401 34.633 1.00 41.92 A ATOM 2260 CB ASN A 299 14.784 18.925 34.561 1.00 43.62 A ATOM 2261 CG ASN A 299 13.930 19.460 33.447 1.00 46.32 A ATOM 2262 OD1 ASN A 299 14.021 18.982 32.312 1.00 46.16 A ATOM 2263 ND2 ASN A 299 13.094 20.456 33.752 1.00 45.79 A ATOM 2264 C ASN A 299 16.093 16.889 35.119 1.00 41.44 A ATOM 2265 O ASN A 299 17.114 17.152 34.487 1.00 41.03 A ATOM 2266 N LYS A 300 16.105 16.162 36.233 1.00 41.82 A ATOM 2267 CA LYS A 300 17.355 15.615 36.753 1.00 40.46 A ATOM 2268 CB LYS A 300 17.286 15.495 38.279 1.00 42.21 A ATOM 2269 CG LYS A 300 16.950 16.803 38.973 1.00 42.69 A ATOM 2270 CD LYS A 300 17.123 16.740 40.487 1.00 44.99 A ATOM 2271 CE LYS A 300 16.055 15.890 41.162 1.00 47.76 A ATOM 2272 NZ LYS A 300 16.154 15.946 42.660 1.00 49.25 A ATOM 2273 C LYS A 300 17.583 14.237 36.121 1.00 38.83 A ATOM 2274 O LYS A 300 18.601 13.581 36.370 1.00 38.08 A ATOM 2275 N LEU A 301 16.628 13.827 35.285 1.00 36.04 A ATOM 2276 CA LEU A 301 16.647 12.531 34.601 1.00 34.97 A ATOM 2277 CB LEU A 301 15.353 11.768 34.924 1.00 32.81 A ATOM 2278 CG LEU A 301 15.066 11.287 36.350 1.00 32.28 A ATOM 2279 CD1 LEU A 301 15.321 12.393 37.346 1.00 34.57 A ATOM 2280 CD2 LEU A 301 13.619 10.856 36.448 1.00 30.89 A ATOM 2281 C LEU A 301 16.766 12.645 33.078 1.00 35.04 A ATOM 2282 O LEU A 301 16.238 13.590 32.484 1.00 36.33 A ATOM 2283 N PHE A 302 17.460 11.697 32.439 1.00 34.85 A ATOM 2284 CA PHE A 302 17.538 11.719 30.973 1.00 33.91 A ATOM 2285 CB PHE A 302 18.796 11.008 30.441 1.00 33.60 A ATOM 2286 CG PHE A 302 18.885 9.555 30.790 1.00 32.97 A ATOM 2287 CD1 PHE A 302 19.357 9.150 32.030 1.00 33.68 A ATOM 2288 CD2 PHE A 302 18.534 8.585 29.855 1.00 34.78 A ATOM 2289 CE1 PHE A 302 19.488 7.788 32.342 1.00 36.33 A ATOM 2290 CE2 PHE A 302 18.657 7.221 30.151 1.00 36.72 A ATOM 2291 CZ PHE A 302 19.139 6.822 31.402 1.00 36.20 A ATOM 2292 C PHE A 302 16.256 11.056 30.439 1.00 32.30 A ATOM 2293 O PHE A 302 15.631 10.246 31.137 1.00 29.60 A ATOM 2294 N TRP A 303 15.857 11.402 29.216 1.00 32.29 A ATOM 2295 CA TRP A 303 14.607 10.881 28.660 1.00 31.71 A ATOM 2296 CB TRP A 303 13.634 12.035 28.421 1.00 30.02 A ATOM 2297 CG TRP A 303 13.095 12.620 29.662 1.00 31.30 A ATOM 2298 CD2 TRP A 303 11.745 12.559 30.113 1.00 31.48 A ATOM 2299 CE2 TRP A 303 11.682 13.259 31.340 1.00 31.80 A ATOM 2300 CE3 TRP A 303 10.579 11.981 29.602 1.00 32.51 A ATOM 2301 CD1 TRP A 303 13.783 13.325 30.603 1.00 31.26 A ATOM 2302 NE1 TRP A 303 12.941 13.714 31.617 1.00 31.13 A ATOM 2303 CZ2 TRP A 303 10.496 13.398 32.062 1.00 31.38 A ATOM 2304 CZ3 TRP A 303 9.399 12.118 30.321 1.00 32.50 A ATOM 2305 CH2 TRP A 303 9.368 12.823 31.538 1.00 32.74 A ATOM 2306 C TRP A 303 14.581 10.016 27.413 1.00 30.99 A ATOM 2307 O TRP A 303 15.311 10.233 26.460 1.00 30.40 A ATOM 2308 N VAL A 304 13.688 9.036 27.443 1.00 31.60 A ATOM 2309 CA VAL A 304 13.469 8.151 26.313 1.00 31.46 A ATOM 2310 CB VAL A 304 14.114 6.774 26.487 1.00 30.67 A ATOM 2311 CG1 VAL A 304 13.707 5.886 25.324 1.00 28.82 A ATOM 2312 CG2 VAL A 304 15.631 6.909 26.533 1.00 30.09 A ATOM 2313 C VAL A 304 11.970 7.961 26.256 1.00 31.13 A ATOM 2314 O VAL A 304 11.416 7.160 27.002 1.00 32.32 A ATOM 2315 N VAL A 305 11.318 8.713 25.377 1.00 30.86 A ATOM 2316 CA VAL A 305 9.869 8.656 25.224 1.00 30.15 A ATOM 2317 CB VAL A 305 9.240 10.050 25.528 1.00 31.70 A ATOM 2318 CG1 VAL A 305 7.786 10.106 25.043 1.00 30.98 A ATOM 2319 CG2 VAL A 305 9.308 10.322 27.028 1.00 30.26 A ATOM 2320 C VAL A 305 9.516 8.220 23.805 1.00 29.92 A ATOM 2321 O VAL A 305 10.157 8.637 22.840 1.00 29.78 A ATOM 2322 N HIS A 306 8.510 7.363 23.679 1.00 29.35 A ATOM 2323 CA HIS A 306 8.105 6.899 22.360 1.00 30.96 A ATOM 2324 CB HIS A 306 6.968 5.877 22.474 1.00 31.60 A ATOM 2325 CG HIS A 306 6.353 5.517 21.160 1.00 32.17 A ATOM 2326 CD2 HIS A 306 5.099 5.701 20.683 1.00 31.92 A ATOM 2327 ND1 HIS A 306 7.063 4.907 20.149 1.00 33.80 A ATOM 2328 CE1 HIS A 306 6.271 4.727 19.105 1.00 34.13 A ATOM 2329 NE2 HIS A 306 5.074 5.201 19.404 1.00 32.34 A ATOM 2330 C HIS A 306 7.672 8.087 21.487 1.00 30.79 A ATOM 2331 O HIS A 306 6.827 8.909 21.881 1.00 30.02 A ATOM 2332 N PRO A 307 8.253 8.192 20.285 1.00 30.01 A ATOM 2333 CD PRO A 307 9.351 7.348 19.777 1.00 29.05 A ATOM 2334 CA PRO A 307 7.946 9.272 19.346 1.00 29.75 A ATOM 2335 CB PRO A 307 9.168 9.273 18.441 1.00 29.53 A ATOM 2336 CG PRO A 307 9.482 7.804 18.352 1.00 28.95 A ATOM 2337 C PRO A 307 6.642 9.052 18.578 1.00 30.91 A ATOM 2338 O PRO A 307 6.641 8.956 17.347 1.00 30.21 A ATOM 2339 N GLY A 308 5.532 8.984 19.308 1.00 32.39 A ATOM 2340 CA GLY A 308 4.243 8.767 18.671 1.00 34.41 A ATOM 2341 C GLY A 308 3.936 9.818 17.622 1.00 35.01 A ATOM 2342 O GLY A 308 3.438 9.505 16.538 1.00 35.38 A ATOM 2343 N GLY A 309 4.246 11.068 17.952 1.00 34.47 A ATOM 2344 CA GLY A 309 4.010 12.181 17.046 1.00 32.80 A ATOM 2345 C GLY A 309 4.426 13.490 17.695 1.00 32.13 A ATOM 2346 O GLY A 309 4.268 13.647 18.901 1.00 31.23 A ATOM 2347 N ARG A 310 4.954 14.426 16.904 1.00 32.09 A ATOM 2348 CA ARG A 310 5.399 15.717 17.424 1.00 33.38 A ATOM 2349 CB ARG A 310 5.408 16.791 16.323 1.00 35.32 A ATOM 2350 CG ARG A 310 5.632 18.197 16.902 1.00 36.45 A ATOM 2351 CD ARG A 310 5.225 19.329 15.976 1.00 38.46 A ATOM 2352 NE ARG A 310 6.254 19.662 14.998 1.00 40.77 A ATOM 2353 CZ ARG A 310 6.164 20.681 14.147 1.00 42.99 A ATOM 2354 NH1 ARG A 310 5.094 21.467 14.156 1.00 44.81 A ATOM 2355 NH2 ARG A 310 7.138 20.918 13.280 1.00 44.76 A ATOM 2356 C ARG A 310 4.536 16.227 18.576 1.00 33.42 A ATOM 2357 O ARG A 310 5.048 16.539 19.653 1.00 32.55 A ATOM 2358 N ALA A 311 3.228 16.301 18.330 1.00 34.76 A ATOM 2359 CA ALA A 311 2.251 16.787 19.304 1.00 34.37 A ATOM 2360 CB ALA A 311 .842 16.595 18.766 1.00 34.77 A ATOM 2361 C ALA A 311 2.383 16.133 20.666 1.00 35.11 A ATOM 2362 O ALA A 311 2.488 16.832 21.673 1.00 36.46 A ATOM 2363 N ILE A 312 2.367 14.800 20.705 1.00 34.41 A ATOM 2364 CA ILE A 312 2.514 14.079 21.971 1.00 33.63 A ATOM 2365 CB ILE A 312 2.652 12.553 21.751 1.00 34.10 A ATOM 2366 CG2 ILE A 312 3.117 11.869 23.044 1.00 31.59 A ATOM 2367 CG1 ILE A 312 1.312 11.965 21.296 1.00 34.90 A ATOM 2368 CD1 ILE A 312 1.319 10.436 21.175 1.00 32.76 A ATOM 2369 C ILE A 312 3.760 14.564 22.717 1.00 32.93 A ATOM 2370 O ILE A 312 3.725 14.810 23.924 1.00 33.02 A ATOM 2371 N LEU A 313 4.865 14.693 21.995 1.00 32.22 A ATOM 2372 CA LEU A 313 6.109 15.152 22.602 1.00 32.28 A ATOM 2373 CB LEU A 313 7.268 14.982 21.615 1.00 30.74 A ATOM 2374 CG LEU A 313 7.430 13.580 21.009 1.00 29.06 A ATOM 2375 CD1 LEU A 313 8.656 13.542 20.117 1.00 27.85 A ATOM 2376 CD2 LEU A 313 7.551 12.544 22.128 1.00 29.06 A ATOM 2377 C LEU A 313 5.988 16.615 23.022 1.00 33.58 A ATOM 2378 O LEU A 313 6.449 17.002 24.095 1.00 31.21 A ATOM 2379 N ASP A 314 5.352 17.428 22.185 1.00 34.88 A ATOM 2380 CA ASP A 314 5.203 18.836 22.512 1.00 37.14 A ATOM 2381 CB ASP A 314 4.623 19.620 21.335 1.00 36.64 A ATOM 2382 CG ASP A 314 5.573 19.681 20.156 1.00 37.32 A ATOM 2383 OD1 ASP A 314 6.778 19.406 20.343 1.00 39.89 A ATOM 2384 OD2 ASP A 314 5.123 20.013 19.039 1.00 38.32 A ATOM 2385 C ASP A 314 4.337 19.038 23.740 1.00 38.58 A ATOM 2386 O ASP A 314 4.613 19.921 24.554 1.00 41.29 A ATOM 2387 N ARG A 315 3.298 18.226 23.891 1.00 38.56 A ATOM 2388 CA ARG A 315 2.420 18.367 25.051 1.00 39.30 A ATOM 2389 CB ARG A 315 1.076 17.661 24.801 1.00 39.89 A ATOM 2390 CG ARG A 315 −.038 18.094 25.756 1.00 41.38 A ATOM 2391 CD ARG A 315 −.534 19.514 25.461 1.00 39.72 A ATOM 2392 NE ARG A 315 −1.525 19.517 24.391 1.00 39.62 A ATOM 2393 CZ ARG A 315 −2.757 19.034 24.517 1.00 38.98 A ATOM 2394 NH1 ARG A 315 −3.151 18.512 25.670 1.00 41.14 A ATOM 2395 NH2 ARG A 315 −3.594 19.063 23.491 1.00 40.18 A ATOM 2396 C ARG A 315 3.095 17.816 26.311 1.00 37.88 A ATOM 2397 O ARG A 315 3.120 18.474 27.345 1.00 38.21 A ATOM 2398 N VAL A 316 3.650 16.614 26.220 1.00 38.10 A ATOM 2399 CA VAL A 316 4.341 16.005 27.353 1.00 37.54 A ATOM 2400 CB VAL A 316 5.071 14.695 26.932 1.00 38.03 A ATOM 2401 CG1 VAL A 316 6.071 14.282 28.005 1.00 35.70 A ATOM 2402 CG2 VAL A 316 4.061 13.579 26.713 1.00 36.09 A ATOM 2403 C VAL A 316 5.379 16.965 27.941 1.00 38.14 A ATOM 2404 O VAL A 316 5.415 17.191 29.145 1.00 37.74 A ATOM 2405 N GLU A 317 6.217 17.520 27.071 1.00 39.36 A ATOM 2406 CA GLU A 317 7.275 18.444 27.462 1.00 40.74 A ATOM 2407 CB GLU A 317 8.078 18.846 26.227 1.00 42.43 A ATOM 2408 CG GLU A 317 9.155 19.873 26.491 1.00 46.61 A ATOM 2409 CD GLU A 317 10.033 20.092 25.280 1.00 49.20 A ATOM 2410 OE1 GLU A 317 9.485 20.393 24.197 1.00 50.31 A ATOM 2411 OE2 GLU A 317 11.269 19.959 25.409 1.00 51.28 A ATOM 2412 C GLU A 317 6.748 19.691 28.161 1.00 40.41 A ATOM 2413 O GLU A 317 7.250 20.092 29.215 1.00 40.12 A ATOM 2414 N ALA A 318 5.736 20.305 27.568 1.00 40.32 A ATOM 2415 CA ALA A 318 5.148 21.502 28.140 1.00 40.04 A ATOM 2416 CB ALA A 318 4.103 22.067 27.197 1.00 39.47 A ATOM 2417 C ALA A 318 4.517 21.164 29.482 1.00 40.63 A ATOM 2418 O ALA A 318 4.609 21.938 30.436 1.00 40.11 A ATOM 2419 N LYS A 319 3.890 19.996 29.561 1.00 40.54 A ATOM 2420 CA LYS A 319 3.236 19.585 30.793 1.00 43.33 A ATOM 2421 CB LYS A 319 2.442 18.294 30.568 1.00 43.96 A ATOM 2422 CG LYS A 319 1.144 18.225 31.361 1.00 44.46 A ATOM 2423 CD LYS A 319 1.434 18.187 32.849 1.00 45.75 A ATOM 2424 CE LYS A 319 .164 18.197 33.671 1.00 46.68 A ATOM 2425 NZ LYS A 319 .483 18.182 35.128 1.00 48.59 A ATOM 2426 C LYS A 319 4.237 19.405 31.930 1.00 44.12 A ATOM 2427 O LYS A 319 4.156 20.091 32.949 1.00 45.62 A ATOM 2428 N LEU A 320 5.186 18.493 31.757 1.00 44.99 A ATOM 2429 CA LEU A 320 6.200 18.242 32.781 1.00 45.19 A ATOM 2430 CB LEU A 320 6.893 16.903 32.521 1.00 43.92 A ATOM 2431 CG LEU A 320 6.180 15.639 33.016 1.00 43.85 A ATOM 2432 CD1 LEU A 320 4.669 15.835 33.062 1.00 43.96 A ATOM 2433 CD2 LEU A 320 6.550 14.490 32.106 1.00 41.61 A ATOM 2434 C LEU A 320 7.243 19.346 32.848 1.00 45.43 A ATOM 2435 O LEU A 320 8.073 19.363 33.752 1.00 47.16 A ATOM 2436 N ASN A 321 7.200 20.268 31.892 1.00 45.91 A ATOM 2437 CA ASN A 321 8.156 21.371 31.857 1.00 46.17 A ATOM 2438 CB ASN A 321 7.984 22.276 33.089 1.00 48.27 A ATOM 2439 CG ASN A 321 7.324 23.613 32.757 1.00 50.11 A ATOM 2440 OD1 ASN A 321 7.887 24.431 32.016 1.00 51.37 A ATOM 2441 ND2 ASN A 321 6.128 23.842 33.306 1.00 47.30 A ATOM 2442 C ASN A 321 9.577 20.826 31.812 1.00 45.21 A ATOM 2443 O ASN A 321 10.381 21.081 32.705 1.00 45.20 A ATOM 2444 N LEU A 322 9.875 20.066 30.766 1.00 43.89 A ATOM 2445 CA LEU A 322 11.195 19.487 30.592 1.00 43.18 A ATOM 2446 CB LEU A 322 11.094 18.173 29.817 1.00 42.20 A ATOM 2447 CG LEU A 322 10.099 17.116 30.300 1.00 41.74 A ATOM 2448 CD1 LEU A 322 10.180 15.896 29.386 1.00 40.69 A ATOM 2449 CD2 LEU A 322 10.398 16.736 31.741 1.00 39.97 A ATOM 2450 C LEU A 322 12.082 20.455 29.818 1.00 44.00 A ATOM 2451 O LEU A 322 11.597 21.240 29.002 1.00 45.63 A ATOM 2452 N ASP A 323 13.381 20.405 30.077 1.00 44.78 A ATOM 2453 CA ASP A 323 14.317 21.265 29.369 1.00 47.10 A ATOM 2454 CB ASP A 323 15.717 21.187 29.992 1.00 49.02 A ATOM 2455 CG ASP A 323 15.898 22.151 31.147 1.00 51.43 A ATOM 2456 OD1 ASP A 323 15.816 23.377 30.911 1.00 52.39 A ATOM 2457 OD2 ASP A 323 16.122 21.687 32.287 1.00 52.60 A ATOM 2458 C ASP A 323 14.390 20.801 27.926 1.00 46.91 A ATOM 2459 O ASP A 323 14.444 19.605 27.655 1.00 48.47 A ATOM 2460 N PRO A 324 14.396 21.743 26.978 1.00 46.22 A ATOM 2461 CD PRO A 324 14.387 23.200 27.195 1.00 46.91 A ATOM 2462 CA PRO A 324 14.465 21.436 25.550 1.00 46.06 A ATOM 2463 CB PRO A 324 14.791 22.787 24.930 1.00 45.50 A ATOM 2464 CG PRO A 324 14.066 23.731 25.817 1.00 46.39 A ATOM 2465 C PRO A 324 15.525 20.393 25.216 1.00 45.77 A ATOM 2466 O PRO A 324 15.591 19.916 24.086 1.00 47.09 A ATOM 2467 N THR A 325 16.359 20.049 26.193 1.00 44.47 A ATOM 2468 CA THR A 325 17.424 19.071 25.974 1.00 43.36 A ATOM 2469 CB THR A 325 18.654 19.335 26.885 1.00 42.49 A ATOM 2470 OG1 THR A 325 18.310 19.086 28.259 1.00 40.55 A ATOM 2471 CG2 THR A 325 19.144 20.768 26.715 1.00 39.78 A ATOM 2472 C THR A 325 16.977 17.635 26.206 1.00 42.40 A ATOM 2473 O THR A 325 17.518 16.716 25.607 1.00 43.43 A ATOM 2474 N LYS A 326 15.994 17.442 27.075 1.00 41.96 A ATOM 2475 CA LYS A 326 15.510 16.104 27.369 1.00 41.14 A ATOM 2476 CB LYS A 326 14.252 16.172 28.233 1.00 40.16 A ATOM 2477 CG LYS A 326 14.337 17.055 29.466 1.00 40.21 A ATOM 2478 CD LYS A 326 15.143 16.444 30.595 1.00 42.29 A ATOM 2479 CE LYS A 326 16.623 16.764 30.488 1.00 42.30 A ATOM 2480 NZ LYS A 326 17.346 16.315 31.715 1.00 42.85 A ATOM 2481 C LYS A 326 15.197 15.314 26.093 1.00 41.72 A ATOM 2482 O LYS A 326 15.702 14.205 25.902 1.00 42.51 A ATOM 2483 N LEU A 327 14.381 15.893 25.214 1.00 42.21 A ATOM 2484 CA LEU A 327 13.976 15.212 23.977 1.00 41.89 A ATOM 2485 CB LEU A 327 12.533 15.590 23.617 1.00 40.14 A ATOM 2486 CG LEU A 327 11.472 15.344 24.689 1.00 40.48 A ATOM 2487 CD1 LEU A 327 10.115 15.709 24.124 1.00 40.17 A ATOM 2488 CD2 LEU A 327 11.491 13.888 25.138 1.00 40.61 A ATOM 2489 C LEU A 327 14.854 15.410 22.740 1.00 41.12 A ATOM 2490 O LEU A 327 14.371 15.279 21.612 1.00 40.40 A ATOM 2491 N ILE A 328 16.129 15.728 22.930 1.00 38.12 A ATOM 2492 CA ILE A 328 17.003 15.895 21.780 1.00 36.92 A ATOM 2493 CB ILE A 328 18.380 16.460 22.183 1.00 36.66 A ATOM 2494 CG2 ILE A 328 19.230 16.700 20.942 1.00 36.52 A ATOM 2495 CG1 ILE A 328 18.199 17.772 22.945 1.00 36.61 A ATOM 2496 CD1 ILE A 328 17.422 18.817 22.186 1.00 35.30 A ATOM 2497 C ILE A 328 17.174 14.509 21.162 1.00 36.34 A ATOM 2498 O ILE A 328 17.106 14.343 19.939 1.00 37.30 A ATOM 2499 N PRO A 329 17.396 13.488 22.003 1.00 34.69 A ATOM 2500 CD PRO A 329 17.854 13.543 23.400 1.00 32.67 A ATOM 2501 CA PRO A 329 17.559 12.135 21.462 1.00 35.34 A ATOM 2502 CB PRO A 329 17.974 11.329 22.687 1.00 33.96 A ATOM 2503 CG PRO A 329 18.737 12.337 23.491 1.00 33.23 A ATOM 2504 C PRO A 329 16.273 11.610 20.819 1.00 33.93 A ATOM 2505 O PRO A 329 16.307 11.036 19.739 1.00 34.28 A ATOM 2506 N THR A 330 15.142 11.826 21.482 1.00 34.73 A ATOM 2507 CA THR A 330 13.848 11.363 20.978 1.00 34.57 A ATOM 2508 CB THR A 330 12.718 11.627 22.004 1.00 35.22 A ATOM 2509 OG1 THR A 330 12.959 10.873 23.200 1.00 36.60 A ATOM 2510 CG2 THR A 330 11.376 11.209 21.430 1.00 36.40 A ATOM 2511 C THR A 330 13.448 12.006 19.651 1.00 32.86 A ATOM 2512 O THR A 330 13.133 11.309 18.685 1.00 32.91 A ATOM 2513 N ARG A 331 13.459 13.334 19.614 1.00 32.31 A ATOM 2514 CA ARG A 331 13.088 14.081 18.418 1.00 31.64 A ATOM 2515 CB ARG A 331 13.008 15.586 18.712 1.00 32.71 A ATOM 2516 CG ARG A 331 11.900 16.012 19.676 1.00 31.50 A ATOM 2517 CD ARG A 331 11.844 17.535 19.818 1.00 33.90 A ATOM 2518 NE ARG A 331 10.822 17.981 20.761 1.00 33.69 A ATOM 2519 CZ ARG A 331 9.509 17.953 20.528 1.00 37.09 A ATOM 2520 NH1 ARG A 331 9.031 17.506 19.373 1.00 36.82 A ATOM 2521 NH2 ARG A 331 8.663 18.357 21.466 1.00 36.77 A ATOM 2522 C ARG A 331 14.065 13.855 17.282 1.00 33.23 A ATOM 2523 O ARG A 331 13.693 13.967 16.116 1.00 36.66 A ATOM 2524 N HIS A 332 15.314 13.540 17.614 1.00 32.09 A ATOM 2525 CA HIS A 332 16.322 13.308 16.588 1.00 32.07 A ATOM 2526 CB HIS A 332 17.720 13.310 17.210 1.00 35.42 A ATOM 2527 CG HIS A 332 18.796 12.893 16.258 1.00 38.11 A ATOM 2528 CD2 HIS A 332 19.765 13.608 15.637 1.00 38.88 A ATOM 2529 ND1 HIS A 332 18.922 11.597 15.800 1.00 38.66 A ATOM 2530 CE1 HIS A 332 19.921 11.534 14.938 1.00 39.10 A ATOM 2531 NE2 HIS A 332 20.448 12.740 14.821 1.00 39.79 A ATOM 2532 C HIS A 332 16.093 12.000 15.821 1.00 31.77 A ATOM 2533 O HIS A 332 16.307 11.935 14.605 1.00 32.24 A ATOM 2534 N VAL A 333 15.677 10.959 16.536 1.00 29.94 A ATOM 2535 CA VAL A 333 15.398 9.673 15.912 1.00 28.63 A ATOM 2536 CB VAL A 333 15.344 8.544 16.975 1.00 29.30 A ATOM 2537 CG1 VAL A 333 14.872 7.221 16.336 1.00 29.02 A ATOM 2538 CG2 VAL A 333 16.731 8.371 17.602 1.00 24.24 A ATOM 2539 C VAL A 333 14.060 9.747 15.156 1.00 28.45 A ATOM 2540 O VAL A 333 13.942 9.263 14.022 1.00 28.50 A ATOM 2541 N MET A 334 13.055 10.363 15.768 1.00 26.42 A ATOM 2542 CA MET A 334 11.771 10.472 15.098 1.00 26.67 A ATOM 2543 CB MET A 334 10.756 11.270 15.937 1.00 23.62 A ATOM 2544 CG MET A 334 9.286 11.001 15.511 1.00 24.33 A ATOM 2545 SD MET A 334 8.068 12.270 15.942 1.00 20.82 A ATOM 2546 CE MET A 334 7.430 11.702 17.373 1.00 19.41 A ATOM 2547 C MET A 334 12.010 11.178 13.774 1.00 27.99 A ATOM 2548 O MET A 334 11.385 10.851 12.767 1.00 29.09 A ATOM 2549 N SER A 335 12.937 12.133 13.776 1.00 29.25 A ATOM 2550 CA SER A 335 13.241 12.888 12.568 1.00 32.40 A ATOM 2551 CB SER A 335 14.107 14.104 12.888 1.00 31.79 A ATOM 2552 OG SER A 335 14.464 14.759 11.683 1.00 32.15 A ATOM 2553 C SER A 335 13.932 12.086 11.475 1.00 32.33 A ATOM 2554 O SER A 335 13.676 12.296 10.288 1.00 34.30 A ATOM 2555 N GLU A 336 14.815 11.181 11.871 1.00 32.37 A ATOM 2556 CA GLU A 336 15.535 10.372 10.901 1.00 31.39 A ATOM 2557 CB GLU A 336 16.951 10.077 11.415 1.00 32.84 A ATOM 2558 CG GLU A 336 17.593 8.849 10.775 1.00 39.41 A ATOM 2559 CD GLU A 336 19.103 8.788 10.950 1.00 42.04 A ATOM 2560 OE1 GLU A 336 19.606 9.199 12.022 1.00 44.89 A ATOM 2561 OE2 GLU A 336 19.785 8.312 10.013 1.00 42.62 A ATOM 2562 C GLU A 336 14.844 9.061 10.514 1.00 29.79 A ATOM 2563 O GLU A 336 15.141 8.502 9.456 1.00 28.00 A ATOM 2564 N TYR A 337 13.914 8.585 11.345 1.00 28.26 A ATOM 2565 CA TYR A 337 13.235 7.313 11.076 1.00 27.55 A ATOM 2566 CB TYR A 337 13.656 6.273 12.118 1.00 25.68 A ATOM 2567 CG TYR A 337 15.134 6.010 12.148 1.00 22.44 A ATOM 2568 CD1 TYR A 337 15.719 5.099 11.272 1.00 21.51 A ATOM 2569 CE1 TYR A 337 17.100 4.881 11.279 1.00 22.79 A ATOM 2570 CD2 TYR A 337 15.959 6.698 13.031 1.00 21.39 A ATOM 2571 CE2 TYR A 337 17.336 6.489 13.046 1.00 23.04 A ATOM 2572 CZ TYR A 337 17.896 5.579 12.170 1.00 22.73 A ATOM 2573 OH TYR A 337 19.244 5.356 12.205 1.00 25.92 A ATOM 2574 C TYR A 337 11.714 7.351 11.047 1.00 28.12 A ATOM 2575 O TYR A 337 11.091 6.623 10.269 1.00 29.61 A ATOM 2576 N GLY A 338 11.122 8.172 11.910 1.00 27.01 A ATOM 2577 CA GLY A 338 9.674 8.261 11.985 1.00 28.08 A ATOM 2578 C GLY A 338 9.171 7.349 13.095 1.00 29.03 A ATOM 2579 O GLY A 338 9.949 6.964 13.973 1.00 30.16 A ATOM 2580 N ASN A 339 7.884 7.003 13.083 1.00 29.06 A ATOM 2581 CA ASN A 339 7.364 6.111 14.112 1.00 28.44 A ATOM 2582 CB ASN A 339 5.871 6.359 14.353 1.00 29.87 A ATOM 2583 CG ASN A 339 5.361 5.702 15.643 1.00 32.77 A ATOM 2584 OD1 ASN A 339 5.898 4.682 16.094 1.00 32.86 A ATOM 2585 ND2 ASN A 339 4.311 6.280 16.233 1.00 31.79 A ATOM 2586 C ASN A 339 7.577 4.662 13.664 1.00 27.69 A ATOM 2587 O ASN A 339 6.814 4.135 12.864 1.00 26.14 A ATOM 2588 N MET A 340 8.643 4.038 14.156 1.00 28.00 A ATOM 2589 CA MET A 340 8.939 2.646 13.834 1.00 26.29 A ATOM 2590 CB MET A 340 10.443 2.411 13.799 1.00 24.42 A ATOM 2591 CG MET A 340 11.178 3.042 12.626 1.00 21.65 A ATOM 2592 SD MET A 340 12.917 2.677 12.788 1.00 11.19 A ATOM 2593 CE MET A 340 13.287 3.727 14.106 1.00 12.59 A ATOM 2594 C MET A 340 8.311 1.787 14.932 1.00 27.65 A ATOM 2595 O MET A 340 8.795 .706 15.263 1.00 29.01 A ATOM 2596 N SER A 341 7.219 2.300 15.487 1.00 28.65 A ATOM 2597 CA SER A 341 6.481 1.638 16.553 1.00 28.94 A ATOM 2598 CB SER A 341 5.703 .440 16.001 1.00 30.35 A ATOM 2599 OG SER A 341 4.905 −.161 17.013 1.00 33.28 A ATOM 2600 C SER A 341 7.368 1.204 17.716 1.00 28.35 A ATOM 2601 O SER A 341 8.144 2.004 18.247 1.00 27.65 A ATOM 2602 N SER A 342 7.253 −.067 18.097 1.00 28.96 A ATOM 2603 CA SER A 342 7.997 −.622 19.222 1.00 29.52 A ATOM 2604 CB SER A 342 7.624 −2.101 19.419 1.00 29.14 A ATOM 2605 OG SER A 342 7.844 −2.873 18.249 1.00 28.82 A ATOM 2606 C SER A 342 9.516 −.474 19.197 1.00 30.70 A ATOM 2607 O SER A 342 10.142 −.355 20.249 1.00 30.85 A ATOM 2608 N ALA A 343 10.118 −.464 18.016 1.00 31.45 A ATOM 2609 CA ALA A 343 11.570 −.344 17.952 1.00 33.64 A ATOM 2610 CB ALA A 343 12.083 −.983 16.662 1.00 35.55 A ATOM 2611 C ALA A 343 12.136 1.080 18.105 1.00 33.98 A ATOM 2612 O ALA A 343 13.344 1.246 18.233 1.00 34.35 A ATOM 2613 N CYS A 344 11.279 2.098 18.108 1.00 33.68 A ATOM 2614 CA CYS A 344 11.746 3.484 18.244 1.00 33.68 A ATOM 2615 CB CYS A 344 10.566 4.455 18.206 1.00 34.53 A ATOM 2616 SG CYS A 344 9.710 4.519 16.638 1.00 37.50 A ATOM 2617 C CYS A 344 12.547 3.761 19.515 1.00 32.20 A ATOM 2618 O CYS A 344 13.679 4.257 19.455 1.00 30.61 A ATOM 2619 N VAL A 345 11.953 3.438 20.661 1.00 30.76 A ATOM 2620 CA VAL A 345 12.594 3.672 21.950 1.00 30.62 A ATOM 2621 CB VAL A 345 11.700 3.227 23.104 1.00 30.70 A ATOM 2622 CG1 VAL A 345 10.457 4.082 23.138 1.00 29.52 A ATOM 2623 CG2 VAL A 345 11.339 1.764 22.939 1.00 29.04 A ATOM 2624 C VAL A 345 13.942 2.984 22.091 1.00 30.41 A ATOM 2625 O VAL A 345 14.762 3.389 22.914 1.00 31.73 A ATOM 2626 N HIS A 346 14.177 1.941 21.306 1.00 29.02 A ATOM 2627 CA HIS A 346 15.456 1.254 21.377 1.00 28.83 A ATOM 2628 CB HIS A 346 15.314 −.201 20.924 1.00 29.96 A ATOM 2629 CG HIS A 346 14.336 −.983 21.747 1.00 32.17 A ATOM 2630 CD2 HIS A 346 13.228 −1.681 21.400 1.00 32.87 A ATOM 2631 ND1 HIS A 346 14.434 −1.083 23.118 1.00 33.79 A ATOM 2632 CE1 HIS A 346 13.430 −1.809 23.580 1.00 34.75 A ATOM 2633 NE2 HIS A 346 12.684 −2.186 22.557 1.00 34.86 A ATOM 2634 C HIS A 346 16.397 2.045 20.486 1.00 28.71 A ATOM 2635 O HIS A 346 17.579 2.204 20.805 1.00 27.87 A ATOM 2636 N PHE A 347 15.864 2.564 19.381 1.00 27.48 A ATOM 2637 CA PHE A 347 16.660 3.398 18.488 1.00 28.08 A ATOM 2638 CB PHE A 347 15.820 3.906 17.314 1.00 25.80 A ATOM 2639 CG PHE A 347 15.953 3.083 16.070 1.00 26.73 A ATOM 2640 CD1 PHE A 347 15.493 1.768 16.031 1.00 24.87 A ATOM 2641 CD2 PHE A 347 16.539 3.621 14.927 1.00 24.25 A ATOM 2642 CE1 PHE A 347 15.613 1.007 14.862 1.00 25.10 A ATOM 2643 CE2 PHE A 347 16.666 2.863 13.758 1.00 23.84 A ATOM 2644 CZ PHE A 347 16.201 1.558 13.727 1.00 25.46 A ATOM 2645 C PHE A 347 17.123 4.595 19.311 1.00 29.17 A ATOM 2646 O PHE A 347 18.265 5.032 19.198 1.00 30.41 A ATOM 2647 N ILE A 348 16.220 5.115 20.144 1.00 29.54 A ATOM 2648 CA ILE A 348 16.519 6.269 20.992 1.00 31.74 A ATOM 2649 CB ILE A 348 15.237 6.805 21.670 1.00 30.12 A ATOM 2650 CG2 ILE A 348 15.585 7.905 22.673 1.00 29.86 A ATOM 2651 CG1 ILE A 348 14.285 7.351 20.600 1.00 30.80 A ATOM 2652 CD1 ILE A 348 12.905 7.697 21.121 1.00 29.48 A ATOM 2653 C ILE A 348 17.564 5.941 22.057 1.00 33.22 A ATOM 2654 O ILE A 348 18.451 6.753 22.331 1.00 32.42 A ATOM 2655 N LEU A 349 17.447 4.756 22.659 1.00 34.52 A ATOM 2656 CA LEU A 349 18.402 4.312 23.673 1.00 33.45 A ATOM 2657 CB LEU A 349 18.131 2.862 24.075 1.00 32.73 A ATOM 2658 CG LEU A 349 17.008 2.663 25.082 1.00 31.86 A ATOM 2659 CD1 LEU A 349 16.621 1.218 25.144 1.00 32.57 A ATOM 2660 CD2 LEU A 349 17.469 3.159 26.437 1.00 35.89 A ATOM 2661 C LEU A 349 19.783 4.393 23.072 1.00 32.83 A ATOM 2662 O LEU A 349 20.693 4.986 23.642 1.00 33.55 A ATOM 2663 N ASP A 350 19.912 3.791 21.898 1.00 32.31 A ATOM 2664 CA ASP A 350 21.160 3.751 21.163 1.00 32.68 A ATOM 2665 CB ASP A 350 20.953 2.948 19.883 1.00 31.76 A ATOM 2666 CG ASP A 350 22.252 2.579 19.211 1.00 33.89 A ATOM 2667 OD1 ASP A 350 23.090 1.926 19.866 1.00 34.37 A ATOM 2668 OD2 ASP A 350 22.431 2.936 18.028 1.00 34.98 A ATOM 2669 C ASP A 350 21.662 5.162 20.836 1.00 34.32 A ATOM 2670 O ASP A 350 22.793 5.513 21.161 1.00 33.23 A ATOM 2671 N GLN A 351 20.820 5.971 20.202 1.00 35.14 A ATOM 2672 CA GLN A 351 21.214 7.332 19.853 1.00 36.60 A ATOM 2673 CB GLN A 351 20.072 8.052 19.134 1.00 37.06 A ATOM 2674 CG GLN A 351 20.442 9.464 18.680 1.00 39.34 A ATOM 2675 CD GLN A 351 21.369 9.479 17.472 1.00 40.13 A ATOM 2676 OE1 GLN A 351 22.018 10.480 17.198 1.00 40.84 A ATOM 2677 NE2 GLN A 351 21.419 8.370 16.736 1.00 41.79 A ATOM 2678 C GLN A 351 21.617 8.128 21.097 1.00 36.53 A ATOM 2679 O GLN A 351 22.511 8.977 21.039 1.00 34.64 A ATOM 2680 N THR A 352 20.945 7.844 22.213 1.00 36.55 A ATOM 2681 CA THR A 352 21.219 8.507 23.481 1.00 37.35 A ATOM 2682 CB THR A 352 20.143 8.164 24.523 1.00 36.83 A ATOM 2683 OG1 THR A 352 18.919 8.808 24.159 1.00 36.13 A ATOM 2684 CG2 THR A 352 20.559 8.628 25.914 1.00 36.00 A ATOM 2685 C THR A 352 22.600 8.137 24.032 1.00 39.55 A ATOM 2686 O THR A 352 23.302 8.996 24.571 1.00 39.76 A ATOM 2687 N ARG A 353 22.995 6.872 23.902 1.00 38.72 A ATOM 2688 CA ARG A 353 24.308 6.468 24.387 1.00 39.16 A ATOM 2689 CB ARG A 353 24.395 4.949 24.547 1.00 38.70 A ATOM 2690 CG ARG A 353 24.307 4.168 23.270 1.00 38.81 A ATOM 2691 CD ARG A 353 24.503 2.685 23.524 1.00 38.69 A ATOM 2692 NE ARG A 353 24.489 1.938 22.272 1.00 37.26 A ATOM 2693 CZ ARG A 353 24.949 .702 22.131 1.00 36.50 A ATOM 2694 NH1 ARG A 353 25.463 .060 23.175 1.00 36.43 A ATOM 2695 NH2 ARG A 353 24.910 .114 20.940 1.00 33.66 A ATOM 2696 C ARG A 353 25.402 6.966 23.441 1.00 38.75 A ATOM 2697 O ARG A 353 26.491 7.322 23.889 1.00 38.89 A ATOM 2698 N LYS A 354 25.110 6.999 22.140 1.00 38.70 A ATOM 2699 CA LYS A 354 26.072 7.483 21.141 1.00 38.91 A ATOM 2700 CB LYS A 354 25.530 7.291 19.716 1.00 39.12 A ATOM 2701 CG LYS A 354 25.177 5.870 19.341 1.00 41.11 A ATOM 2702 CD LYS A 354 26.367 4.939 19.472 1.00 41.53 A ATOM 2703 CE LYS A 354 25.948 3.481 19.275 1.00 43.16 A ATOM 2704 NZ LYS A 354 25.334 3.220 17.934 1.00 42.80 A ATOM 2705 C LYS A 354 26.345 8.981 21.355 1.00 39.02 A ATOM 2706 O LYS A 354 27.486 9.438 21.281 1.00 39.72 A ATOM 2707 N ALA A 355 25.284 9.740 21.610 1.00 37.76 A ATOM 2708 CA ALA A 355 25.403 11.168 21.827 1.00 37.38 A ATOM 2709 CB ALA A 355 24.016 11.788 21.926 1.00 35.63 A ATOM 2710 C ALA A 355 26.214 11.460 23.093 1.00 38.06 A ATOM 2711 O ALA A 355 27.016 12.392 23.124 1.00 39.13 A ATOM 2712 N SER A 356 26.003 10.660 24.134 1.00 38.24 A ATOM 2713 CA SER A 356 26.717 10.834 25.396 1.00 38.77 A ATOM 2714 CB SER A 356 26.194 9.849 26.448 1.00 39.74 A ATOM 2715 OG SER A 356 24.828 10.086 26.754 1.00 40.96 A ATOM 2716 C SER A 356 28.200 10.579 25.167 1.00 39.15 A ATOM 2717 O SER A 356 29.061 11.172 25.811 1.00 40.88 A ATOM 2718 N LEU A 357 28.486 9.700 24.224 1.00 37.61 A ATOM 2719 CA LEU A 357 29.847 9.341 23.900 1.00 37.06 A ATOM 2720 CB LEU A 357 29.813 8.048 23.096 1.00 34.46 A ATOM 2721 CG LEU A 357 31.079 7.221 22.966 1.00 35.15 A ATOM 2722 CD1 LEU A 357 31.762 7.084 24.316 1.00 33.86 A ATOM 2723 CD2 LEU A 357 30.701 5.861 22.387 1.00 35.10 A ATOM 2724 C LEU A 357 30.569 10.455 23.130 1.00 38.07 A ATOM 2725 O LEU A 357 31.624 10.935 23.554 1.00 37.75 A ATOM 2726 N GLN A 358 29.992 10.860 22.003 1.00 39.64 A ATOM 2727 CA GLN A 358 30.555 11.912 21.150 1.00 41.15 A ATOM 2728 CB GLN A 358 29.603 12.218 19.987 1.00 43.94 A ATOM 2729 CG GLN A 358 29.325 11.065 19.026 1.00 46.51 A ATOM 2730 CD GLN A 358 30.239 11.076 17.807 1.00 49.21 A ATOM 2731 OE1 GLN A 358 30.413 12.109 17.150 1.00 50.20 A ATOM 2732 NE2 GLN A 358 30.817 9.923 17.491 1.00 50.25 A ATOM 2733 C GLN A 358 30.807 13.213 21.901 1.00 41.73 A ATOM 2734 O GLN A 358 31.811 13.894 21.676 1.00 41.83 A ATOM 2735 N ASN A 359 29.885 13.557 22.792 1.00 41.97 A ATOM 2736 CA ASN A 359 29.978 14.795 23.549 1.00 42.02 A ATOM 2737 CB ASN A 359 28.585 15.207 24.022 1.00 42.01 A ATOM 2738 CG ASN A 359 27.546 15.082 22.924 1.00 42.17 A ATOM 2739 OD1 ASN A 359 27.892 14.891 21.761 1.00 44.07 A ATOM 2740 ND2 ASN A 359 26.269 15.186 23.285 1.00 42.37 A ATOM 2741 C ASN A 359 30.930 14.721 24.728 1.00 43.88 A ATOM 2742 O ASN A 359 31.404 15.755 25.208 1.00 45.52 A ATOM 2743 N GLY A 360 31.207 13.506 25.197 1.00 43.60 A ATOM 2744 CA GLY A 360 32.118 13.332 26.320 1.00 41.65 A ATOM 2745 C GLY A 360 31.478 13.426 27.695 1.00 40.93 A ATOM 2746 O GLY A 360 32.099 13.920 28.641 1.00 39.86 A ATOM 2747 N CYS A 361 30.244 12.938 27.813 1.00 40.23 A ATOM 2748 CA CYS A 361 29.508 12.974 29.071 1.00 39.86 A ATOM 2749 CB CYS A 361 28.021 12.710 28.816 1.00 41.39 A ATOM 2750 SG CYS A 361 27.254 13.841 27.604 1.00 46.32 A ATOM 2751 C CYS A 361 30.043 11.968 30.083 1.00 39.25 A ATOM 2752 O CYS A 361 30.757 11.038 29.730 1.00 39.13 A ATOM 2753 N SER A 362 29.680 12.163 31.344 1.00 39.05 A ATOM 2754 CA SER A 362 30.128 11.303 32.428 1.00 38.13 A ATOM 2755 CB SER A 362 29.856 11.983 33.765 1.00 37.35 A ATOM 2756 OG SER A 362 28.480 12.268 33.906 1.00 37.41 A ATOM 2757 C SER A 362 29.487 9.920 32.432 1.00 39.61 A ATOM 2758 O SER A 362 30.080 8.962 32.926 1.00 39.97 A ATOM 2759 N THR A 363 28.273 9.814 31.902 1.00 39.04 A ATOM 2760 CA THR A 363 27.582 8.527 31.864 1.00 38.14 A ATOM 2761 CB THR A 363 26.482 8.449 32.943 1.00 38.58 A ATOM 2762 OG1 THR A 363 25.378 9.284 32.569 1.00 34.35 A ATOM 2763 CG2 THR A 363 27.028 8.903 34.289 1.00 38.03 A ATOM 2764 C THR A 363 26.928 8.299 30.507 1.00 37.71 A ATOM 2765 O THR A 363 26.925 9.185 29.652 1.00 38.00 A ATOM 2766 N THR A 364 26.373 7.107 30.312 1.00 36.07 A ATOM 2767 CA THR A 364 25.710 6.779 29.055 1.00 34.36 A ATOM 2768 CB THR A 364 25.442 5.262 28.944 1.00 32.76 A ATOM 2769 OG1 THR A 364 25.132 4.734 30.238 1.00 31.72 A ATOM 2770 CG2 THR A 364 26.657 4.547 28.389 1.00 33.27 A ATOM 2771 C THR A 364 24.397 7.539 28.917 1.00 34.89 A ATOM 2772 O THR A 364 23.788 7.552 27.855 1.00 33.55 A ATOM 2773 N GLY A 365 23.971 8.174 30.001 1.00 37.02 A ATOM 2774 CA GLY A 365 22.738 8.939 29.985 1.00 39.62 A ATOM 2775 C GLY A 365 23.031 10.424 29.873 1.00 41.66 A ATOM 2776 O GLY A 365 22.526 11.231 30.655 1.00 41.20 A ATOM 2777 N GLU A 366 23.864 10.776 28.899 1.00 42.25 A ATOM 2778 CA GLU A 366 24.248 12.161 28.660 1.00 44.72 A ATOM 2779 CB GLU A 366 23.085 12.903 27.996 1.00 47.19 A ATOM 2780 CG GLU A 366 22.598 12.219 26.721 1.00 52.43 A ATOM 2781 CD GLU A 366 21.451 12.950 26.035 1.00 56.02 A ATOM 2782 OE1 GLU A 366 20.404 13.181 26.686 1.00 56.50 A ATOM 2783 OE2 GLU A 366 21.600 13.285 24.837 1.00 57.47 A ATOM 2784 C GLU A 366 24.700 12.887 29.933 1.00 44.50 A ATOM 2785 O GLU A 366 24.523 14.100 30.064 1.00 42.81 A ATOM 2786 N GLY A 367 25.279 12.134 30.869 1.00 43.97 A ATOM 2787 CA GLY A 367 25.770 12.721 32.106 1.00 42.81 A ATOM 2788 C GLY A 367 24.962 12.462 33.368 1.00 40.85 A ATOM 2789 O GLY A 367 25.489 12.538 34.478 1.00 40.69 A ATOM 2790 N LEU A 368 23.683 12.158 33.204 1.00 39.07 A ATOM 2791 CA LEU A 368 22.815 11.904 34.340 1.00 37.27 A ATOM 2792 CB LEU A 368 21.374 12.223 33.947 1.00 37.69 A ATOM 2793 CG LEU A 368 21.029 13.698 33.694 1.00 38.92 A ATOM 2794 CD1 LEU A 368 22.240 14.489 33.220 1.00 38.52 A ATOM 2795 CD2 LEU A 368 19.906 13.766 32.678 1.00 37.84 A ATOM 2796 C LEU A 368 22.942 10.458 34.831 1.00 37.05 A ATOM 2797 O LEU A 368 23.465 9.590 34.127 1.00 36.30 A ATOM 2798 N GLU A 369 22.458 10.206 36.041 1.00 36.23 A ATOM 2799 CA GLU A 369 22.539 8.883 36.641 1.00 37.09 A ATOM 2800 CB GLU A 369 22.701 9.009 38.157 1.00 41.29 A ATOM 2801 CG GLU A 369 23.398 10.294 38.642 1.00 46.01 A ATOM 2802 CD GLU A 369 22.517 11.551 38.547 1.00 47.44 A ATOM 2803 OE1 GLU A 369 22.444 12.167 37.454 1.00 44.74 A ATOM 2804 OE2 GLU A 369 21.894 11.914 39.578 1.00 49.56 A ATOM 2805 C GLU A 369 21.327 7.999 36.340 1.00 35.30 A ATOM 2806 O GLU A 369 21.481 6.847 35.939 1.00 35.73 A ATOM 2807 N MET A 370 20.130 8.540 36.549 1.00 32.75 A ATOM 2808 CA MET A 370 18.886 7.808 36.308 1.00 31.28 A ATOM 2809 CB MET A 370 18.032 7.785 37.584 1.00 31.18 A ATOM 2810 CG MET A 370 18.348 6.665 38.567 1.00 29.86 A ATOM 2811 SD MET A 370 17.143 6.652 39.910 1.00 28.54 A ATOM 2812 CE MET A 370 17.895 7.805 40.972 1.00 31.46 A ATOM 2813 C MET A 370 18.056 8.413 35.159 1.00 31.15 A ATOM 2814 O MET A 370 18.125 9.615 34.893 1.00 29.39 A ATOM 2815 N GLY A 371 17.268 7.574 34.491 1.00 28.64 A ATOM 2816 CA GLY A 371 16.449 8.051 33.388 1.00 28.20 A ATOM 2817 C GLY A 371 15.117 7.328 33.246 1.00 26.64 A ATOM 2818 O GLY A 371 14.882 6.297 33.879 1.00 24.42 A ATOM 2819 N VAL A 372 14.236 7.861 32.408 1.00 25.98 A ATOM 2820 CA VAL A 372 12.929 7.253 32.223 1.00 25.78 A ATOM 2821 CB VAL A 372 11.784 8.175 32.695 1.00 25.32 A ATOM 2822 CG1 VAL A 372 11.584 9.324 31.708 1.00 24.95 A ATOM 2823 CG2 VAL A 372 10.496 7.371 32.830 1.00 25.78 A ATOM 2824 C VAL A 372 12.670 6.920 30.776 1.00 26.21 A ATOM 2825 O VAL A 372 13.163 7.587 29.869 1.00 27.38 A ATOM 2826 N LEU A 373 11.892 5.873 30.566 1.00 27.08 A ATOM 2827 CA LEU A 373 11.536 5.466 29.223 1.00 27.81 A ATOM 2828 CB LEU A 373 12.218 4.149 28.866 1.00 29.56 A ATOM 2829 CG LEU A 373 11.907 3.634 27.459 1.00 31.75 A ATOM 2830 CD1 LEU A 373 13.171 3.065 26.836 1.00 29.26 A ATOM 2831 CD2 LEU A 373 10.791 2.591 27.531 1.00 31.43 A ATOM 2832 C LEU A 373 10.026 5.317 29.194 1.00 27.20 A ATOM 2833 O LEU A 373 9.427 4.811 30.148 1.00 26.34 A ATOM 2834 N PHE A 374 9.418 5.779 28.106 1.00 26.82 A ATOM 2835 CA PHE A 374 7.972 5.712 27.942 1.00 27.12 A ATOM 2836 CB PHE A 374 7.369 7.108 28.029 1.00 28.61 A ATOM 2837 CG PHE A 374 7.242 7.630 29.421 1.00 31.11 A ATOM 2838 CD1 PHE A 374 6.239 7.159 30.263 1.00 32.22 A ATOM 2839 CD2 PHE A 374 8.110 8.609 29.891 1.00 31.24 A ATOM 2840 CE1 PHE A 374 6.093 7.655 31.558 1.00 32.81 A ATOM 2841 CE2 PHE A 374 7.977 9.118 31.187 1.00 33.42 A ATOM 2842 CZ PHE A 374 6.960 8.637 32.024 1.00 33.49 A ATOM 2843 C PHE A 374 7.537 5.087 26.622 1.00 28.09 A ATOM 2844 O PHE A 374 8.186 5.247 25.592 1.00 28.61 A ATOM 2845 N GLY A 375 6.423 4.370 26.671 1.00 27.67 A ATOM 2846 CA GLY A 375 5.870 3.765 25.480 1.00 25.79 A ATOM 2847 C GLY A 375 4.377 4.025 25.530 1.00 25.72 A ATOM 2848 O GLY A 375 3.764 3.878 26.583 1.00 26.86 A ATOM 2849 N PHE A 376 3.789 4.430 24.410 1.00 27.30 A ATOM 2850 CA PHE A 376 2.349 4.694 24.363 1.00 26.31 A ATOM 2851 CB PHE A 376 2.061 6.168 24.072 1.00 27.66 A ATOM 2852 CG PHE A 376 2.995 7.120 24.748 1.00 28.81 A ATOM 2853 CD1 PHE A 376 3.222 7.044 26.115 1.00 30.56 A ATOM 2854 CD2 PHE A 376 3.628 8.117 24.019 1.00 28.26 A ATOM 2855 CE1 PHE A 376 4.069 7.949 26.751 1.00 30.43 A ATOM 2856 CE2 PHE A 376 4.475 9.026 24.643 1.00 29.11 A ATOM 2857 CZ PHE A 376 4.698 8.943 26.011 1.00 29.04 A ATOM 2858 C PHE A 376 1.708 3.870 23.259 1.00 25.27 A ATOM 2859 O PHE A 376 2.239 3.781 22.156 1.00 25.32 A ATOM 2860 N GLY A 377 .555 3.284 23.552 1.00 25.39 A ATOM 2861 CA GLY A 377 −.127 2.502 22.545 1.00 24.04 A ATOM 2862 C GLY A 377 −1.590 2.234 22.854 1.00 23.88 A ATOM 2863 O GLY A 377 −2.155 2.812 23.785 1.00 20.92 A ATOM 2864 N PRO A 378 −2.225 1.347 22.068 1.00 24.59 A ATOM 2865 CD PRO A 378 −1.538 .702 20.934 1.00 22.15 A ATOM 2866 CA PRO A 378 −3.617 .900 22.134 1.00 26.44 A ATOM 2867 CB PRO A 378 −3.608 −.340 21.259 1.00 23.96 A ATOM 2868 CG PRO A 378 −2.682 .086 20.164 1.00 23.62 A ATOM 2869 C PRO A 378 −4.134 .609 23.529 1.00 28.16 A ATOM 2870 O PRO A 378 −3.376 .220 24.411 1.00 27.70 A ATOM 2871 N GLY A 379 −5.446 .775 23.690 1.00 31.23 A ATOM 2872 CA GLY A 379 −6.111 .572 24.963 1.00 33.70 A ATOM 2873 C GLY A 379 −5.864 1.875 25.669 1.00 36.78 A ATOM 2874 O GLY A 379 −6.661 2.378 26.468 1.00 35.21 A ATOM 2875 N LEU A 380 −4.724 2.421 25.259 1.00 38.76 A ATOM 2876 CA LEU A 380 −4.119 3.652 25.716 1.00 37.20 A ATOM 2877 CB LEU A 380 −5.125 4.780 25.869 1.00 38.70 A ATOM 2878 CG LEU A 380 −4.492 6.083 25.356 1.00 41.13 A ATOM 2879 CD1 LEU A 380 −3.071 6.240 25.923 1.00 42.02 A ATOM 2880 CD2 LEU A 380 −4.421 6.061 23.837 1.00 40.14 A ATOM 2881 C LEU A 380 −3.443 3.328 27.021 1.00 34.99 A ATOM 2882 O LEU A 380 −3.848 3.763 28.098 1.00 34.48 A ATOM 2883 N THR A 381 −2.406 2.514 26.893 1.00 31.04 A ATOM 2884 CA THR A 381 −1.639 2.088 28.034 1.00 30.02 A ATOM 2885 CB THR A 381 −1.361 .549 28.000 1.00 29.09 A ATOM 2886 OG1 THR A 381 −.002 .288 27.613 1.00 28.59 A ATOM 2887 CG2 THR A 381 −2.282 −.117 27.011 1.00 26.08 A ATOM 2888 C THR A 381 −.355 2.860 27.933 1.00 29.20 A ATOM 2889 O THR A 381 −.025 3.380 26.874 1.00 29.92 A ATOM 2890 N ILE A 382 .358 2.951 29.042 1.00 29.88 A ATOM 2891 CA ILE A 382 1.622 3.663 29.073 1.00 28.14 A ATOM 2892 CB ILE A 382 1.520 4.957 29.914 1.00 26.61 A ATOM 2893 CG2 ILE A 382 2.809 5.750 29.803 1.00 28.80 A ATOM 2894 CG1 ILE A 382 .324 5.800 29.461 1.00 29.96 A ATOM 2895 CD1 ILE A 382 .455 6.415 28.079 1.00 29.52 A ATOM 2896 C ILE A 382 2.607 2.729 29.759 1.00 27.30 A ATOM 2897 O ILE A 382 2.322 2.189 30.829 1.00 26.16 A ATOM 2898 N GLU A 383 3.747 2.502 29.130 1.00 27.01 A ATOM 2899 CA GLU A 383 4.758 1.667 29.753 1.00 28.35 A ATOM 2900 CB GLU A 383 5.385 .701 28.751 1.00 28.01 A ATOM 2901 CG GLU A 383 4.434 −.408 28.312 1.00 29.73 A ATOM 2902 CD GLU A 383 4.552 −1.679 29.141 1.00 29.55 A ATOM 2903 OE1 GLU A 383 5.000 −1.623 30.304 1.00 30.70 A ATOM 2904 OE2 GLU A 383 4.179 −2.748 28.626 1.00 31.96 A ATOM 2905 C GLU A 383 5.792 2.644 30.261 1.00 28.17 A ATOM 2906 O GLU A 383 6.263 3.496 29.523 1.00 28.48 A ATOM 2907 N THR A 384 6.098 2.535 31.545 1.00 29.87 A ATOM 2908 CA THR A 384 7.083 3.379 32.192 1.00 29.87 A ATOM 2909 CB THR A 384 6.516 4.060 33.458 1.00 31.48 A ATOM 2910 OG1 THR A 384 5.424 4.922 33.099 1.00 35.27 A ATOM 2911 CG2 THR A 384 7.617 4.869 34.160 1.00 29.36 A ATOM 2912 C THR A 384 8.240 2.496 32.620 1.00 29.37 A ATOM 2913 O THR A 384 8.040 1.476 33.286 1.00 27.65 A ATOM 2914 N VAL A 385 9.447 2.888 32.230 1.00 28.94 A ATOM 2915 CA VAL A 385 10.632 2.137 32.603 1.00 28.87 A ATOM 2916 CB VAL A 385 11.220 1.386 31.392 1.00 26.12 A ATOM 2917 CG1 VAL A 385 12.213 .339 31.862 1.00 28.78 A ATOM 2918 CG2 VAL A 385 10.125 .744 30.601 1.00 25.84 A ATOM 2919 C VAL A 385 11.702 3.074 33.177 1.00 30.37 A ATOM 2920 O VAL A 385 12.218 3.957 32.475 1.00 31.40 A ATOM 2921 N VAL A 386 12.014 2.900 34.461 1.00 31.00 A ATOM 2922 CA VAL A 386 13.044 3.709 35.104 1.00 30.62 A ATOM 2923 CB VAL A 386 12.781 3.842 36.636 1.00 30.34 A ATOM 2924 CG1 VAL A 386 12.562 2.499 37.232 1.00 31.84 A ATOM 2925 CG2 VAL A 386 13.953 4.525 37.332 1.00 31.28 A ATOM 2926 C VAL A 386 14.377 3.012 34.818 1.00 30.23 A ATOM 2927 O VAL A 386 14.593 1.855 35.190 1.00 30.15 A ATOM 2928 N LEU A 387 15.254 3.725 34.120 1.00 30.35 A ATOM 2929 CA LEU A 387 16.556 3.213 33.724 1.00 29.55 A ATOM 2930 CB LEU A 387 16.787 3.490 32.244 1.00 27.05 A ATOM 2931 CG LEU A 387 15.906 2.768 31.236 1.00 24.51 A ATOM 2932 CD1 LEU A 387 16.047 3.379 29.854 1.00 23.58 A ATOM 2933 CD2 LEU A 387 16.310 1.333 31.215 1.00 23.31 A ATOM 2934 C LEU A 387 17.722 3.801 34.498 1.00 32.46 A ATOM 2935 O LEU A 387 17.719 4.977 34.866 1.00 33.52 A ATOM 2936 N LYS A 388 18.726 2.965 34.724 1.00 34.19 A ATOM 2937 CA LYS A 388 19.938 3.373 35.414 1.00 35.44 A ATOM 2938 CB LYS A 388 20.313 2.348 36.483 1.00 37.24 A ATOM 2939 CG LYS A 388 20.113 2.838 37.904 1.00 37.74 A ATOM 2940 CD LYS A 388 21.123 3.910 38.251 1.00 37.39 A ATOM 2941 CE LYS A 388 22.518 3.331 38.292 1.00 36.28 A ATOM 2942 NZ LYS A 388 22.602 2.295 39.339 1.00 37.97 A ATOM 2943 C LYS A 388 21.056 3.445 34.379 1.00 37.08 A ATOM 2944 O LYS A 388 21.298 2.484 33.633 1.00 36.42 A ATOM 2945 N SER A 389 21.726 4.590 34.320 1.00 36.60 A ATOM 2946 CA SER A 389 22.825 4.769 33.387 1.00 36.00 A ATOM 2947 CB SER A 389 23.022 6.259 33.114 1.00 37.01 A ATOM 2948 OG SER A 389 24.013 6.455 32.130 1.00 38.47 A ATOM 2949 C SER A 389 24.100 4.173 33.995 1.00 35.19 A ATOM 2950 O SER A 389 24.103 3.753 35.152 1.00 32.14 A ATOM 2951 N VAL A 390 25.171 4.125 33.208 1.00 36.45 A ATOM 2952 CA VAL A 390 26.465 3.617 33.677 1.00 38.33 A ATOM 2953 CB VAL A 390 26.885 2.274 32.987 1.00 39.52 A ATOM 2954 CG1 VAL A 390 25.856 1.194 33.265 1.00 38.28 A ATOM 2955 CG2 VAL A 390 27.069 2.473 31.481 1.00 38.97 A ATOM 2956 C VAL A 390 27.521 4.669 33.355 1.00 39.34 A ATOM 2957 O VAL A 390 27.405 5.399 32.367 1.00 39.68 A ATOM 2958 N PRO A 391 28.567 4.767 34.189 1.00 40.39 A ATOM 2959 CD PRO A 391 28.836 4.016 35.428 1.00 39.55 A ATOM 2960 CA PRO A 391 29.614 5.759 33.937 1.00 40.79 A ATOM 2961 CB PRO A 391 30.398 5.773 35.248 1.00 39.73 A ATOM 2962 CG PRO A 391 30.282 4.369 35.712 1.00 39.36 A ATOM 2963 C PRO A 391 30.473 5.395 32.736 1.00 42.01 A ATOM 2964 O PRO A 391 30.563 4.223 32.354 1.00 42.53 A ATOM 2965 N ILE A 392 31.084 6.414 32.135 1.00 43.00 A ATOM 2966 CA ILE A 392 31.949 6.240 30.978 1.00 43.81 A ATOM 2967 CB ILE A 392 31.547 7.201 29.836 1.00 43.31 A ATOM 2968 CG2 ILE A 392 32.465 7.006 28.631 1.00 43.26 A ATOM 2969 CG1 ILE A 392 30.100 6.932 29.424 1.00 43.24 A ATOM 2970 CD1 ILE A 392 29.649 7.728 28.224 1.00 43.15 A ATOM 2971 C ILE A 392 33.389 6.526 31.391 1.00 46.16 A ATOM 2972 O ILE A 392 33.938 7.571 31.052 1.00 46.65 A ATOM 2973 N GLN A 393 33.978 5.586 32.130 1.00 48.86 A ATOM 2974 CA GLN A 393 35.349 5.683 32.631 1.00 52.16 A ATOM 2975 CB GLN A 393 35.644 7.096 33.149 1.00 54.15 A ATOM 2976 CG GLN A 393 36.288 8.014 32.121 1.00 56.36 A ATOM 2977 CD GLN A 393 37.683 7.566 31.722 1.00 57.85 A ATOM 2978 OE1 GLN A 393 37.946 6.370 31.554 1.00 57.70 A ATOM 2979 NE2 GLN A 393 38.585 8.529 31.553 1.00 58.57 A ATOM 2980 C GLN A 393 35.601 4.682 33.756 1.00 53.17 A ATOM 2981 O GLN A 393 34.634 4.021 34.186 1.00 54.06 A ATOM 2982 OXT GLN A 393 36.764 4.579 34.205 1.00 54.19 A

[0268] APPENDIX B Arachis hypogaea STS ATOM # TYPE RES X Y Z OCC B ATOM 1 CB VAL A 8 6.075 38.920 83.477 1.00 46.46 A ATOM 2 CG1 VAL A 8 5.638 40.112 82.631 1.00 47.07 A ATOM 3 CG2 VAL A 8 6.142 37.664 82.618 1.00 46.26 A ATOM 4 C VAL A 8 7.420 40.545 84.830 1.00 43.72 A ATOM 5 O VAL A 8 7.656 41.588 84.215 1.00 43.86 A ATOM 6 N VAL A 8 7.847 38.099 85.052 1.00 45.93 A ATOM 7 CA VAL A 8 7.460 39.195 84.117 1.00 45.01 A ATOM 8 N GLN A 9 7.122 40.527 86.125 1.00 40.46 A ATOM 9 CA GLN A 9 7.067 41.763 86.892 1.00 36.43 A ATOM 10 CB GLN A 9 5.854 41.761 87.831 1.00 38.00 A ATOM 11 CG GLN A 9 5.885 40.706 88.921 1.00 41.02 A ATOM 12 CD GLN A 9 4.619 40.706 89.764 1.00 43.48 A ATOM 13 OE1 GLN A 9 3.533 40.370 89.283 1.00 43.47 A ATOM 14 NE2 GLN A 9 4.752 41.091 91.029 1.00 46.37 A ATOM 15 C GLN A 9 8.354 41.972 87.688 1.00 32.96 A ATOM 16 O GLN A 9 8.509 42.974 88.380 1.00 30.32 A ATOM 17 N ARG A 10 9.278 41.024 87.575 1.00 29.75 A ATOM 18 CA ARG A 10 10.556 41.114 88.277 1.00 28.77 A ATOM 19 CB ARG A 10 10.931 39.750 88.860 1.00 30.32 A ATOM 20 CG ARG A 10 11.250 38.689 87.819 1.00 31.19 A ATOM 21 CD ARG A 10 11.006 37.297 88.382 1.00 33.88 A ATOM 22 NE ARG A 10 11.685 37.098 89.662 1.00 34.38 A ATOM 23 CZ ARG A 10 11.524 36.031 90.441 1.00 35.70 A ATOM 24 NH1 ARG A 10 10.700 35.053 90.078 1.00 34.56 A ATOM 25 NH2 ARG A 10 12.189 35.942 91.587 1.00 30.48 A ATOM 26 C ARG A 10 11.643 41.582 87.314 1.00 27.02 A ATOM 27 O ARG A 10 11.532 41.382 86.107 1.00 24.60 A ATOM 28 N ALA A 11 12.686 42.215 87.848 1.00 24.89 A ATOM 29 CA ALA A 11 13.791 42.692 87.023 1.00 23.28 A ATOM 30 CB ALA A 11 14.584 43.761 87.765 1.00 23.85 A ATOM 31 C ALA A 11 14.689 41.510 86.674 1.00 24.68 A ATOM 32 O ALA A 11 14.634 40.467 87.332 1.00 23.55 A ATOM 33 N GLU A 12 15.521 41.674 85.649 1.00 24.82 A ATOM 34 CA GLU A 12 16.402 40.597 85.208 1.00 27.69 A ATOM 35 CB GLU A 12 16.503 40.599 83.682 1.00 29.83 A ATOM 36 CG GLU A 12 15.246 40.125 82.979 1.00 36.49 A ATOM 37 CD GLU A 12 14.809 38.741 83.440 1.00 39.68 A ATOM 38 OE1 GLU A 12 14.131 38.637 84.489 1.00 42.41 A ATOM 39 OE2 GLU A 12 15.155 37.754 82.756 1.00 42.52 A ATOM 40 C GLU A 12 17.813 40.577 85.783 1.00 27.17 A ATOM 41 O GLU A 12 18.260 39.553 86.306 1.00 28.17 A ATOM 42 N GLY A 13 18.515 41.699 85.673 1.00 23.56 A ATOM 43 CA GLY A 13 19.887 41.758 86.147 1.00 22.50 A ATOM 44 C GLY A 13 20.132 42.174 87.584 1.00 19.30 A ATOM 45 O GLY A 13 19.203 42.469 88.335 1.00 18.70 A ATOM 46 N PRO A 14 21.402 42.203 87.997 1.00 17.89 A ATOM 47 CD PRO A 14 22.595 41.786 87.239 1.00 19.36 A ATOM 48 CA PRO A 14 21.751 42.591 89.366 1.00 17.15 A ATOM 49 CB PRO A 14 23.218 42.177 89.475 1.00 18.61 A ATOM 50 CG PRO A 14 23.721 42.365 88.068 1.00 19.45 A ATOM 51 C PRO A 14 21.546 44.085 89.615 1.00 15.71 A ATOM 52 O PRO A 14 21.722 44.896 88.710 1.00 16.79 A ATOM 53 N ALA A 15 21.153 44.433 90.837 1.00 13.60 A ATOM 54 CA ALA A 15 20.950 45.831 91.205 1.00 13.69 A ATOM 55 CB ALA A 15 20.537 45.933 92.662 1.00 16.43 A ATOM 56 C ALA A 15 22.270 46.562 90.973 1.00 14.74 A ATOM 57 O ALA A 15 23.349 46.064 91.325 1.00 15.66 A ATOM 58 N THR A 16 22.181 47.748 90.391 1.00 14.49 A ATOM 59 CA THR A 16 23.369 48.520 90.063 1.00 14.54 A ATOM 60 CB THR A 16 23.540 48.550 88.540 1.00 16.93 A ATOM 61 OG1 THR A 16 23.544 47.204 88.044 1.00 18.63 A ATOM 62 CG2 THR A 16 24.837 49.247 88.151 1.00 19.92 A ATOM 63 C THR A 16 23.309 49.957 90.578 1.00 15.11 A ATOM 64 O THR A 16 22.254 50.580 90.570 1.00 13.61 A ATOM 65 N VAL A 17 24.446 50.468 91.039 1.00 14.91 A ATOM 66 CA VAL A 17 24.522 51.846 91.520 1.00 15.45 A ATOM 67 CB VAL A 17 25.762 52.059 92.407 1.00 16.50 A ATOM 68 CG1 VAL A 17 25.853 53.524 92.836 1.00 16.06 A ATOM 69 CG2 VAL A 17 25.683 51.144 93.628 1.00 16.07 A ATOM 70 C VAL A 17 24.644 52.691 90.249 1.00 14.23 A ATOM 71 O VAL A 17 25.572 52.499 89.462 1.00 14.44 A ATOM 72 N LEU A 18 23.701 53.606 90.052 1.00 13.45 A ATOM 73 CA LEU A 18 23.665 54.443 88.857 1.00 14.26 A ATOM 74 CB LEU A 18 22.253 54.403 88.255 1.00 15.14 A ATOM 75 CG LEU A 18 21.680 52.998 88.049 1.00 16.97 A ATOM 76 CD1 LEU A 18 20.242 53.088 87.568 1.00 18.78 A ATOM 77 CD2 LEU A 18 22.549 52.235 87.047 1.00 17.90 A ATOM 78 C LEU A 18 24.073 55.898 89.076 1.00 14.73 A ATOM 79 O LEU A 18 24.351 56.613 88.120 1.00 14.38 A ATOM 80 N ALA A 19 24.098 56.340 90.329 1.00 15.35 A ATOM 81 CA ALA A 19 24.475 57.717 90.636 1.00 15.25 A ATOM 82 CB ALA A 19 23.388 58.680 90.168 1.00 14.75 A ATOM 83 C ALA A 19 24.694 57.874 92.133 1.00 14.72 A ATOM 84 O ALA A 19 24.086 57.166 92.942 1.00 14.23 A ATOM 85 N ILE A 20 25.572 58.804 92.484 1.00 12.39 A ATOM 86 CA ILE A 20 25.891 59.091 93.877 1.00 13.68 A ATOM 87 CB ILE A 20 27.221 58.442 94.304 1.00 14.33 A ATOM 88 CG2 ILE A 20 27.465 58.691 95.795 1.00 14.65 A ATOM 89 CG1 ILE A 20 27.188 56.939 94.044 1.00 13.59 A ATOM 90 CD1 ILE A 20 28.534 56.272 94.254 1.00 14.71 A ATOM 91 C ILE A 20 26.066 60.598 94.048 1.00 13.50 A ATOM 92 O ILE A 20 26.766 61.231 93.260 1.00 15.34 A ATOM 93 N GLY A 21 25.433 61.152 95.075 1.00 14.62 A ATOM 94 CA GLY A 21 25.554 62.571 95.373 1.00 14.32 A ATOM 95 C GLY A 21 25.774 62.738 96.872 1.00 15.92 A ATOM 96 O GLY A 21 25.226 61.975 97.667 1.00 15.96 A ATOM 97 N THR A 22 26.573 63.718 97.279 1.00 14.15 A ATOM 98 CA THR A 22 26.816 63.918 98.703 1.00 13.46 A ATOM 99 CB THR A 22 28.236 63.435 99.115 1.00 16.43 A ATOM 100 OG1 THR A 22 29.230 64.250 98.474 1.00 14.65 A ATOM 101 CG2 THR A 22 28.450 61.966 98.705 1.00 14.38 A ATOM 102 C THR A 22 26.677 65.382 99.094 1.00 13.65 A ATOM 103 O THR A 22 26.700 66.267 98.239 1.00 13.92 A ATOM 104 N ALA A 23 26.555 65.625 100.394 1.00 12.89 A ATOM 105 CA ALA A 23 26.417 66.981 100.911 1.00 13.53 A ATOM 106 CB ALA A 23 24.999 67.467 100.696 1.00 13.62 A ATOM 107 C ALA A 23 26.759 67.018 102.394 1.00 13.65 A ATOM 108 O ALA A 23 26.660 66.007 103.090 1.00 12.16 A ATOM 109 N ASN A 24 27.171 68.186 102.879 1.00 13.77 A ATOM 110 CA ASN A 24 27.510 68.348 104.291 1.00 12.71 A ATOM 111 CB ASN A 24 29.010 68.177 104.559 1.00 15.73 A ATOM 112 CG ASN A 24 29.599 66.941 103.929 1.00 16.23 A ATOM 113 OD1 ASN A 24 29.953 66.940 102.747 1.00 16.19 A ATOM 114 ND2 ASN A 24 29.726 65.881 104.719 1.00 13.70 A ATOM 115 C ASN A 24 27.199 69.776 104.702 1.00 15.49 A ATOM 116 O ASN A 24 27.161 70.675 103.865 1.00 14.90 A ATOM 117 N PRO A 25 26.965 70.001 105.998 1.00 17.07 A ATOM 118 CD PRO A 25 26.692 69.058 107.094 1.00 16.81 A ATOM 119 CA PRO A 25 26.694 71.381 106.403 1.00 17.11 A ATOM 120 CB PRO A 25 26.360 71.250 107.892 1.00 17.63 A ATOM 121 CG PRO A 25 26.961 69.912 108.300 1.00 19.53 A ATOM 122 C PRO A 25 27.996 72.152 106.118 1.00 20.50 A ATOM 123 O PRO A 25 29.087 71.580 106.161 1.00 18.51 A ATOM 124 N PRO A 26 27.897 73.451 105.805 1.00 20.76 A ATOM 125 CD PRO A 26 26.654 74.240 105.817 1.00 22.95 A ATOM 126 CA PRO A 26 29.053 74.305 105.499 1.00 21.72 A ATOM 127 CB PRO A 26 28.399 75.619 105.080 1.00 24.14 A ATOM 128 CG PRO A 26 27.176 75.660 105.947 1.00 25.19 A ATOM 129 C PRO A 26 30.106 74.512 106.590 1.00 21.55 A ATOM 130 O PRO A 26 31.299 74.601 106.296 1.00 23.48 A ATOM 131 N ASN A 27 29.671 74.598 107.839 1.00 20.95 A ATOM 132 CA ASN A 27 30.589 74.813 108.954 1.00 21.75 A ATOM 133 CB ASN A 27 29.788 74.956 110.245 1.00 20.97 A ATOM 134 CG ASN A 27 30.650 75.307 111.433 1.00 22.82 A ATOM 135 OD1 ASN A 27 31.412 76.273 111.396 1.00 21.91 A ATOM 136 ND2 ASN A 27 30.524 74.530 112.507 1.00 21.17 A ATOM 137 C ASN A 27 31.620 73.695 109.108 1.00 21.96 A ATOM 138 O ASN A 27 31.258 72.544 109.367 1.00 21.55 A ATOM 139 N CYS A 28 32.898 74.042 108.957 1.00 21.41 A ATOM 140 CA CYS A 28 33.993 73.077 109.082 1.00 24.36 A ATOM 141 CB CYS A 28 34.957 73.194 107.905 1.00 26.72 A ATOM 142 SG CYS A 28 34.296 72.622 106.349 1.00 32.06 A ATOM 143 C CYS A 28 34.793 73.287 110.351 1.00 25.08 A ATOM 144 O CYS A 28 35.100 74.422 110.713 1.00 26.06 A ATOM 145 N ILE A 29 35.143 72.197 111.024 1.00 23.86 A ATOM 146 CA ILE A 29 35.940 72.317 112.233 1.00 23.59 A ATOM 147 CB ILE A 29 35.266 71.650 113.451 1.00 26.59 A ATOM 148 CG2 ILE A 29 33.906 72.300 113.715 1.00 26.52 A ATOM 149 CG1 ILE A 29 35.128 70.148 113.215 1.00 27.45 A ATOM 150 CD1 ILE A 29 34.664 69.387 114.434 1.00 32.28 A ATOM 151 C ILE A 29 37.322 71.711 112.042 1.00 22.44 A ATOM 152 O ILE A 29 37.474 70.597 111.536 1.00 19.22 A ATOM 153 N ASP A 30 38.334 72.476 112.435 1.00 21.63 A ATOM 154 CA ASP A 30 39.718 72.044 112.340 1.00 21.62 A ATOM 155 CB ASP A 30 40.640 73.254 112.432 1.00 25.37 A ATOM 156 CG ASP A 30 42.069 72.915 112.107 1.00 26.61 A ATOM 157 OD1 ASP A 30 42.551 71.875 112.595 1.00 29.92 A ATOM 158 OD2 ASP A 30 42.713 73.691 111.369 1.00 31.88 A ATOM 159 C ASP A 30 39.978 71.105 113.517 1.00 20.05 A ATOM 160 O ASP A 30 39.899 71.513 114.671 1.00 19.05 A ATOM 161 N GLN A 31 40.292 69.849 113.221 1.00 20.36 A ATOM 162 CA GLN A 31 40.529 68.856 114.265 1.00 19.11 A ATOM 163 CB GLN A 31 40.742 67.480 113.625 1.00 17.44 A ATOM 164 CG GLN A 31 40.787 66.306 114.596 1.00 21.06 A ATOM 165 CD GLN A 31 39.430 65.957 115.189 1.00 21.80 A ATOM 166 OE1 GLN A 31 39.207 64.826 115.619 1.00 25.66 A ATOM 167 NE2 GLN A 31 38.525 66.926 115.230 1.00 18.69 A ATOM 168 C GLN A 31 41.722 69.200 115.151 1.00 19.87 A ATOM 169 O GLN A 31 41.703 68.931 116.348 1.00 18.46 A ATOM 170 N SER A 32 42.752 69.803 114.564 1.00 20.70 A ATOM 171 CA SER A 32 43.956 70.157 115.311 1.00 22.04 A ATOM 172 CB SER A 32 45.019 70.734 114.363 1.00 22.43 A ATOM 173 OG SER A 32 44.665 72.032 113.906 1.00 24.69 A ATOM 174 C SER A 32 43.694 71.143 116.453 1.00 22.19 A ATOM 175 O SER A 32 44.441 71.178 117.429 1.00 22.11 A ATOM 176 N THR A 33 42.631 71.933 116.342 1.00 21.38 A ATOM 177 CA THR A 33 42.308 72.911 117.379 1.00 20.69 A ATOM 178 CB THR A 33 42.300 74.343 116.801 1.00 22.44 A ATOM 179 OG1 THR A 33 41.251 74.459 115.834 1.00 22.63 A ATOM 180 CG2 THR A 33 43.635 74.664 116.132 1.00 24.73 A ATOM 181 C THR A 33 40.943 72.663 118.028 1.00 18.62 A ATOM 182 O THR A 33 40.438 73.515 118.754 1.00 18.50 A ATOM 183 N TYR A 34 40.346 71.499 117.787 1.00 16.74 A ATOM 184 CA TYR A 34 39.029 71.226 118.355 1.00 16.94 A ATOM 185 CB TYR A 34 38.451 69.928 117.801 1.00 17.19 A ATOM 186 CG TYR A 34 36.975 69.790 118.083 1.00 17.35 A ATOM 187 CD1 TYR A 34 36.058 70.685 117.526 1.00 17.15 A ATOM 188 CE1 TYR A 34 34.693 70.575 117.788 1.00 19.47 A ATOM 189 CD2 TYR A 34 36.491 68.780 118.911 1.00 16.08 A ATOM 190 CE2 TYR A 34 35.133 68.661 119.183 1.00 17.26 A ATOM 191 CZ TYR A 34 34.237 69.562 118.617 1.00 17.18 A ATOM 192 OH TYR A 34 32.891 69.457 118.893 1.00 16.72 A ATOM 193 C TYR A 34 38.992 71.157 119.874 1.00 17.22 A ATOM 194 O TYR A 34 38.015 71.583 120.490 1.00 18.03 A ATOM 195 N ALA A 35 40.043 70.604 120.474 1.00 17.84 A ATOM 196 CA ALA A 35 40.107 70.489 121.926 1.00 18.20 A ATOM 197 CB ALA A 35 41.448 69.913 122.355 1.00 18.99 A ATOM 198 C ALA A 35 39.904 71.867 122.550 1.00 18.82 A ATOM 199 O ALA A 35 39.091 72.028 123.448 1.00 17.85 A ATOM 200 N ASP A 36 40.653 72.858 122.073 1.00 18.76 A ATOM 201 CA ASP A 36 40.516 74.213 122.604 1.00 19.92 A ATOM 202 CB ASP A 36 41.438 75.190 121.864 1.00 22.24 A ATOM 203 CG ASP A 36 42.903 74.972 122.181 1.00 25.34 A ATOM 204 OD1 ASP A 36 43.217 74.578 123.324 1.00 25.77 A ATOM 205 OD2 ASP A 36 43.745 75.213 121.287 1.00 29.04 A ATOM 206 C ASP A 36 39.078 74.709 122.478 1.00 20.11 A ATOM 207 O ASP A 36 38.477 75.179 123.452 1.00 19.46 A ATOM 208 N TYR A 37 38.538 74.611 121.266 1.00 18.02 A ATOM 209 CA TYR A 37 37.180 75.057 120.991 1.00 17.23 A ATOM 210 CB TYR A 37 36.846 74.817 119.514 1.00 16.64 A ATOM 211 CG TYR A 37 35.399 75.092 119.152 1.00 19.58 A ATOM 212 CD1 TYR A 37 34.945 76.396 118.946 1.00 19.88 A ATOM 213 CE1 TYR A 37 33.615 76.654 118.611 1.00 21.95 A ATOM 214 CD2 TYR A 37 34.482 74.046 119.020 1.00 18.32 A ATOM 215 CE2 TYR A 37 33.153 74.290 118.690 1.00 21.26 A ATOM 216 CZ TYR A 37 32.725 75.598 118.483 1.00 22.45 A ATOM 217 OH TYR A 37 31.417 75.846 118.136 1.00 22.04 A ATOM 218 C TYR A 37 36.158 74.342 121.865 1.00 17.32 A ATOM 219 O TYR A 37 35.352 74.977 122.553 1.00 17.84 A ATOM 220 N TYR A 38 36.198 73.013 121.829 1.00 17.92 A ATOM 221 CA TYR A 38 35.270 72.178 122.585 1.00 17.56 A ATOM 222 CB TYR A 38 35.626 70.702 122.369 1.00 16.77 A ATOM 223 CG TYR A 38 34.755 69.726 123.116 1.00 16.04 A ATOM 224 CD1 TYR A 38 33.436 69.484 122.724 1.00 17.14 A ATOM 225 CE1 TYR A 38 32.635 68.580 123.420 1.00 17.33 A ATOM 226 CD2 TYR A 38 35.251 69.039 124.224 1.00 16.93 A ATOM 227 CE2 TYR A 38 34.466 68.140 124.923 1.00 17.51 A ATOM 228 CZ TYR A 38 33.161 67.913 124.519 1.00 16.76 A ATOM 229 OH TYR A 38 32.398 67.030 125.234 1.00 17.13 A ATOM 230 C TYR A 38 35.248 72.506 124.076 1.00 18.55 A ATOM 231 O TYR A 38 34.185 72.752 124.646 1.00 18.23 A ATOM 232 N PHE A 39 36.412 72.517 124.714 1.00 19.37 A ATOM 233 CA PHE A 39 36.453 72.813 126.143 1.00 19.56 A ATOM 234 CB PHE A 39 37.816 72.429 126.722 1.00 19.04 A ATOM 235 CG PHE A 39 37.907 70.975 127.108 1.00 20.13 A ATOM 236 CD1 PHE A 39 37.759 70.583 128.434 1.00 21.28 A ATOM 237 CD2 PHE A 39 38.075 69.993 126.135 1.00 19.97 A ATOM 238 CE1 PHE A 39 37.774 69.230 128.788 1.00 21.03 A ATOM 239 CE2 PHE A 39 38.091 68.645 126.476 1.00 19.95 A ATOM 240 CZ PHE A 39 37.939 68.262 127.806 1.00 21.19 A ATOM 241 C PHE A 39 36.086 74.255 126.485 1.00 20.19 A ATOM 242 O PHE A 39 35.732 74.553 127.622 1.00 22.34 A ATOM 243 N ARG A 40 36.144 75.143 125.499 1.00 20.54 A ATOM 244 CA ARG A 40 35.773 76.534 125.734 1.00 20.65 A ATOM 245 CB ARG A 40 36.470 77.456 124.726 1.00 19.69 A ATOM 246 CG ARG A 40 36.044 78.918 124.836 1.00 22.28 A ATOM 247 CD ARG A 40 36.875 79.813 123.925 1.00 23.38 A ATOM 248 NE ARG A 40 36.646 79.562 122.503 1.00 23.95 A ATOM 249 CZ ARG A 40 35.519 79.851 121.861 1.00 24.46 A ATOM 250 NH1 ARG A 40 34.507 80.404 122.510 1.00 25.71 A ATOM 251 NH2 ARG A 40 35.403 79.585 120.567 1.00 26.85 A ATOM 252 C ARG A 40 34.257 76.707 125.627 1.00 20.55 A ATOM 253 O ARG A 40 33.620 77.242 126.540 1.00 18.76 A ATOM 254 N VAL A 41 33.674 76.245 124.522 1.00 20.21 A ATOM 255 CA VAL A 41 32.236 76.385 124.338 1.00 21.46 A ATOM 256 CB VAL A 41 31.790 76.005 122.892 1.00 22.92 A ATOM 257 CG1 VAL A 41 32.537 76.875 121.879 1.00 23.74 A ATOM 258 CG2 VAL A 41 32.037 74.524 122.619 1.00 21.78 A ATOM 259 C VAL A 41 31.417 75.599 125.350 1.00 21.29 A ATOM 260 O VAL A 41 30.261 75.928 125.588 1.00 20.77 A ATOM 261 N THR A 42 32.001 74.562 125.949 1.00 21.64 A ATOM 262 CA THR A 42 31.274 73.785 126.951 1.00 22.13 A ATOM 263 CB THR A 42 31.532 72.254 126.828 1.00 21.03 A ATOM 264 OG1 THR A 42 32.914 71.968 127.082 1.00 19.85 A ATOM 265 CG2 THR A 42 31.155 71.758 125.440 1.00 18.84 A ATOM 266 C THR A 42 31.670 74.237 128.360 1.00 24.77 A ATOM 267 O THR A 42 31.365 73.564 129.344 1.00 24.42 A ATOM 268 N ASN A 43 32.357 75.375 128.442 1.00 25.63 A ATOM 269 CA ASN A 43 32.781 75.945 129.722 1.00 27.73 A ATOM 270 CB ASN A 43 31.560 76.502 130.452 1.00 32.42 A ATOM 271 CG ASN A 43 30.721 77.407 129.570 1.00 36.22 A ATOM 272 OD1 ASN A 43 31.175 78.472 129.145 1.00 39.75 A ATOM 273 ND2 ASN A 43 29.492 76.985 129.285 1.00 38.09 A ATOM 274 C ASN A 43 33.494 74.939 130.624 1.00 27.61 A ATOM 275 O ASN A 43 33.232 74.876 131.829 1.00 26.66 A ATOM 276 N SER A 44 34.405 74.168 130.046 1.00 26.69 A ATOM 277 CA SER A 44 35.125 73.152 130.799 1.00 27.90 A ATOM 278 CB SER A 44 34.892 71.781 130.161 1.00 26.68 A ATOM 279 OG SER A 44 33.509 71.489 130.100 1.00 28.08 A ATOM 280 C SER A 44 36.616 73.438 130.870 1.00 28.33 A ATOM 281 O SER A 44 37.422 72.520 130.989 1.00 28.25 A ATOM 282 N GLU A 45 36.973 74.717 130.803 1.00 30.31 A ATOM 283 CA GLU A 45 38.372 75.137 130.855 1.00 32.52 A ATOM 284 CB GLU A 45 38.460 76.666 130.804 1.00 36.20 A ATOM 285 CG GLU A 45 37.862 77.296 129.556 1.00 40.59 A ATOM 286 CD GLU A 45 38.635 76.954 128.297 1.00 43.46 A ATOM 287 OE1 GLU A 45 38.290 77.492 127.224 1.00 44.77 A ATOM 288 OE2 GLU A 45 39.589 76.148 128.378 1.00 46.65 A ATOM 289 C GLU A 45 39.082 74.635 132.109 1.00 31.09 A ATOM 290 O GLU A 45 40.261 74.288 132.069 1.00 32.23 A ATOM 291 N HIS A 46 38.356 74.590 133.220 1.00 30.26 A ATOM 292 CA HIS A 46 38.921 74.148 134.489 1.00 30.21 A ATOM 293 CB HIS A 46 37.915 74.373 135.624 1.00 30.18 A ATOM 294 CG HIS A 46 36.608 73.672 135.423 1.00 31.08 A ATOM 295 CD2 HIS A 46 36.080 72.580 136.025 1.00 31.68 A ATOM 296 ND1 HIS A 46 35.678 74.082 134.491 1.00 31.46 A ATOM 297 CE1 HIS A 46 34.635 73.272 134.527 1.00 31.49 A ATOM 298 NE2 HIS A 46 34.854 72.352 135.450 1.00 31.69 A ATOM 299 C HIS A 46 39.384 72.691 134.505 1.00 29.90 A ATOM 300 O HIS A 46 40.153 72.301 135.383 1.00 28.22 A ATOM 301 N MET A 47 38.920 71.891 133.544 1.00 29.28 A ATOM 302 CA MET A 47 39.307 70.477 133.471 1.00 28.84 A ATOM 303 CB MET A 47 38.214 69.664 132.771 1.00 28.86 A ATOM 304 CG MET A 47 36.808 69.935 133.286 1.00 30.82 A ATOM 305 SD MET A 47 35.578 68.879 132.493 1.00 31.81 A ATOM 306 CE MET A 47 35.684 67.427 133.551 1.00 33.73 A ATOM 307 C MET A 47 40.621 70.327 132.705 1.00 28.88 A ATOM 308 O MET A 47 40.689 69.627 131.693 1.00 27.03 A ATOM 309 N THR A 48 41.665 70.983 133.199 1.00 29.25 A ATOM 310 CA THR A 48 42.974 70.955 132.554 1.00 29.28 A ATOM 311 CB THR A 48 44.045 71.626 133.450 1.00 30.40 A ATOM 312 OG1 THR A 48 44.133 70.932 134.699 1.00 31.38 A ATOM 313 CG2 THR A 48 43.681 73.081 133.710 1.00 31.23 A ATOM 314 C THR A 48 43.485 69.575 132.128 1.00 29.36 A ATOM 315 O THR A 48 43.883 69.394 130.977 1.00 30.13 A ATOM 316 N ASP A 49 43.475 68.603 133.036 1.00 28.72 A ATOM 317 CA ASP A 49 43.974 67.271 132.697 1.00 29.59 A ATOM 318 CB ASP A 49 43.992 66.367 133.928 1.00 33.21 A ATOM 319 CG ASP A 49 44.545 64.985 133.621 1.00 36.83 A ATOM 320 OD1 ASP A 49 45.679 64.903 133.102 1.00 39.96 A ATOM 321 OD2 ASP A 49 43.850 63.981 133.893 1.00 38.97 A ATOM 322 C ASP A 49 43.172 66.588 131.592 1.00 28.05 A ATOM 323 O ASP A 49 43.744 66.023 130.660 1.00 28.22 A ATOM 324 N LEU A 50 41.851 66.637 131.701 1.00 25.60 A ATOM 325 CA LEU A 50 40.991 66.011 130.704 1.00 23.87 A ATOM 326 CB LEU A 50 39.527 66.120 131.131 1.00 21.93 A ATOM 327 CG LEU A 50 38.534 65.261 130.350 1.00 19.98 A ATOM 328 CD1 LEU A 50 38.945 63.789 130.429 1.00 19.09 A ATOM 329 CD2 LEU A 50 37.146 65.460 130.927 1.00 20.31 A ATOM 330 C LEU A 50 41.189 66.662 129.336 1.00 23.68 A ATOM 331 O LEU A 50 41.215 65.976 128.313 1.00 22.19 A ATOM 332 N LYS A 51 41.332 67.985 129.316 1.00 23.84 A ATOM 333 CA LYS A 51 41.532 68.686 128.052 1.00 25.09 A ATOM 334 CB LYS A 51 41.650 70.199 128.283 1.00 25.49 A ATOM 335 CG LYS A 51 41.828 71.005 126.999 1.00 26.33 A ATOM 336 CD LYS A 51 41.886 72.504 127.280 1.00 28.75 A ATOM 337 CE LYS A 51 42.142 73.288 126.007 1.00 29.76 A ATOM 338 NZ LYS A 51 42.144 74.756 126.260 1.00 30.99 A ATOM 339 C LYS A 51 42.785 68.170 127.344 1.00 26.21 A ATOM 340 O LYS A 51 42.782 67.971 126.130 1.00 24.74 A ATOM 341 N LYS A 52 43.856 67.949 128.103 1.00 27.17 A ATOM 342 CA LYS A 52 45.098 67.449 127.516 1.00 28.10 A ATOM 343 CB LYS A 52 46.194 67.352 128.582 1.00 30.83 A ATOM 344 CG LYS A 52 46.591 68.687 129.190 1.00 34.28 A ATOM 345 CD LYS A 52 47.635 68.497 130.279 1.00 37.20 A ATOM 346 CE LYS A 52 47.985 69.816 130.945 1.00 38.95 A ATOM 347 NZ LYS A 52 48.982 69.624 132.030 1.00 41.28 A ATOM 348 C LYS A 52 44.873 66.076 126.888 1.00 26.97 A ATOM 349 O LYS A 52 45.366 65.792 125.797 1.00 26.02 A ATOM 350 N LYS A 53 44.122 65.228 127.583 1.00 26.21 A ATOM 351 CA LYS A 53 43.831 63.892 127.086 1.00 25.04 A ATOM 352 CB LYS A 53 43.067 63.086 128.140 1.00 24.64 A ATOM 353 CG LYS A 53 43.877 62.781 129.392 1.00 28.22 A ATOM 354 CD LYS A 53 43.065 61.990 130.408 1.00 30.66 A ATOM 355 CE LYS A 53 43.880 61.718 131.666 1.00 33.54 A ATOM 356 NZ LYS A 53 43.126 60.909 132.667 1.00 36.02 A ATOM 357 C LYS A 53 43.012 63.962 125.798 1.00 23.42 A ATOM 358 O LYS A 53 43.226 63.173 124.879 1.00 22.62 A ATOM 359 N PHE A 54 42.086 64.915 125.732 1.00 23.36 A ATOM 360 CA PHE A 54 41.237 65.066 124.550 1.00 22.90 A ATOM 361 CB PHE A 54 40.098 66.055 124.820 1.00 22.20 A ATOM 362 CG PHE A 54 39.044 66.072 123.740 1.00 20.84 A ATOM 363 CD1 PHE A 54 38.409 64.897 123.352 1.00 19.63 A ATOM 364 CD2 PHE A 54 38.682 67.260 123.115 1.00 20.10 A ATOM 365 CE1 PHE A 54 37.432 64.905 122.357 1.00 18.43 A ATOM 366 CE2 PHE A 54 37.706 67.276 122.122 1.00 19.37 A ATOM 367 CZ PHE A 54 37.081 66.097 121.742 1.00 18.82 A ATOM 368 C PHE A 54 42.048 65.539 123.354 1.00 23.85 A ATOM 369 O PHE A 54 41.812 65.112 122.219 1.00 23.78 A ATOM 370 N GLN A 55 43.000 66.432 123.603 1.00 24.10 A ATOM 371 CA GLN A 55 43.842 66.930 122.528 1.00 24.91 A ATOM 372 CB GLN A 55 44.832 67.974 123.062 1.00 26.37 A ATOM 373 CG GLN A 55 45.921 68.373 122.072 1.00 28.68 A ATOM 374 CD GLN A 55 45.411 69.175 120.884 1.00 30.30 A ATOM 375 OE1 GLN A 55 46.060 69.228 119.839 1.00 31.71 A ATOM 376 NE2 GLN A 55 44.259 69.820 121.044 1.00 30.29 A ATOM 377 C GLN A 55 44.586 65.725 121.967 1.00 24.46 A ATOM 378 O GLN A 55 44.767 65.601 120.761 1.00 22.48 A ATOM 379 N ARG A 56 44.997 64.828 122.858 1.00 24.95 A ATOM 380 CA ARG A 56 45.719 63.625 122.468 1.00 25.91 A ATOM 381 CB ARG A 56 46.171 62.866 123.720 1.00 29.99 A ATOM 382 CG ARG A 56 47.559 62.249 123.624 1.00 36.86 A ATOM 383 CD ARG A 56 48.647 63.324 123.571 1.00 40.43 A ATOM 384 NE ARG A 56 48.699 64.137 124.787 1.00 44.69 A ATOM 385 CZ ARG A 56 48.992 63.667 125.998 1.00 46.01 A ATOM 386 NH1 ARG A 56 49.263 62.379 126.168 1.00 47.48 A ATOM 387 NH2 ARG A 56 49.015 64.485 127.044 1.00 46.66 A ATOM 388 C ARG A 56 44.804 62.739 121.618 1.00 24.27 A ATOM 389 O ARG A 56 45.215 62.221 120.574 1.00 24.04 A ATOM 390 N ILE A 57 43.565 62.572 122.075 1.00 21.82 A ATOM 391 CA ILE A 57 42.579 61.765 121.367 1.00 20.34 A ATOM 392 CB ILE A 57 41.237 61.729 122.129 1.00 20.57 A ATOM 393 CG2 ILE A 57 40.154 61.093 121.261 1.00 21.54 A ATOM 394 CG1 ILE A 57 41.399 60.948 123.438 1.00 20.21 A ATOM 395 CD1 ILE A 57 40.171 60.973 124.315 1.00 19.50 A ATOM 396 C ILE A 57 42.337 62.329 119.968 1.00 20.51 A ATOM 397 O ILE A 57 42.396 61.599 118.986 1.00 20.89 A ATOM 398 N CYS A 58 42.076 63.630 119.879 1.00 19.30 A ATOM 399 CA CYS A 58 41.823 64.251 118.587 1.00 20.99 A ATOM 400 CB CYS A 58 41.533 65.745 118.759 1.00 19.32 A ATOM 401 SG CYS A 58 39.917 66.082 119.509 1.00 18.88 A ATOM 402 C CYS A 58 42.966 64.047 117.601 1.00 22.44 A ATOM 403 O CYS A 58 42.732 63.850 116.412 1.00 23.07 A ATOM 404 N GLU A 59 44.200 64.077 118.092 1.00 24.02 A ATOM 405 CA GLU A 59 45.363 63.892 117.225 1.00 26.24 A ATOM 406 CB GLU A 59 46.644 64.284 117.972 1.00 28.50 A ATOM 407 CG GLU A 59 46.606 65.706 118.527 1.00 33.23 A ATOM 408 CD GLU A 59 47.855 66.085 119.315 1.00 35.09 A ATOM 409 OE1 GLU A 59 48.343 65.248 120.109 1.00 36.66 A ATOM 410 OE2 GLU A 59 48.338 67.227 119.149 1.00 34.23 A ATOM 411 C GLU A 59 45.455 62.445 116.741 1.00 26.77 A ATOM 412 O GLU A 59 45.872 62.177 115.614 1.00 26.70 A ATOM 413 N ARG A 60 45.046 61.518 117.596 1.00 26.73 A ATOM 414 CA ARG A 60 45.079 60.100 117.264 1.00 28.79 A ATOM 415 CB ARG A 60 44.919 59.274 118.544 1.00 33.01 A ATOM 416 CG ARG A 60 46.132 59.301 119.456 1.00 39.19 A ATOM 417 CD ARG A 60 47.211 58.346 118.956 1.00 45.62 A ATOM 418 NE ARG A 60 47.412 57.224 119.875 1.00 49.49 A ATOM 419 CZ ARG A 60 46.455 56.383 120.261 1.00 51.76 A ATOM 420 NH1 ARG A 60 45.215 56.526 119.809 1.00 52.07 A ATOM 421 NH2 ARG A 60 46.735 55.399 121.109 1.00 53.18 A ATOM 422 C ARG A 60 44.024 59.664 116.240 1.00 25.81 A ATOM 423 O ARG A 60 44.225 58.686 115.524 1.00 23.81 A ATOM 424 N THR A 61 42.911 60.388 116.160 1.00 23.41 A ATOM 425 CA THR A 61 41.834 60.023 115.235 1.00 22.16 A ATOM 426 CB THR A 61 40.629 60.966 115.359 1.00 19.80 A ATOM 427 OG1 THR A 61 41.003 62.269 114.896 1.00 17.03 A ATOM 428 CG2 THR A 61 40.150 61.047 116.802 1.00 20.05 A ATOM 429 C THR A 61 42.237 60.045 113.768 1.00 22.06 A ATOM 430 O THR A 61 41.616 59.382 112.942 1.00 20.90 A ATOM 431 N GLN A 62 43.275 60.814 113.457 1.00 21.51 A ATOM 432 CA GLN A 62 43.749 60.979 112.089 1.00 21.94 A ATOM 433 CB GLN A 62 44.232 59.649 111.503 1.00 24.19 A ATOM 434 CG GLN A 62 45.428 59.093 112.270 1.00 25.12 A ATOM 435 CD GLN A 62 46.325 58.218 111.429 1.00 28.57 A ATOM 436 OE1 GLN A 62 45.857 57.352 110.687 1.00 28.23 A ATOM 437 NE2 GLN A 62 47.633 58.430 111.550 1.00 29.81 A ATOM 438 C GLN A 62 42.654 61.602 111.227 1.00 21.62 A ATOM 439 O GLN A 62 42.545 61.345 110.021 1.00 21.13 A ATOM 440 N ILE A 63 41.829 62.413 111.881 1.00 18.54 A ATOM 441 CA ILE A 63 40.763 63.155 111.220 1.00 16.85 A ATOM 442 CB ILE A 63 39.475 63.188 112.062 1.00 15.18 A ATOM 443 CG2 ILE A 63 38.482 64.153 111.446 1.00 17.26 A ATOM 444 CG1 ILE A 63 38.854 61.793 112.138 1.00 13.24 A ATOM 445 CD1 ILE A 63 37.704 61.705 113.129 1.00 12.22 A ATOM 446 C ILE A 63 41.334 64.572 111.167 1.00 18.36 A ATOM 447 O ILE A 63 41.882 65.053 112.160 1.00 17.80 A ATOM 448 N LYS A 64 41.227 65.231 110.022 1.00 18.39 A ATOM 449 CA LYS A 64 41.757 66.587 109.884 1.00 20.17 A ATOM 450 CB LYS A 64 42.534 66.715 108.568 1.00 21.80 A ATOM 451 CG LYS A 64 43.868 65.976 108.573 1.00 27.09 A ATOM 452 CD LYS A 64 44.813 66.599 109.588 1.00 31.09 A ATOM 453 CE LYS A 64 46.056 65.749 109.806 1.00 33.75 A ATOM 454 NZ LYS A 64 45.731 64.450 110.462 1.00 36.45 A ATOM 455 C LYS A 64 40.661 67.637 109.930 1.00 20.31 A ATOM 456 O LYS A 64 40.845 68.725 110.491 1.00 17.10 A ATOM 457 N ASN A 65 39.520 67.301 109.335 1.00 19.52 A ATOM 458 CA ASN A 65 38.376 68.206 109.273 1.00 19.30 A ATOM 459 CB ASN A 65 38.409 68.985 107.950 1.00 21.83 A ATOM 460 CG ASN A 65 37.084 69.676 107.634 1.00 25.41 A ATOM 461 OD1 ASN A 65 36.120 69.041 107.184 1.00 26.40 A ATOM 462 ND2 ASN A 65 37.031 70.978 107.871 1.00 24.80 A ATOM 463 C ASN A 65 37.056 67.454 109.391 1.00 18.97 A ATOM 464 O ASN A 65 36.943 66.299 108.969 1.00 17.44 A ATOM 465 N ARG A 66 36.069 68.117 109.986 1.00 18.13 A ATOM 466 CA ARG A 66 34.733 67.553 110.146 1.00 16.96 A ATOM 467 CB ARG A 66 34.529 67.023 111.566 1.00 16.26 A ATOM 468 CG ARG A 66 35.173 65.679 111.852 1.00 16.61 A ATOM 469 CD ARG A 66 34.738 65.183 113.224 1.00 16.24 A ATOM 470 NE ARG A 66 35.405 65.920 114.289 1.00 15.56 A ATOM 471 CZ ARG A 66 34.992 65.947 115.550 1.00 17.32 A ATOM 472 NH1 ARG A 66 33.901 65.287 115.908 1.00 17.58 A ATOM 473 NH2 ARG A 66 35.685 66.616 116.465 1.00 17.79 A ATOM 474 C ARG A 66 33.701 68.637 109.880 1.00 17.04 A ATOM 475 O ARG A 66 33.912 69.796 110.237 1.00 17.53 A ATOM 476 N HIS A 67 32.602 68.277 109.228 1.00 15.73 A ATOM 477 CA HIS A 67 31.546 69.245 108.984 1.00 17.68 A ATOM 478 CB HIS A 67 30.864 68.997 107.635 1.00 18.72 A ATOM 479 CG HIS A 67 31.713 69.348 106.454 1.00 21.98 A ATOM 480 CD2 HIS A 67 31.716 70.441 105.653 1.00 20.76 A ATOM 481 ND1 HIS A 67 32.714 68.527 105.982 1.00 21.72 A ATOM 482 CE1 HIS A 67 33.295 69.097 104.941 1.00 21.39 A ATOM 483 NE2 HIS A 67 32.707 70.259 104.721 1.00 23.60 A ATOM 484 C HIS A 67 30.540 69.069 110.118 1.00 18.33 A ATOM 485 O HIS A 67 30.176 67.941 110.464 1.00 17.18 A ATOM 486 N MET A 68 30.117 70.178 110.713 1.00 16.86 A ATOM 487 CA MET A 68 29.163 70.124 111.807 1.00 20.49 A ATOM 488 CB MET A 68 29.893 70.228 113.155 1.00 23.32 A ATOM 489 CG MET A 68 30.914 69.116 113.386 1.00 28.72 A ATOM 490 SD MET A 68 31.545 69.023 115.086 1.00 37.96 A ATOM 491 CE MET A 68 31.064 67.331 115.520 1.00 34.14 A ATOM 492 C MET A 68 28.106 71.213 111.710 1.00 19.55 A ATOM 493 O MET A 68 28.424 72.397 111.603 1.00 19.23 A ATOM 494 N TYR A 69 26.844 70.800 111.736 1.00 19.71 A ATOM 495 CA TYR A 69 25.733 71.738 111.685 1.00 20.15 A ATOM 496 CB TYR A 69 24.401 70.981 111.659 1.00 20.47 A ATOM 497 CG TYR A 69 23.253 71.748 112.277 1.00 20.28 A ATOM 498 CD1 TYR A 69 22.713 72.874 111.650 1.00 22.00 A ATOM 499 CE1 TYR A 69 21.668 73.595 112.239 1.00 22.79 A ATOM 500 CD2 TYR A 69 22.723 71.363 113.502 1.00 20.81 A ATOM 501 CE2 TYR A 69 21.688 72.069 114.094 1.00 21.13 A ATOM 502 CZ TYR A 69 21.163 73.184 113.461 1.00 22.53 A ATOM 503 OH TYR A 69 20.136 73.877 114.063 1.00 22.91 A ATOM 504 C TYR A 69 25.789 72.632 112.918 1.00 19.58 A ATOM 505 O TYR A 69 25.474 73.820 112.853 1.00 18.63 A ATOM 506 N LEU A 70 26.195 72.052 114.044 1.00 17.07 A ATOM 507 CA LEU A 70 26.286 72.799 115.290 1.00 18.70 A ATOM 508 CB LEU A 70 26.548 71.846 116.466 1.00 16.86 A ATOM 509 CG LEU A 70 25.399 70.921 116.867 1.00 17.66 A ATOM 510 CD1 LEU A 70 25.866 69.928 117.930 1.00 17.33 A ATOM 511 CD2 LEU A 70 24.229 71.755 117.384 1.00 16.30 A ATOM 512 C LEU A 70 27.387 73.842 115.230 1.00 19.34 A ATOM 513 O LEU A 70 28.546 73.515 114.963 1.00 19.14 A ATOM 514 N THR A 71 27.017 75.094 115.483 1.00 19.06 A ATOM 515 CA THR A 71 27.965 76.198 115.478 1.00 19.11 A ATOM 516 CB THR A 71 27.529 77.305 114.514 1.00 20.64 A ATOM 517 OG1 THR A 71 26.319 77.892 114.997 1.00 18.72 A ATOM 518 CG2 THR A 71 27.288 76.737 113.123 1.00 21.99 A ATOM 519 C THR A 71 28.023 76.794 116.878 1.00 19.23 A ATOM 520 O THR A 71 27.180 76.500 117.727 1.00 17.80 A ATOM 521 N GLU A 72 29.015 77.644 117.118 1.00 19.93 A ATOM 522 CA GLU A 72 29.164 78.269 118.425 1.00 21.10 A ATOM 523 CB GLU A 72 30.386 79.196 118.431 1.00 22.65 A ATOM 524 CG GLU A 72 30.715 79.745 119.814 1.00 25.51 A ATOM 525 CD GLU A 72 32.066 80.436 119.887 1.00 26.76 A ATOM 526 OE1 GLU A 72 32.356 81.053 120.939 1.00 29.43 A ATOM 527 OE2 GLU A 72 32.835 80.361 118.908 1.00 25.78 A ATOM 528 C GLU A 72 27.908 79.049 118.806 1.00 21.16 A ATOM 529 O GLU A 72 27.479 79.035 119.965 1.00 19.47 A ATOM 530 N GLU A 73 27.315 79.727 117.830 1.00 22.57 A ATOM 531 CA GLU A 73 26.108 80.506 118.082 1.00 23.75 A ATOM 532 CB GLU A 73 25.756 81.340 116.849 1.00 28.49 A ATOM 533 CG GLU A 73 26.548 82.651 116.717 1.00 35.51 A ATOM 534 CD GLU A 73 27.929 82.617 117.382 1.00 41.12 A ATOM 535 OE1 GLU A 73 27.995 82.619 118.635 1.00 43.42 A ATOM 536 OE2 GLU A 73 28.950 82.594 116.656 1.00 44.19 A ATOM 537 C GLU A 73 24.947 79.594 118.466 1.00 21.96 A ATOM 538 O GLU A 73 24.190 79.895 119.390 1.00 20.37 A ATOM 539 N ILE A 74 24.810 78.470 117.770 1.00 19.89 A ATOM 540 CA ILE A 74 23.738 77.535 118.089 1.00 18.76 A ATOM 541 CB ILE A 74 23.659 76.390 117.043 1.00 18.90 A ATOM 542 CG2 ILE A 74 22.714 75.295 117.521 1.00 16.71 A ATOM 543 CG1 ILE A 74 23.170 76.954 115.705 1.00 20.30 A ATOM 544 CD1 ILE A 74 23.046 75.924 114.596 1.00 18.88 A ATOM 545 C ILE A 74 23.964 76.960 119.493 1.00 18.52 A ATOM 546 O ILE A 74 23.041 76.895 120.306 1.00 20.62 A ATOM 547 N LEU A 75 25.193 76.561 119.788 1.00 18.16 A ATOM 548 CA LEU A 75 25.498 76.010 121.104 1.00 17.27 A ATOM 549 CB LEU A 75 26.954 75.553 121.153 1.00 17.79 A ATOM 550 CG LEU A 75 27.280 74.382 120.222 1.00 14.50 A ATOM 551 CD1 LEU A 75 28.761 74.033 120.299 1.00 15.68 A ATOM 552 CD2 LEU A 75 26.416 73.189 120.613 1.00 18.83 A ATOM 553 C LEU A 75 25.225 77.028 122.212 1.00 19.75 A ATOM 554 O LEU A 75 24.815 76.666 123.318 1.00 18.99 A ATOM 555 N LYS A 76 25.441 78.303 121.906 1.00 20.65 A ATOM 556 CA LYS A 76 25.212 79.369 122.874 1.00 23.67 A ATOM 557 CB LYS A 76 25.660 80.713 122.294 1.00 25.80 A ATOM 558 CG LYS A 76 25.558 81.874 123.277 1.00 31.54 A ATOM 559 CD LYS A 76 25.830 83.205 122.590 1.00 34.91 A ATOM 560 CE LYS A 76 25.581 84.377 123.528 1.00 36.18 A ATOM 561 NZ LYS A 76 25.622 85.681 122.801 1.00 39.35 A ATOM 562 C LYS A 76 23.734 79.434 123.251 1.00 23.97 A ATOM 563 O LYS A 76 23.389 79.720 124.395 1.00 23.57 A ATOM 564 N GLU A 77 22.865 79.152 122.283 1.00 23.60 A ATOM 565 CA GLU A 77 21.424 79.182 122.516 1.00 25.27 A ATOM 566 CB GLU A 77 20.668 79.378 121.197 1.00 27.47 A ATOM 567 CG GLU A 77 21.266 80.405 120.247 1.00 34.00 A ATOM 568 CD GLU A 77 21.546 81.740 120.909 1.00 36.99 A ATOM 569 OE1 GLU A 77 20.633 82.284 121.566 1.00 40.32 A ATOM 570 OE2 GLU A 77 22.679 82.250 120.764 1.00 40.16 A ATOM 571 C GLU A 77 20.941 77.886 123.161 1.00 24.62 A ATOM 572 O GLU A 77 19.773 77.770 123.521 1.00 24.54 A ATOM 573 N ASN A 78 21.838 76.913 123.307 1.00 22.72 A ATOM 574 CA ASN A 78 21.468 75.627 123.884 1.00 22.16 A ATOM 575 CB ASN A 78 21.406 74.571 122.782 1.00 20.72 A ATOM 576 CG ASN A 78 20.246 74.789 121.843 1.00 21.61 A ATOM 577 OD1 ASN A 78 19.115 74.375 122.123 1.00 19.12 A ATOM 578 ND2 ASN A 78 20.512 75.457 120.724 1.00 18.54 A ATOM 579 C ASN A 78 22.402 75.146 124.984 1.00 22.23 A ATOM 580 O ASN A 78 23.104 74.149 124.820 1.00 22.58 A ATOM 581 N PRO A 79 22.412 75.844 126.130 1.00 21.67 A ATOM 582 CD PRO A 79 21.562 76.985 126.514 1.00 21.10 A ATOM 583 CA PRO A 79 23.283 75.441 127.237 1.00 21.96 A ATOM 584 CB PRO A 79 22.958 76.465 128.327 1.00 22.78 A ATOM 585 CG PRO A 79 21.530 76.853 128.023 1.00 23.42 A ATOM 586 C PRO A 79 23.036 74.000 127.689 1.00 22.12 A ATOM 587 O PRO A 79 23.959 73.316 128.119 1.00 20.55 A ATOM 588 N ASN A 80 21.793 73.537 127.594 1.00 21.11 A ATOM 589 CA ASN A 80 21.489 72.173 128.006 1.00 22.35 A ATOM 590 CB ASN A 80 19.982 71.931 128.012 1.00 24.80 A ATOM 591 CG ASN A 80 19.266 72.794 129.026 1.00 27.03 A ATOM 592 OD1 ASN A 80 19.790 73.058 130.109 1.00 27.86 A ATOM 593 ND2 ASN A 80 18.060 73.233 128.687 1.00 30.50 A ATOM 594 C ASN A 80 22.184 71.144 127.118 1.00 22.01 A ATOM 595 O ASN A 80 22.410 70.009 127.536 1.00 21.27 A ATOM 596 N MET A 81 22.530 71.541 125.898 1.00 20.53 A ATOM 597 CA MET A 81 23.221 70.635 124.986 1.00 21.23 A ATOM 598 CB MET A 81 22.919 70.996 123.523 1.00 20.11 A ATOM 599 CG MET A 81 21.541 70.549 123.044 1.00 17.66 A ATOM 600 SD MET A 81 21.145 71.070 121.348 1.00 20.66 A ATOM 601 CE MET A 81 22.478 70.287 120.420 1.00 19.72 A ATOM 602 C MET A 81 24.728 70.677 125.235 1.00 20.83 A ATOM 603 O MET A 81 25.447 69.745 124.884 1.00 19.87 A ATOM 604 N CYS A 82 25.203 71.758 125.850 1.00 20.43 A ATOM 605 CA CYS A 82 26.625 71.890 126.140 1.00 20.36 A ATOM 606 CB CYS A 82 27.016 73.365 126.252 1.00 19.40 A ATOM 607 SG CYS A 82 26.921 74.261 124.692 1.00 22.96 A ATOM 608 C CYS A 82 26.971 71.159 127.428 1.00 19.46 A ATOM 609 O CYS A 82 28.126 70.807 127.664 1.00 21.85 A ATOM 610 N ALA A 83 25.963 70.932 128.261 1.00 19.79 A ATOM 611 CA ALA A 83 26.167 70.232 129.518 1.00 19.82 A ATOM 612 CB ALA A 83 24.960 70.417 130.414 1.00 20.37 A ATOM 613 C ALA A 83 26.361 68.756 129.207 1.00 21.03 A ATOM 614 O ALA A 83 25.891 68.272 128.175 1.00 18.48 A ATOM 615 N TYR A 84 27.053 68.043 130.091 1.00 20.86 A ATOM 616 CA TYR A 84 27.269 66.615 129.883 1.00 21.75 A ATOM 617 CB TYR A 84 28.207 66.045 130.946 1.00 20.13 A ATOM 618 CG TYR A 84 28.198 64.531 130.988 1.00 20.20 A ATOM 619 CD1 TYR A 84 28.805 63.782 129.986 1.00 19.11 A ATOM 620 CE1 TYR A 84 28.762 62.387 130.008 1.00 21.15 A ATOM 621 CD2 TYR A 84 27.547 63.850 132.017 1.00 19.79 A ATOM 622 CE2 TYR A 84 27.495 62.468 132.047 1.00 23.38 A ATOM 623 CZ TYR A 84 28.101 61.740 131.044 1.00 21.82 A ATOM 624 OH TYR A 84 28.027 60.369 131.072 1.00 22.42 A ATOM 625 C TYR A 84 25.936 65.885 129.969 1.00 22.94 A ATOM 626 O TYR A 84 25.678 64.949 129.212 1.00 24.58 A ATOM 627 N LYS A 85 25.091 66.329 130.895 1.00 24.59 A ATOM 628 CA LYS A 85 23.786 65.715 131.116 1.00 27.30 A ATOM 629 CB LYS A 85 23.937 64.572 132.128 1.00 28.97 A ATOM 630 CG LYS A 85 22.680 64.203 132.905 1.00 33.37 A ATOM 631 CD LYS A 85 23.016 63.202 134.011 1.00 35.36 A ATOM 632 CE LYS A 85 21.856 63.001 134.975 1.00 36.29 A ATOM 633 NZ LYS A 85 20.630 62.504 134.289 1.00 37.50 A ATOM 634 C LYS A 85 22.743 66.717 131.613 1.00 26.53 A ATOM 635 O LYS A 85 22.744 67.089 132.786 1.00 28.76 A ATOM 636 N ALA A 86 21.862 67.150 130.713 1.00 23.82 A ATOM 637 CA ALA A 86 20.789 68.089 131.040 1.00 21.57 A ATOM 638 CB ALA A 86 21.283 69.519 130.892 1.00 20.90 A ATOM 639 C ALA A 86 19.638 67.823 130.065 1.00 21.98 A ATOM 640 O ALA A 86 19.885 67.469 128.913 1.00 20.68 A ATOM 641 N PRO A 87 18.374 67.982 130.513 1.00 23.00 A ATOM 642 CD PRO A 87 17.985 68.429 131.864 1.00 25.15 A ATOM 643 CA PRO A 87 17.179 67.756 129.682 1.00 23.11 A ATOM 644 CB PRO A 87 16.046 68.277 130.561 1.00 25.66 A ATOM 645 CG PRO A 87 16.553 67.972 131.951 1.00 26.07 A ATOM 646 C PRO A 87 17.290 68.510 128.368 1.00 23.09 A ATOM 647 O PRO A 87 17.312 69.741 128.363 1.00 20.97 A ATOM 648 N SER A 88 17.342 67.780 127.253 1.00 19.74 A ATOM 649 CA SER A 88 17.517 68.434 125.962 1.00 16.92 A ATOM 650 CB SER A 88 18.992 68.805 125.804 1.00 16.86 A ATOM 651 OG SER A 88 19.797 67.642 125.909 1.00 14.70 A ATOM 652 C SER A 88 17.095 67.626 124.737 1.00 17.40 A ATOM 653 O SER A 88 17.387 68.027 123.613 1.00 17.18 A ATOM 654 N LEU A 89 16.419 66.499 124.931 1.00 16.77 A ATOM 655 CA LEU A 89 16.011 65.691 123.786 1.00 18.16 A ATOM 656 CB LEU A 89 15.315 64.408 124.245 1.00 19.74 A ATOM 657 CG LEU A 89 14.896 63.525 123.066 1.00 20.68 A ATOM 658 CD1 LEU A 89 16.117 62.910 122.420 1.00 20.92 A ATOM 659 CD2 LEU A 89 13.971 62.457 123.551 1.00 22.54 A ATOM 660 C LEU A 89 15.107 66.441 122.808 1.00 17.08 A ATOM 661 O LEU A 89 15.295 66.344 121.598 1.00 18.35 A ATOM 662 N ASP A 90 14.135 67.191 123.320 1.00 17.39 A ATOM 663 CA ASP A 90 13.222 67.943 122.453 1.00 16.14 A ATOM 664 CB ASP A 90 12.218 68.737 123.294 1.00 19.36 A ATOM 665 CG ASP A 90 11.162 67.858 123.942 1.00 20.42 A ATOM 666 OD1 ASP A 90 10.253 68.421 124.581 1.00 22.07 A ATOM 667 OD2 ASP A 90 11.234 66.612 123.821 1.00 21.79 A ATOM 668 C ASP A 90 13.959 68.906 121.511 1.00 17.32 A ATOM 669 O ASP A 90 13.725 68.920 120.291 1.00 14.74 A ATOM 670 N ALA A 91 14.833 69.729 122.078 1.00 15.85 A ATOM 671 CA ALA A 91 15.593 70.679 121.273 1.00 16.35 A ATOM 672 CB ALA A 91 16.476 71.533 122.175 1.00 16.94 A ATOM 673 C ALA A 91 16.449 69.951 120.235 1.00 16.25 A ATOM 674 O ALA A 91 16.524 70.369 119.076 1.00 13.95 A ATOM 675 N ARG A 92 17.085 68.855 120.647 1.00 14.79 A ATOM 676 CA ARG A 92 17.937 68.091 119.739 1.00 14.64 A ATOM 677 CB ARG A 92 18.672 66.981 120.499 1.00 14.18 A ATOM 678 CG ARG A 92 19.654 67.461 121.572 1.00 13.74 A ATOM 679 CD ARG A 92. 20.045 66.282 122.463 1.00 13.80 A ATOM 680 NE ARG A 92 20.992 66.630 123.523 1.00 13.20 A ATOM 681 CZ ARG A 92 22.310 66.719 123.359 1.00 13.36 A ATOM 682 NH1 ARG A 92 22.858 66.491 122.171 1.00 12.28 A ATOM 683 NH2 ARG A 92 23.087 67.010 124.398 1.00 15.07 A ATOM 684 C ARG A 92 17.130 67.475 118.598 1.00 14.35 A ATOM 685 O ARG A 92 17.492 67.605 117.432 1.00 13.62 A ATOM 686 N GLU A 93 16.037 66.803 118.939 1.00 14.60 A ATOM 687 CA GLU A 93 15.192 66.178 117.925 1.00 15.88 A ATOM 688 CB GLU A 93 14.073 65.379 118.597 1.00 16.99 A ATOM 689 CG GLU A 93 14.580 64.128 119.313 1.00 20.99 A ATOM 690 CD GLU A 93 15.046 63.032 118.348 1.00 23.76 A ATOM 691 OE1 GLU A 93 16.010 62.305 118.675 1.00 23.78 A ATOM 692 OE2 GLU A 93 14.442 62.889 117.267 1.00 26.26 A ATOM 693 C GLU A 93 14.614 67.214 116.966 1.00 15.22 A ATOM 694 O GLU A 93 14.458 66.947 115.776 1.00 15.96 A ATOM 695 N ASP A 94 14.309 68.406 117.465 1.00 15.22 A ATOM 696 CA ASP A 94 13.777 69.430 116.576 1.00 14.70 A ATOM 697 CB ASP A 94 13.340 70.673 117.360 1.00 17.50 A ATOM 698 CG ASP A 94 12.052 70.448 118.151 1.00 21.10 A ATOM 699 OD1 ASP A 94 11.253 69.564 117.768 1.00 23.41 A ATOM 700 OD2 ASP A 94 11.826 71.167 119.150 1.00 23.08 A ATOM 701 C ASP A 94 14.829 69.801 115.530 1.00 15.14 A ATOM 702 O ASP A 94 14.501 70.018 114.364 1.00 14.99 A ATOM 703 N MET A 95 16.094 69.860 115.944 1.00 16.52 A ATOM 704 CA MET A 95 17.183 70.187 115.031 1.00 13.82 A ATOM 705 CB MET A 95 18.507 70.321 115.789 1.00 14.37 A ATOM 706 CG MET A 95 18.598 71.520 116.725 1.00 15.94 A ATOM 707 SD MET A 95 20.178 71.517 117.624 1.00 19.13 A ATOM 708 CE MET A 95 20.074 73.098 118.500 1.00 19.01 A ATOM 709 C MET A 95 17.316 69.071 114.003 1.00 15.95 A ATOM 710 O MET A 95 17.440 69.324 112.806 1.00 15.19 A ATOM 711 N MET A 96 17.313 67.833 114.490 1.00 14.58 A ATOM 712 CA MET A 96 17.428 66.670 113.618 1.00 14.52 A ATOM 713 CB MET A 96 17.341 65.376 114.447 1.00 13.66 A ATOM 714 CG MET A 96 18.498 65.155 115.417 1.00 15.74 A ATOM 715 SD MET A 96 20.095 64.978 114.615 1.00 18.80 A ATOM 716 CE MET A 96 20.010 63.239 114.121 1.00 15.04 A ATOM 717 C MET A 96 16.328 66.673 112.554 1.00 14.12 A ATOM 718 O MET A 96 16.609 66.556 111.366 1.00 17.99 A ATOM 719 N ILE A 97 15.079 66.806 112.983 1.00 14.93 A ATOM 720 CA ILE A 97 13.944 66.804 112.058 1.00 15.15 A ATOM 721 CB ILE A 97 12.615 66.959 112.835 1.00 15.85 A ATOM 722 CG2 ILE A 97 11.431 67.096 111.861 1.00 17.38 A ATOM 723 CG1 ILE A 97 12.405 65.737 113.735 1.00 13.08 A ATOM 724 CD1 ILE A 97 11.277 65.901 114.736 1.00 14.10 A ATOM 725 C ILE A 97 14.062 67.891 110.984 1.00 16.23 A ATOM 726 O ILE A 97 13.664 67.694 109.829 1.00 15.33 A ATOM 727 N ARG A 98 14.624 69.033 111.356 1.00 15.97 A ATOM 728 CA ARG A 98 14.796 70.123 110.400 1.00 18.43 A ATOM 729 CB ARG A 98 15.015 71.435 111.150 1.00 19.15 A ATOM 730 CG ARG A 98 15.092 72.667 110.267 1.00 24.01 A ATOM 731 CD ARG A 98 15.425 73.900 111.093 1.00 25.52 A ATOM 732 NE ARG A 98 14.794 73.866 112.412 1.00 27.90 A ATOM 733 CZ ARG A 98 15.447 73.645 113.548 1.00 27.71 A ATOM 734 NH1 ARG A 98 16.758 73.437 113.529 1.00 33.63 A ATOM 735 NH2 ARG A 98 14.793 73.635 114.704 1.00 31.02 A ATOM 736 C ARG A 98 15.979 69.889 109.456 1.00 17.85 A ATOM 737 O ARG A 98 15.850 69.980 108.230 1.00 16.62 A ATOM 738 N GLU A 99 17.127 69.561 110.034 1.00 16.61 A ATOM 739 CA GLU A 99 18.352 69.379 109.267 1.00 16.47 A ATOM 740 CB GLU A 99 19.543 69.659 110.181 1.00 17.68 A ATOM 741 CG GLU A 99 19.471 71.041 110.816 1.00 19.11 A ATOM 742 CD GLU A 99 19.564 72.152 109.786 1.00 21.20 A ATOM 743 OE1 GLU A 99 19.074 73.271 110.061 1.00 23.07 A ATOM 744 OE2 GLU A 99 20.139 71.904 108.705 1.00 21.85 A ATOM 745 C GLU A 99 18.598 68.083 108.514 1.00 16.27 A ATOM 746 O GLU A 99 19.213 68.098 107.449 1.00 16.09 A ATOM 747 N VAL A 100 18.141 66.962 109.053 1.00 15.95 A ATOM 748 CA VAL A 100 18.379 65.681 108.402 1.00 16.57 A ATOM 749 CB VAL A 100 17.809 64.528 109.258 1.00 18.24 A ATOM 750 CG1 VAL A 100 17.921 63.197 108.521 1.00 20.43 A ATOM 751 CG2 VAL A 100 18.591 64.453 110.562 1.00 19.88 A ATOM 752 C VAL A 100 17.827 65.644 106.980 1.00 16.27 A ATOM 753 O VAL A 100 18.548 65.308 106.041 1.00 14.58 A ATOM 754 N PRO A 101 16.549 66.013 106.792 1.00 18.57 A ATOM 755 CD PRO A 101 15.480 66.240 107.782 1.00 20.19 A ATOM 756 CA PRO A 101 16.013 65.983 105.425 1.00 18.96 A ATOM 757 CB PRO A 101 14.503 66.063 105.646 1.00 20.79 A ATOM 758 CG PRO A 101 14.379 66.821 106.941 1.00 21.86 A ATOM 759 C PRO A 101 16.540 67.100 104.522 1.00 17.94 A ATOM 760 O PRO A 101 16.618 66.945 103.308 1.00 18.12 A ATOM 761 N ARG A 102 16.910 68.222 105.122 1.00 18.08 A ATOM 762 CA ARG A 102 17.411 69.361 104.365 1.00 19.16 A ATOM 763 CB ARG A 102 17.530 70.555 105.314 1.00 22.01 A ATOM 764 CG ARG A 102 18.080 71.815 104.712 1.00 26.94 A ATOM 765 CD ARG A 102 17.796 72.989 105.634 1.00 28.29 A ATOM 766 NE ARG A 102 18.545 74.166 105.225 1.00 30.92 A ATOM 767 CZ ARG A 102 19.826 74.361 105.506 1.00 32.08 A ATOM 768 NH1 ARG A 102 20.496 73.459 106.210 1.00 31.02 A ATOM 769 NH2 ARG A 102 20.441 75.449 105.059 1.00 33.44 A ATOM 770 C ARG A 102 18.741 69.055 103.664 1.00 18.26 A ATOM 771 O ARG A 102 18.887 69.286 102.464 1.00 18.02 A ATOM 772 N VAL A 103 19.705 68.517 104.402 1.00 15.63 A ATOM 773 CA VAL A 103 20.999 68.175 103.817 1.00 16.43 A ATOM 774 CB VAL A 103 22.037 67.828 104.907 1.00 16.44 A ATOM 775 CG1 VAL A 103 23.378 67.471 104.263 1.00 17.24 A ATOM 776 CG2 VAL A 103 22.194 69.011 105.856 1.00 19.29 A ATOM 777 C VAL A 103 20.795 66.967 102.911 1.00 15.93 A ATOM 778 O VAL A 103 21.452 66.834 101.881 1.00 14.17 A ATOM 779 N GLY A 104 19.871 66.094 103.302 1.00 16.69 A ATOM 780 CA GLY A 104 19.580 64.918 102.499 1.00 14.99 A ATOM 781 C GLY A 104 19.068 65.333 101.126 1.00 16.35 A ATOM 782 O GLY A 104 19.437 64.745 100.112 1.00 17.10 A ATOM 783 N LYS A 105 18.221 66.356 101.084 1.00 16.15 A ATOM 784 CA LYS A 105 17.702 66.820 99.803 1.00 17.34 A ATOM 785 CB LYS A 105 16.675 67.936 99.990 1.00 17.80 A ATOM 786 CG LYS A 105 16.189 68.486 98.653 1.00 21.22 A ATOM 787 CD LYS A 105 15.789 69.941 98.756 1.00 25.56 A ATOM 788 CE LYS A 105 15.600 70.553 97.374 1.00 28.16 A ATOM 789 NZ LYS A 105 16.888 70.618 96.620 1.00 29.98 A ATOM 790 C LYS A 105 18.818 67.336 98.902 1.00 16.20 A ATOM 791 O LYS A 105 18.807 67.091 97.700 1.00 17.34 A ATOM 792 N GLU A 106 19.773 68.062 99.477 1.00 16.91 A ATOM 793 CA GLU A 106 20.881 68.598 98.696 1.00 19.15 A ATOM 794 CB GLU A 106 21.835 69.387 99.600 1.00 20.83 A ATOM 795 CG GLU A 106 23.047 69.922 98.862 1.00 25.52 A ATOM 796 CD GLU A 106 23.920 70.828 99.716 1.00 26.98 A ATOM 797 OE1 GLU A 106 25.035 71.164 99.260 1.00 27.30 A ATOM 798 OE2 GLU A 106 23.495 71.204 100.832 1.00 27.96 A ATOM 799 C GLU A 106 21.629 67.450 98.016 1.00 18.67 A ATOM 800 O GLU A 106 21.938 67.504 96.817 1.00 16.99 A ATOM 801 N ALA A 107 21.907 66.401 98.783 1.00 15.83 A ATOM 802 CA ALA A 107 22.610 65.244 98.243 1.00 15.27 A ATOM 803 CB ALA A 107 22.928 64.251 99.359 1.00 14.32 A ATOM 804 C ALA A 107 21.778 64.556 97.162 1.00 13.90 A ATOM 805 O ALA A 107 22.299 64.189 96.105 1.00 13.71 A ATOM 806 N ALA A 108 20.488 64.380 97.431 1.00 14.03 A ATOM 807 CA ALA A 108 19.599 63.720 96.477 1.00 15.72 A ATOM 808 CB ALA A 108 18.219 63.519 97.091 1.00 15.61 A ATOM 809 C ALA A 108 19.480 64.494 95.175 1.00 16.95 A ATOM 810 O ALA A 108 19.442 63.899 94.098 1.00 16.28 A ATOM 811 N THR A 109 19.412 65.820 95.269 1.00 15.93 A ATOM 812 CA THR A 109 19.309 66.642 94.071 1.00 17.23 A ATOM 813 CB THR A 109 19.206 68.148 94.432 1.00 17.73 A ATOM 814 OG1 THR A 109 17.994 68.381 95.160 1.00 16.64 A ATOM 815 CG2 THR A 109 19.207 69.004 93.176 1.00 21.91 A ATOM 816 C THR A 109 20.538 66.396 93.192 1.00 16.50 A ATOM 817 O THR A 109 20.430 66.291 91.969 1.00 15.20 A ATOM 818 N LYS A 110 21.707 66.286 93.817 1.00 15.38 A ATOM 819 CA LYS A 110 22.940 66.048 93.074 1.00 15.76 A ATOM 820 CB LYS A 110 24.149 66.168 94.002 1.00 16.69 A ATOM 821 CG LYS A 110 24.428 67.571 94.486 1.00 19.70 A ATOM 822 CD LYS A 110 25.648 67.563 95.384 1.00 20.65 A ATOM 823 CE LYS A 110 25.940 68.937 95.931 1.00 22.93 A ATOM 824 NZ LYS A 110 27.124 68.891 96.839 1.00 21.69 A ATOM 825 C LYS A 110 22.957 64.672 92.401 1.00 13.93 A ATOM 826 O LYS A 110 23.397 64.530 91.257 1.00 13.99 A ATOM 827 N ALA A 111 22.482 63.659 93.115 1.00 15.58 A ATOM 828 CA ALA A 111 22.449 62.306 92.561 1.00 14.44 A ATOM 829 CB ALA A 111 22.046 61.318 93.640 1.00 14.66 A ATOM 830 C ALA A 111 21.466 62.245 91.387 1.00 15.71 A ATOM 831 O ALA A 111 21.762 61.673 90.338 1.00 14.80 A ATOM 832 N ILE A 112 20.297 62.851 91.560 1.00 16.78 A ATOM 833 CA ILE A 112 19.298 62.851 90.499 1.00 17.55 A ATOM 834 CB ILE A 112 17.973 63.474 90.993 1.00 17.59 A ATOM 835 CG2 ILE A 112 16.986 63.620 89.837 1.00 17.13 A ATOM 836 CG1 ILE A 112 17.386 62.580 92.092 1.00 20.85 A ATOM 837 CD1 ILE A 112 16.066 63.064 92.660 1.00 22.77 A ATOM 838 C ILE A 112 19.828 63.586 89.268 1.00 18.57 A ATOM 839 O ILE A 112 19.568 63.179 88.139 1.00 16.83 A ATOM 840 N LYS A 113 20.594 64.651 89.484 1.00 19.85 A ATOM 841 CA LYS A 113 21.177 65.401 88.375 1.00 21.93 A ATOM 842 CB LYS A 113 21.924 66.633 88.894 1.00 24.29 A ATOM 843 CG LYS A 113 22.557 67.478 87.785 1.00 26.16 A ATOM 844 CD LYS A 113 23.249 68.717 88.343 1.00 30.15 A ATOM 845 CE LYS A 113 23.865 69.549 87.227 1.00 32.17 A ATOM 846 NZ LYS A 113 22.832 69.994 86.246 1.00 33.78 A ATOM 847 C LYS A 113 22.141 64.515 87.576 1.00 22.24 A ATOM 848 O LYS A 113 22.113 64.514 86.346 1.00 20.23 A ATOM 849 N GLU A 114 22.994 63.763 88.274 1.00 20.31 A ATOM 850 CA GLU A 114 23.941 62.872 87.603 1.00 20.76 A ATOM 851 CB GLU A 114 24.858 62.174 88.615 1.00 20.34 A ATOM 852 CG GLU A 114 25.945 61.318 87.961 1.00 22.36 A ATOM 853 CD GLU A 114 26.594 60.333 88.922 1.00 25.31 A ATOM 854 OE1 GLU A 114 26.524 60.562 90.148 1.00 23.40 A ATOM 855 OE2 GLU A 114 27.188 59.335 88.449 1.00 27.34 A ATOM 856 C GLU A 114 23.192 61.797 86.825 1.00 20.63 A ATOM 857 O GLU A 114 23.520 61.506 85.677 1.00 20.09 A ATOM 858 N TRP A 115 22.197 61.206 87.483 1.00 19.11 A ATOM 859 CA TRP A 115 21.373 60.148 86.912 1.00 19.80 A ATOM 860 CB TRP A 115 20.271 59.788 87.909 1.00 16.70 A ATOM 861 CG TRP A 115 19.386 58.655 87.513 1.00 17.51 A ATOM 862 CD2 TRP A 115 18.002 58.504 87.841 1.00 18.01 A ATOM 863 CE2 TRP A 115 17.583 57.255 87.325 1.00 19.36 A ATOM 864 CE3 TRP A 115 17.073 59.302 88.520 1.00 18.64 A ATOM 865 CD1 TRP A 115 19.744 57.524 86.829 1.00 17.50 A ATOM 866 NE1 TRP A 115 18.666 56.679 86.714 1.00 16.73 A ATOM 867 CZ2 TRP A 115 16.274 56.788 87.470 1.00 20.10 A ATOM 868 CZ3 TRP A 115 15.769 58.837 88.663 1.00 18.36 A ATOM 869 CH2 TRP A 115 15.384 57.589 88.139 1.00 19.75 A ATOM 870 C TRP A 115 20.786 60.613 85.581 1.00 20.41 A ATOM 871 O TRP A 115 20.804 59.873 84.598 1.00 20.70 A ATOM 872 N GLY A 116 20.278 61.844 85.560 1.00 20.64 A ATOM 873 CA GLY A 116 19.727 62.414 84.341 1.00 22.03 A ATOM 874 C GLY A 116 18.297 62.044 83.998 1.00 22.10 A ATOM 875 O GLY A 116 17.767 62.487 82.976 1.00 21.00 A ATOM 876 N GLN A 117 17.667 61.237 84.844 1.00 22.18 A ATOM 877 CA GLN A 117 16.295 60.812 84.611 1.00 21.98 A ATOM 878 CB GLN A 117 16.146 59.319 84.916 1.00 22.79 A ATOM 879 CG GLN A 117 16.986 58.429 84.031 1.00 26.38 A ATOM 880 CD GLN A 117 16.533 58.474 82.589 1.00 30.18 A ATOM 881 OE1 GLN A 117 15.401 58.104 82.273 1.00 34.37 A ATOM 882 NE2 GLN A 117 17.409 58.933 81.708 1.00 31.61 A ATOM 883 C GLN A 117 15.330 61.597 85.482 1.00 22.74 A ATOM 884 O GLN A 117 15.709 62.116 86.538 1.00 20.98 A ATOM 885 N PRO A 118 14.063 61.698 85.049 1.00 22.98 A ATOM 886 CD PRO A 118 13.555 61.274 83.735 1.00 24.02 A ATOM 887 CA PRO A 118 13.028 62.418 85.790 1.00 23.87 A ATOM 888 CB PRO A 118 11.800 62.261 84.903 1.00 24.03 A ATOM 889 CG PRO A 118 12.382 62.200 83.541 1.00 25.61 A ATOM 890 C PRO A 118 12.805 61.816 87.176 1.00 25.25 A ATOM 891 O PRO A 118 12.820 60.595 87.351 1.00 23.22 A ATOM 892 N MET A 119 12.596 62.694 88.145 1.00 24.78 A ATOM 893 CA MET A 119 12.354 62.320 89.530 1.00 26.74 A ATOM 894 CB MET A 119 12.156 63.606 90.334 1.00 29.70 A ATOM 895 CG MET A 119 11.815 63.454 91.789 1.00 32.65 A ATOM 896 SD MET A 119 11.655 65.110 92.524 1.00 35.58 A ATOM 897 CE MET A 119 10.351 65.815 91.532 1.00 38.18 A ATOM 898 C MET A 119 11.131 61.400 89.638 1.00 25.23 A ATOM 899 O MET A 119 11.059 60.538 90.517 1.00 23.60 A ATOM 900 N SER A 120 10.178 61.578 88.727 1.00 24.22 A ATOM 901 CA SER A 120 8.964 60.768 88.712 1.00 23.87 A ATOM 902 CB SER A 120 8.015 61.275 87.618 1.00 25.63 A ATOM 903 OG SER A 120 8.630 61.217 86.343 1.00 26.27 A ATOM 904 C SER A 120 9.247 59.277 88.492 1.00 22.48 A ATOM 905 O SER A 120 8.394 58.432 88.762 1.00 21.93 A ATOM 906 N LYS A 121 10.441 58.946 88.006 1.00 21.07 A ATOM 907 CA LYS A 121 10.770 57.538 87.759 1.00 19.67 A ATOM 908 CB LYS A 121 11.766 57.421 86.606 1.00 20.18 A ATOM 909 CG LYS A 121 11.291 58.113 85.333 1.00 22.53 A ATOM 910 CD LYS A 121 12.096 57.675 84.121 1.00 26.21 A ATOM 911 CE LYS A 121 11.351 56.608 83.328 1.00 29.93 A ATOM 912 NZ LYS A 121 10.074 57.129 82.751 1.00 28.97 A ATOM 913 C LYS A 121 11.307 56.806 88.993 1.00 18.98 A ATOM 914 O LYS A 121 11.593 55.604 88.935 1.00 18.06 A ATOM 915 N ILE A 122 11.451 57.532 90.099 1.00 17.26 A ATOM 916 CA ILE A 122 11.909 56.936 91.352 1.00 15.68 A ATOM 917 CB ILE A 122 12.485 58.015 92.321 1.00 16.42 A ATOM 918 CG2 ILE A 122 12.747 57.406 93.690 1.00 16.72 A ATOM 919 CG1 ILE A 122 13.789 58.579 91.748 1.00 16.79 A ATOM 920 CD1 ILE A 122 14.329 59.777 92.500 1.00 16.88 A ATOM 921 C ILE A 122 10.679 56.263 91.962 1.00 15.84 A ATOM 922 O ILE A 122 9.640 56.900 92.173 1.00 15.43 A ATOM 923 N THR A 123 10.796 54.966 92.226 1.00 14.18 A ATOM 924 CA THR A 123 9.689 54.175 92.752 1.00 14.74 A ATOM 925 CB THR A 123 9.549 52.891 91.934 1.00 16.36 A ATOM 926 OG1 THR A 123 10.802 52.199 91.937 1.00 15.10 A ATOM 927 CG2 THR A 123 9.198 53.221 90.493 1.00 17.32 A ATOM 928 C THR A 123 9.810 53.785 94.221 1.00 13.87 A ATOM 929 O THR A 123 8.812 53.493 94.884 1.00 12.09 A ATOM 930 N HIS A 124 11.032 53.769 94.725 1.00 12.46 A ATOM 931 CA HIS A 124 11.255 53.404 96.114 1.00 13.52 A ATOM 932 CB HIS A 124 11.896 52.015 96.200 1.00 14.17 A ATOM 933 CG HIS A 124 11.078 50.931 95.567 1.00 14.73 A ATOM 934 CD2 HIS A 124 10.806 50.666 94.270 1.00 14.15 A ATOM 935 ND1 HIS A 124 10.440 49.951 96.300 1.00 17.98 A ATOM 936 CE1 HIS A 124 9.812 49.128 95.479 1.00 13.68 A ATOM 937 NE2 HIS A 124 10.019 49.539 94.241 1.00 18.64 A ATOM 938 C HIS A 124 12.168 54.415 96.778 1.00 13.52 A ATOM 939 O HIS A 124 13.081 54.952 96.147 1.00 15.74 A ATOM 940 N LEU A 125 11.921 54.660 98.057 1.00 15.22 A ATOM 941 CA LEU A 125 12.737 55.586 98.826 1.00 13.70 A ATOM 942 CB LEU A 125 11.969 56.874 99.138 1.00 12.90 A ATOM 943 CG LEU A 125 12.658 57.787 100.168 1.00 14.85 A ATOM 944 CD1 LEU A 125 13.951 58.355 99.576 1.00 13.04 A ATOM 945 CD2 LEU A 125 11.717 58.916 100.575 1.00 13.73 A ATOM 946 C LEU A 125 13.159 54.966 100.143 1.00 11.88 A ATOM 947 O LEU A 125 12.311 54.615 100.960 1.00 12.37 A ATOM 948 N ILE A 126 14.466 54.837 100.340 1.00 11.11 A ATOM 949 CA ILE A 126 15.008 54.328 101.598 1.00 11.89 A ATOM 950 CB ILE A 126 16.074 53.234 101.380 1.00 11.91 A ATOM 951 CG2 ILE A 126 16.614 52.751 102.736 1.00 14.16 A ATOM 952 CG1 ILE A 126 15.468 52.057 100.615 1.00 11.59 A ATOM 953 CD1 ILE A 126 16.504 51.045 100.138 1.00 11.98 A ATOM 954 C ILE A 126 15.691 55.518 102.274 1.00 12.26 A ATOM 955 O ILE A 126 16.632 56.084 101.726 1.00 12.65 A ATOM 956 N PHE A 127 15.211 55.895 103.453 1.00 10.80 A ATOM 957 CA PHE A 127 15.795 57.007 104.188 1.00 12.32 A ATOM 958 CB PHE A 127 14.752 58.082 104.485 1.00 13.70 A ATOM 959 CG PHE A 127 15.353 59.410 104.858 1.00 16.44 A ATOM 960 CD1 PHE A 127 16.100 59.550 106.025 1.00 19.42 A ATOM 961 CD2 PHE A 127 15.197 60.515 104.025 1.00 18.87 A ATOM 962 CE1 PHE A 127 16.689 60.778 106.358 1.00 20.68 A ATOM 963 CE2 PHE A 127 15.780 61.744 104.348 1.00 19.48 A ATOM 964 CZ PHE A 127 16.525 61.875 105.514 1.00 19.21 A ATOM 965 C PHE A 127 16.353 56.469 105.497 1.00 12.78 A ATOM 966 O PHE A 127 15.640 55.831 106.278 1.00 14.15 A ATOM 967 N CYS A 128 17.626 56.748 105.737 1.00 13.01 A ATOM 968 CA CYS A 128 18.301 56.259 106.930 1.00 13.64 A ATOM 969 CB CYS A 128 19.359 55.233 106.513 1.00 15.39 A ATOM 970 SG CYS A 128 20.377 54.571 107.831 1.00 20.31 A ATOM 971 C CYS A 128 18.952 57.380 107.714 1.00 15.17 A ATOM 972 O CYS A 128 19.726 58.159 107.161 1.00 14.59 A ATOM 973 N THR A 129 18.622 57.466 108.999 1.00 14.32 A ATOM 974 CA THR A 129 19.205 58.482 109.868 1.00 16.20 A ATOM 975 CB THR A 129 18.473 59.832 109.740 1.00 18.34 A ATOM 976 OG1 THR A 129 19.107 60.794 110.596 1.00 18.62 A ATOM 977 CG2 THR A 129 17.006 59.692 110.122 1.00 14.76 A ATOM 978 C THR A 129 19.174 58.022 111.324 1.00 16.46 A ATOM 979 O THR A 129 18.273 57.287 111.731 1.00 17.28 A ATOM 980 N THR A 130 20.158 58.463 112.102 1.00 18.56 A ATOM 981 CA THR A 130 20.263 58.082 113.506 1.00 20.61 A ATOM 982 CB THR A 130 21.558 58.633 114.131 1.00 22.58 A ATOM 983 OG1 THR A 130 22.683 57.978 113.531 1.00 24.26 A ATOM 984 CG2 THR A 130 21.579 58.379 115.635 1.00 24.22 A ATOM 985 C THR A 130 19.074 58.501 114.359 1.00 20.30 A ATOM 986 O THR A 130 18.636 57.741 115.220 1.00 21.48 A ATOM 987 N SER A 131 18.552 59.703 114.140 1.00 20.01 A ATOM 988 CA SER A 131 17.398 60.141 114.911 1.00 22.06 A ATOM 989 CB SER A 131 17.836 60.640 116.290 1.00 23.91 A ATOM 990 OG SER A 131 16.787 60.471 117.229 1.00 24.77 A ATOM 991 C SER A 131 16.578 61.211 114.189 1.00 22.16 A ATOM 992 O SER A 131 16.799 61.476 113.008 1.00 22.30 A ATOM 993 N GLY A 132 15.633 61.817 114.906 1.00 22.15 A ATOM 994 CA GLY A 132 14.761 62.829 114.322 1.00 20.74 A ATOM 995 C GLY A 132 13.403 62.167 114.193 1.00 19.96 A ATOM 996 O GLY A 132 12.845 62.049 113.101 1.00 18.89 A ATOM 997 N VAL A 133 12.868 61.750 115.335 1.00 19.25 A ATOM 998 CA VAL A 133 11.606 61.020 115.401 1.00 18.86 A ATOM 999 CB VAL A 133 11.562 60.138 116.673 1.00 19.36 A ATOM 1000 CG1 VAL A 133 10.316 59.272 116.662 1.00 20.48 A ATOM 1001 CG2 VAL A 133 12.815 59.288 116.764 1.00 21.42 A ATOM 1002 C VAL A 133 10.307 61.810 115.343 1.00 18.12 A ATOM 1003 O VAL A 133 9.972 62.554 116.257 1.00 15.85 A ATOM 1004 N ALA A 134 9.566 61.603 114.260 1.00 17.33 A ATOM 1005 CA ALA A 134 8.281 62.253 114.054 1.00 18.39 A ATOM 1006 CB ALA A 134 8.480 63.600 113.376 1.00 18.75 A ATOM 1007 C ALA A 134 7.428 61.353 113.170 1.00 20.02 A ATOM 1008 O ALA A 134 7.955 60.526 112.426 1.00 20.00 A ATOM 1009 N LEU A 135 6.112 61.500 113.275 1.00 20.90 A ATOM 1010 CA LEU A 135 5.181 60.740 112.454 1.00 22.04 A ATOM 1011 CB LEU A 135 4.401 59.715 113.284 1.00 22.48 A ATOM 1012 CG LEU A 135 5.190 58.568 113.918 1.00 24.17 A ATOM 1013 CD1 LEU A 135 5.842 59.046 115.204 1.00 24.79 A ATOM 1014 CD2 LEU A 135 4.254 57.399 114.203 1.00 25.37 A ATOM 1015 C LEU A 135 4.213 61.753 111.849 1.00 21.49 A ATOM 1016 O LEU A 135 3.499 62.446 112.579 1.00 20.88 A ATOM 1017 N PRO A 136 4.212 61.887 110.511 1.00 21.73 A ATOM 1018 CD PRO A 136 3.328 62.816 109.783 1.00 22.31 A ATOM 1019 CA PRO A 136 5.063 61.143 109.576 1.00 22.02 A ATOM 1020 CB PRO A 136 4.528 61.570 108.209 1.00 21.01 A ATOM 1021 CG PRO A 136 4.042 62.958 108.460 1.00 21.68 A ATOM 1022 C PRO A 136 6.541 61.479 109.775 1.00 21.66 A ATOM 1023 O PRO A 136 6.877 62.527 110.326 1.00 20.41 A ATOM 1024 N GLY A 137 7.412 60.582 109.326 1.00 21.85 A ATOM 1025 CA GLY A 137 8.843 60.771 109.499 1.00 22.07 A ATOM 1026 C GLY A 137 9.555 61.689 108.528 1.00 21.47 A ATOM 1027 O GLY A 137 8.929 62.373 107.711 1.00 20.25 A ATOM 1028 N VAL A 138 10.881 61.705 108.627 1.00 21.01 A ATOM 1029 CA VAL A 138 11.693 62.538 107.758 1.00 21.43 A ATOM 1030 CB VAL A 138 13.150 62.616 108.258 1.00 21.99 A ATOM 1031 CG1 VAL A 138 13.198 63.423 109.546 1.00 22.78 A ATOM 1032 CG2 VAL A 138 13.712 61.223 108.483 1.00 20.43 A ATOM 1033 C VAL A 138 11.655 62.064 106.308 1.00 20.81 A ATOM 1034 O VAL A 138 12.009 62.815 105.396 1.00 20.37 A ATOM 1035 N ASP A 139 11.223 60.824 106.086 1.00 20.30 A ATOM 1036 CA ASP A 139 11.116 60.324 104.719 1.00 20.26 A ATOM 1037 CB ASP A 139 10.771 58.822 104.710 1.00 20.86 A ATOM 1038 CG ASP A 139 9.488 58.497 105.465 1.00 21.95 A ATOM 1039 OD1 ASP A 139 9.282 59.048 106.568 1.00 21.43 A ATOM 1040 OD2 ASP A 139 8.689 57.673 104.959 1.00 19.82 A ATOM 1041 C ASP A 139 10.019 61.153 104.045 1.00 20.31 A ATOM 1042 O ASP A 139 10.116 61.516 102.870 1.00 19.88 A ATOM 1043 N TYR A 140 8.981 61.465 104.811 1.00 19.31 A ATOM 1044 CA TYR A 140 7.875 62.273 104.311 1.00 20.68 A ATOM 1045 CB TYR A 140 6.746 62.317 105.346 1.00 22.10 A ATOM 1046 CG TYR A 140 5.689 63.360 105.062 1.00 25.72 A ATOM 1047 CD1 TYR A 140 4.629 63.093 104.196 1.00 24.85 A ATOM 1048 CE1 TYR A 140 3.664 64.058 103.921 1.00 27.16 A ATOM 1049 CD2 TYR A 140 5.760 64.624 105.646 1.00 26.43 A ATOM 1050 CE2 TYR A 140 4.804 65.596 105.374 1.00 28.31 A ATOM 1051 CZ TYR A 140 3.758 65.306 104.512 1.00 27.72 A ATOM 1052 OH TYR A 140 2.812 66.265 104.241 1.00 30.75 A ATOM 1053 C TYR A 140 8.378 63.692 104.034 1.00 21.06 A ATOM 1054 O TYR A 140 8.059 64.284 103.007 1.00 21.05 A ATOM 1055 N GLU A 141 9.172 64.238 104.950 1.00 22.40 A ATOM 1056 CA GLU A 141 9.697 65.587 104.766 1.00 23.04 A ATOM 1057 CB GLU A 141 10.550 65.990 105.973 1.00 25.22 A ATOM 1058 CG GLU A 141 9.806 65.891 107.310 1.00 29.34 A ATOM 1059 CD GLU A 141 8.717 66.944 107.473 1.00 32.95 A ATOM 1060 OE1 GLU A 141 7.895 66.815 108.407 1.00 31.49 A ATOM 1061 OE2 GLU A 141 8.687 67.906 106.673 1.00 35.80 A ATOM 1062 C GLU A 141 10.522 65.675 103.480 1.00 22.86 A ATOM 1063 O GLU A 141 10.411 66.643 102.725 1.00 23.57 A ATOM 1064 N LEU A 142 11.344 64.659 103.232 1.00 20.18 A ATOM 1065 CA LEU A 142 12.178 64.628 102.033 1.00 19.91 A ATOM 1066 CB LEU A 142 13.115 63.412 102.057 1.00 18.95 A ATOM 1067 CG LEU A 142 14.028 63.267 100.831 1.00 18.48 A ATOM 1068 CD1 LEU A 142 15.022 64.433 100.771 1.00 16.40 A ATOM 1069 CD2 LEU A 142 14.770 61.950 100.906 1.00 20.85 A ATOM 1070 C LEU A 142 11.305 64.579 100.779 1.00 19.21 A ATOM 1071 O LEU A 142 11.585 65.260 99.796 1.00 17.35 A ATOM 1072 N ILE A 143 10.246 63.773 100.821 1.00 17.49 A ATOM 1073 CA ILE A 143 9.331 63.648 99.683 1.00 19.30 A ATOM 1074 CB ILE A 143 8.175 62.680 100.010 1.00 19.22 A ATOM 1075 CG2 ILE A 143 7.062 62.809 98.972 1.00 18.33 A ATOM 1076 CG1 ILE A 143 8.717 61.250 100.077 1.00 19.66 A ATOM 1077 CD1 ILE A 143 7.730 60.236 100.615 1.00 22.67 A ATOM 1078 C ILE A 143 8.755 65.019 99.327 1.00 20.59 A ATOM 1079 O ILE A 143 8.663 65.382 98.152 1.00 20.63 A ATOM 1080 N VAL A 144 8.373 65.770 100.353 1.00 21.01 A ATOM 1081 CA VAL A 144 7.818 67.102 100.165 1.00 23.53 A ATOM 1082 CB VAL A 144 7.307 67.679 101.501 1.00 24.60 A ATOM 1083 CG1 VAL A 144 6.932 69.145 101.329 1.00 27.88 A ATOM 1084 CG2 VAL A 144 6.111 66.883 101.979 1.00 26.36 A ATOM 1085 C VAL A 144 8.860 68.055 99.590 1.00 22.64 A ATOM 1086 O VAL A 144 8.578 68.805 98.660 1.00 21.65 A ATOM 1087 N LEU A 145 10.069 68.015 100.141 1.00 23.18 A ATOM 1088 CA LEU A 145 11.142 68.894 99.685 1.00 24.35 A ATOM 1089 CB LEU A 145 12.331 68.823 100.644 1.00 25.00 A ATOM 1090 CG LEU A 145 12.167 69.569 101.968 1.00 25.62 A ATOM 1091 CD1 LEU A 145 13.325 69.229 102.901 1.00 25.97 A ATOM 1092 CD2 LEU A 145 12.109 71.071 101.703 1.00 27.80 A ATOM 1093 C LEU A 145 11.624 68.627 98.270 1.00 25.21 A ATOM 1094 O LEU A 145 11.994 69.563 97.562 1.00 25.41 A ATOM 1095 N LEU A 146 11.628 67.360 97.860 1.00 24.69 A ATOM 1096 CA LEU A 146 12.074 66.988 96.519 1.00 23.80 A ATOM 1097 CB LEU A 146 12.652 65.571 96.506 1.00 24.17 A ATOM 1098 CG LEU A 146 14.086 65.321 96.952 1.00 22.03 A ATOM 1099 CD1 LEU A 146 14.373 63.824 96.883 1.00 20.90 A ATOM 1100 CD2 LEU A 146 15.048 66.100 96.055 1.00 24.88 A ATOM 1101 C LEU A 146 10.958 67.037 95.495 1.00 24.42 A ATOM 1102 O LEU A 146 11.162 67.482 94.366 1.00 26.11 A ATOM 1103 N GLY A 147 9.787 66.550 95.890 1.00 23.14 A ATOM 1104 CA GLY A 147 8.655 66.515 94.985 1.00 22.12 A ATOM 1105 C GLY A 147 8.494 65.121 94.405 1.00 21.57 A ATOM 1106 O GLY A 147 8.049 64.965 93.268 1.00 21.52 A ATOM 1107 N LEU A 148 8.874 64.107 95.183 1.00 20.27 A ATOM 1108 CA LEU A 148 8.757 62.711 94.759 1.00 21.34 A ATOM 1109 CB LEU A 148 9.387 61.777 95.802 1.00 20.35 A ATOM 1110 CG LEU A 148 10.909 61.838 95.961 1.00 22.06 A ATOM 1111 CD1 LEU A 148 11.357 60.867 97.037 1.00 21.03 A ATOM 1112 CD2 LEU A 148 11.571 61.512 94.625 1.00 21.84 A ATOM 1113 C LEU A 148 7.291 62.336 94.577 1.00 20.24 A ATOM 1114 O LEU A 148 6.408 62.970 95.150 1.00 19.49 A ATOM 1115 N ASP A 149 7.035 61.303 93.779 1.00 21.19 A ATOM 1116 CA ASP A 149 5.669 60.854 93.526 1.00 20.81 A ATOM 1117 CB ASP A 149 5.678 59.672 92.550 1.00 23.34 A ATOM 1118 CG ASP A 149 4.286 59.342 92.019 1.00 25.67 A ATOM 1119 OD1 ASP A 149 3.482 58.732 92.757 1.00 23.21 A ATOM 1120 OD2 ASP A 149 3.991 59.715 90.863 1.00 28.37 A ATOM 1121 C ASP A 149 5.007 60.436 94.837 1.00 21.87 A ATOM 1122 O ASP A 149 5.628 59.759 95.672 1.00 22.11 A ATOM 1123 N PRO A 150 3.741 60.834 95.044 1.00 19.56 A ATOM 1124 CD PRO A 150 2.883 61.659 94.177 1.00 21.27 A ATOM 1125 CA PRO A 150 3.037 60.472 96.278 1.00 19.66 A ATOM 1126 CB PRO A 150 1.696 61.199 96.141 1.00 20.41 A ATOM 1127 CG PRO A 150 1.498 61.272 94.651 1.00 22.21 A ATOM 1128 C PRO A 150 2.880 58.961 96.448 1.00 18.44 A ATOM 1129 O PRO A 150 2.565 58.480 97.539 1.00 18.21 A ATOM 1130 N CYS A 151 3.110 58.217 95.371 1.00 17.66 A ATOM 1131 CA CYS A 151 3.000 56.762 95.425 1.00 18.31 A ATOM 1132 CB CYS A 151 2.269 56.241 94.190 1.00 19.55 A ATOM 1133 SG CYS A 151 .546 56.775 94.144 1.00 24.40 A ATOM 1134 C CYS A 151 4.349 56.073 95.561 1.00 17.28 A ATOM 1135 O CYS A 151 4.465 54.862 95.353 1.00 16.35 A ATOM 1136 N VAL A 152 5.377 56.837 95.913 1.00 16.24 A ATOM 1137 CA VAL A 152 6.700 56.247 96.086 1.00 15.84 A ATOM 1138 CB VAL A 152 7.764 57.336 96.339 1.00 15.86 A ATOM 1139 CG1 VAL A 152 7.489 58.033 97.667 1.00 18.85 A ATOM 1140 CG2 VAL A 152 9.159 56.726 96.323 1.00 16.14 A ATOM 1141 C VAL A 152 6.632 55.308 97.302 1.00 16.12 A ATOM 1142 O VAL A 152 5.989 55.630 98.302 1.00 16.07 A ATOM 1143 N LYS A 153 7.264 54.140 97.208 1.00 15.09 A ATOM 1144 CA LYS A 153 7.268 53.196 98.325 1.00 15.78 A ATOM 1145 CB LYS A 153 7.422 51.764 97.810 1.00 15.41 A ATOM 1146 CG LYS A 153 6.190 51.244 97.072 1.00 18.15 A ATOM 1147 CD LYS A 153 6.434 49.827 96.560 1.00 21.61 A ATOM 1148 CE LYS A 153 5.205 49.245 95.886 1.00 24.97 A ATOM 1149 NZ LYS A 153 4.778 50.049 94.708 1.00 28.12 A ATOM 1150 C LYS A 153 8.405 53.551 99.291 1.00 14.03 A ATOM 1151 O LYS A 153 9.573 53.586 98.909 1.00 14.56 A ATOM 1152 N ARG A 154 8.047 53.803 100.546 1.00 14.71 A ATOM 1153 CA ARG A 154 9.014 54.215 101.559 1.00 14.98 A ATOM 1154 CB ARG A 154 8.448 55.402 102.346 1.00 15.82 A ATOM 1155 CG ARG A 154 8.113 56.614 101.492 1.00 16.52 A ATOM 1156 CD ARG A 154 6.666 57.044 101.681 1.00 19.72 A ATOM 1157 NE ARG A 154 6.382 57.386 103.070 1.00 19.17 A ATOM 1158 CZ ARG A 154 5.158 57.536 103.566 1.00 22.61 A ATOM 1159 NH1 ARG A 154 4.097 57.379 102.786 1.00 22.37 A ATOM 1160 NH2 ARG A 154 4.992 57.826 104.848 1.00 24.78 A ATOM 1161 C ARG A 154 9.493 53.170 102.565 1.00 14.29 A ATOM 1162 O ARG A 154 8.757 52.274 102.961 1.00 12.71 A ATOM 1163 N TYR A 155 10.746 53.329 102.983 1.00 14.99 A ATOM 1164 CA TYR A 155 11.375 52.466 103.972 1.00 15.35 A ATOM 1165 CB TYR A 155 12.312 51.462 103.283 1.00 15.70 A ATOM 1166 CG TYR A 155 11.596 50.631 102.228 1.00 15.84 A ATOM 1167 CD1 TYR A 155 11.282 51.176 100.985 1.00 16.66 A ATOM 1168 CE1 TYR A 155 10.528 50.467 100.051 1.00 16.19 A ATOM 1169 CD2 TYR A 155 11.144 49.338 102.511 1.00 16.71 A ATOM 1170 CE2 TYR A 155 10.388 48.613 101.581 1.00 17.09 A ATOM 1171 CZ TYR A 155 10.078 49.189 100.355 1.00 17.25 A ATOM 1172 OH TYR A 155 9.283 48.526 99.447 1.00 15.92 A ATOM 1173 C TYR A 155 12.148 53.425 104.882 1.00 14.71 A ATOM 1174 O TYR A 155 13.241 53.869 104.546 1.00 14.74 A ATOM 1175 N MET A 156 11.550 53.752 106.022 1.00 14.82 A ATOM 1176 CA MET A 156 12.134 54.679 106.992 1.00 17.67 A ATOM 1177 CB MET A 156 10.997 55.466 107.663 1.00 19.67 A ATOM 1178 CG MET A 156 11.412 56.537 108.663 1.00 20.86 A ATOM 1179 SD MET A 156 12.370 57.875 107.942 1.00 19.21 A ATOM 1180 CE MET A 156 13.973 57.560 108.704 1.00 20.63 A ATOM 1181 C MET A 156 12.963 53.915 108.027 1.00 17.40 A ATOM 1182 O MET A 156 12.421 53.225 108.896 1.00 16.91 A ATOM 1183 N MET A 157 14.279 54.050 107.927 1.00 17.80 A ATOM 1184 CA MET A 157 15.199 53.363 108.828 1.00 18.64 A ATOM 1185 CB MET A 157 16.338 52.745 108.008 1.00 18.72 A ATOM 1186 CG MET A 157 15.867 52.052 106.719 1.00 20.59 A ATOM 1187 SD MET A 157 14.560 50.808 106.973 1.00 23.41 A ATOM 1188 CE MET A 157 15.566 49.431 107.583 1.00 23.66 A ATOM 1189 C MET A 157 15.769 54.291 109.911 1.00 20.02 A ATOM 1190 O MET A 157 16.658 55.108 109.647 1.00 17.80 A ATOM 1191 N TYR A 158 15.253 54.156 111.131 1.00 19.95 A ATOM 1192 CA TYR A 158 15.695 54.972 112.256 1.00 19.35 A ATOM 1193 CB TYR A 158 14.483 55.463 113.064 1.00 19.50 A ATOM 1194 CG TYR A 158 13.763 56.698 112.550 1.00 20.57 A ATOM 1195 CD1 TYR A 158 14.397 57.942 112.528 1.00 18.96 A ATOM 1196 CE1 TYR A 158 13.713 59.097 112.154 1.00 19.96 A ATOM 1197 CD2 TYR A 158 12.418 56.641 112.173 1.00 19.97 A ATOM 1198 CE2 TYR A 158 11.723 57.801 111.797 1.00 21.41 A ATOM 1199 CZ TYR A 158 12.379 59.024 111.794 1.00 21.79 A ATOM 1200 OH TYR A 158 11.703 60.185 111.455 1.00 21.85 A ATOM 1201 C TYR A 158 16.622 54.198 113.210 1.00 20.02 A ATOM 1202 O TYR A 158 16.527 52.974 113.340 1.00 19.80 A ATOM 1203 N HIS A 159 17.518 54.925 113.872 1.00 19.60 A ATOM 1204 CA HIS A 159 18.422 54.340 114.863 1.00 20.67 A ATOM 1205 CB HIS A 159 17.648 54.094 116.157 1.00 21.27 A ATOM 1206 CG HIS A 159 16.600 55.123 116.445 1.00 22.15 A ATOM 1207 CD2 HIS A 159 15.253 55.021 116.534 1.00 21.57 A ATOM 1208 ND1 HIS A 159 16.902 56.444 116.699 1.00 22.61 A ATOM 1209 CE1 HIS A 159 15.785 57.110 116.934 1.00 22.64 A ATOM 1210 NE2 HIS A 159 14.771 56.270 116.841 1.00 24.23 A ATOM 1211 C HIS A 159 19.062 53.023 114.436 1.00 23.07 A ATOM 1212 O HIS A 159 19.092 52.069 115.218 1.00 23.59 A ATOM 1213 N GLN A 160 19.584 52.970 113.218 1.00 22.10 A ATOM 1214 CA GLN A 160 20.190 51.746 112.703 1.00 25.43 A ATOM 1215 CB GLN A 160 20.173 51.759 111.175 1.00 24.14 A ATOM 1216 CG GLN A 160 18.831 52.116 110.568 1.00 26.85 A ATOM 1217 CD GLN A 160 17.869 50.948 110.516 1.00 28.45 A ATOM 1218 OE1 GLN A 160 18.111 49.964 109.811 1.00 28.85 A ATOM 1219 NE2 GLN A 160 16.767 51.049 111.256 1.00 25.36 A ATOM 1220 C GLN A 160 21.620 51.550 113.181 1.00 26.36 A ATOM 1221 O GLN A 160 22.037 50.431 113.465 1.00 30.01 A ATOM 1222 N GLY A 161 22.377 52.637 113.257 1.00 26.59 A ATOM 1223 CA GLY A 161 23.754 52.524 113.691 1.00 26.91 A ATOM 1224 C GLY A 161 24.746 52.665 112.549 1.00 26.02 A ATOM 1225 O GLY A 161 24.369 52.731 111.374 1.00 25.41 A ATOM 1226 N CYS A 162 26.026 52.682 112.904 1.00 22.86 A ATOM 1227 CA CYS A 162 27.108 52.848 111.942 1.00 21.74 A ATOM 1228 CB CYS A 162 28.428 53.028 112.698 1.00 24.49 A ATOM 1229 SG CYS A 162 28.529 54.618 113.582 1.00 31.19 A ATOM 1230 C CYS A 162 27.282 51.787 110.855 1.00 19.91 A ATOM 1231 O CYS A 162 28.078 51.979 109.941 1.00 19.35 A ATOM 1232 N PHE A 163 26.561 50.673 110.940 1.00 17.83 A ATOM 1233 CA PHE A 163 26.692 49.640 109.914 1.00 19.23 A ATOM 1234 CB PHE A 163 26.621 48.239 110.544 1.00 19.59 A ATOM 1235 CG PHE A 163 25.314 47.939 111.239 1.00 19.53 A ATOM 1236 CD1 PHE A 163 24.135 47.796 110.513 1.00 19.57 A ATOM 1237 CD2 PHE A 163 25.264 47.817 112.626 1.00 21.14 A ATOM 1238 CE1 PHE A 163 22.924 47.539 111.156 1.00 19.62 A ATOM 1239 CE2 PHE A 163 24.061 47.559 113.279 1.00 20.54 A ATOM 1240 CZ PHE A 163 22.889 47.421 112.542 1.00 24.00 A ATOM 1241 C PHE A 163 25.606 49.775 108.846 1.00 18.82 A ATOM 1242 O PHE A 163 25.630 49.077 107.829 1.00 19.22 A ATOM 1243 N ALA A 164 24.663 50.679 109.088 1.00 16.89 A ATOM 1244 CA ALA A 164 23.534 50.900 108.186 1.00 17.06 A ATOM 1245 CB ALA A 164 22.663 52.040 108.710 1.00 18.50 A ATOM 1246 C ALA A 164 23.877 51.142 106.724 1.00 16.53 A ATOM 1247 O ALA A 164 23.015 50.985 105.859 1.00 18.01 A ATOM 1248 N GLY A 165 25.115 51.543 106.443 1.00 15.99 A ATOM 1249 CA GLY A 165 25.521 51.758 105.064 1.00 16.79 A ATOM 1250 C GLY A 165 25.337 50.452 104.309 1.00 18.19 A ATOM 1251 O GLY A 165 24.874 50.420 103.160 1.00 19.45 A ATOM 1252 N GLY A 166 25.700 49.358 104.965 1.00 18.25 A ATOM 1253 CA GLY A 166 25.531 48.056 104.352 1.00 17.94 A ATOM 1254 C GLY A 166 24.063 47.644 104.344 1.00 17.15 A ATOM 1255 O GLY A 166 23.597 47.031 103.384 1.00 18.05 A ATOM 1256 N THR A 167 23.339 47.988 105.408 1.00 17.80 A ATOM 1257 CA THR A 167 21.921 47.647 105.545 1.00 17.61 A ATOM 1258 CB THR A 167 21.331 48.188 106.866 1.00 20.13 A ATOM 1259 OG1 THR A 167 22.114 47.730 107.978 1.00 22.66 A ATOM 1260 CG2 THR A 167 19.896 47.709 107.040 1.00 20.30 A ATOM 1261 C THR A 167 21.076 48.208 104.400 1.00 16.77 A ATOM 1262 O THR A 167 20.233 47.504 103.837 1.00 14.42 A ATOM 1263 N VAL A 168 21.295 49.473 104.050 1.00 14.03 A ATOM 1264 CA VAL A 168 20.512 50.071 102.974 1.00 13.42 A ATOM 1265 CB VAL A 168 20.710 51.608 102.899 1.00 13.78 A ATOM 1266 CG1 VAL A 168 20.145 52.250 104.155 1.00 13.71 A ATOM 1267 CG2 VAL A 168 22.183 51.955 102.740 1.00 15.67 A ATOM 1268 C VAL A 168 20.804 49.438 101.620 1.00 13.51 A ATOM 1269 O VAL A 168 19.898 49.307 100.800 1.00 15.08 A ATOM 1270 N LEU A 169 22.054 49.037 101.379 1.00 13.10 A ATOM 1271 CA LEU A 169 22.397 48.397 100.107 1.00 14.82 A ATOM 1272 CB LEU A 169 23.920 48.257 99.954 1.00 15.02 A ATOM 1273 CG LEU A 169 24.672 49.559 99.643 1.00 15.90 A ATOM 1274 CD1 LEU A 169 26.175 49.323 99.692 1.00 18.49 A ATOM 1275 CD2 LEU A 169 24.259 50.063 98.272 1.00 16.52 A ATOM 1276 C LEU A 169 21.731 47.021 100.059 1.00 14.69 A ATOM 1277 O LEU A 169 21.208 46.609 99.019 1.00 14.57 A ATOM 1278 N ARG A 170 21.743 46.323 101.194 1.00 14.14 A ATOM 1279 CA ARG A 170 21.123 45.003 101.309 1.00 13.98 A ATOM 1280 CB ARG A 170 21.363 44.457 102.727 1.00 18.76 A ATOM 1281 CG ARG A 170 20.615 43.185 103.107 1.00 18.37 A ATOM 1282 CD ARG A 170 21.288 42.496 104.306 1.00 18.20 A ATOM 1283 NE ARG A 170 21.420 43.343 105.500 1.00 18.43 A ATOM 1284 CZ ARG A 170 20.434 43.602 106.355 1.00 18.99 A ATOM 1285 NH1 ARG A 170 19.231 43.082 106.159 1.00 15.93 A ATOM 1286 NH2 ARG A 170 20.650 44.378 107.415 1.00 18.98 A ATOM 1287 C ARG A 170 19.626 45.116 101.006 1.00 15.04 A ATOM 1288 O ARG A 170 19.045 44.266 100.325 1.00 13.87 A ATOM 1289 N LEU A 171 19.010 46.185 101.496 1.00 14.48 A ATOM 1290 CA LEU A 171 17.588 46.412 101.269 1.00 16.01 A ATOM 1291 CB LEU A 171 17.066 47.488 102.229 1.00 16.51 A ATOM 1292 CG LEU A 171 15.657 48.037 101.983 1.00 18.42 A ATOM 1293 CD1 LEU A 171 14.644 46.910 101.951 1.00 19.05 A ATOM 1294 CD2 LEU A 171 15.305 49.032 103.076 1.00 17.79 A ATOM 1295 C LEU A 171 17.323 46.834 99.823 1.00 15.61 A ATOM 1296 O LEU A 171 16.413 46.313 99.174 1.00 16.14 A ATOM 1297 N ALA A 172 18.116 47.775 99.314 1.00 15.72 A ATOM 1298 CA ALA A 172 17.934 48.241 97.942 1.00 15.52 A ATOM 1299 CB ALA A 172 18.911 49.378 97.636 1.00 17.06 A ATOM 1300 C ALA A 172 18.109 47.115 96.923 1.00 15.78 A ATOM 1301 O ALA A 172 17.430 47.083 95.896 1.00 14.10 A ATOM 1302 N LYS A 173 19.008 46.184 97.211 1.00 15.48 A ATOM 1303 CA LYS A 173 19.251 45.083 96.288 1.00 15.99 A ATOM 1304 CB LYS A 173 20.325 44.148 96.851 1.00 15.75 A ATOM 1305 CG LYS A 173 20.576 42.910 96.001 1.00 16.03 A ATOM 1306 CD LYS A 173 21.788 42.147 96.512 1.00 19.74 A ATOM 1307 CE LYS A 173 21.600 40.640 96.392 1.00 22.75 A ATOM 1308 NZ LYS A 173 21.274 40.183 95.023 1.00 21.00 A ATOM 1309 C LYS A 173 17.985 44.289 95.972 1.00 16.47 A ATOM 1310 O LYS A 173 17.703 44.008 94.804 1.00 16.32 A ATOM 1311 N ASP A 174 17.230 43.924 97.005 1.00 15.20 A ATOM 1312 CA ASP A 174 16.006 43.158 96.804 1.00 17.12 A ATOM 1313 CB ASP A 174 15.496 42.574 98.126 1.00 18.01 A ATOM 1314 CG ASP A 174 16.319 41.378 98.597 1.00 21.22 A ATOM 1315 OD1 ASP A 174 16.943 40.698 97.752 1.00 23.11 A ATOM 1316 OD2 ASP A 174 16.323 41.103 99.814 1.00 19.95 A ATOM 1317 C ASP A 174 14.909 43.988 96.149 1.00 15.70 A ATOM 1318 O ASP A 174 14.155 43.479 95.318 1.00 14.62 A ATOM 1319 N LEU A 175 14.814 45.263 96.522 1.00 14.64 A ATOM 1320 CA LEU A 175 13.804 46.138 95.936 1.00 16.58 A ATOM 1321 CB LEU A 175 13.841 47.529 96.592 1.00 16.05 A ATOM 1322 CG LEU A 175 13.445 47.613 98.070 1.00 16.89 A ATOM 1323 CD1 LEU A 175 13.483 49.061 98.527 1.00 16.97 A ATOM 1324 CD2 LEU A 175 12.060 47.041 98.269 1.00 17.52 A ATOM 1325 C LEU A 175 14.015 46.298 94.430 1.00 15.43 A ATOM 1326 O LEU A 175 13.073 46.163 93.642 1.00 17.97 A ATOM 1327 N ALA A 176 15.246 46.589 94.021 1.00 14.64 A ATOM 1328 CA ALA A 176 15.529 46.777 92.601 1.00 14.54 A ATOM 1329 CB ALA A 176 16.918 47.382 92.412 1.00 16.05 A ATOM 1330 C ALA A 176 15.421 45.508 91.764 1.00 15.09 A ATOM 1331 O ALA A 176 14.923 45.536 90.637 1.00 13.49 A ATOM 1332 N GLU A 177 15.899 44.398 92.309 1.00 14.74 A ATOM 1333 CA GLU A 177 15.898 43.143 91.571 1.00 16.33 A ATOM 1334 CB GLU A 177 16.949 42.196 92.170 1.00 16.12 A ATOM 1335 CG GLU A 177 18.370 42.756 92.074 1.00 17.28 A ATOM 1336 CD GLU A 177 19.425 41.845 92.680 1.00 18.83 A ATOM 1337 OE1 GLU A 177 19.056 40.938 93.457 1.00 16.57 A ATOM 1338 OE2 GLU A 177 20.624 42.051 92.388 1.00 16.51 A ATOM 1339 C GLU A 177 14.568 42.422 91.445 1.00 15.11 A ATOM 1340 O GLU A 177 14.355 41.688 90.479 1.00 16.69 A ATOM 1341 N ASN A 178 13.667 42.633 92.398 1.00 15.01 A ATOM 1342 CA ASN A 178 12.387 41.945 92.370 1.00 16.15 A ATOM 1343 CB ASN A 178 11.944 41.597 93.793 1.00 14.81 A ATOM 1344 CG ASN A 178 10.875 40.519 93.815 1.00 18.14 A ATOM 1345 OD1 ASN A 178 11.012 39.493 93.148 1.00 14.61 A ATOM 1346 ND2 ASN A 178 9.813 40.743 94.578 1.00 16.87 A ATOM 1347 C ASN A 178 11.279 42.726 91.677 1.00 17.15 A ATOM 1348 O ASN A 178 10.161 42.233 91.550 1.00 15.08 A ATOM 1349 N ASN A 179 11.594 43.932 91.215 1.00 17.66 A ATOM 1350 CA ASN A 179 10.595 44.773 90.568 1.00 18.39 A ATOM 1351 CB ASN A 179 10.162 45.870 91.545 1.00 19.49 A ATOM 1352 CG ASN A 179 9.505 45.303 92.787 1.00 18.74 A ATOM 1353 OD1 ASN A 179 8.377 44.818 92.734 1.00 19.10 A ATOM 1354 ND2 ASN A 179 10.216 45.341 93.909 1.00 19.12 A ATOM 1355 C ASN A 179 11.069 45.393 89.262 1.00 18.82 A ATOM 1356 O ASN A 179 11.957 46.248 89.251 1.00 18.76 A ATOM 1357 N LYS A 180 10.469 44.960 88.157 1.00 18.18 A ATOM 1358 CA LYS A 180 10.841 45.484 86.856 1.00 17.68 A ATOM 1359 CB LYS A 180 9.980 44.851 85.759 1.00 19.83 A ATOM 1360 CG LYS A 180 10.364 45.309 84.357 1.00 22.78 A ATOM 1361 CD LYS A 180 9.565 44.576 83.284 1.00 28.75 A ATOM 1362 CE LYS A 180 9.922 45.066 81.883 1.00 29.71 A ATOM 1363 NZ LYS A 180 11.333 44.765 81.500 1.00 32.99 A ATOM 1364 C LYS A 180 10.686 47.005 86.833 1.00 16.88 A ATOM 1365 O LYS A 180 9.668 47.541 87.268 1.00 15.93 A ATOM 1366 N ASP A 181 11.725 47.684 86.355 1.00 18.30 A ATOM 1367 CA ASP A 181 11.755 49.144 86.243 1.00 20.40 A ATOM 1368 CB ASP A 181 10.514 49.645 85.496 1.00 22.88 A ATOM 1369 CG ASP A 181 10.441 49.128 84.070 1.00 25.36 A ATOM 1370 OD1 ASP A 181 11.469 49.186 83.369 1.00 27.75 A ATOM 1371 OD2 ASP A 181 9.354 48.677 83.647 1.00 28.77 A ATOM 1372 C ASP A 181 11.886 49.907 87.561 1.00 19.53 A ATOM 1373 O ASP A 181 11.843 51.140 87.572 1.00 20.09 A ATOM 1374 N ALA A 182 12.055 49.195 88.668 1.00 17.14 A ATOM 1375 CA ALA A 182 12.181 49.873 89.950 1.00 16.34 A ATOM 1376 CB ALA A 182 12.174 48.858 91.094 1.00 16.60 A ATOM 1377 C ALA A 182 13.463 50.694 90.000 1.00 14.49 A ATOM 1378 O ALA A 182 14.517 50.241 89.567 1.00 13.96 A ATOM 1379 N ARG A 183 13.357 51.916 90.510 1.00 14.46 A ATOM 1380 CA ARG A 183 14.516 52.788 90.668 1.00 15.12 A ATOM 1381 CB ARG A 183 14.474 53.953 89.679 1.00 14.27 A ATOM 1382 CG ARG A 183 14.834 53.538 88.266 1.00 14.93 A ATOM 1383 CD ARG A 183 16.287 53.084 88.169 1.00 13.32 A ATOM 1384 NE ARG A 183 16.653 52.650 86.819 1.00 16.28 A ATOM 1385 CZ ARG A 183 16.497 51.413 86.349 1.00 17.08 A ATOM 1386 NH1 ARG A 183 15.975 50.459 87.112 1.00 15.62 A ATOM 1387 NH2 ARG A 183 16.892 51.118 85.119 1.00 19.64 A ATOM 1388 C ARG A 183 14.446 53.273 92.104 1.00 14.84 A ATOM 1389 O ARG A 183 13.512 53.989 92.495 1.00 13.87 A ATOM 1390 N VAL A 184 15.435 52.851 92.886 1.00 13.98 A ATOM 1391 CA VAL A 184 15.500 53.157 94.313 1.00 13.66 A ATOM 1392 CB VAL A 184 15.984 51.919 95.105 1.00 12.76 A ATOM 1393 CG1 VAL A 184 15.823 52.141 96.617 1.00 13.61 A ATOM 1394 CG2 VAL A 184 15.224 50.693 94.651 1.00 14.50 A ATOM 1395 C VAL A 184 16.413 54.322 94.663 1.00 13.84 A ATOM 1396 O VAL A 184 17.550 54.395 94.202 1.00 15.51 A ATOM 1397 N LEU A 185 15.894 55.236 95.475 1.00 12.87 A ATOM 1398 CA LEU A 185 16.672 56.375 95.931 1.00 12.68 A ATOM 1399 CB LEU A 185 15.861 57.679 95.834 1.00 11.22 A ATOM 1400 CG LEU A 185 16.532 58.905 96.466 1.00 11.54 A ATOM 1401 CD1 LEU A 185 17.866 59.176 95.778 1.00 13.85 A ATOM 1402 CD2 LEU A 185 15.612 60.122 96.370 1.00 11.09 A ATOM 1403 C LEU A 185 17.017 56.106 97.394 1.00 11.63 A ATOM 1404 O LEU A 185 16.127 55.958 98.230 1.00 13.09 A ATOM 1405 N ILE A 186 18.305 56.010 97.695 1.00 12.57 A ATOM 1406 CA ILE A 186 18.721 55.803 99.072 1.00 12.90 A ATOM 1407 CB ILE A 186 19.867 54.790 99.209 1.00 12.53 A ATOM 1408 CG2 ILE A 186 20.293 54.706 100.672 1.00 15.79 A ATOM 1409 CG1 ILE A 186 19.441 53.411 98.703 1.00 17.58 A ATOM 1410 CD1 ILE A 186 20.562 52.372 98.791 1.00 15.67 A ATOM 1411 C ILE A 186 19.265 57.126 99.580 1.00 12.87 A ATOM 1412 O ILE A 186 20.041 57.782 98.899 1.00 12.60 A ATOM 1413 N VAL A 187 18.851 57.515 100.776 1.00 13.22 A ATOM 1414 CA VAL A 187 19.359 58.741 101.361 1.00 13.67 A ATOM 1415 CB VAL A 187 18.316 59.866 101.349 1.00 14.26 A ATOM 1416 CG1 VAL A 187 18.866 61.083 102.088 1.00 15.07 A ATOM 1417 CG2 VAL A 187 17.967 60.228 99.917 1.00 17.12 A ATOM 1418 C VAL A 187 19.763 58.463 102.795 1.00 11.28 A ATOM 1419 O VAL A 187 18.930 58.089 103.618 1.00 12.82 A ATOM 1420 N CYS A 188 21.051 58.621 103.071 1.00 13.30 A ATOM 1421 CA CYS A 188 21.609 58.430 104.410 1.00 13.30 A ATOM 1422 CB CYS A 188 22.816 57.490 104.382 1.00 14.21 A ATOM 1423 SG CYS A 188 22.413 55.739 104.060 1.00 17.94 A ATOM 1424 C CYS A 188 22.058 59.817 104.839 1.00 11.22 A ATOM 1425 O CYS A 188 22.938 60.401 104.220 1.00 13.60 A ATOM 1426 N SER A 189 21.452 60.332 105.899 1.00 12.04 A ATOM 1427 CA SER A 189 21.765 61.675 106.377 1.00 12.31 A ATOM 1428 CB SER A 189 20.612 62.615 106.024 1.00 14.07 A ATOM 1429 OG SER A 189 20.919 63.953 106.369 1.00 13.79 A ATOM 1430 C SER A 189 21.976 61.646 107.882 1.00 11.93 A ATOM 1431 O SER A 189 21.054 61.336 108.638 1.00 13.29 A ATOM 1432 N GLU A 190 23.185 61.993 108.314 1.00 14.10 A ATOM 1433 CA GLU A 190 23.530 61.959 109.734 1.00 13.97 A ATOM 1434 CB GLU A 190 24.692 60.989 109.951 1.00 16.13 A ATOM 1435 CG GLU A 190 24.461 59.577 109.378 1.00 17.69 A ATOM 1436 CD GLU A 190 23.440 58.747 110.160 1.00 20.46 A ATOM 1437 OE1 GLU A 190 22.984 59.185 111.237 1.00 17.84 A ATOM 1438 OE2 GLU A 190 23.096 57.638 109.692 1.00 22.18 A ATOM 1439 C GLU A 190 23.890 63.345 110.270 1.00 14.72 A ATOM 1440 O GLU A 190 24.438 64.184 109.551 1.00 13.22 A ATOM 1441 N ASN A 191 23.584 63.569 111.542 1.00 14.47 A ATOM 1442 CA ASN A 191 23.826 64.860 112.174 1.00 16.59 A ATOM 1443 CB ASN A 191 22.577 65.726 111.979 1.00 15.33 A ATOM 1444 CG ASN A 191 22.778 67.164 112.405 1.00 16.18 A ATOM 1445 OD1 ASN A 191 23.151 67.441 113.540 1.00 16.84 A ATOM 1446 ND2 ASN A 191 22.505 68.094 111.492 1.00 16.25 A ATOM 1447 C ASN A 191 24.113 64.643 113.665 1.00 17.21 A ATOM 1448 O ASN A 191 23.396 63.894 114.334 1.00 16.87 A ATOM 1449 N THR A 192 25.141 65.310 114.187 1.00 17.46 A ATOM 1450 CA THR A 192 25.527 65.144 115.594 1.00 17.77 A ATOM 1451 CB THR A 192 27.025 65.466 115.792 1.00 19.46 A ATOM 1452 OG1 THR A 192 27.302 66.792 115.326 1.00 21.72 A ATOM 1453 CG2 THR A 192 27.885 64.475 115.021 1.00 24.93 A ATOM 1454 C THR A 192 24.719 65.923 116.637 1.00 17.73 A ATOM 1455 O THR A 192 25.014 65.861 117.835 1.00 17.54 A ATOM 1456 N ALA A 193 23.693 66.643 116.199 1.00 16.98 A ATOM 1457 CA ALA A 193 22.872 67.407 117.131 1.00 17.82 A ATOM 1458 CB ALA A 193 21.695 68.043 116.395 1.00 17.73 A ATOM 1459 C ALA A 193 22.357 66.533 118.276 1.00 19.11 A ATOM 1460 O ALA A 193 22.269 66.978 119.420 1.00 17.05 A ATOM 1461 N VAL A 194 22.033 65.279 117.973 1.00 18.73 A ATOM 1462 CA VAL A 194 21.505 64.391 119.000 1.00 18.68 A ATOM 1463 CB VAL A 194 20.586 63.299 118.366 1.00 20.01 A ATOM 1464 CG1 VAL A 194 21.429 62.229 117.676 1.00 21.94 A ATOM 1465 CG2 VAL A 194 19.681 62.688 119.427 1.00 20.08 A ATOM 1466 C VAL A 194 22.556 63.715 119.894 1.00 18.19 A ATOM 1467 O VAL A 194 22.203 63.188 120.947 1.00 18.53 A ATOM 1468 N THR A 195 23.830 63.737 119.497 1.00 18.59 A ATOM 1469 CA THR A 195 24.892 63.100 120.293 1.00 19.00 A ATOM 1470 CB THR A 195 25.701 62.079 119.456 1.00 19.71 A ATOM 1471 OG1 THR A 195 26.401 62.754 118.405 1.00 19.52 A ATOM 1472 CG2 THR A 195 24.785 61.028 118.860 1.00 22.73 A ATOM 1473 C THR A 195 25.902 64.061 120.940 1.00 18.87 A ATOM 1474 O THR A 195 26.621 63.692 121.870 1.00 18.50 A ATOM 1475 N PHE A 196 25.971 65.290 120.454 1.00 19.16 A ATOM 1476 CA PHE A 196 26.917 66.244 121.024 1.00 16.16 A ATOM 1477 CB PHE A 196 26.878 67.552 120.230 1.00 17.37 A ATOM 1478 CG PHE A 196 27.756 68.625 120.797 1.00 18.14 A ATOM 1479 CD1 PHE A 196 27.339 69.384 121.885 1.00 19.21 A ATOM 1480 CD2 PHE A 196 29.030 68.834 120.285 1.00 17.83 A ATOM 1481 CE1 PHE A 196 28.185 70.333 122.459 1.00 19.80 A ATOM 1482 CE2 PHE A 196 29.878 69.779 120.854 1.00 18.39 A ATOM 1483 CZ PHE A 196 29.455 70.525 121.940 1.00 16.80 A ATOM 1484 C PHE A 196 26.614 66.533 122.497 1.00 15.24 A ATOM 1485 O PHE A 196 25.466 66.703 122.874 1.00 15.60 A ATOM 1486 N ARG A 197 27.645 66.567 123.334 1.00 15.68 A ATOM 1487 CA ARG A 197 27.447 66.885 124.745 1.00 17.09 A ATOM 1488 CB ARG A 197 26.765 65.729 125.500 1.00 16.77 A ATOM 1489 CG ARG A 197 27.647 64.546 125.839 1.00 18.42 A ATOM 1490 CD ARG A 197 26.830 63.452 126.527 1.00 17.90 A ATOM 1491 NE ARG A 197 25.711 63.026 125.689 1.00 18.84 A ATOM 1492 CZ ARG A 197 24.453 63.420 125.855 1.00 17.63 A ATOM 1493 NH1 ARG A 197 24.133 64.249 126.843 1.00 16.56 A ATOM 1494 NH2 ARG A 197 23.517 63.008 125.012 1.00 16.66 A ATOM 1495 C ARG A 197 28.758 67.250 125.421 1.00 17.09 A ATOM 1496 O ARG A 197 29.842 66.951 124.904 1.00 16.37 A ATOM 1497 N GLY A 198 28.642 67.909 126.572 1.00 16.23 A ATOM 1498 CA GLY A 198 29.806 68.325 127.330 1.00 16.62 A ATOM 1499 C GLY A 198 30.669 67.174 127.809 1.00 16.44 A ATOM 1500 O GLY A 198 30.266 66.010 127.727 1.00 17.18 A ATOM 1501 N PRO A 199 31.866 67.470 128.330 1.00 16.69 A ATOM 1502 CD PRO A 199 32.552 68.775 128.239 1.00 16.86 A ATOM 1503 CA PRO A 199 32.781 66.435 128.814 1.00 16.94 A ATOM 1504 CB PRO A 199 34.146 67.038 128.518 1.00 17.97 A ATOM 1505 CG PRO A 199 33.912 68.487 128.865 1.00 16.67 A ATOM 1506 C PRO A 199 32.643 66.060 130.280 1.00 18.52 A ATOM 1507 O PRO A 199 32.167 66.841 131.097 1.00 17.68 A ATOM 1508 N SER A 200 33.073 64.847 130.598 1.00 19.80 A ATOM 1509 CA SER A 200 33.057 64.349 131.964 1.00 20.75 A ATOM 1510 CB SER A 200 31.718 63.701 132.311 1.00 22.74 A ATOM 1511 OG SER A 200 31.780 63.121 133.608 1.00 23.95 A ATOM 1512 C SER A 200 34.162 63.317 132.105 1.00 21.76 A ATOM 1513 O SER A 200 34.274 62.396 131.287 1.00 18.77 A ATOM 1514 N GLU A 201 34.974 63.480 133.146 1.00 19.44 A ATOM 1515 CA GLU A 201 36.076 62.568 133.425 1.00 22.42 A ATOM 1516 CB GLU A 201 36.836 63.045 134.670 1.00 23.51 A ATOM 1517 CG GLU A 201 37.728 64.257 134.419 1.00 28.88 A ATOM 1518 CD GLU A 201 38.211 64.911 135.704 1.00 32.82 A ATOM 1519 OE1 GLU A 201 38.427 64.177 136.694 1.00 32.22 A ATOM 1520 OE2 GLU A 201 38.381 66.156 135.717 1.00 32.99 A ATOM 1521 C GLU A 201 35.554 61.152 133.646 1.00 21.15 A ATOM 1522 O GLU A 201 36.291 60.176 133.492 1.00 21.69 A ATOM 1523 N THR A 202 34.276 61.053 133.990 1.00 21.62 A ATOM 1524 CA THR A 202 33.631 59.766 134.249 1.00 23.21 A ATOM 1525 CB THR A 202 32.438 59.943 135.214 1.00 24.29 A ATOM 1526 OG1 THR A 202 31.389 60.665 134.550 1.00 25.61 A ATOM 1527 CG2 THR A 202 32.870 60.724 136.454 1.00 23.67 A ATOM 1528 C THR A 202 33.111 59.048 132.996 1.00 24.32 A ATOM 1529 O THR A 202 32.641 57.909 133.087 1.00 23.55 A ATOM 1530 N ASP A 203 33.206 59.699 131.837 1.00 24.26 A ATOM 1531 CA ASP A 203 32.706 59.123 130.586 1.00 23.45 A ATOM 1532 CB ASP A 203 31.356 59.772 130.253 1.00 23.20 A ATOM 1533 CG ASP A 203 30.514 58.945 129.295 1.00 24.79 A ATOM 1534 OD1 ASP A 203 29.302 59.243 129.174 1.00 25.03 A ATOM 1535 OD2 ASP A 203 31.045 58.010 128.664 1.00 23.91 A ATOM 1536 C ASP A 203 33.691 59.328 129.430 1.00 23.07 A ATOM 1537 O ASP A 203 33.483 60.191 128.572 1.00 20.44 A ATOM 1538 N MET A 204 34.761 58.535 129.410 1.00 21.83 A ATOM 1539 CA MET A 204 35.771 58.643 128.362 1.00 21.76 A ATOM 1540 CB MET A 204 37.010 57.808 128.720 1.00 24.97 A ATOM 1541 CG MET A 204 37.825 58.362 129.886 1.00 27.70 A ATOM 1542 SD MET A 204 38.360 60.089 129.663 1.00 29.97 A ATOM 1543 CE MET A 204 37.140 60.917 130.571 1.00 29.70 A ATOM 1544 C MET A 204 35.225 58.200 127.010 1.00 22.24 A ATOM 1545 O MET A 204 35.629 58.722 125.967 1.00 20.89 A ATOM 1546 N ASP A 205 34.309 57.232 127.032 1.00 21.97 A ATOM 1547 CA ASP A 205 33.690 56.736 125.805 1.00 22.89 A ATOM 1548 CB ASP A 205 32.629 55.690 126.133 1.00 25.54 A ATOM 1549 CG ASP A 205 33.214 54.327 126.373 1.00 29.64 A ATOM 1550 OD1 ASP A 205 34.441 54.243 126.610 1.00 29.17 A ATOM 1551 OD2 ASP A 205 32.441 53.343 126.332 1.00 27.49 A ATOM 1552 C ASP A 205 33.023 57.883 125.071 1.00 21.88 A ATOM 1553 O ASP A 205 33.260 58.105 123.884 1.00 19.23 A ATOM 1554 N SER A 206 32.172 58.606 125.793 1.00 21.39 A ATOM 1555 CA SER A 206 31.452 59.726 125.210 1.00 22.34 A ATOM 1556 CB SER A 206 30.534 60.361 126.260 1.00 24.35 A ATOM 1557 OG SER A 206 29.801 61.441 125.711 1.00 28.36 A ATOM 1558 C SER A 206 32.419 60.765 124.651 1.00 22.11 A ATOM 1559 O SER A 206 32.205 61.294 123.560 1.00 22.41 A ATOM 1560 N LEU A 207 33.489 61.042 125.395 1.00 20.55 A ATOM 1561 CA LEU A 207 34.487 62.018 124.972 1.00 19.96 A ATOM 1562 CB LEU A 207 35.563 62.184 126.055 1.00 19.69 A ATOM 1563 CG LEU A 207 36.586 63.301 125.825 1.00 21.16 A ATOM 1564 CD1 LEU A 207 35.909 64.664 125.936 1.00 20.91 A ATOM 1565 CD2 LEU A 207 37.712 63.182 126.845 1.00 22.85 A ATOM 1566 C LEU A 207 35.129 61.598 123.648 1.00 18.93 A ATOM 1567 O LEU A 207 35.369 62.430 122.778 1.00 19.49 A ATOM 1568 N VAL A 208 35.402 60.304 123.491 1.00 19.50 A ATOM 1569 CA VAL A 208 35.993 59.811 122.252 1.00 18.09 A ATOM 1570 CB VAL A 208 36.308 58.299 122.351 1.00 19.75 A ATOM 1571 CG1 VAL A 208 36.723 57.760 120.995 1.00 22.42 A ATOM 1572 CG2 VAL A 208 37.408 58.068 123.378 1.00 22.62 A ATOM 1573 C VAL A 208 35.020 60.059 121.090 1.00 18.11 A ATOM 1574 O VAL A 208 35.428 60.418 119.982 1.00 17.15 A ATOM 1575 N GLY A 209 33.730 59.875 121.349 1.00 17.76 A ATOM 1576 CA GLY A 209 32.744 60.102 120.308 1.00 18.19 A ATOM 1577 C GLY A 209 32.715 61.554 119.858 1.00 19.02 A ATOM 1578 O GLY A 209 32.445 61.843 118.689 1.00 20.34 A ATOM 1579 N GLN A 210 32.993 62.472 120.780 1.00 17.40 A ATOM 1580 CA GLN A 210 32.987 63.901 120.465 1.00 17.84 A ATOM 1581 CB GLN A 210 33.053 64.729 121.754 1.00 16.99 A ATOM 1582 CG GLN A 210 31.942 64.396 122.742 1.00 19.21 A ATOM 1583 CD GLN A 210 30.542 64.568 122.154 1.00 20.53 A ATOM 1584 OE1 GLN A 210 29.627 63.805 122.470 1.00 20.22 A ATOM 1585 NE2 GLN A 210 30.369 65.578 121.314 1.00 12.91 A ATOM 1586 C GLN A 210 34.133 64.284 119.534 1.00 16.80 A ATOM 1587 O GLN A 210 34.113 65.350 118.921 1.00 18.59 A ATOM 1588 N ALA A 211 35.123 63.405 119.415 1.00 16.27 A ATOM 1589 CA ALA A 211 36.268 63.654 118.546 1.00 16.35 A ATOM 1590 CB ALA A 211 37.552 63.197 119.239 1.00 18.22 A ATOM 1591 C ALA A 211 36.115 62.931 117.207 1.00 15.81 A ATOM 1592 O ALA A 211 36.803 63.251 116.227 1.00 16.08 A ATOM 1593 N LEU A 212 35.192 61.976 117.166 1.00 14.42 A ATOM 1594 CA LEU A 212 34.961 61.172 115.968 1.00 15.87 A ATOM 1595 CB LEU A 212 34.778 59.703 116.370 1.00 15.09 A ATOM 1596 CG LEU A 212 35.978 58.937 116.915 1.00 20.51 A ATOM 1597 CD1 LEU A 212 35.522 57.536 117.328 1.00 20.17 A ATOM 1598 CD2 LEU A 212 37.067 58.856 115.853 1.00 20.66 A ATOM 1599 C LEU A 212 33.805 61.529 115.040 1.00 15.76 A ATOM 1600 O LEU A 212 33.991 61.646 113.830 1.00 17.03 A ATOM 1601 N PHE A 213 32.609 61.675 115.605 1.00 16.08 A ATOM 1602 CA PHE A 213 31.408 61.918 114.806 1.00 16.97 A ATOM 1603 CB PHE A 213 30.164 61.636 115.651 1.00 17.71 A ATOM 1604 CG PHE A 213 30.186 60.292 116.314 1.00 20.56 A ATOM 1605 CD1 PHE A 213 30.512 59.152 115.587 1.00 22.69 A ATOM 1606 CD2 PHE A 213 29.923 60.168 117.671 1.00 21.84 A ATOM 1607 CE1 PHE A 213 30.583 57.913 116.206 1.00 24.50 A ATOM 1608 CE2 PHE A 213 29.992 58.928 118.297 1.00 22.58 A ATOM 1609 CZ PHE A 213 30.323 57.805 117.566 1.00 20.73 A ATOM 1610 C PHE A 213 31.260 63.254 114.101 1.00 15.36 A ATOM 1611 O PHE A 213 31.551 64.304 114.659 1.00 12.76 A ATOM 1612 N ALA A 214 30.771 63.184 112.863 1.00 16.63 A ATOM 1613 CA ALA A 214 30.586 64.363 112.018 1.00 15.40 A ATOM 1614 CB ALA A 214 31.759 64.497 111.050 1.00 16.43 A ATOM 1615 C ALA A 214 29.276 64.260 111.243 1.00 15.29 A ATOM 1616 O ALA A 214 28.595 63.232 111.301 1.00 16.79 A ATOM 1617 N ASP A 215 28.946 65.316 110.502 1.00 16.01 A ATOM 1618 CA ASP A 215 27.700 65.379 109.735 1.00 15.93 A ATOM 1619 CB ASP A 215 26.972 66.703 109.998 1.00 17.66 A ATOM 1620 CG ASP A 215 26.788 66.996 111.474 1.00 22.88 A ATOM 1621 OD1 ASP A 215 26.964 66.080 112.302 1.00 22.93 A ATOM 1622 OD2 ASP A 215 26.452 68.151 111.805 1.00 21.11 A ATOM 1623 C ASP A 215 27.896 65.251 108.231 1.00 13.47 A ATOM 1624 O ASP A 215 28.892 65.710 107.682 1.00 12.91 A ATOM 1625 N GLY A 216 26.914 64.642 107.571 1.00 14.99 A ATOM 1626 CA GLY A 216 26.969 64.472 106.135 1.00 14.98 A ATOM 1627 C GLY A 216 25.807 63.636 105.626 1.00 15.88 A ATOM 1628 O GLY A 216 25.154 62.929 106.398 1.00 14.93 A ATOM 1629 N ALA A 217 25.537 63.731 104.329 1.00 16.39 A ATOM 1630 CA ALA A 217 24.461 62.961 103.719 1.00 15.08 A ATOM 1631 CB ALA A 217 23.207 63.820 103.543 1.00 14.14 A ATOM 1632 C ALA A 217 24.925 62.454 102.373 1.00 14.86 A ATOM 1633 O ALA A 217 25.679 63.121 101.666 1.00 15.64 A ATOM 1634 N ALA A 218 24.478 61.256 102.027 1.00 13.54 A ATOM 1635 CA ALA A 218 24.828 60.671 100.750 1.00 14.40 A ATOM 1636 CB ALA A 218 25.784 59.499 100.950 1.00 13.37 A ATOM 1637 C ALA A 218 23.521 60.202 100.131 1.00 14.12 A ATOM 1638 O ALA A 218 22.622 59.752 100.845 1.00 15.69 A ATOM 1639 N ALA A 219 23.408 60.336 98.815 1.00 14.03 A ATOM 1640 CA ALA A 219 22.212 59.908 98.103 1.00 15.39 A ATOM 1641 CB ALA A 219 21.447 61.112 97.556 1.00 15.27 A ATOM 1642 C ALA A 219 22.667 59.003 96.971 1.00 14.28 A ATOM 1643 O ALA A 219 23.623 59.315 96.251 1.00 14.99 A ATOM 1644 N ILE A 220 21.974 57.882 96.823 1.00 13.67 A ATOM 1645 CA ILE A 220 22.325 56.893 95.819 1.00 13.44 A ATOM 1646 CB ILE A 220 22.991 55.672 96.495 1.00 14.33 A ATOM 1647 CG2 ILE A 220 23.609 54.782 95.461 1.00 14.98 A ATOM 1648 CG1 ILE A 220 24.037 56.134 97.515 1.00 14.70 A ATOM 1649 CD1 ILE A 220 23.478 56.354 98.914 1.00 16.90 A ATOM 1650 C ILE A 220 21.114 56.389 95.029 1.00 13.38 A ATOM 1651 O ILE A 220 20.061 56.123 95.598 1.00 14.24 A ATOM 1652 N ILE A 221 21.273 56.264 93.717 1.00 13.12 A ATOM 1653 CA ILE A 221 20.207 55.747 92.867 1.00 14.15 A ATOM 1654 CB ILE A 221 20.057 56.561 91.562 1.00 15.24 A ATOM 1655 CG2 ILE A 221 18.984 55.924 90.679 1.00 14.91 A ATOM 1656 CG1 ILE A 221 19.692 58.013 91.886 1.00 16.31 A ATOM 1657 CD1 ILE A 221 18.300 58.187 92.471 1.00 17.99 A ATOM 1658 C ILE A 221 20.623 54.331 92.496 1.00 15.28 A ATOM 1659 O ILE A 221 21.730 54.121 91.989 1.00 14.96 A ATOM 1660 N ILE A 222 19.735 53.372 92.749 1.00 15.38 A ATOM 1661 CA ILE A 222 19.995 51.971 92.443 1.00 15.44 A ATOM 1662 CB ILE A 222 20.102 51.136 93.720 1.00 16.28 A ATOM 1663 CG2 ILE A 222 20.159 49.646 93.368 1.00 15.57 A ATOM 1664 CG1 ILE A 222 21.346 51.553 94.510 1.00 21.06 A ATOM 1665 CD1 ILE A 222 21.400 50.945 95.884 1.00 23.56 A ATOM 1666 C ILE A 222 18.881 51.365 91.595 1.00 15.66 A ATOM 1667 O ILE A 222 17.703 51.641 91.818 1.00 12.27 A ATOM 1668 N GLY A 223 19.263 50.531 90.634 1.00 13.58 A ATOM 1669 CA GLY A 223 18.270 49.885 89.792 1.00 15.55 A ATOM 1670 C GLY A 223 18.839 48.726 88.998 1.00 15.80 A ATOM 1671 O GLY A 223 20.040 48.677 88.737 1.00 15.51 A ATOM 1672 N SER A 224 17.985 47.777 88.630 1.00 15.62 A ATOM 1673 CA SER A 224 18.426 46.645 87.819 1.00 17.60 A ATOM 1674 CB SER A 224 17.697 45.357 88.235 1.00 17.65 A ATOM 1675 CG SER A 224 18.151 44.877 89.495 1.00 15.67 A ATOM 1676 C SER A 224 18.106 46.970 86.352 1.00 18.97 A ATOM 1677 O SER A 224 17.281 47.835 86.074 1.00 16.29 A ATOM 1678 N ASP A 225 18.772 46.288 85.427 1.00 19.29 A ATOM 1679 CA ASP A 225 18.550 46.486 83.996 1.00 20.50 A ATOM 1680 CB ASP A 225 17.159 45.973 83.610 1.00 22.70 A ATOM 1681 CG ASP A 225 16.916 44.546 84.075 1.00 24.43 A ATOM 1682 OD1 ASP A 225 17.893 43.773 84.138 1.00 25.70 A ATOM 1683 OD2 ASP A 225 15.752 44.198 84.366 1.00 25.65 A ATOM 1684 C ASP A 225 18.695 47.941 83.559 1.00 21.75 A ATOM 1685 O ASP A 225 17.724 48.571 83.124 1.00 19.34 A ATOM 1686 N PRO A 226 19.910 48.499 83.675 1.00 22.11 A ATOM 1687 CD PRO A 226 21.149 47.915 84.216 1.00 22.58 A ATOM 1688 CA PRO A 226 20.113 49.893 83.272 1.00 22.76 A ATOM 1689 CB PRO A 226 21.543 50.183 83.726 1.00 23.77 A ATOM 1690 CG PRO A 226 22.201 48.835 83.655 1.00 24.27 A ATOM 1691 C PRO A 226 19.917 50.108 81.776 1.00 24.18 A ATOM 1692 O PRO A 226 20.359 49.300 80.959 1.00 23.57 A ATOM 1693 N VAL A 227 19.241 51.200 81.433 1.00 25.11 A ATOM 1694 CA VAL A 227 18.983 51.552 80.041 1.00 27.09 A ATOM 1695 CB VAL A 227 18.034 52.766 79.941 1.00 27.14 A ATOM 1696 CG1 VAL A 227 17.822 53.145 78.475 1.00 28.54 A ATOM 1697 CG2 VAL A 227 16.704 52.444 80.614 1.00 26.13 A ATOM 1698 C VAL A 227 20.309 51.909 79.385 1.00 29.32 A ATOM 1699 O VAL A 227 20.960 52.883 79.762 1.00 30.05 A ATOM 1700 N PRO A 228 20.726 51.127 78.382 1.00 31.26 A ATOM 1701 CD PRO A 228 19.997 50.035 77.714 1.00 31.51 A ATOM 1702 CA PRO A 228 21.994 51.402 77.707 1.00 32.21 A ATOM 1703 CB PRO A 228 22.097 50.258 76.698 1.00 33.57 A ATOM 1704 CG PRO A 228 20.662 49.991 76.358 1.00 33.69 A ATOM 1705 C PRO A 228 22.077 52.779 77.053 1.00 33.32 A ATOM 1706 O PRO A 228 21.109 53.270 76.468 1.00 33.41 A ATOM 1707 N GLU A 229 23.245 53.398 77.180 1.00 35.15 A ATOM 1708 CA GLU A 229 23.510 54.708 76.600 1.00 35.98 A ATOM 1709 CB GLU A 229 23.274 54.662 75.086 1.00 39.82 A ATOM 1710 CG GLU A 229 24.112 55.656 74.289 1.00 44.78 A ATOM 1711 CD GLU A 229 25.586 55.274 74.233 1.00 48.37 A ATOM 1712 OE1 GLU A 229 26.221 55.162 75.307 1.00 50.63 A ATOM 1713 OE2 GLU A 229 26.111 55.087 73.113 1.00 49.28 A ATOM 1714 C GLU A 229 22.677 55.830 77.221 1.00 34.20 A ATOM 1715 O GLU A 229 22.714 56.969 76.751 1.00 34.48 A ATOM 1716 N VAL A 230 21.926 55.509 78.270 1.00 30.04 A ATOM 1717 CA VAL A 230 21.109 56.508 78.956 1.00 27.19 A ATOM 1718 CB VAL A 230 19.614 56.160 78.878 1.00 28.09 A ATOM 1719 CG1 VAL A 230 18.810 57.139 79.712 1.00 26.44 A ATOM 1720 CG2 VAL A 230 19.153 56.198 77.428 1.00 29.81 A ATOM 1721 C VAL A 230 21.543 56.580 80.418 1.00 25.17 A ATOM 1722 O VAL A 230 21.904 57.643 80.919 1.00 24.16 A ATOM 1723 N GLU A 231 21.498 55.442 81.099 1.00 20.97 A ATOM 1724 CA GLU A 231 21.929 55.371 82.491 1.00 22.09 A ATOM 1725 CB GLU A 231 21.017 54.425 83.285 1.00 19.51 A ATOM 1726 CG GLU A 231 19.598 54.962 83.442 1.00 20.55 A ATOM 1727 CD GLU A 231 18.638 53.974 84.084 1.00 18.71 A ATOM 1728 OE1 GLU A 231 18.623 52.804 83.655 1.00 19.07 A ATOM 1729 OE2 GLU A 231 17.890 54.370 85.004 1.00 17.90 A ATOM 1730 C GLU A 231 23.367 54.855 82.460 1.00 22.54 A ATOM 1731 O GLU A 231 23.778 54.217 81.487 1.00 23.20 A ATOM 1732 N LYS A 232 24.136 55.120 83.511 1.00 22.05 A ATOM 1733 CA LYS A 232 25.525 54.684 83.522 1.00 22.17 A ATOM 1734 CB LYS A 232 26.435 55.886 83.249 1.00 25.60 A ATOM 1735 CG LYS A 232 26.106 56.608 81.942 1.00 30.76 A ATOM 1736 CD LYS A 232 26.256 55.672 80.745 1.00 36.23 A ATOM 1737 CE LYS A 232 25.664 56.271 79.471 1.00 38.29 A ATOM 1738 NZ LYS A 232 26.334 57.539 79.069 1.00 37.95 A ATOM 1739 C LYS A 232 25.956 53.989 84.807 1.00 21.43 A ATOM 1740 O LYS A 232 26.191 54.635 85.831 1.00 18.89 A ATOM 1741 N PRO A 233 26.076 52.653 84.762 1.00 20.17 A ATOM 1742 CD PRO A 233 25.704 51.783 83.629 1.00 19.69 A ATOM 1743 CA PRO A 233 26.485 51.853 85.920 1.00 18.06 A ATOM 1744 CB PRO A 233 26.556 50.441 85.348 1.00 17.95 A ATOM 1745 CG PRO A 233 25.475 50.451 84.307 1.00 19.68 A ATOM 1746 C PRO A 233 27.820 52.297 86.523 1.00 17.74 A ATOM 1747 O PRO A 233 28.701 52.797 85.814 1.00 17.95 A ATOM 1748 N ILE A 234 27.955 52.107 87.833 1.00 16.92 A ATOM 1749 CA ILE A 234 29.174 52.449 88.566 1.00 16.46 A ATOM 1750 CB ILE A 234 28.901 53.555 89.610 1.00 17.04 A ATOM 1751 CG2 ILE A 234 30.204 53.975 90.274 1.00 17.44 A ATOM 1752 CG1 ILE A 234 28.248 54.759 88.926 1.00 16.08 A ATOM 1753 CD1 ILE A 234 27.885 55.908 89.868 1.00 15.92 A ATOM 1754 C ILE A 234 29.695 51.194 89.282 1.00 16.04 A ATOM 1755 O ILE A 234 30.876 50.859 89.191 1.00 15.88 A ATOM 1756 N PHE A 235 28.799 50.509 89.987 1.00 14.55 A ATOM 1757 CA PHE A 235 29.125 49.275 90.703 1.00 15.26 A ATOM 1758 CB PHE A 235 29.483 49.545 92.174 1.00 15.43 A ATOM 1759 CG PHE A 235 30.769 50.301 92.372 1.00 16.25 A ATOM 1760 CD1 PHE A 235 31.996 49.687 92.154 1.00 15.90 A ATOM 1761 CD2 PHE A 235 30.745 51.633 92.788 1.00 17.19 A ATOM 1762 CE1 PHE A 235 33.194 50.386 92.346 1.00 17.25 A ATOM 1763 CE2 PHE A 235 31.927 52.344 92.983 1.00 14.62 A ATOM 1764 CZ PHE A 235 33.157 51.723 92.762 1.00 15.37 A ATOM 1765 C PHE A 235 27.870 48.414 90.681 1.00 16.08 A ATOM 1766 O PHE A 235 26.763 48.938 90.602 1.00 15.87 A ATOM 1767 N GLU A 236 28.043 47.099 90.739 1.00 15.93 A ATOM 1768 CA GLU A 236 26.907 46.180 90.781 1.00 16.34 A ATOM 1769 CB GLU A 236 27.027 45.090 89.715 1.00 17.35 A ATOM 1770 CG GLU A 236 27.058 45.559 88.281 1.00 20.47 A ATOM 1771 CD GLU A 236 26.908 44.398 87.313 1.00 25.69 A ATOM 1772 OE1 GLU A 236 27.460 43.312 87.600 1.00 24.01 A ATOM 1773 OE2 GLU A 236 26.248 44.571 86.267 1.00 28.51 A ATOM 1774 C GLU A 236 26.949 45.504 92.149 1.00 16.24 A ATOM 1775 O GLU A 236 28.034 45.240 92.673 1.00 17.59 A ATOM 1776 N LEU A 237 25.781 45.226 92.721 1.00 16.37 A ATOM 1777 CA LEU A 237 25.695 44.558 94.013 1.00 17.59 A ATOM 1778 CB LEU A 237 24.447 45.034 94.764 1.00 18.64 A ATOM 1779 CG LEU A 237 24.363 46.549 95.008 1.00 18.69 A ATOM 1780 CD1 LEU A 237 23.085 46.887 95.785 1.00 18.52 A ATOM 1781 CD2 LEU A 237 25.589 47.006 95.779 1.00 19.96 A ATOM 1782 C LEU A 237 25.629 43.050 93.746 1.00 18.31 A ATOM 1783 O LEU A 237 24.752 42.586 93.025 1.00 18.78 A ATOM 1784 N VAL A 238 26.557 42.297 94.329 1.00 19.02 A ATOM 1785 CA VAL A 238 26.637 40.849 94.127 1.00 18.34 A ATOM 1786 CB VAL A 238 28.117 40.419 93.976 1.00 19.89 A ATOM 1787 CG1 VAL A 238 28.216 38.929 93.689 1.00 20.10 A ATOM 1788 CG2 VAL A 238 28.765 41.213 92.855 1.00 19.49 A ATOM 1789 C VAL A 238 25.982 40.027 95.243 1.00 18.89 A ATOM 1790 O VAL A 238 25.114 39.187 94.989 1.00 18.23 A ATOM 1791 N SER A 239 26.410 40.259 96.479 1.00 17.69 A ATOM 1792 CA SER A 239 25.853 39.544 97.621 1.00 18.25 A ATOM 1793 CB SER A 239 26.626 38.252 97.890 1.00 18.69 A ATOM 1794 OG SER A 239 27.964 38.546 98.228 1.00 19.05 A ATOM 1795 C SER A 239 25.935 40.437 98.844 1.00 18.67 A ATOM 1796 O SER A 239 26.749 41.352 98.892 1.00 18.20 A ATOM 1797 N THR A 240 25.079 40.167 99.823 1.00 20.47 A ATOM 1798 CA THR A 240 25.040 40.933 101.061 1.00 21.73 A ATOM 1799 CB THR A 240 23.894 41.977 101.038 1.00 22.77 A ATOM 1800 OG1 THR A 240 22.642 41.316 100.814 1.00 23.88 A ATOM 1801 CG2 THR A 240 24.115 42.997 99.928 1.00 23.12 A ATOM 1802 C THR A 240 24.819 39.988 102.241 1.00 22.20 A ATOM 1803 O THR A 240 23.843 39.236 102.264 1.00 23.37 A ATOM 1804 N ASP A 241 25.738 40.011 103.203 1.00 19.70 A ATOM 1805 CA ASP A 241 25.636 39.175 104.397 1.00 18.27 A ATOM 1806 CB ASP A 241 26.845 38.232 104.520 1.00 20.13 A ATOM 1807 CG ASP A 241 26.980 37.278 103.344 1.00 21.50 A ATOM 1808 OD1 ASP A 241 25.994 36.577 103.024 1.00 21.04 A ATOM 1809 OD2 ASP A 241 28.082 37.220 102.746 1.00 20.42 A ATOM 1810 C ASP A 241 25.622 40.096 105.616 1.00 18.38 A ATOM 1811 O ASP A 241 26.094 41.234 105.545 1.00 17.12 A ATOM 1812 N GLN A 242 25.063 39.613 106.722 1.00 14.47 A ATOM 1813 CA GLN A 242 25.039 40.379 107.961 1.00 17.92 A ATOM 1814 CB GLN A 242 23.684 41.068 108.189 1.00 16.66 A ATOM 1815 CG GLN A 242 23.701 42.010 109.410 1.00 18.83 A ATOM 1816 CD GLN A 242 22.334 42.557 109.787 1.00 17.48 A ATOM 1817 OE1 GLN A 242 21.344 41.834 109.772 1.00 21.26 A ATOM 1818 NE2 GLN A 242 22.281 43.837 110.162 1.00 17.14 A ATOM 1819 C GLN A 242 25.309 39.389 109.083 1.00 17.83 A ATOM 1820 O GLN A 242 24.858 38.244 109.023 1.00 19.34 A ATOM 1821 N LYS A 243 26.047 39.817 110.099 1.00 18.25 A ATOM 1822 CA LYS A 243 26.354 38.927 111.209 1.00 17.86 A ATOM 1823 CB LYS A 243 27.610 38.114 110.910 1.00 18.91 A ATOM 1824 CG LYS A 243 27.935 37.098 112.007 1.00 20.00 A ATOM 1825 CD LYS A 243 29.136 36.244 111.667 1.00 22.37 A ATOM 1826 CE LYS A 243 29.250 35.069 112.631 1.00 26.37 A ATOM 1827 NZ LYS A 243 29.364 35.524 114.037 1.00 25.10 A ATOM 1828 C LYS A 243 26.552 39.623 112.548 1.00 19.29 A ATOM 1829 O LYS A 243 27.176 40.687 112.633 1.00 16.88 A ATOM 1830 N LEU A 244 26.019 38.993 113.589 1.00 18.07 A ATOM 1831 CA LEU A 244 26.151 39.481 114.950 1.00 18.71 A ATOM 1832 CB LEU A 244 24.867 39.232 115.746 1.00 19.92 A ATOM 1833 CG LEU A 244 23.763 40.289 115.745 1.00 21.98 A ATOM 1834 CD1 LEU A 244 22.516 39.719 116.407 1.00 21.24 A ATOM 1835 CD2 LEU A 244 24.248 41.533 116.491 1.00 22.15 A ATOM 1836 C LEU A 244 27.272 38.675 115.582 1.00 18.89 A ATOM 1837 O LEU A 244 27.307 37.453 115.456 1.00 18.50 A ATOM 1838 N VAL A 245 28.200 39.354 116.241 1.00 19.19 A ATOM 1839 CA VAL A 245 29.286 38.656 116.919 1.00 20.00 A ATOM 1840 CB VAL A 245 30.556 39.522 116.976 1.00 21.57 A ATOM 1841 CG1 VAL A 245 31.655 38.800 117.743 1.00 19.12 A ATOM 1842 CG2 VAL A 245 31.017 39.838 115.553 1.00 22.63 A ATOM 1843 C VAL A 245 28.783 38.368 118.332 1.00 19.85 A ATOM 1844 O VAL A 245 28.518 39.288 119.114 1.00 17.71 A ATOM 1845 N PRO A 246 28.623 37.081 118.672 1.00 19.89 A ATOM 1846 CD PRO A 246 28.880 35.885 117.856 1.00 21.03 A ATOM 1847 CA PRO A 246 28.142 36.706 120.006 1.00 21.13 A ATOM 1848 CB PRO A 246 28.244 35.182 119.996 1.00 21.02 A ATOM 1849 CG PRO A 246 28.038 34.840 118.561 1.00 21.01 A ATOM 1850 C PRO A 246 28.978 37.320 121.117 1.00 19.52 A ATOM 1851 O PRO A 246 30.173 37.545 120.950 1.00 20.14 A ATOM 1852 N GLY A 247 28.329 37.593 122.243 1.00 21.22 A ATOM 1853 CA GLY A 247 29.006 38.152 123.399 1.00 21.01 A ATOM 1854 C GLY A 247 29.635 39.525 123.242 1.00 22.29 A ATOM 1855 O GLY A 247 30.659 39.802 123.863 1.00 23.76 A ATOM 1856 N SER A 248 29.034 40.396 122.439 1.00 20.11 A ATOM 1857 CA SER A 248 29.607 41.724 122.257 1.00 19.92 A ATOM 1858 CB SER A 248 30.412 41.774 120.952 1.00 19.95 A ATOM 1859 OG SER A 248 29.602 41.489 119.822 1.00 20.22 A ATOM 1860 C SER A 248 28.584 42.854 122.282 1.00 19.40 A ATOM 1861 O SER A 248 28.761 43.870 121.613 1.00 18.71 A ATOM 1862 N HIS A 249 27.524 42.692 123.068 1.00 19.08 A ATOM 1863 CA HIS A 249 26.494 43.729 123.156 1.00 20.12 A ATOM 1864 CB HIS A 249 25.364 43.277 124.088 1.00 21.72 A ATOM 1865 CG HIS A 249 24.341 44.339 124.359 1.00 21.96 A ATOM 1866 CD2 HIS A 249 24.221 45.219 125.382 1.00 23.31 A ATOM 1867 ND1 HIS A 249 23.290 44.600 123.505 1.00 24.75 A ATOM 1868 CE1 HIS A 249 22.566 45.593 123.991 1.00 20.55 A ATOM 1869 NE2 HIS A 249 23.110 45.988 125.128 1.00 23.96 A ATOM 1870 C HIS A 249 27.087 45.037 123.682 1.00 20.12 A ATOM 1871 O HIS A 249 26.687 46.133 123.261 1.00 17.34 A ATOM 1872 N GLY A 250 28.045 44.908 124.599 1.00 18.18 A ATOM 1873 CA GLY A 250 28.679 46.074 125.196 1.00 21.10 A ATOM 1874 C GLY A 250 29.815 46.741 124.427 1.00 21.47 A ATOM 1875 O GLY A 250 30.439 47.677 124.938 1.00 21.77 A ATOM 1876 N ALA A 251 30.087 46.286 123.206 1.00 19.97 A ATOM 1877 CA ALA A 251 31.160 46.869 122.407 1.00 20.87 A ATOM 1878 CB ALA A 251 31.528 45.932 121.257 1.00 21.00 A ATOM 1879 C ALA A 251 30.785 48.252 121.858 1.00 21.86 A ATOM 1880 O ALA A 251 31.551 49.209 121.990 1.00 20.74 A ATOM 1881 N ILE A 252 29.611 48.350 121.242 1.00 20.93 A ATOM 1882 CA ILE A 252 29.147 49.615 120.667 1.00 22.07 A ATOM 1883 CB ILE A 252 29.434 49.698 119.155 1.00 24.82 A ATOM 1884 CG2 ILE A 252 29.122 51.102 118.649 1.00 25.36 A ATOM 1885 CG1 ILE A 252 30.889 49.343 118.861 1.00 26.65 A ATOM 1886 CD1 ILE A 252 31.154 49.143 117.378 1.00 29.75 A ATOM 1887 C ILE A 252 27.636 49.709 120.814 1.00 20.47 A ATOM 1888 O ILE A 252 26.922 48.788 120.440 1.00 19.94 A ATOM 1889 N GLY A 253 27.143 50.826 121.336 1.00 18.99 A ATOM 1890 CA GLY A 253 25.709 50.958 121.488 1.00 18.83 A ATOM 1891 C GLY A 253 25.288 52.292 122.059 1.00 18.02 A ATOM 1892 O GLY A 253 26.093 53.220 122.166 1.00 16.78 A ATOM 1893 N GLY A 254 24.019 52.378 122.429 1.00 18.04 A ATOM 1894 CA GLY A 254 23.503 53.610 122.981 1.00 19.32 A ATOM 1895 C GLY A 254 22.028 53.515 123.295 1.00 19.30 A ATOM 1896 O GLY A 254 21.379 52.497 123.029 1.00 18.05 A ATOM 1897 N LEU A 255 21.510 54.587 123.885 1.00 18.15 A ATOM 1898 CA LEU A 255 20.107 54.686 124.251 1.00 17.89 A ATOM 1899 CB LEU A 255 19.909 54.384 125.734 1.00 19.68 A ATOM 1900 CG LEU A 255 20.124 52.976 126.283 1.00 23.45 A ATOM 1901 CD1 LEU A 255 19.989 53.011 127.798 1.00 23.78 A ATOM 1902 CD2 LEU A 255 19.114 52.020 125.679 1.00 23.72 A ATOM 1903 C LEU A 255 19.653 56.112 124.006 1.00 18.61 A ATOM 1904 O LEU A 255 20.425 57.053 124.198 1.00 18.26 A ATOM 1905 N LEU A 256 18.408 56.275 123.575 1.00 17.55 A ATOM 1906 CA LEU A 256 17.871 57.608 123.367 1.00 17.89 A ATOM 1907 CB LEU A 256 16.779 57.596 122.291 1.00 17.89 A ATOM 1908 CG LEU A 256 16.201 58.956 121.868 1.00 19.06 A ATOM 1909 CD1 LEU A 256 17.325 59.921 121.508 1.00 19.37 A ATOM 1910 CD2 LEU A 256 15.260 58.763 120.680 1.00 17.30 A ATOM 1911 C LEU A 256 17.297 57.972 124.733 1.00 17.61 A ATOM 1912 O LEU A 256 16.453 57.262 125.276 1.00 17.82 A ATOM 1913 N ARG A 257 17.765 59.076 125.296 1.00 17.36 A ATOM 1914 CA ARG A 257 17.319 59.491 126.617 1.00 16.80 A ATOM 1915 CB ARG A 257 18.474 59.343 127.609 1.00 17.15 A ATOM 1916 CG ARG A 257 19.105 57.958 127.670 1.00 18.55 A ATOM 1917 CD ARG A 257 18.355 57.031 128.616 1.00 17.31 A ATOM 1918 NE ARG A 257 17.311 56.261 127.945 1.00 17.17 A ATOM 1919 CZ ARG A 257 16.626 55.279 128.525 1.00 16.27 A ATOM 1920 NH1 ARG A 257 16.871 54.952 129.790 1.00 13.61 A ATOM 1921 NH2 ARG A 257 15.722 54.600 127.833 1.00 16.69 A ATOM 1922 C ARG A 257 16.852 60.940 126.624 1.00 17.15 A ATOM 1923 O ARG A 257 16.933 61.637 125.612 1.00 16.73 A ATOM 1924 N GLU A 258 16.381 61.390 127.782 1.00 17.18 A ATOM 1925 CA GLU A 258 15.913 62.757 127.926 1.00 17.36 A ATOM 1926 CB GLU A 258 15.210 62.911 129.283 1.00 20.05 A ATOM 1927 CG GLU A 258 14.011 61.956 129.408 1.00 22.85 A ATOM 1928 CD GLU A 258 13.427 61.842 130.811 1.00 25.37 A ATOM 1929 OE1 GLU A 258 12.878 60.761 131.128 1.00 19.60 A ATOM 1930 OE2 GLU A 258 13.497 62.819 131.590 1.00 24.69 A ATOM 1931 C GLU A 258 17.074 63.743 127.755 1.00 16.92 A ATOM 1932 O GLU A 258 16.857 64.935 127.509 1.00 17.03 A ATOM 1933 N VAL A 259 18.304 63.238 127.858 1.00 16.14 A ATOM 1934 CA VAL A 259 19.492 64.066 127.679 1.00 16.37 A ATOM 1935 CB VAL A 259 20.598 63.720 128.707 1.00 16.27 A ATOM 1936 CG1 VAL A 259 20.035 63.814 130.117 1.00 18.16 A ATOM 1937 CG2 VAL A 259 21.158 62.319 128.428 1.00 18.20 A ATOM 1938 C VAL A 259 20.072 63.891 126.276 1.00 15.70 A ATOM 1939 O VAL A 259 21.175 64.360 125.984 1.00 13.21 A ATOM 1940 N GLY A 260 19.323 63.210 125.411 1.00 17.11 A ATOM 1941 CA GLY A 260 19.779 62.983 124.052 1.00 16.11 A ATOM 1942 C GLY A 260 20.218 61.545 123.847 1.00 16.55 A ATOM 1943 O GLY A 260 19.886 60.674 124.644 1.00 17.86 A ATOM 1944 N LEU A 261 20.968 61.294 122.781 1.00 15.96 A ATOM 1945 CA LEU A 261 21.442 59.946 122.485 1.00 18.55 A ATOM 1946 CB LEU A 261 21.558 59.750 120.967 1.00 20.11 A ATOM 1947 CG LEU A 261 22.175 58.437 120.472 1.00 20.59 A ATOM 1948 CD1 LEU A 261 21.420 57.265 121.058 1.00 21.27 A ATOM 1949 CD2 LEU A 261 22.126 58.391 118.943 1.00 21.87 A ATOM 1950 C LEU A 261 22.794 59.680 123.143 1.00 19.66 A ATOM 1951 O LEU A 261 23.817 60.224 122.730 1.00 21.17 A ATOM 1952 N THR A 262 22.788 58.852 124.176 1.00 19.32 A ATOM 1953 CA THR A 262 24.016 58.513 124.875 1.00 22.73 A ATOM 1954 CB THR A 262 23.734 58.130 126.332 1.00 22.38 A ATOM 1955 OG1 THR A 262 22.958 56.927 126.367 1.00 22.08 A ATOM 1956 CG2 THR A 262 22.953 59.239 127.022 1.00 22.93 A ATOM 1957 C THR A 262 24.604 57.320 124.143 1.00 23.97 A ATOM 1958 O THR A 262 23.877 56.588 123.464 1.00 24.96 A ATOM 1959 N PHE A 263 25.912 57.122 124.260 1.00 22.66 A ATOM 1960 CA PHE A 263 26.541 56.001 123.580 1.00 23.58 A ATOM 1961 CB PHE A 263 26.870 56.396 122.144 1.00 23.86 A ATOM 1962 CG PHE A 263 27.863 57.515 122.044 1.00 24.17 A ATOM 1963 CD1 PHE A 263 29.226 57.249 121.994 1.00 22.87 A ATOM 1964 CD2 PHE A 263 27.432 58.840 122.026 1.00 25.32 A ATOM 1965 CE1 PHE A 263 30.153 58.290 121.928 1.00 26.00 A ATOM 1966 CE2 PHE A 263 28.348 59.888 121.961 1.00 26.02 A ATOM 1967 CZ PHE A 263 29.712 59.613 121.912 1.00 25.32 A ATOM 1968 C PHE A 263 27.801 55.525 124.281 1.00 22.97 A ATOM 1969 O PHE A 263 28.412 56.253 125.067 1.00 21.66 A ATOM 1970 N TYR A 264 28.173 54.283 123.995 1.00 22.70 A ATOM 1971 CA TYR A 264 29.362 53.678 124.565 1.00 21.47 A ATOM 1972 CB TYR A 264 28.998 52.613 125.611 1.00 21.41 A ATOM 1973 CG TYR A 264 28.038 51.534 125.150 1.00 21.74 A ATOM 1974 CD1 TYR A 264 26.662 51.666 125.346 1.00 23.63 A ATOM 1975 CE1 TYR A 264 25.775 50.647 124.971 1.00 23.76 A ATOM 1976 CD2 TYR A 264 28.509 50.358 124.557 1.00 23.02 A ATOM 1977 CE2 TYR A 264 27.633 49.337 124.178 1.00 23.26 A ATOM 1978 CZ TYR A 264 26.267 49.488 124.391 1.00 23.52 A ATOM 1979 OH TYR A 264 25.394 48.478 124.041 1.00 21.37 A ATOM 1980 C TYR A 264 30.186 53.060 123.447 1.00 22.11 A ATOM 1981 O TYR A 264 29.648 52.648 122.418 1.00 22.24 A ATOM 1982 N LEU A 265 31.495 53.014 123.652 1.00 23.91 A ATOM 1983 CA LEU A 265 32.421 52.474 122.667 1.00 26.53 A ATOM 1984 CB LEU A 265 32.998 53.610 121.815 1.00 28.16 A ATOM 1985 CG LEU A 265 32.020 54.644 121.236 1.00 32.15 A ATOM 1986 CD1 LEU A 265 32.800 55.799 120.631 1.00 33.28 A ATOM 1987 CD2 LEU A 265 31.120 54.003 120.189 1.00 34.40 A ATOM 1988 C LEU A 265 33.544 51.788 123.432 1.00 26.95 A ATOM 1989 O LEU A 265 34.476 52.442 123.901 1.00 28.53 A ATOM 1990 N ASN A 266 33.455 50.470 123.566 1.00 26.30 A ATOM 1991 CA ASN A 266 34.473 49.731 124.292 1.00 25.13 A ATOM 1992 CB ASN A 266 34.018 48.296 124.530 1.00 27.85 A ATOM 1993 CG ASN A 266 34.746 47.651 125.683 1.00 30.74 A ATOM 1994 OD1 ASN A 266 34.492 47.971 126.845 1.00 33.50 A ATOM 1995 ND2 ASN A 266 35.669 46.750 125.374 1.00 31.85 A ATOM 1996 C ASN A 266 35.826 49.712 123.580 1.00 23.31 A ATOM 1997 O ASN A 266 35.900 49.755 122.354 1.00 20.14 A ATOM 1998 N LYS A 267 36.896 49.633 124.366 1.00 22.48 A ATOM 1999 CA LYS A 267 38.254 49.593 123.832 1.00 23.80 A ATOM 2000 CB LYS A 267 39.261 49.664 124.988 1.00 27.81 A ATOM 2001 CG LYS A 267 39.011 50.813 125.958 1.00 32.09 A ATOM 2002 CD LYS A 267 39.933 50.764 127.182 1.00 35.92 A ATOM 2003 CE LYS A 267 39.613 49.595 128.127 1.00 39.38 A ATOM 2004 NZ LYS A 267 40.014 48.253 127.603 1.00 40.18 A ATOM 2005 C LYS A 267 38.505 48.311 123.027 1.00 22.43 A ATOM 2006 O LYS A 267 39.444 48.232 122.234 1.00 20.97 A ATOM 2007 N SER A 268 37.658 47.310 123.228 1.00 21.81 A ATOM 2008 CA SER A 268 37.817 46.029 122.545 1.00 22.21 A ATOM 2009 CB SER A 268 37.109 44.940 123.342 1.00 24.17 A ATOM 2010 OG SER A 268 35.709 45.155 123.318 1.00 27.22 A ATOM 2011 C SER A 268 37.299 45.985 121.107 1.00 21.22 A ATOM 2012 O SER A 268 37.464 44.974 120.421 1.00 20.98 A ATOM 2013 N VAL A 269 36.681 47.067 120.647 1.00 19.08 A ATOM 2014 CA VAL A 269 36.122 47.085 119.301 1.00 19.55 A ATOM 2015 CB VAL A 269 35.463 48.454 118.996 1.00 18.98 A ATOM 2016 CG1 VAL A 269 35.028 48.515 117.536 1.00 19.74 A ATOM 2017 CG2 VAL A 269 34.260 48.652 119.902 1.00 18.22 A ATOM 2018 C VAL A 269 37.090 46.698 118.180 1.00 19.21 A ATOM 2019 O VAL A 269 36.813 45.774 117.420 1.00 21.42 A ATOM 2020 N PRO A 270 38.235 47.391 118.057 1.00 19.54 A ATOM 2021 CD PRO A 270 38.711 48.550 118.833 1.00 19.24 A ATOM 2022 CA PRO A 270 39.186 47.047 116.995 1.00 18.50 A ATOM 2023 CB PRO A 270 40.388 47.929 117.321 1.00 19.89 A ATOM 2024 CG PRO A 270 39.743 49.149 117.915 1.00 19.70 A ATOM 2025 C PRO A 270 39.538 45.557 116.994 1.00 19.27 A ATOM 2026 O PRO A 270 39.626 44.917 115.938 1.00 16.45 A ATOM 2027 N ASP A 271 39.734 45.007 118.187 1.00 17.58 A ATOM 2028 CA ASP A 271 40.071 43.600 118.332 1.00 19.43 A ATOM 2029 CB ASP A 271 40.500 43.321 119.785 1.00 23.68 A ATOM 2030 CG ASP A 271 39.756 42.157 120.413 1.00 30.76 A ATOM 2031 OD1 ASP A 271 38.543 42.298 120.707 1.00 36.55 A ATOM 2032 OD2 ASP A 271 40.383 41.092 120.617 1.00 35.24 A ATOM 2033 C ASP A 271 38.924 42.670 117.919 1.00 18.78 A ATOM 2034 O ASP A 271 39.154 41.637 117.279 1.00 18.87 A ATOM 2035 N ILE A 272 37.694 43.035 118.274 1.00 16.19 A ATOM 2036 CA ILE A 272 36.541 42.209 117.935 1.00 16.45 A ATOM 2037 CB ILE A 272 35.247 42.753 118.587 1.00 17.46 A ATOM 2038 CG2 ILE A 272 34.056 41.880 118.200 1.00 20.28 A ATOM 2039 CG1 ILE A 272 35.403 42.775 120.110 1.00 19.02 A ATOM 2040 CD1 ILE A 272 34.200 43.307 120.849 1.00 20.37 A ATOM 2041 C ILE A 272 36.363 42.142 116.426 1.00 17.03 A ATOM 2042 O ILE A 272 36.192 41.060 115.856 1.00 15.04 A ATOM 2043 N ILE A 273 36.412 43.301 115.777 1.00 17.12 A ATOM 2044 CA ILE A 273 36.264 43.369 114.328 1.00 17.75 A ATOM 2045 CB ILE A 273 36.243 44.836 113.845 1.00 19.23 A ATOM 2046 CG2 ILE A 273 36.289 44.892 112.329 1.00 18.88 A ATOM 2047 CG1 ILE A 273 34.986 45.532 114.361 1.00 19.64 A ATOM 2048 CD1 ILE A 273 34.965 47.032 114.095 1.00 19.97 A ATOM 2049 C ILE A 273 37.389 42.636 113.597 1.00 19.28 A ATOM 2050 O ILE A 273 37.137 41.844 112.684 1.00 18.02 A ATOM 2051 N SER A 274 38.631 42.888 113.996 1.00 19.59 A ATOM 2052 CA SER A 274 39.759 42.246 113.328 1.00 21.11 A ATOM 2053 CB SER A 274 41.087 42.873 113.790 1.00 23.23 A ATOM 2054 OG SER A 274 41.285 42.719 115.183 1.00 22.56 A ATOM 2055 C SER A 274 39.783 40.732 113.530 1.00 21.08 A ATOM 2056 O SER A 274 40.322 39.999 112.702 1.00 21.78 A ATOM 2057 N GLN A 275 39.186 40.261 114.617 1.00 21.60 A ATOM 2058 CA GLN A 275 39.147 38.824 114.896 1.00 22.43 A ATOM 2059 CB GLN A 275 39.056 38.583 116.406 1.00 24.09 A ATOM 2060 CG GLN A 275 40.334 38.941 117.162 1.00 28.75 A ATOM 2061 CD GLN A 275 40.235 38.671 118.658 1.00 33.27 A ATOM 2062 OE1 GLN A 275 41.170 38.958 119.411 1.00 37.52 A ATOM 2063 NE2 GLN A 275 39.105 38.118 119.096 1.00 31.46 A ATOM 2064 C GLN A 275 37.986 38.104 114.196 1.00 21.53 A ATOM 2065 O GLN A 275 37.927 36.872 114.178 1.00 21.17 A ATOM 2066 N ASN A 276 37.068 38.870 113.620 1.00 19.32 A ATOM 2067 CA ASN A 276 35.915 38.279 112.943 1.00 19.41 A ATOM 2068 CB ASN A 276 34.631 38.724 113.641 1.00 20.01 A ATOM 2069 CG ASN A 276 34.423 38.029 114.965 1.00 20.81 A ATOM 2070 OD1 ASN A 276 33.911 36.911 115.013 1.00 21.49 A ATOM 2071 ND2 ASN A 276 34.839 38.677 116.051 1.00 20.50 A ATOM 2072 C ASN A 276 35.828 38.635 111.468 1.00 19.52 A ATOM 2073 O ASN A 276 34.927 38.170 110.763 1.00 19.26 A ATOM 2074 N ILE A 277 36.763 39.457 111.002 1.00 17.49 A ATOM 2075 CA ILE A 277 36.756 39.895 109.613 1.00 19.10 A ATOM 2076 CB ILE A 277 37.721 41.093 109.429 1.00 20.08 A ATOM 2077 CG2 ILE A 277 39.162 40.614 109.402 1.00 21.44 A ATOM 2078 CG1 ILE A 277 37.369 41.855 108.147 1.00 20.38 A ATOM 2079 CD1 ILE A 277 36.025 42.526 108.204 1.00 20.97 A ATOM 2080 C ILE A 277 37.099 38.775 108.619 1.00 19.93 A ATOM 2081 O ILE A 277 36.548 38.713 107.520 1.00 18.82 A ATOM 2082 N ASN A 278 38.005 37.884 109.002 1.00 19.09 A ATOM 2083 CA ASN A 278 38.374 36.795 108.116 1.00 21.07 A ATOM 2084 CB ASN A 278 39.536 35.994 108.715 1.00 21.91 A ATOM 2085 CG ASN A 278 40.884 36.662 108.491 1.00 25.15 A ATOM 2086 OD1 ASN A 278 41.864 36.352 109.172 1.00 29.31 A ATOM 2087 ND2 ASN A 278 40.945 37.569 107.525 1.00 24.39 A ATOM 2088 C ASN A 278 37.183 35.883 107.832 1.00 18.75 A ATOM 2089 O ASN A 278 36.996 35.446 106.696 1.00 20.29 A ATOM 2090 N ASP A 279 36.374 35.600 108.848 1.00 18.61 A ATOM 2091 CA ASP A 279 35.198 34.749 108.652 1.00 18.90 A ATOM 2092 CB ASP A 279 34.489 34.482 109.987 1.00 22.33 A ATOM 2093 CG ASP A 279 35.247 33.495 110.874 1.00 25.45 A ATOM 2094 OD1 ASP A 279 34.914 33.395 112.074 1.00 25.88 A ATOM 2095 OD2 ASP A 279 36.166 32.809 110.369 1.00 26.85 A ATOM 2096 C ASP A 279 34.233 35.426 107.676 1.00 20.29 A ATOM 2097 O ASP A 279 33.655 34.770 106.808 1.00 16.75 A ATOM 2098 N ALA A 280 34.066 36.742 107.813 1.00 17.50 A ATOM 2099 CA ALA A 280 33.175 37.487 106.922 1.00 17.54 A ATOM 2100 CB ALA A 280 33.037 38.933 107.405 1.00 16.55 A ATOM 2101 C ALA A 280 33.674 37.468 105.475 1.00 15.17 A ATOM 2102 O ALA A 280 32.896 37.246 104.545 1.00 16.87 A ATOM 2103 N LEU A 281 34.969 37.707 105.288 1.00 14.58 A ATOM 2104 CA LEU A 281 35.569 37.715 103.953 1.00 14.95 A ATOM 2105 CB LEU A 281 37.049 38.099 104.033 1.00 14.87 A ATOM 2106 CG LEU A 281 37.369 39.579 104.261 1.00 13.37 A ATOM 2107 CD1 LEU A 281 38.829 39.744 104.677 1.00 15.16 A ATOM 2108 CD2 LEU A 281 37.082 40.346 102.981 1.00 14.81 A ATOM 2109 C LEU A 281 35.445 36.349 103.286 1.00 16.22 A ATOM 2110 O LEU A 281 35.119 36.254 102.104 1.00 16.95 A ATOM 2111 N ASN A 282 35.712 35.301 104.060 1.00 17.34 A ATOM 2112 CA ASN A 282 35.641 33.924 103.582 1.00 18.01 A ATOM 2113 CB ASN A 282 36.099 32.970 104.687 1.00 20.09 A ATOM 2114 CG ASN A 282 37.607 32.909 104.825 1.00 22.43 A ATOM 2115 OD1 ASN A 282 38.128 32.318 105.772 1.00 23.93 A ATOM 2116 ND2 ASN A 282 38.316 33.506 103.877 1.00 22.40 A ATOM 2117 C ASN A 282 34.233 33.533 103.140 1.00 18.34 A ATOM 2118 O ASN A 282 34.041 32.933 102.078 1.00 17.60 A ATOM 2119 N LYS A 283 33.247 33.861 103.965 1.00 17.04 A ATOM 2120 CA LYS A 283 31.865 33.538 103.641 1.00 17.42 A ATOM 2121 CB LYS A 283 30.956 33.927 104.809 1.00 17.63 A ATOM 2122 CG LYS A 283 29.481 33.667 104.564 1.00 20.90 A ATOM 2123 CD LYS A 283 28.671 33.796 105.848 1.00 22.60 A ATOM 2124 CE LYS A 283 27.207 33.456 105.613 1.00 23.23 A ATOM 2125 NZ LYS A 283 26.396 33.654 106.842 1.00 21.50 A ATOM 2126 C LYS A 283 31.402 34.240 102.361 1.00 16.87 A ATOM 2127 O LYS A 283 30.646 33.681 101.572 1.00 14.25 A ATOM 2128 N ALA A 284 31.874 35.464 102.148 1.00 16.88 A ATOM 2129 CA ALA A 284 31.476 36.232 100.974 1.00 17.52 A ATOM 2130 CB ALA A 284 31.625 37.733 101.263 1.00 17.75 A ATOM 2131 C ALA A 284 32.224 35.879 99.691 1.00 18.24 A ATOM 2132 O ALA A 284 31.629 35.844 98.607 1.00 16.71 A ATOM 2133 N PHE A 285 33.520 35.606 99.811 1.00 17.45 A ATOM 2134 CA PHE A 285 34.338 35.314 98.644 1.00 18.98 A ATOM 2135 CB PHE A 285 35.633 36.116 98.738 1.00 18.50 A ATOM 2136 CG PHE A 285 35.433 37.578 98.496 1.00 16.04 A ATOM 2137 CD1 PHE A 285 35.225 38.054 97.206 1.00 17.03 A ATOM 2138 CD2 PHE A 285 35.378 38.470 99.559 1.00 16.70 A ATOM 2139 CE1 PHE A 285 34.960 39.405 96.976 1.00 15.69 A ATOM 2140 CE2 PHE A 285 35.113 39.819 99.341 1.00 15.47 A ATOM 2141 CZ PHE A 285 34.904 40.286 98.053 1.00 15.01 A ATOM 2142 C PHE A 285 34.639 33.860 98.300 1.00 19.52 A ATOM 2143 O PHE A 285 34.928 33.565 97.144 1.00 21.87 A ATOM 2144 N ASP A 286 34.586 32.954 99.273 1.00 21.95 A ATOM 2145 CA ASP A 286 34.837 31.546 98.965 1.00 20.77 A ATOM 2146 CB ASP A 286 34.539 30.646 100.169 1.00 23.34 A ATOM 2147 CG ASP A 286 35.656 30.642 101.204 1.00 24.33 A ATOM 2148 OD1 ASP A 286 36.803 31.013 100.871 1.00 27.05 A ATOM 2149 OD2 ASP A 286 35.382 30.247 102.359 1.00 28.19 A ATOM 2150 C ASP A 286 33.972 31.093 97.779 1.00 22.10 A ATOM 2151 O ASP A 286 34.462 30.438 96.860 1.00 21.16 A ATOM 2152 N PRO A 287 32.671 31.436 97.786 1.00 22.48 A ATOM 2153 CD PRO A 287 31.932 32.149 98.842 1.00 23.33 A ATOM 2154 CA PRO A 287 31.765 31.049 96.696 1.00 23.96 A ATOM 2155 CB PRO A 287 30.428 31.661 97.120 1.00 24.38 A ATOM 2156 CG PRO A 287 30.520 31.683 98.613 1.00 24.07 A ATOM 2157 C PRO A 287 32.200 31.567 95.329 1.00 22.69 A ATOM 2158 O PRO A 287 31.804 31.030 94.298 1.00 23.56 A ATOM 2159 N LEU A 288 33.012 32.617 95.324 1.00 22.92 A ATOM 2160 CA LEU A 288 33.473 33.217 94.077 1.00 22.67 A ATOM 2161 CB LEU A 288 33.445 34.740 94.201 1.00 23.12 A ATOM 2162 CG LEU A 288 32.092 35.359 94.544 1.00 23.50 A ATOM 2163 CD1 LEU A 288 32.286 36.818 94.917 1.00 24.46 A ATOM 2164 CD2 LEU A 288 31.147 35.227 93.357 1.00 24.22 A ATOM 2165 C LEU A 288 34.875 32.772 93.682 1.00 22.51 A ATOM 2166 O LEU A 288 35.400 33.203 92.656 1.00 22.48 A ATOM 2167 N GLY A 289 35.483 31.923 94.506 1.00 22.66 A ATOM 2168 CA GLY A 289 36.819 31.445 94.214 1.00 22.32 A ATOM 2169 C GLY A 289 37.894 32.502 94.378 1.00 23.21 A ATOM 2170 O GLY A 289 38.919 32.451 93.701 1.00 25.59 A ATOM 2171 N ILE A 290 37.668 33.454 95.281 1.00 21.89 A ATOM 2172 CA ILE A 290 38.628 34.527 95.536 1.00 21.83 A ATOM 2173 CB ILE A 290 37.950 35.909 95.392 1.00 22.82 A ATOM 2174 CG2 ILE A 290 38.870 37.006 95.899 1.00 22.10 A ATOM 2175 CG1 ILE A 290 37.565 36.135 93.929 1.00 23.68 A ATOM 2176 CD1 ILE A 290 36.795 37.419 93.684 1.00 26.43 A ATOM 2177 C ILE A 290 39.210 34.397 96.944 1.00 22.08 A ATOM 2178 O ILE A 290 38.467 34.401 97.924 1.00 19.27 A ATOM 2179 N SER A 291 40.536 34.297 97.041 1.00 22.84 A ATOM 2180 CA SER A 291 41.196 34.150 98.339 1.00 23.66 A ATOM 2181 CB SER A 291 41.870 32.777 98.430 1.00 23.67 A ATOM 2182 OG SER A 291 42.768 32.582 97.355 1.00 26.92 A ATOM 2183 C SER A 291 42.224 35.241 98.645 1.00 23.75 A ATOM 2184 O SER A 291 42.541 35.491 99.811 1.00 22.93 A ATOM 2185 N ASP A 292 42.749 35.875 97.601 1.00 21.84 A ATOM 2186 CA ASP A 292 43.732 36.946 97.754 1.00 21.38 A ATOM 2187 CB ASP A 292 44.600 37.027 96.499 1.00 23.29 A ATOM 2188 CG ASP A 292 45.573 38.195 96.526 1.00 25.31 A ATOM 2189 OD1 ASP A 292 46.344 38.334 95.552 1.00 25.14 A ATOM 2190 OD2 ASP A 292 45.568 38.968 97.507 1.00 25.25 A ATOM 2191 C ASP A 292 42.959 38.251 97.944 1.00 21.41 A ATOM 2192 O ASP A 292 42.425 38.807 96.984 1.00 21.93 A ATOM 2193 N TYR A 293 42.905 38.739 99.177 1.00 18.89 A ATOM 2194 CA TYR A 293 42.154 39.956 99.463 1.00 18.84 A ATOM 2195 CB TYR A 293 41.693 39.932 100.924 1.00 19.73 A ATOM 2196 CG TYR A 293 40.867 38.694 101.219 1.00 20.84 A ATOM 2197 CD1 TYR A 293 39.776 38.355 100.417 1.00 20.08 A ATOM 2198 CE1 TYR A 293 39.041 37.194 100.647 1.00 22.81 A ATOM 2199 CD2 TYR A 293 41.199 37.841 102.268 1.00 22.83 A ATOM 2200 CE2 TYR A 293 40.472 36.677 102.509 1.00 22.45 A ATOM 2201 CZ TYR A 293 39.398 36.359 101.695 1.00 22.48 A ATOM 2202 OH TYR A 293 38.694 35.198 101.921 1.00 24.63 A ATOM 2203 C TYR A 293 42.842 41.263 99.098 1.00 19.82 A ATOM 2204 O TYR A 293 42.291 42.351 99.306 1.00 17.41 A ATOM 2205 N ASN A 294 44.047 41.166 98.538 1.00 18.72 A ATOM 2206 CA ASN A 294 44.733 42.360 98.075 1.00 20.17 A ATOM 2207 CB ASN A 294 46.251 42.222 98.206 1.00 19.86 A ATOM 2208 CG ASN A 294 46.758 42.686 99.550 1.00 20.29 A ATOM 2209 OD1 ASN A 294 46.625 43.860 99.902 1.00 18.17 A ATOM 2210 ND2 ASN A 294 47.338 41.767 100.314 1.00 16.51 A ATOM 2211 C ASN A 294 44.364 42.526 96.603 1.00 20.20 A ATOM 2212 O ASN A 294 44.704 43.534 95.983 1.00 22.64 A ATOM 2213 N SER A 295 43.661 41.535 96.052 1.00 18.20 A ATOM 2214 CA SER A 295 43.269 41.568 94.642 1.00 17.41 A ATOM 2215 CB SER A 295 43.334 40.161 94.025 1.00 18.06 A ATOM 2216 OG SER A 295 42.218 39.371 94.403 1.00 19.73 A ATOM 2217 C SER A 295 41.886 42.153 94.401 1.00 15.25 A ATOM 2218 O SER A 295 41.413 42.179 93.263 1.00 16.23 A ATOM 2219 N ILE A 296 41.227 42.609 95.463 1.00 11.98 A ATOM 2220 CA ILE A 296 39.902 43.217 95.328 1.00 13.58 A ATOM 2221 CB ILE A 296 38.838 42.449 96.145 1.00 13.48 A ATOM 2222 CG2 ILE A 296 38.699 41.018 95.600 1.00 15.53 A ATOM 2223 CG1 ILE A 296 39.233 42.414 97.629 1.00 11.74 A ATOM 2224 CD1 ILE A 296 38.169 41.828 98.546 1.00 14.12 A ATOM 2225 C ILE A 296 39.992 44.638 95.867 1.00 13.88 A ATOM 2226 O ILE A 296 40.947 44.959 96.575 1.00 15.39 A ATOM 2227 N PHE A 297 39.029 45.492 95.527 1.00 14.99 A ATOM 2228 CA PHE A 297 39.051 46.849 96.064 1.00 15.65 A ATOM 2229 CB PHE A 297 38.472 47.885 95.081 1.00 14.57 A ATOM 2230 CG PHE A 297 37.069 47.603 94.611 1.00 15.26 A ATOM 2231 CD1 PHE A 297 36.843 46.812 93.487 1.00 15.33 A ATOM 2232 CD2 PHE A 297 35.979 48.191 95.244 1.00 15.89 A ATOM 2233 CE1 PHE A 297 35.554 46.618 92.996 1.00 15.51 A ATOM 2234 CE2 PHE A 297 34.684 48.005 94.764 1.00 16.37 A ATOM 2235 CZ PHE A 297 34.469 47.219 93.636 1.00 16.21 A ATOM 2236 C PHE A 297 38.294 46.866 97.383 1.00 15.79 A ATOM 2237 O PHE A 297 37.377 46.063 97.596 1.00 15.96 A ATOM 2238 N TRP A 298 38.672 47.792 98.261 1.00 13.76 A ATOM 2239 CA TRP A 298 38.078 47.891 99.589 1.00 13.84 A ATOM 2240 CB TRP A 298 39.170 47.690 100.652 1.00 15.00 A ATOM 2241 CG TRP A 298 39.590 46.272 100.872 1.00 15.82 A ATOM 2242 CD2 TRP A 298 39.394 45.499 102.066 1.00 16.38 A ATOM 2243 CE2 TRP A 298 39.943 44.220 101.831 1.00 16.53 A ATOM 2244 CE3 TRP A 298 38.805 45.766 103.313 1.00 15.24 A ATOM 2245 CD1 TRP A 298 40.232 45.454 99.986 1.00 16.86 A ATOM 2246 NE1 TRP A 298 40.448 44.216 100.556 1.00 16.65 A ATOM 2247 CZ2 TRP A 298 39.922 43.204 102.799 1.00 16.35 A ATOM 2248 CZ3 TRP A 298 38.783 44.756 104.275 1.00 17.36 A ATOM 2249 CH2 TRP A 298 39.342 43.489 104.009 1.00 16.55 A ATOM 2250 C TRP A 298 37.343 49.181 99.931 1.00 15.44 A ATOM 2251 O TRP A 298 37.838 50.274 99.674 1.00 15.12 A ATOM 2252 N ILE A 299 36.161 49.033 100.521 1.00 14.10 A ATOM 2253 CA ILE A 299 35.367 50.163 100.984 1.00 14.84 A ATOM 2254 CB ILE A 299 34.126 50.423 100.098 1.00 12.44 A ATOM 2255 CG2 ILE A 299 33.252 51.511 100.741 1.00 12.82 A ATOM 2256 CG1 ILE A 299 34.584 50.866 98.704 1.00 11.52 A ATOM 2257 CD1 ILE A 299 33.463 51.004 97.691 1.00 14.86 A ATOM 2258 C ILE A 299 34.930 49.777 102.390 1.00 15.35 A ATOM 2259 O ILE A 299 34.006 48.991 102.566 1.00 18.17 A ATOM 2260 N ALA A 300 35.613 50.316 103.393 1.00 16.48 A ATOM 2261 CA ALA A 300 35.290 49.991 104.779 1.00 16.75 A ATOM 2262 CB ALA A 300 36.514 49.376 105.460 1.00 17.74 A ATOM 2263 C ALA A 300 34.808 51.191 105.583 1.00 18.52 A ATOM 2264 O ALA A 300 35.309 52.303 105.410 1.00 17.89 A ATOM 2265 N HIS A 301 33.836 50.961 106.464 1.00 16.34 A ATOM 2266 CA HIS A 301 33.325 52.024 107.319 1.00 17.03 A ATOM 2267 CB HIS A 301 32.164 51.524 108.179 1.00 16.06 A ATOM 2268 CG HIS A 301 31.682 52.532 109.179 1.00 17.35 A ATOM 2269 CD2 HIS A 301 31.646 52.501 110.533 1.00 18.74 A ATOM 2270 ND1 HIS A 301 31.211 53.776 108.813 1.00 18.35 A ATOM 2271 CE1 HIS A 301 30.906 54.468 109.897 1.00 18.11 A ATOM 2272 NE2 HIS A 301 31.160 53.718 110.955 1.00 18.22 A ATOM 2273 C HIS A 301 34.472 52.467 108.224 1.00 17.49 A ATOM 2274 O HIS A 301 35.043 51.655 108.947 1.00 18.95 A ATOM 2275 N PRO A 302 34.834 53.760 108.184 1.00 18.79 A ATOM 2276 CD PRO A 302 34.297 54.826 107.317 1.00 17.58 A ATOM 2277 CA PRO A 302 35.927 54.261 109.022 1.00 18.96 A ATOM 2278 CB PRO A 302 36.359 55.527 108.287 1.00 19.58 A ATOM 2279 CG PRO A 302 35.052 56.068 107.800 1.00 19.28 A ATOM 2280 C PRO A 302 35.465 54.544 110.453 1.00 19.81 A ATOM 2281 O PRO A 302 35.482 55.691 110.911 1.00 19.60 A ATOM 2282 N GLY A 303 35.044 53.497 111.155 1.00 19.20 A ATOM 2283 CA GLY A 303 34.582 53.671 112.521 1.00 20.12 A ATOM 2284 C GLY A 303 35.644 54.332 113.377 1.00 23.33 A ATOM 2285 O GLY A 303 35.337 55.051 114.333 1.00 23.31 A ATOM 2286 N GLY A 304 36.903 54.092 113.019 1.00 23.07 A ATOM 2287 CA GLY A 304 38.011 54.668 113.757 1.00 23.38 A ATOM 2288 C GLY A 304 39.348 54.218 113.199 1.00 23.14 A ATOM 2289 O GLY A 304 39.438 53.186 112.535 1.00 20.51 A ATOM 2290 N ARG A 305 40.387 54.999 113.467 1.00 22.81 A ATOM 2291 CA ARG A 305 41.737 54.697 112.997 1.00 23.64 A ATOM 2292 CB ARG A 305 42.710 55.725 113.576 1.00 28.06 A ATOM 2293 CG ARG A 305 44.174 55.458 113.274 1.00 32.94 A ATOM 2294 CD ARG A 305 45.033 55.993 114.403 1.00 37.33 A ATOM 2295 NE ARG A 305 46.429 56.179 114.021 1.00 40.67 A ATOM 2296 CZ ARG A 305 47.327 56.795 114.783 1.00 42.66 A ATOM 2297 NH1 ARG A 305 46.971 57.280 115.965 1.00 43.64 A ATOM 2298 NH2 ARG A 305 48.578 56.938 114.363 1.00 45.35 A ATOM 2299 C ARG A 305 42.197 53.289 113.392 1.00 22.76 A ATOM 2300 O ARG A 305 42.684 52.522 112.556 1.00 20.99 A ATOM 2301 N ALA A 306 42.037 52.968 114.673 1.00 20.50 A ATOM 2302 CA ALA A 306 42.440 51.676 115.224 1.00 20.59 A ATOM 2303 CB ALA A 306 42.125 51.638 116.718 1.00 21.66 A ATOM 2304 C ALA A 306 41.804 50.472 114.527 1.00 19.21 A ATOM 2305 O ALA A 306 42.460 49.452 114.330 1.00 18.90 A ATOM 2306 N ILE A 307 40.523 50.578 114.183 1.00 19.28 A ATOM 2307 CA ILE A 307 39.837 49.488 113.496 1.00 17.80 A ATOM 2308 CB ILE A 307 38.336 49.810 113.287 1.00 19.27 A ATOM 2309 CG2 ILE A 307 37.675 48.727 112.429 1.00 18.14 A ATOM 2310 CG1 ILE A 307 37.639 49.907 114.644 1.00 20.87 A ATOM 2311 CD1 ILE A 307 36.228 50.441 114.578 1.00 22.85 A ATOM 2312 C ILE A 307 40.489 49.241 112.138 1.00 19.21 A ATOM 2313 O ILE A 307 40.796 48.102 111.782 1.00 19.01 A ATOM 2314 N LEU A 308 40.709 50.308 111.376 1.00 17.31 A ATOM 2315 CA LEU A 308 41.326 50.156 110.069 1.00 18.79 A ATOM 2316 CB LEU A 308 41.352 51.503 109.329 1.00 16.84 A ATOM 2317 CG LEU A 308 39.986 52.166 109.093 1.00 16.60 A ATOM 2318 CD1 LEU A 308 40.178 53.524 108.421 1.00 15.51 A ATOM 2319 CD2 LEU A 308 39.109 51.256 108.237 1.00 17.66 A ATOM 2320 C LEU A 308 42.744 49.588 110.203 1.00 17.81 A ATOM 2321 O LEU A 308 43.110 48.655 109.486 1.00 18.53 A ATOM 2322 N ASP A 309 43.535 50.134 111.124 1.00 18.08 A ATOM 2323 CA ASP A 309 44.900 49.648 111.317 1.00 19.43 A ATOM 2324 CB ASP A 309 45.591 50.381 112.476 1.00 19.58 A ATOM 2325 CG ASP A 309 45.864 51.850 112.176 1.00 22.23 A ATOM 2326 OD1 ASP A 309 45.633 52.295 111.032 1.00 20.80 A ATOM 2327 OD2 ASP A 309 46.319 52.559 113.100 1.00 21.47 A ATOM 2328 C ASP A 309 44.924 48.147 111.607 1.00 18.66 A ATOM 2329 O ASP A 309 45.695 47.394 110.999 1.00 19.55 A ATOM 2330 N GLN A 310 44.079 47.704 112.530 1.00 19.17 A ATOM 2331 CA GLN A 310 44.063 46.292 112.893 1.00 19.27 A ATOM 2332 CB GLN A 310 43.334 46.107 114.221 1.00 20.83 A ATOM 2333 CG GLN A 310 44.151 46.673 115.379 1.00 24.30 A ATOM 2334 CD GLN A 310 43.560 46.375 116.735 1.00 26.80 A ATOM 2335 OE1 GLN A 310 43.182 45.239 117.026 1.00 29.98 A ATOM 2336 NE2 GLN A 310 43.486 47.393 117.582 1.00 28.79 A ATOM 2337 C GLN A 310 43.524 45.344 111.825 1.00 19.13 A ATOM 2338 O GLN A 310 43.979 44.207 111.727 1.00 17.24 A ATOM 2339 N VAL A 311 42.576 45.812 111.019 1.00 17.16 A ATOM 2340 CA VAL A 311 42.031 44.990 109.948 1.00 17.35 A ATOM 2341 CB VAL A 311 40.769 45.643 109.330 1.00 17.80 A ATOM 2342 CG1 VAL A 311 40.413 44.973 107.995 1.00 19.45 A ATOM 2343 CG2 VAL A 311 39.606 45.506 110.299 1.00 16.82 A ATOM 2344 C VAL A 311 43.115 44.799 108.881 1.00 18.13 A ATOM 2345 O VAL A 311 43.300 43.690 108.370 1.00 15.50 A ATOM 2346 N GLU A 312 43.841 45.872 108.559 1.00 18.03 A ATOM 2347 CA GLU A 312 44.923 45.801 107.572 1.00 20.30 A ATOM 2348 CB GLU A 312 45.571 47.176 107.369 1.00 22.51 A ATOM 2349 CG GLU A 312 44.802 48.102 106.456 1.00 27.98 A ATOM 2350 CD GLU A 312 45.431 49.483 106.368 1.00 30.36 A ATOM 2351 OE1 GLU A 312 46.632 49.578 106.053 1.00 32.69 A ATOM 2352 OE2 GLU A 312 44.721 50.477 106.614 1.00 37.60 A ATOM 2353 C GLU A 312 45.998 44.820 108.034 1.00 19.51 A ATOM 2354 O GLU A 312 46.588 44.095 107.230 1.00 18.40 A ATOM 2355 N GLN A 313 46.261 44.820 109.336 1.00 21.42 A ATOM 2356 CA GLN A 313 47.255 43.932 109.919 1.00 22.77 A ATOM 2357 CB GLN A 313 47.501 44.318 111.378 1.00 24.05 A ATOM 2358 CG GLN A 313 48.585 45.356 111.572 1.00 30.88 A ATOM 2359 CD GLN A 313 49.975 44.748 111.512 1.00 35.25 A ATOM 2360 OE1 GLN A 313 50.409 44.255 110.473 1.00 36.85 A ATOM 2361 NE2 GLN A 313 50.677 44.769 112.639 1.00 40.09 A ATOM 2362 C GLN A 313 46.818 42.472 109.837 1.00 21.31 A ATOM 2363 O GLN A 313 47.577 41.608 109.399 1.00 22.70 A ATOM 2364 N LYS A 314 45.585 42.208 110.249 1.00 21.15 A ATOM 2365 CA LYS A 314 45.040 40.855 110.236 1.00 20.71 A ATOM 2366 CB LYS A 314 43.665 40.836 110.904 1.00 20.52 A ATOM 2367 CG LYS A 314 43.101 39.443 111.099 1.00 22.86 A ATOM 2368 CD LYS A 314 43.948 38.650 112.092 1.00 26.70 A ATOM 2369 CE LYS A 314 43.390 37.253 112.316 1.00 28.35 A ATOM 2370 NZ LYS A 314 44.240 36.482 113.266 1.00 30.58 A ATOM 2371 C LYS A 314 44.915 40.275 108.834 1.00 21.15 A ATOM 2372 O LYS A 314 45.290 39.132 108.596 1.00 19.91 A ATOM 2373 N VAL A 315 44.388 41.062 107.902 1.00 20.16 A ATOM 2374 CA VAL A 315 44.207 40.589 106.538 1.00 18.60 A ATOM 2375 CB VAL A 315 43.032 41.338 105.847 1.00 17.87 A ATOM 2376 CG1 VAL A 315 42.788 40.768 104.465 1.00 16.87 A ATOM 2377 CG2 VAL A 315 41.760 41.215 106.693 1.00 16.04 A ATOM 2378 C VAL A 315 45.476 40.736 105.699 1.00 19.02 A ATOM 2379 O VAL A 315 45.562 40.199 104.595 1.00 18.12 A ATOM 2380 N ASN A 316 46.461 41.456 106.235 1.00 19.03 A ATOM 2381 CA ASN A 316 47.733 41.683 105.548 1.00 17.21 A ATOM 2382 CB ASN A 316 48.421 40.338 105.251 1.00 17.36 A ATOM 2383 CG ASN A 316 49.882 40.499 104.883 1.00 18.38 A ATOM 2384 OD1 ASN A 316 50.580 41.357 105.430 1.00 16.26 A ATOM 2385 ND2 ASN A 316 50.360 39.665 103.964 1.00 20.02 A ATOM 2386 C ASN A 316 47.535 42.481 104.255 1.00 16.62 A ATOM 2387 O ASN A 316 48.041 42.110 103.192 1.00 16.59 A ATOM 2388 N LEU A 317 46.811 43.593 104.362 1.00 15.63 A ATOM 2389 CA LEU A 317 46.522 44.447 103.212 1.00 17.20 A ATOM 2390 CB LEU A 317 45.210 45.212 103.441 1.00 16.66 A ATOM 2391 CG LEU A 317 43.936 44.404 103.701 1.00 18.52 A ATOM 2392 CD1 LEU A 317 42.778 45.353 104.044 1.00 17.08 A ATOM 2393 CD2 LEU A 317 43.601 43.585 102.470 1.00 17.68 A ATOM 2394 C LEU A 317 47.609 45.467 102.918 1.00 17.33 A ATOM 2395 O LEU A 317 48.164 46.074 103.836 1.00 17.14 A ATOM 2396 N LYS A 318 47.906 45.660 101.637 1.00 16.70 A ATOM 2397 CA LYS A 318 48.881 46.665 101.243 1.00 17.06 A ATOM 2398 CB LYS A 318 49.074 46.657 99.727 1.00 17.35 A ATOM 2399 CG LYS A 318 49.847 45.446 99.211 1.00 18.37 A ATOM 2400 CD LYS A 318 49.921 45.426 97.698 1.00 21.60 A ATOM 2401 CE LYS A 318 48.542 45.255 97.074 1.00 24.87 A ATOM 2402 NZ LYS A 318 48.600 45.204 95.581 1.00 27.70 A ATOM 2403 C LYS A 318 48.261 47.987 101.694 1.00 18.31 A ATOM 2404 O LYS A 318 47.041 48.155 101.637 1.00 18.82 A ATOM 2405 N PRO A 319 49.087 48.939 102.149 1.00 17.96 A ATOM 2406 CD PRO A 319 50.558 48.856 102.225 1.00 19.64 A ATOM 2407 CA PRO A 319 48.625 50.249 102.621 1.00 18.88 A ATOM 2408 CB PRO A 319 49.929 51.020 102.821 1.00 20.93 A ATOM 2409 CG PRO A 319 50.885 49.952 103.210 1.00 19.51 A ATOM 2410 C PRO A 319 47.658 51.003 101.712 1.00 19.97 A ATOM 2411 O PRO A 319 46.757 51.691 102.195 1.00 18.40 A ATOM 2412 N GLU A 320 47.843 50.883 100.401 1.00 21.10 A ATOM 2413 CA GLU A 320 46.979 51.588 99.463 1.00 22.71 A ATOM 2414 CB GLU A 320 47.555 51.508 98.044 1.00 24.81 A ATOM 2415 CG GLU A 320 48.939 52.155 97.890 1.00 33.10 A ATOM 2416 CD GLU A 320 48.985 53.612 98.339 1.00 35.66 A ATOM 2417 OE1 GLU A 320 48.827 53.883 99.548 1.00 39.88 A ATOM 2418 OE2 GLU A 320 49.184 54.495 97.479 1.00 40.62 A ATOM 2419 C GLU A 320 45.531 51.106 99.464 1.00 20.57 A ATOM 2420 O GLU A 320 44.631 51.859 99.105 1.00 18.61 A ATOM 2421 N LYS A 321 45.300 49.863 99.874 1.00 18.41 A ATOM 2422 CA LYS A 321 43.941 49.318 99.901 1.00 17.42 A ATOM 2423 CB LYS A 321 43.957 47.914 100.525 1.00 18.91 A ATOM 2424 CG LYS A 321 44.603 46.871 99.627 1.00 18.63 A ATOM 2425 CD LYS A 321 43.749 46.700 98.385 1.00 23.06 A ATOM 2426 CE LYS A 321 44.484 46.048 97.247 1.00 25.54 A ATOM 2427 NZ LYS A 321 43.617 46.071 96.032 1.00 22.67 A ATOM 2428 C LYS A 321 42.941 50.216 100.645 1.00 18.06 A ATOM 2429 O LYS A 321 41.819 50.436 100.176 1.00 14.96 A ATOM 2430 N MET A 322 43.352 50.736 101.800 1.00 17.37 A ATOM 2431 CA MET A 322 42.496 51.606 102.613 1.00 16.72 A ATOM 2432 CB MET A 322 42.793 51.380 104.097 1.00 18.06 A ATOM 2433 CG MET A 322 42.387 50.017 104.612 1.00 21.77 A ATOM 2434 SD MET A 322 40.608 49.856 104.615 1.00 26.83 A ATOM 2435 CE MET A 322 40.379 48.447 105.741 1.00 26.99 A ATOM 2436 C MET A 322 42.652 53.099 102.313 1.00 17.42 A ATOM 2437 O MET A 322 42.136 53.940 103.055 1.00 14.58 A ATOM 2438 N LYS A 323 43.353 53.439 101.237 1.00 16.80 A ATOM 2439 CA LYS A 323 43.570 54.846 100.923 1.00 18.31 A ATOM 2440 CB LYS A 323 44.413 54.994 99.654 1.00 20.83 A ATOM 2441 CG LYS A 323 44.660 56.440 99.277 1.00 22.34 A ATOM 2442 CD LYS A 323 45.599 56.576 98.090 1.00 25.20 A ATOM 2443 CE LYS A 323 45.679 58.028 97.661 1.00 27.32 A ATOM 2444 NZ LYS A 323 45.942 58.916 98.833 1.00 27.74 A ATOM 2445 C LYS A 323 42.291 55.668 100.788 1.00 18.02 A ATOM 2446 O LYS A 323 42.161 56.717 101.423 1.00 16.95 A ATOM 2447 N ALA A 324 41.347 55.207 99.970 1.00 17.17 A ATOM 2448 CA ALA A 324 40.094 55.946 99.784 1.00 16.35 A ATOM 2449 CB ALA A 324 39.206 55.241 98.752 1.00 16.45 A ATOM 2450 C ALA A 324 39.359 56.070 101.116 1.00 16.75 A ATOM 2451 O ALA A 324 38.813 57.127 101.456 1.00 14.58 A ATOM 2452 N THR A 325 39.358 54.984 101.876 1.00 14.25 A ATOM 2453 CA THR A 325 38.699 54.969 103.174 1.00 14.58 A ATOM 2454 CB THR A 325 38.752 53.568 103.792 1.00 15.15 A ATOM 2455 OG1 THR A 325 37.986 52.670 102.974 1.00 15.01 A ATOM 2456 CG2 THR A 325 38.181 53.589 105.205 1.00 13.11 A ATOM 2457 C THR A 325 39.314 55.967 104.162 1.00 14.64 A ATOM 2458 O THR A 325 38.601 56.719 104.820 1.00 14.11 A ATOM 2459 N ARG A 326 40.636 55.977 104.263 1.00 15.97 A ATOM 2460 CA ARG A 326 41.298 56.883 105.194 1.00 14.76 A ATOM 2461 CB ARG A 326 42.766 56.485 105.367 1.00 17.17 A ATOM 2462 CG ARG A 326 42.970 55.120 106.039 1.00 19.48 A ATOM 2463 CD ARG A 326 44.462 54.809 106.181 1.00 21.00 A ATOM 2464 NE ARG A 326 44.729 53.505 106.789 1.00 22.68 A ATOM 2465 CZ ARG A 326 44.655 53.237 108.091 1.00 23.59 A ATOM 2466 NH1 ARG A 326 44.314 54.181 108.960 1.00 19.97 A ATOM 2467 NH2 ARG A 326 44.947 52.018 108.529 1.00 21.31 A ATOM 2468 C ARG A 326 41.199 58.343 104.763 1.00 15.95 A ATOM 2469 O ARG A 326 41.204 59.244 105.607 1.00 15.73 A ATOM 2470 N ASP A 327 41.116 58.586 103.458 1.00 14.52 A ATOM 2471 CA ASP A 327 41.015 59.965 102.974 1.00 16.76 A ATOM 2472 CB ASP A 327 41.272 60.025 101.463 1.00 17.65 A ATOM 2473 CG ASP A 327 42.758 59.881 101.119 1.00 22.23 A ATOM 2474 OD1 ASP A 327 43.584 59.866 102.059 1.00 22.40 A ATOM 2475 OD2 ASP A 327 43.105 59.789 99.917 1.00 22.97 A ATOM 2476 C ASP A 327 39.660 60.582 103.331 1.00 15.90 A ATOM 2477 O ASP A 327 39.570 61.782 103.623 1.00 16.46 A ATOM 2478 N VAL A 328 38.610 59.767 103.317 1.00 14.20 A ATOM 2479 CA VAL A 328 37.278 60.247 103.685 1.00 12.95 A ATOM 2480 CB VAL A 328 36.187 59.206 103.338 1.00 11.54 A ATOM 2481 CG1 VAL A 328 34.883 59.551 104.045 1.00 13.59 A ATOM 2482 CG2 VAL A 328 35.964 59.185 101.824 1.00 12.86 A ATOM 2483 C VAL A 328 37.281 60.513 105.188 1.00 13.33 A ATOM 2484 O VAL A 328 36.744 61.519 105.660 1.00 13.72 A ATOM 2485 N LEU A 329 37.899 59.612 105.942 1.00 13.61 A ATOM 2486 CA LEU A 329 37.980 59.794 107.380 1.00 15.20 A ATOM 2487 CB LEU A 329 38.674 58.594 108.028 1.00 18.20 A ATOM 2488 CG LEU A 329 38.996 58.680 109.524 1.00 20.07 A ATOM 2489 CD1 LEU A 329 37.723 58.841 110.346 1.00 20.82 A ATOM 2490 CD2 LEU A 329 39.742 57.416 109.938 1.00 21.93 A ATOM 2491 C LEU A 329 38.761 61.081 107.684 1.00 15.58 A ATOM 2492 O LEU A 329 38.367 61.858 108.543 1.00 16.85 A ATOM 2493 N SER A 330 39.859 61.307 106.974 1.00 15.16 A ATOM 2494 CA SER A 330 40.663 62.507 107.208 1.00 18.06 A ATOM 2495 CB SER A 330 41.946 62.489 106.371 1.00 19.28 A ATOM 2496 OG SER A 330 42.770 61.393 106.713 1.00 25.07 A ATOM 2497 C SER A 330 39.933 63.800 106.901 1.00 16.71 A ATOM 2498 O SER A 330 40.085 64.787 107.620 1.00 17.70 A ATOM 2499 N ASN A 331 39.146 63.791 105.832 1.00 17.19 A ATOM 2500 CA ASN A 331 38.434 64.984 105.390 1.00 18.16 A ATOM 2501 CB ASN A 331 38.402 65.014 103.858 1.00 20.73 A ATOM 2502 CG ASN A 331 39.792 65.061 103.251 1.00 28.36 A ATOM 2503 OD1 ASN A 331 40.259 64.090 102.651 1.00 30.89 A ATOM 2504 ND2 ASN A 331 40.465 66.191 103.413 1.00 27.88 A ATOM 2505 C ASN A 331 37.019 65.203 105.917 1.00 17.12 A ATOM 2506 O ASN A 331 36.514 66.329 105.874 1.00 14.65 A ATOM 2507 N TYR A 332 36.382 64.152 106.422 1.00 14.10 A ATOM 2508 CA TYR A 332 35.011 64.284 106.902 1.00 15.56 A ATOM 2509 CB TYR A 332 34.056 63.599 105.919 1.00 15.57 A ATOM 2510 CG TYR A 332 34.102 64.155 104.522 1.00 16.22 A ATOM 2511 CD1 TYR A 332 33.342 65.269 104.165 1.00 17.52 A ATOM 2512 CE1 TYR A 332 33.378 65.773 102.865 1.00 19.70 A ATOM 2513 CD2 TYR A 332 34.901 63.562 103.547 1.00 17.03 A ATOM 2514 CE2 TYR A 332 34.945 64.055 102.254 1.00 18.80 A ATOM 2515 CZ TYR A 332 34.183 65.155 101.919 1.00 20.10 A ATOM 2516 OH TYR A 332 34.234 65.629 100.633 1.00 22.65 A ATOM 2517 C TYR A 332 34.732 63.728 108.285 1.00 14.80 A ATOM 2518 O TYR A 332 33.714 64.056 108.887 1.00 13.27 A ATOM 2519 N GLY A 333 35.618 62.880 108.792 1.00 16.28 A ATOM 2520 CA GLY A 333 35.371 62.290 110.090 1.00 16.15 A ATOM 2521 C GLY A 333 34.397 61.131 109.935 1.00 18.11 A ATOM 2522 O GLY A 333 34.141 60.682 108.819 1.00 17.58 A ATOM 2523 N ASN A 334 33.848 60.660 111.051 1.00 17.54 A ATOM 2524 CA ASN A 334 32.908 59.540 111.053 1.00 18.71 A ATOM 2525 CB ASN A 334 33.058 58.749 112.361 1.00 17.01 A ATOM 2526 CG ASN A 334 32.251 57.462 112.370 1.00 21.08 A ATOM 2527 OD1 ASN A 334 31.230 57.342 111.691 1.00 21.26 A ATOM 2528 ND2 ASN A 334 32.700 56.493 113.160 1.00 19.04 A ATOM 2529 C ASN A 334 31.459 60.008 110.898 1.00 16.98 A ATOM 2530 O ASN A 334 30.834 60.434 111.867 1.00 16.99 A ATOM 2531 N MET A 335 30.931 59.911 109.678 1.00 16.95 A ATOM 2532 CA MET A 335 29.559 60.317 109.381 1.00 17.01 A ATOM 2533 CB MET A 335 29.506 60.953 107.986 1.00 15.24 A ATOM 2534 CG MET A 335 30.446 62.147 107.832 1.00 13.35 A ATOM 2535 SD MET A 335 30.472 62.793 106.156 1.00 14.73 A ATOM 2536 CE MET A 335 31.510 61.522 105.336 1.00 11.91 A ATOM 2537 C MET A 335 28.552 59.160 109.469 1.00 18.59 A ATOM 2538 O MET A 335 27.514 59.167 108.806 1.00 17.45 A ATOM 2539 N SER A 336 28.860 58.170 110.299 1.00 16.90 A ATOM 2540 CA SER A 336 27.984 57.015 110.470 1.00 17.61 A ATOM 2541 CB SER A 336 26.719 57.421 111.241 1.00 19.09 A ATOM 2542 OG SER A 336 25.946 56.279 111.582 1.00 22.75 A ATOM 2543 C SER A 336 27.602 56.337 109.144 1.00 16.31 A ATOM 2544 O SER A 336 28.465 56.038 108.324 1.00 15.30 A ATOM 2545 N SER A 337 26.313 56.103 108.925 1.00 17.61 A ATOM 2546 CA SER A 337 25.875 55.419 107.708 1.00 18.36 A ATOM 2547 CB SER A 337 24.351 55.237 107.722 1.00 20.03 A ATOM 2548 OG SER A 337 23.682 56.467 107.520 1.00 23.69 A ATOM 2549 C SER A 337 26.295 56.038 106.367 1.00 18.79 A ATOM 2550 O SER A 337 26.441 55.320 105.378 1.00 19.51 A ATOM 2551 N ALA A 338 26.499 57.352 106.319 1.00 16.65 A ATOM 2552 CA ALA A 338 26.879 57.996 105.059 1.00 15.68 A ATOM 2553 CB ALA A 338 26.664 59.499 105.162 1.00 15.38 A ATOM 2554 C ALA A 338 28.313 57.703 104.595 1.00 16.86 A ATOM 2555 O ALA A 338 28.601 57.725 103.396 1.00 14.14 A ATOM 2556 N CYS A 339 29.205 57.409 105.540 1.00 17.12 A ATOM 2557 CA CYS A 339 30.611 57.142 105.222 1.00 18.43 A ATOM 2558 CB CYS A 339 31.313 56.504 106.420 1.00 20.52 A ATOM 2559 SG CYS A 339 31.572 57.633 107.785 1.00 28.72 A ATOM 2560 C CYS A 339 30.936 56.309 103.994 1.00 17.20 A ATOM 2561 O CYS A 339 31.583 56.789 103.068 1.00 16.64 A ATOM 2562 N VAL A 340 30.507 55.052 103.986 1.00 15.01 A ATOM 2563 CA VAL A 340 30.824 54.181 102.865 1.00 15.41 A ATOM 2564 CB VAL A 340 30.187 52.785 103.054 1.00 15.58 A ATOM 2565 CG1 VAL A 340 30.751 52.143 104.320 1.00 17.48 A ATOM 2566 CG2 VAL A 340 28.678 52.900 103.154 1.00 14.74 A ATOM 2567 C VAL A 340 30.449 54.741 101.493 1.00 13.89 A ATOM 2568 O VAL A 340 31.066 54.385 100.495 1.00 15.42 A ATOM 2569 N PHE A 341 29.456 55.623 101.441 1.00 13.57 A ATOM 2570 CA PHE A 341 29.042 56.194 100.161 1.00 12.42 A ATOM 2571 CB PHE A 341 27.574 56.622 100.232 1.00 12.79 A ATOM 2572 CG PHE A 341 26.655 55.482 100.543 1.00 13.77 A ATOM 2573 CD1 PHE A 341 26.541 54.414 99.661 1.00 16.75 A ATOM 2574 CD2 PHE A 341 25.992 55.417 101.763 1.00 17.19 A ATOM 2575 CE1 PHE A 341 25.788 53.287 99.992 1.00 17.00 A ATOM 2576 CE2 PHE A 341 25.234 54.291 102.108 1.00 18.62 A ATOM 2577 CZ PHE A 341 25.137 53.224 101.216 1.00 18.80 A ATOM 2578 C PHE A 341 29.957 57.334 99.732 1.00 13.00 A ATOM 2579 O PHE A 341 30.159 57.550 98.537 1.00 13.53 A ATOM 2580 N PHE A 342 30.524 58.056 100.698 1.00 13.71 A ATOM 2581 CA PHE A 342 31.476 59.116 100.361 1.00 13.53 A ATOM 2582 CB PHE A 342 31.854 59.952 101.592 1.00 13.59 A ATOM 2583 CG PHE A 342 30.880 61.058 101.907 1.00 14.46 A ATOM 2584 CD1 PHE A 342 29.606 60.776 102.386 1.00 12.57 A ATOM 2585 CD2 PHE A 342 31.254 62.388 101.738 1.00 17.01 A ATOM 2586 CE1 PHE A 342 28.708 61.813 102.702 1.00 15.37 A ATOM 2587 CE2 PHE A 342 30.369 63.429 102.047 1.00 15.22 A ATOM 2588 CZ PHE A 342 29.097 63.140 102.531 1.00 14.23 A ATOM 2589 C PHE A 342 32.731 58.410 99.836 1.00 12.98 A ATOM 2590 O PHE A 342 33.405 58.895 98.932 1.00 11.91 A ATOM 2591 N ILE A 343 33.033 57.248 100.412 1.00 12.62 A ATOM 2592 CA ILE A 343 34.201 56.473 100.011 1.00 13.59 A ATOM 2593 CB ILE A 343 34.500 55.344 101.038 1.00 12.49 A ATOM 2594 CG2 ILE A 343 35.671 54.512 100.561 1.00 12.36 A ATOM 2595 CG1 ILE A 343 34.814 55.964 102.412 1.00 14.83 A ATOM 2596 CD1 ILE A 343 34.874 54.980 103.572 1.00 13.14 A ATOM 2597 C ILE A 343 33.962 55.868 98.627 1.00 13.20 A ATOM 2598 O ILE A 343 34.832 55.911 97.764 1.00 13.62 A ATOM 2599 N MET A 344 32.782 55.293 98.427 1.00 13.40 A ATOM 2600 CA MET A 344 32.427 54.721 97.131 1.00 13.12 A ATOM 2601 CB MET A 344 31.003 54.157 97.188 1.00 14.23 A ATOM 2602 CG MET A 344 30.511 53.546 95.877 1.00 16.48 A ATOM 2603 SD MET A 344 28.804 52.931 95.975 1.00 17.54 A ATOM 2604 CE MET A 344 29.016 51.477 97.056 1.00 17.01 A ATOM 2605 C MET A 344 32.506 55.817 96.060 1.00 11.32 A ATOM 2606 O MET A 344 33.005 55.599 94.959 1.00 10.54 A ATOM 2607 N ASP A 345 32.025 57.008 96.399 1.00 12.42 A ATOM 2608 CA ASP A 345 32.021 58.121 95.445 1.00 13.38 A ATOM 2609 CB ASP A 345 31.203 59.298 96.006 1.00 11.94 A ATOM 2610 CG ASP A 345 30.908 60.365 94.957 1.00 19.30 A ATOM 2611 OD1 ASP A 345 30.675 60.005 93.781 1.00 17.49 A ATOM 2612 OD2 ASP A 345 30.896 61.566 95.313 1.00 22.09 A ATOM 2613 C ASP A 345 33.442 58.557 95.108 1.00 12.01 A ATOM 2614 O ASP A 345 33.761 58.776 93.943 1.00 11.34 A ATOM 2615 N LEU A 346 34.291 58.669 96.126 1.00 11.80 A ATOM 2616 CA LEU A 346 35.687 59.055 95.932 1.00 12.85 A ATOM 2617 CB LEU A 346 36.409 59.176 97.274 1.00 12.43 A ATOM 2618 CG LEU A 346 37.879 59.603 97.208 1.00 14.56 A ATOM 2619 CD1 LEU A 346 37.981 60.981 96.550 1.00 16.43 A ATOM 2620 CD2 LEU A 346 38.462 59.650 98.612 1.00 14.89 A ATOM 2621 C LEU A 346 36.413 58.012 95.097 1.00 12.74 A ATOM 2622 O LEU A 346 37.178 58.348 94.199 1.00 12.63 A ATOM 2623 N MET A 347 36.172 56.741 95.402 1.00 11.90 A ATOM 2624 CA MET A 347 36.832 55.667 94.675 1.00 13.12 A ATOM 2625 CB MET A 347 36.423 54.298 95.223 1.00 15.14 A ATOM 2626 CG MET A 347 37.188 53.175 94.563 1.00 13.55 A ATOM 2627 SD MET A 347 36.836 51.538 95.229 1.00 18.57 A ATOM 2628 CE MET A 347 37.681 51.612 96.825 1.00 16.80 A ATOM 2629 C MET A 347 36.533 55.698 93.185 1.00 13.68 A ATOM 2630 O MET A 347 37.449 55.649 92.371 1.00 13.15 A ATOM 2631 N ARG A 348 35.258 55.767 92.816 1.00 13.41 A ATOM 2632 CA ARG A 348 34.940 55.795 91.398 1.00 13.56 A ATOM 2633 CB ARG A 348 33.434 55.614 91.175 1.00 14.13 A ATOM 2634 CG ARG A 348 32.567 56.688 91.771 1.00 16.43 A ATOM 2635 CD ARG A 348 31.890 57.508 90.683 1.00 15.10 A ATOM 2636 NE ARG A 348 30.971 58.478 91.263 1.00 17.74 A ATOM 2637 CZ ARG A 348 29.944 59.021 90.614 1.00 19.42 A ATOM 2638 NH1 ARG A 348 29.692 58.693 89.350 1.00 17.83 A ATOM 2639 NH2 ARG A 348 29.161 59.883 91.236 1.00 18.56 A ATOM 2640 C ARG A 348 35.440 57.076 90.733 1.00 13.82 A ATOM 2641 O ARG A 348 35.909 57.042 89.596 1.00 12.96 A ATOM 2642 N LYS A 349 35.352 58.202 91.436 1.00 14.40 A ATOM 2643 CA LYS A 349 35.815 59.463 90.866 1.00 16.03 A ATOM 2644 CB LYS A 349 35.438 60.639 91.779 1.00 19.29 A ATOM 2645 CG LYS A 349 33.987 61.107 91.627 1.00 22.73 A ATOM 2646 CD LYS A 349 33.657 62.225 92.615 1.00 25.81 A ATOM 2647 CE LYS A 349 32.356 62.941 92.264 1.00 28.02 A ATOM 2648 NZ LYS A 349 31.184 62.031 92.147 1.00 29.68 A ATOM 2649 C LYS A 349 37.325 59.441 90.624 1.00 16.60 A ATOM 2650 O LYS A 349 37.803 59.892 89.583 1.00 15.58 A ATOM 2651 N ARG A 350 38.080 58.917 91.582 1.00 16.64 A ATOM 2652 CA ARG A 350 39.527 58.845 91.430 1.00 16.97 A ATOM 2653 CB ARG A 350 40.191 58.429 92.738 1.00 19.36 A ATOM 2654 CG ARG A 350 40.260 59.531 93.768 1.00 23.11 A ATOM 2655 CD ARG A 350 41.012 59.072 95.001 1.00 25.31 A ATOM 2656 NE ARG A 350 41.301 60.187 95.897 1.00 26.05 A ATOM 2657 CZ ARG A 350 41.851 60.050 97.096 1.00 25.60 A ATOM 2658 NH1 ARG A 350 42.174 58.842 97.540 1.00 24.33 A ATOM 2659 NH2 ARG A 350 42.070 61.118 97.851 1.00 27.53 A ATOM 2660 C ARG A 350 39.921 57.863 90.342 1.00 16.79 A ATOM 2661 O ARG A 350 40.840 58.132 89.574 1.00 15.18 A ATOM 2662 N SER A 351 39.237 56.723 90.276 1.00 15.93 A ATOM 2663 CA SER A 351 39.559 55.731 89.257 1.00 15.20 A ATOM 2664 CB SER A 351 38.727 54.462 89.468 1.00 16.39 A ATOM 2665 OG SER A 351 39.017 53.893 90.735 1.00 14.41 A ATOM 2666 C SER A 351 39.316 56.319 87.863 1.00 15.10 A ATOM 2667 O SER A 351 40.113 56.122 86.946 1.00 13.78 A ATOM 2668 N LEU A 352 38.221 57.056 87.716 1.00 16.59 A ATOM 2669 CA LEU A 352 37.897 57.692 86.444 1.00 18.06 A ATOM 2670 CB LEU A 352 36.540 58.389 86.541 1.00 19.15 A ATOM 2671 CG LEU A 352 35.292 57.505 86.519 1.00 19.76 A ATOM 2672 CD1 LEU A 352 34.098 58.301 87.018 1.00 21.28 A ATOM 2673 CD2 LEU A 352 35.053 56.988 85.112 1.00 21.19 A ATOM 2674 C LEU A 352 38.969 58.725 86.097 1.00 19.07 A ATOM 2675 O LEU A 352 39.462 58.779 84.968 1.00 17.65 A ATOM 2676 N GLU A 353 39.322 59.540 87.086 1.00 19.59 A ATOM 2677 CA GLU A 353 40.320 60.594 86.921 1.00 20.60 A ATOM 2678 CB GLU A 353 40.422 61.400 88.218 1.00 23.38 A ATOM 2679 CG GLU A 353 41.485 62.485 88.211 1.00 27.60 A ATOM 2680 CD GLU A 353 41.544 63.238 89.530 1.00 29.84 A ATOM 2681 OE1 GLU A 353 41.839 62.606 90.570 1.00 31.36 A ATOM 2682 OE2 GLU A 353 41.290 64.460 89.525 1.00 32.62 A ATOM 2683 C GLU A 353 41.700 60.070 86.532 1.00 20.58 A ATOM 2684 O GLU A 353 42.410 60.696 85.739 1.00 18.53 A ATOM 2685 N GLU A 354 42.075 58.919 87.089 1.00 19.90 A ATOM 2686 CA GLU A 354 43.379 58.318 86.823 1.00 20.37 A ATOM 2687 CB GLU A 354 43.824 57.507 88.052 1.00 24.66 A ATOM 2688 CG GLU A 354 43.839 58.333 89.339 1.00 27.87 A ATOM 2689 CD GLU A 354 43.942 57.486 90.598 1.00 31.64 A ATOM 2690 OE1 GLU A 354 43.427 56.346 90.602 1.00 31.88 A ATOM 2691 OE2 GLU A 354 44.518 57.972 91.595 1.00 32.79 A ATOM 2692 C GLU A 354 43.396 57.437 85.574 1.00 21.48 A ATOM 2693 O GLU A 354 44.415 56.819 85.253 1.00 19.63 A ATOM 2694 N GLY A 355 42.268 57.390 84.872 1.00 19.45 A ATOM 2695 CA GLY A 355 42.166 56.588 83.664 1.00 21.36 A ATOM 2696 C GLY A 355 42.349 55.093 83.868 1.00 21.53 A ATOM 2697 O GLY A 355 42.909 54.419 83.010 1.00 21.87 A ATOM 2698 N LEU A 356 41.869 54.569 84.992 1.00 20.13 A ATOM 2699 CA LEU A 356 42.001 53.141 85.289 1.00 20.12 A ATOM 2700 CB LEU A 356 41.774 52.898 86.783 1.00 20.13 A ATOM 2701 CG LEU A 356 42.667 53.735 87.711 1.00 19.29 A ATOM 2702 CD1 LEU A 356 42.382 53.378 89.163 1.00 19.65 A ATOM 2703 CD2 LEU A 356 44.129 53.492 87.381 1.00 19.63 A ATOM 2704 C LEU A 356 41.042 52.287 84.460 1.00 20.67 A ATOM 2705 O LEU A 356 40.156 52.817 83.785 1.00 18.66 A ATOM 2706 N LYS A 357 41.218 50.966 84.523 1.00 19.35 A ATOM 2707 CA LYS A 357 40.398 50.030 83.754 1.00 19.96 A ATOM 2708 CB LYS A 357 41.085 48.663 83.692 1.00 23.34 A ATOM 2709 CG LYS A 357 42.598 48.754 83.565 1.00 30.70 A ATOM 2710 CD LYS A 357 43.246 47.382 83.544 1.00 33.70 A ATOM 2711 CE LYS A 357 42.888 46.623 82.278 1.00 36.65 A ATOM 2712 NZ LYS A 357 43.583 45.304 82.212 1.00 38.22 A ATOM 2713 C LYS A 357 38.979 49.843 84.276 1.00 18.13 A ATOM 2714 O LYS A 357 38.084 49.476 83.517 1.00 18.43 A ATOM 2715 N THR A 358 38.771 50.068 85.569 1.00 15.16 A ATOM 2716 CA THR A 358 37.442 49.918 86.150 1.00 14.31 A ATOM 2717 CB THR A 358 37.243 48.550 86.838 1.00 14.13 A ATOM 2718 OG1 THR A 358 37.870 48.575 88.131 1.00 15.36 A ATOM 2719 CG2 THR A 358 37.830 47.424 85.995 1.00 14.35 A ATOM 2720 C THR A 358 37.218 50.970 87.218 1.00 14.15 A ATOM 2721 O THR A 358 38.165 51.593 87.689 1.00 15.99 A ATOM 2722 N THR A 359 35.963 51.132 87.620 1.00 13.93 A ATOM 2723 CA THR A 359 35.594 52.101 88.645 1.00 14.78 A ATOM 2724 CB THR A 359 34.074 52.257 88.732 1.00 17.18 A ATOM 2725 OG1 THR A 359 33.472 50.957 88.692 1.00 16.70 A ATOM 2726 CG2 THR A 359 33.544 53.102 87.570 1.00 18.46 A ATOM 2727 C THR A 359 36.095 51.664 90.015 1.00 14.99 A ATOM 2728 O THR A 359 36.123 52.459 90.949 1.00 14.02 A ATOM 2729 N GLY A 360 36.478 50.395 90.128 1.00 13.30 A ATOM 2730 CA GLY A 360 36.970 49.879 91.392 1.00 14.14 A ATOM 2731 C GLY A 360 38.486 49.805 91.423 1.00 14.17 A ATOM 2732 O GLY A 360 39.066 48.736 91.628 1.00 13.42 A ATOM 2733 N GLU A 361 39.131 50.947 91.214 1.00 14.93 A ATOM 2734 CA GLU A 361 40.590 51.025 91.214 1.00 16.26 A ATOM 2735 CB GLU A 361 41.131 50.779 92.633 1.00 16.95 A ATOM 2736 CG GLU A 361 40.426 51.624 93.709 1.00 21.62 A ATOM 2737 CD GLU A 361 41.057 51.514 95.098 1.00 23.55 A ATOM 2738 OE1 GLU A 361 41.466 50.403 95.497 1.00 24.80 A ATOM 2739 OE2 GLU A 361 41.124 52.544 95.804 1.00 24.47 A ATOM 2740 C GLU A 361 41.229 50.052 90.210 1.00 15.01 A ATOM 2741 O GLU A 361 42.313 49.512 90.437 1.00 14.46 A ATOM 2742 N GLY A 362 40.550 49.841 89.089 1.00 13.08 A ATOM 2743 CA GLY A 362 41.071 48.955 88.066 1.00 16.80 A ATOM 2744 C GLY A 362 40.894 47.472 88.342 1.00 17.02 A ATOM 2745 O GLY A 362 41.318 46.641 87.539 1.00 18.60 A ATOM 2746 N LEU A 363 40.281 47.134 89.473 1.00 17.18 A ATOM 2747 CA LEU A 363 40.051 45.740 89.827 1.00 18.00 A ATOM 2748 CB LEU A 363 40.383 45.514 91.307 1.00 19.02 A ATOM 2749 CG LEU A 363 41.826 45.853 91.697 1.00 19.57 A ATOM 2750 CD1 LEU A 363 42.048 45.584 93.180 1.00 20.85 A ATOM 2751 CD2 LEU A 363 42.781 45.022 90.863 1.00 22.14 A ATOM 2752 C LEU A 363 38.590 45.367 89.541 1.00 17.57 A ATOM 2753 O LEU A 363 37.718 46.238 89.508 1.00 17.19 A ATOM 2754 N ASP A 364 38.323 44.079 89.332 1.00 17.36 A ATOM 2755 CA ASP A 364 36.961 43.629 89.030 1.00 17.54 A ATOM 2756 CB ASP A 364 36.985 42.329 88.214 1.00 21.31 A ATOM 2757 CG ASP A 364 37.599 42.504 86.835 1.00 24.11 A ATOM 2758 OD1 ASP A 364 37.602 43.638 86.305 1.00 23.48 A ATOM 2759 OD2 ASP A 364 38.064 41.487 86.272 1.00 25.37 A ATOM 2760 C ASP A 364 36.027 43.418 90.226 1.00 17.38 A ATOM 2761 O ASP A 364 34.835 43.728 90.143 1.00 15.70 A ATOM 2762 N TRP A 365 36.542 42.870 91.324 1.00 14.37 A ATOM 2763 CA TRP A 365 35.699 42.634 92.491 1.00 16.23 A ATOM 2764 CB TRP A 365 35.699 41.148 92.877 1.00 19.04 A ATOM 2765 CG TRP A 365 35.319 40.238 91.760 1.00 22.12 A ATOM 2766 CD2 TRP A 365 34.027 39.675 91.515 1.00 23.55 A ATOM 2767 CE2 TRP A 365 34.123 38.908 90.331 1.00 25.41 A ATOM 2768 CE3 TRP A 365 32.795 39.745 92.179 1.00 22.91 A ATOM 2769 CD1 TRP A 365 36.126 39.803 90.750 1.00 23.60 A ATOM 2770 NE1 TRP A 365 35.415 39.003 89.886 1.00 24.40 A ATOM 2771 CZ2 TRP A 365 33.031 38.214 89.794 1.00 25.90 A ATOM 2772 CZ3 TRP A 365 31.707 39.054 91.645 1.00 25.49 A ATOM 2773 CH2 TRP A 365 31.835 38.299 90.464 1.00 28.06 A ATOM 2774 C TRP A 365 36.131 43.449 93.704 1.00 13.48 A ATOM 2775 O TRP A 365 37.304 43.791 93.849 1.00 16.37 A ATOM 2776 N GLY A 366 35.170 43.735 94.575 1.00 14.49 A ATOM 2777 CA GLY A 366 35.452 44.497 95.774 1.00 15.11 A ATOM 2778 C GLY A 366 34.515 44.126 96.907 1.00 14.59 A ATOM 2779 O GLY A 366 33.565 43.361 96.732 1.00 16.03 A ATOM 2780 N VAL A 367 34.791 44.674 98.082 1.00 14.23 A ATOM 2781 CA VAL A 367 33.981 44.422 99.258 1.00 12.28 A ATOM 2782 CB VAL A 367 34.721 43.482 100.248 1.00 12.07 A ATOM 2783 CG1 VAL A 367 35.988 44.156 100.753 1.00 13.16 A ATOM 2784 CG2 VAL A 367 33.820 43.111 101.406 1.00 10.94 A ATOM 2785 C VAL A 367 33.705 45.749 99.957 1.00 11.97 A ATOM 2786 O VAL A 367 34.550 46.650 99.961 1.00 13.50 A ATOM 2787 N LEU A 368 32.510 45.864 100.521 1.00 13.10 A ATOM 2788 CA LEU A 368 32.103 47.049 101.273 1.00 14.05 A ATOM 2789 CB LEU A 368 30.920 47.755 100.581 1.00 13.70 A ATOM 2790 CG LEU A 368 30.298 48.978 101.269 1.00 12.89 A ATOM 2791 CD1 LEU A 368 29.573 49.875 100.259 1.00 13.87 A ATOM 2792 CD2 LEU A 368 29.340 48.498 102.343 1.00 16.70 A ATOM 2793 C LEU A 368 31.710 46.526 102.652 1.00 14.47 A ATOM 2794 O LEU A 368 30.937 45.564 102.760 1.00 15.42 A ATOM 2795 N PHE A 369 32.271 47.136 103.697 1.00 15.36 A ATOM 2796 CA PHE A 369 32.017 46.735 105.081 1.00 15.36 A ATOM 2797 CB PHE A 369 33.328 46.375 105.795 1.00 17.30 A ATOM 2798 CG PHE A 369 33.837 44.996 105.504 1.00 16.57 A ATOM 2799 CD1 PHE A 369 33.112 43.875 105.897 1.00 17.75 A ATOM 2800 CD2 PHE A 369 35.048 44.817 104.849 1.00 15.72 A ATOM 2801 CE1 PHE A 369 33.593 42.587 105.637 1.00 18.32 A ATOM 2802 CE2 PHE A 369 35.540 43.533 104.581 1.00 18.65 A ATOM 2803 CZ PHE A 369 34.807 42.415 104.978 1.00 17.23 A ATOM 2804 C PHE A 369 31.337 47.787 105.946 1.00 17.12 A ATOM 2805 O PHE A 369 31.725 48.964 105.952 1.00 15.30 A ATOM 2806 N GLY A 370 30.329 47.345 106.688 1.00 16.03 A ATOM 2807 CA GLY A 370 29.650 48.217 107.623 1.00 15.32 A ATOM 2808 C GLY A 370 29.907 47.618 109.002 1.00 15.98 A ATOM 2809 O GLY A 370 29.788 46.397 109.160 1.00 15.42 A ATOM 2810 N PHE A 371 30.267 48.446 109.986 1.00 15.18 A ATOM 2811 CA PHE A 371 30.519 47.969 111.356 1.00 16.88 A ATOM 2812 CB PHE A 371 31.994 48.167 111.748 1.00 16.02 A ATOM 2813 CG PHE A 371 32.980 47.576 110.776 1.00 18.36 A ATOM 2814 CD1 PHE A 371 33.002 46.202 110.522 1.00 19.96 A ATOM 2815 CD2 PHE A 371 33.899 48.393 110.122 1.00 19.62 A ATOM 2816 CE1 PHE A 371 33.925 45.655 109.631 1.00 20.17 A ATOM 2817 CE2 PHE A 371 34.827 47.859 109.229 1.00 20.30 A ATOM 2818 CZ PHE A 371 34.842 46.484 108.982 1.00 21.44 A ATOM 2819 C PHE A 371 29.643 48.749 112.345 1.00 17.73 A ATOM 2820 O PHE A 371 29.607 49.986 112.311 1.00 20.57 A ATOM 2821 N GLY A 372 28.959 48.037 113.235 1.00 17.64 A ATOM 2822 CA GLY A 372 28.095 48.706 114.193 1.00 18.38 A ATOM 2823 C GLY A 372 27.792 47.924 115.461 1.00 18.00 A ATOM 2824 O GLY A 372 28.347 46.860 115.687 1.00 16.36 A ATOM 2825 N PRO A 373 26.887 48.432 116.305 1.00 20.27 A ATOM 2826 CD PRO A 373 26.146 49.670 116.005 1.00 21.14 A ATOM 2827 CA PRO A 373 26.444 47.861 117.588 1.00 22.67 A ATOM 2828 CB PRO A 373 25.456 48.913 118.104 1.00 24.87 A ATOM 2829 CG PRO A 373 25.821 50.173 117.373 1.00 23.22 A ATOM 2830 C PRO A 373 25.753 46.484 117.592 1.00 23.21 A ATOM 2831 O PRO A 373 25.010 46.202 116.641 1.00 22.66 A ATOM 2832 N GLY A 374 26.016 45.617 118.597 1.00 23.17 A ATOM 2833 CA GLY A 374 25.178 44.436 118.666 1.00 25.29 A ATOM 2834 C GLY A 374 26.141 43.404 119.175 1.00 23.83 A ATOM 2835 O GLY A 374 25.862 42.558 120.092 1.00 25.91 A ATOM 2836 N LEU A 375 27.563 43.367 118.304 1.00 24.44 A ATOM 2837 CA LEU A 375 28.323 43.906 117.199 1.00 23.26 A ATOM 2838 CB LEU A 375 29.771 44.208 117.541 1.00 23.81 A ATOM 2839 CG LEU A 375 30.492 44.899 116.384 1.00 25.97 A ATOM 2840 CD1 LEU A 375 31.706 45.711 116.830 1.00 27.70 A ATOM 2841 CD2 LEU A 375 31.005 43.917 115.329 1.00 25.62 A ATOM 2842 C LEU A 375 28.226 43.150 115.907 1.00 21.89 A ATOM 2843 O LEU A 375 28.728 42.015 115.805 1.00 23.04 A ATOM 2844 N THR A 376 27.598 43.904 115.007 1.00 22.34 A ATOM 2845 CA THR A 376 27.220 43.607 113.645 1.00 19.04 A ATOM 2846 CB THR A 376 25.952 44.396 113.271 1.00 19.55 A ATOM 2847 OG1 THR A 376 24.994 44.305 114.330 1.00 18.35 A ATOM 2848 CG2 THR A 376 25.352 43.860 111.974 1.00 19.52 A ATOM 2849 C THR A 376 28.241 44.005 112.607 1.00 18.79 A ATOM 2850 O THR A 376 28.837 45.093 112.662 1.00 17.92 A ATOM 2851 N ILE A 377 28.406 43.115 111.641 1.00 17.26 A ATOM 2852 CA ILE A 377 29.277 43.347 110.513 1.00 17.21 A ATOM 2853 CB ILE A 377 30.458 42.354 110.473 1.00 16.53 A ATOM 2854 CG2 ILE A 377 31.241 42.543 109.184 1.00 16.65 A ATOM 2855 CG1 ILE A 377 31.367 42.561 111.686 1.00 18.63 A ATOM 2856 CD1 ILE A 377 32.527 41.576 111.751 1.00 21.55 A ATOM 2857 C ILE A 377 28.400 43.096 109.290 1.00 17.23 A ATOM 2858 O ILE A 377 27.761 42.050 109.189 1.00 17.27 A ATOM 2859 N GLU A 378 28.337 44.072 108.393 1.00 15.61 A ATOM 2860 CA GLU A 378 27.576 43.934 107.155 1.00 16.65 A ATOM 2861 CB GLU A 378 26.732 45.188 106.873 1.00 16.43 A ATOM 2862 CG GLU A 378 25.547 45.389 107.813 1.00 20.23 A ATOM 2863 CD GLU A 378 24.203 44.968 107.214 1.00 21.67 A ATOM 2864 OE1 GLU A 378 24.176 44.331 106.137 1.00 21.94 A ATOM 2865 OE2 GLU A 378 23.163 45.277 107.834 1.00 23.26 A ATOM 2866 C GLU A 378 28.641 43.785 106.078 1.00 15.61 A ATOM 2867 O GLU A 378 29.575 44.595 106.009 1.00 16.34 A ATOM 2868 N THR A 379 28.523 42.743 105.259 1.00 16.22 A ATOM 2869 CA THR A 379 29.494 42.504 104.194 1.00 15.92 A ATOM 2870 CB THR A 379 30.224 41.159 104.378 1.00 18.24 A ATOM 2871 OG1 THR A 379 30.715 41.052 105.720 1.00 18.54 A ATOM 2872 CG2 THR A 379 31.390 41.063 103.404 1.00 17.22 A ATOM 2873 C THR A 379 28.817 42.460 102.832 1.00 16.86 A ATOM 2874 O THR A 379 28.045 41.533 102.540 1.00 16.09 A ATOM 2875 N VAL A 380 29.112 43.450 101.997 1.00 12.76 A ATOM 2876 CA VAL A 380 28.534 43.513 100.655 1.00 13.53 A ATOM 2877 CB VAL A 380 27.864 44.885 100.401 1.00 13.13 A ATOM 2878 CG1 VAL A 380 27.209 44.906 99.009 1.00 14.37 A ATOM 2879 CG2 VAL A 380 26.844 45.171 101.483 1.00 14.22 A ATOM 2880 C VAL A 380 29.620 43.299 99.597 1.00 14.42 A ATOM 2881 O VAL A 380 30.661 43.958 99.619 1.00 13.41 A ATOM 2882 N VAL A 381 29.397 42.362 98.679 1.00 14.62 A ATOM 2883 CA VAL A 381 30.374 42.131 97.618 1.00 12.94 A ATOM 2884 CB VAL A 381 30.424 40.663 97.169 1.00 13.15 A ATOM 2885 CG1 VAL A 381 31.315 40.537 95.932 1.00 11.65 A ATOM 2886 CG2 VAL A 381 30.962 39.795 98.298 1.00 12.83 A ATOM 2887 C VAL A 381 29.962 42.987 96.439 1.00 15.10 A ATOM 2888 O VAL A 381 28.787 43.033 96.082 1.00 15.48 A ATOM 2889 N LEU A 382 30.935 43.665 95.841 1.00 15.57 A ATOM 2890 CA LEU A 382 30.678 44.540 94.707 1.00 15.16 A ATOM 2891 CB LEU A 382 31.110 45.971 95.047 1.00 14.71 A ATOM 2892 CG LEU A 382 30.478 46.644 96.269 1.00 15.25 A ATOM 2893 CD1 LEU A 382 31.191 47.967 96.546 1.00 16.34 A ATOM 2894 CD2 LEU A 382 28.999 46.872 96.024 1.00 16.09 A ATOM 2895 C LEU A 382 31.417 44.114 93.445 1.00 16.18 A ATOM 2896 O LEU A 382 32.433 43.423 93.485 1.00 15.42 A ATOM 2897 N ARG A 383 30.893 44.561 92.313 1.00 16.91 A ATOM 2898 CA ARG A 383 31.504 44.283 91.039 1.00 18.58 A ATOM 2899 CB ARG A 383 30.560 43.438 90.187 1.00 23.70 A ATOM 2900 CG ARG A 383 31.212 42.230 89.552 1.00 29.01 A ATOM 2901 CD ARG A 383 32.112 42.639 88.406 1.00 34.91 A ATOM 2902 NE ARG A 383 32.578 41.484 87.646 1.00 38.99 A ATOM 2903 CZ ARG A 383 33.297 41.570 86.532 1.00 41.42 A ATOM 2904 NH1 ARG A 383 33.631 42.760 86.047 1.00 42.61 A ATOM 2905 NH2 ARG A 383 33.688 40.468 85.906 1.00 42.22 A ATOM 2906 C ARG A 383 31.709 45.663 90.425 1.00 18.51 A ATOM 2907 O ARG A 383 30.798 46.493 90.441 1.00 18.35 A ATOM 2908 N SER A 384 32.908 45.918 89.916 1.00 17.71 A ATOM 2909 CA SER A 384 33.221 47.205 89.305 1.00 17.18 A ATOM 2910 CB SER A 384 34.737 47.429 89.301 1.00 16.78 A ATOM 2911 OG SER A 384 35.377 46.504 88.434 1.00 19.20 A ATOM 2912 C SER A 384 32.704 47.244 87.873 1.00 16.69 A ATOM 2913 O SER A 384 32.259 46.231 87.333 1.00 14.89 A ATOM 2914 N VAL A 385 32.763 48.422 87.266 1.00 16.95 A ATOM 2915 CA VAL A 385 32.318 48.602 85.892 1.00 18.01 A ATOM 2916 CB VAL A 385 31.210 49.679 85.807 1.00 19.03 A ATOM 2917 CG1 VAL A 385 30.892 49.986 84.356 1.00 19.61 A ATOM 2918 CG2 VAL A 385 29.968 49.200 86.538 1.00 19.12 A ATOM 2919 C VAL A 385 33.503 49.047 85.034 1.00 19.45 A ATOM 2920 O VAL A 385 34.277 49.916 85.437 1.00 18.07 A ATOM 2921 N ALA A 386 33.637 48.448 83.853 1.00 18.41 A ATOM 2922 CA ALA A 386 34.719 48.783 82.937 1.00 19.71 A ATOM 2923 CB ALA A 386 34.692 47.833 81.736 1.00 21.24 A ATOM 2924 C ALA A 386 34.633 50.237 82.459 1.00 20.60 A ATOM 2925 O ALA A 386 33.573 50.698 82.038 1.00 19.64 A ATOM 2926 N ILE A 387 35.757 50.949 82.530 1.00 20.08 A ATOM 2927 CA ILE A 387 35.832 52.344 82.093 1.00 21.90 A ATOM 2928 CB ILE A 387 35.864 53.324 83.293 1.00 20.45 A ATOM 2929 CG2 ILE A 387 34.507 53.353 83.977 1.00 20.07 A ATOM 2930 CG1 ILE A 387 36.969 52.923 84.274 1.00 20.21 A ATOM 2931 CD1 ILE A 387 37.124 53.867 85.451 1.00 17.62 A ATOM 2932 C ILE A 387 37.076 52.591 81.233 1.00 23.48 A ATOM 2933 O ILE A 387 37.190 53.699 80.664 1.00 24.34 A ATOM 2934 OXT ILE A 387 37.929 51.679 81.143 1.00 24.25 A

[0269] APPENDIX C 18xCHS Mutant ATOM # TYPE RES X Y Z OCC B ATOM 1 CB VAL A 2 −13.230 29.022 69.882 1.00 30.61 A ATOM 2 CG1 VAL A 2 −12.890 29.579 71.256 1.00 31.32 A ATOM 3 CG2 VAL A 2 −13.703 27.583 69.999 1.00 31.29 A ATOM 4 C VAL A 2 −14.560 29.365 67.801 1.00 29.09 A ATOM 5 O VAL A 2 −15.501 28.610 67.557 1.00 29.96 A ATOM 6 N VAL A 2 −15.591 29.845 70.002 1.00 30.39 A ATOM 7 CA VAL A 2 −14.326 29.883 69.216 1.00 29.93 A ATOM 8 N SER A 3 −13.700 29.774 66.873 1.00 27.49 A ATOM 9 CA SER A 3 −13.814 29.352 65.482 1.00 25.81 A ATOM 10 CB SER A 3 −13.481 30.514 64.548 1.00 25.39 A ATOM 11 OG SER A 3 −12.104 30.840 64.623 1.00 24.75 A ATOM 12 C SER A 3 −12.866 28.195 65.190 1.00 25.08 A ATOM 13 O SER A 3 −11.910 27.961 65.931 1.00 24.70 A ATOM 14 N VAL A 4 −13.134 27.478 64.102 1.00 24.03 A ATOM 15 CA VAL A 4 −12.298 26.352 63.704 1.00 23.31 A ATOM 16 CB VAL A 4 −12.904 25.609 62.491 1.00 23.50 A ATOM 17 CG1 VAL A 4 −11.986 24.474 62.058 1.00 23.11 A ATOM 18 CG2 VAL A 4 −14.275 25.069 62.848 1.00 23.81 A ATOM 19 C VAL A 4 −10.895 26.833 63.338 1.00 22.89 A ATOM 20 O VAL A 4 −9.910 26.129 63.557 1.00 22.82 A ATOM 21 N SER A 5 −10.813 28.037 62.778 1.00 22.60 A ATOM 22 CA SER A 5 −9.529 28.613 62.383 1.00 22.06 A ATOM 23 CB SER A 5 −9.742 29.969 61.704 1.00 21.99 A ATOM 24 OG SER A 5 −8.505 30.545 61.320 1.00 22.10 A ATOM 25 C SER A 5 −8.610 28.788 63.587 1.00 21.94 A ATOM 26 O SER A 5 −7.435 28.423 63.542 1.00 22.12 A ATOM 27 N GLU A 6 −9.151 29.345 64.665 1.00 21.69 A ATOM 28 CA GLU A 6 −8.372 29.572 65.875 1.00 21.71 A ATOM 29 CB GLU A 6 −9.195 30.387 66.879 1.00 23.91 A ATOM 30 CG GLU A 6 −8.390 30.969 68.040 1.00 28.22 A ATOM 31 CD GLU A 6 −7.384 32.032 67.608 1.00 30.05 A ATOM 32 OE1 GLU A 6 −6.670 32.566 68.486 1.00 31.96 A ATOM 33 OE2 GLU A 6 −7.302 32.340 66.399 1.00 32.23 A ATOM 34 C GLU A 6 −7.945 28.234 66.488 1.00 20.55 A ATOM 35 O GLU A 6 −6.842 28.109 67.019 1.00 19.81 A ATOM 36 N ILE A 7 −8.820 27.235 66.402 1.00 18.95 A ATOM 37 CA ILE A 7 −8.522 25.909 66.937 1.00 17.56 A ATOM 38 CB ILE A 7 −9.766 24.987 66.864 1.00 17.72 A ATOM 39 CG2 ILE A 7 −9.396 23.560 67.269 1.00 17.42 A ATOM 40 CG1 ILE A 7 −10.863 25.532 67.784 1.00 17.63 A ATOM 41 CD1 ILE A 7 −12.178 24.790 67.693 1.00 17.98 A ATOM 42 C ILE A 7 −7.367 25.263 66.169 1.00 16.69 A ATOM 43 O ILE A 7 −6.415 24.767 66.773 1.00 16.31 A ATOM 44 N ARG A 8 −7.450 25.283 64.839 1.00 15.59 A ATOM 45 CA ARG A 8 −6.411 24.697 63.984 1.00 15.15 A ATOM 46 CB ARG A 8 −6.803 24.836 62.506 1.00 14.73 A ATOM 47 CG ARG A 8 −5.829 24.202 61.507 1.00 13.64 A ATOM 48 CD ARG A 8 −6.090 22.708 61.297 1.00 13.58 A ATOM 49 NE ARG A 8 −5.526 21.844 62.336 1.00 12.35 A ATOM 50 CZ ARG A 8 −4.284 21.358 62.326 1.00 13.34 A ATOM 51 NH1 ARG A 8 −3.453 21.644 61.327 1.00 12.64 A ATOM 52 NH2 ARG A 8 −3.870 20.578 63.319 1.00 12.49 A ATOM 53 C ARG A 8 −5.048 25.359 64.211 1.00 15.17 A ATOM 54 O ARG A 8 −4.027 24.678 64.286 1.00 14.78 A ATOM 55 N LYS A 9 −5.034 26.687 64.320 1.00 15.05 A ATOM 56 CA LYS A 9 −3.781 27.418 64.528 1.00 15.25 A ATOM 57 CB LYS A 9 −4.039 28.932 64.545 1.00 14.94 A ATOM 58 CG LYS A 9 −4.332 29.532 63.178 1.00 15.21 A ATOM 59 CD LYS A 9 −4.522 31.041 63.280 1.00 16.42 A ATOM 60 CE LYS A 9 −4.697 31.688 61.910 1.00 16.68 A ATOM 61 NZ LYS A 9 −4.801 33.172 62.035 1.00 17.12 A ATOM 62 C LYS A 9 −3.037 27.028 65.799 1.00 15.06 A ATOM 63 O LYS A 9 −1.804 27.007 65.822 1.00 15.26 A ATOM 64 N ALA A 10 −3.789 26.718 66.852 1.00 15.12 A ATOM 65 CA ALA A 10 −3.206 26.349 68.141 1.00 14.75 A ATOM 66 CB ALA A 10 −4.121 26.830 69.267 1.00 15.94 A ATOM 67 C ALA A 10 −2.979 24.848 68.268 1.00 14.60 A ATOM 68 O ALA A 10 −2.392 24.380 69.248 1.00 14.85 A ATOM 69 N GLN A 11 −3.426 24.099 67.267 1.00 13.64 A ATOM 70 CA GLN A 11 −3.308 22.644 67.278 1.00 13.50 A ATOM 71 CB GLN A 11 −4.549 22.038 66.608 1.00 12.91 A ATOM 72 CG GLN A 11 −4.852 20.588 66.973 1.00 13.41 A ATOM 73 CD GLN A 11 −6.114 20.076 66.292 1.00 13.72 A ATOM 74 OE1 GLN A 11 −6.101 19.746 65.106 1.00 14.06 A ATOM 75 NE2 GLN A 11 −7.214 20.031 67.036 1.00 11.82 A ATOM 76 C GLN A 11 −2.048 22.072 66.611 1.00 13.38 A ATOM 77 O GLN A 11 −1.550 21.025 67.032 1.00 13.66 A ATOM 78 N ARG A 12 −1.531 22.752 65.589 1.00 13.00 A ATOM 79 CA ARG A 12 −0.364 22.256 64.850 1.00 12.85 A ATOM 80 CB ARG A 12 −0.338 22.881 63.442 1.00 12.22 A ATOM 81 CG ARG A 12 −0.209 24.409 63.409 1.00 12.52 A ATOM 82 CD ARG A 12 0.264 24.892 62.036 1.00 13.75 A ATOM 83 NE ARG A 12 −0.672 24.561 60.957 1.00 14.03 A ATOM 84 CZ ARG A 12 −1.757 25.271 60.657 1.00 14.40 A ATOM 85 NH1 ARG A 12 −2.052 26.364 61.353 1.00 14.54 A ATOM 86 NH2 ARG A 12 −2.549 24.892 59.659 1.00 13.01 A ATOM 87 C ARG A 12 1.022 22.425 65.489 1.00 13.09 A ATOM 88 O ARG A 12 1.246 23.329 66.296 1.00 13.33 A ATOM 89 N ALA A 13 1.950 21.541 65.116 1.00 13.02 A ATOM 90 CA ALA A 13 3.333 21.606 65.607 1.00 13.42 A ATOM 91 CB ALA A 13 3.973 20.214 65.580 1.00 13.07 A ATOM 92 C ALA A 13 4.078 22.552 64.657 1.00 14.07 A ATOM 93 O ALA A 13 3.503 22.988 63.662 1.00 13.68 A ATOM 94 N GLU A 14 5.342 22.870 64.938 1.00 15.31 A ATOM 95 CA GLU A 14 6.072 23.788 64.055 1.00 16.79 A ATOM 96 CB GLU A 14 6.634 24.983 64.844 1.00 19.19 A ATOM 97 CG GLU A 14 7.664 25.800 64.043 1.00 22.25 A ATOM 98 CD GLU A 14 7.866 27.218 64.565 1.00 24.73 A ATOM 99 OE1 GLU A 14 8.977 27.766 64.379 1.00 26.12 A ATOM 100 OE2 GLU A 14 6.916 27.794 65.144 1.00 25.41 A ATOM 101 C GLU A 14 7.190 23.226 63.180 1.00 16.32 A ATOM 102 O GLU A 14 7.170 23.420 61.964 1.00 16.46 A ATOM 103 N GLY A 15 8.162 22.548 63.787 1.00 15.23 A ATOM 104 CA GLY A 15 9.282 22.024 63.019 1.00 14.11 A ATOM 105 C GLY A 15 9.151 20.637 62.408 1.00 13.41 A ATOM 106 O GLY A 15 8.109 19.999 62.521 1.00 12.54 A ATOM 107 N PRO A 16 10.216 20.142 61.755 1.00 12.96 A ATOM 108 CD PRO A 16 11.490 20.849 61.524 1.00 13.60 A ATOM 109 CA PRO A 16 10.229 18.821 61.116 1.00 13.35 A ATOM 110 CB PRO A 16 11.467 18.892 60.224 1.00 13.76 A ATOM 111 CG PRO A 16 12.407 19.735 61.052 1.00 14.19 A ATOM 112 C PRO A 16 10.298 17.666 62.115 1.00 13.11 A ATOM 113 O PRO A 16 10.893 17.800 63.188 1.00 13.04 A ATOM 114 N ALA A 17 9.685 16.540 61.759 1.00 11.96 A ATOM 115 CA ALA A 17 9.686 15.355 62.614 1.00 12.09 A ATOM 116 CB ALA A 17 8.824 14.262 61.993 1.00 11.81 A ATOM 117 C ALA A 17 11.119 14.862 62.794 1.00 11.94 A ATOM 118 O ALA A 17 11.883 14.766 61.826 1.00 11.18 A ATOM 119 N THR A 18 11.480 14.543 64.035 1.00 11.49 A ATOM 120 CA THR A 18 12.834 14.098 64.338 1.00 11.65 A ATOM 121 CB THR A 18 13.589 15.190 65.134 1.00 13.41 A ATOM 122 OG1 THR A 18 13.434 16.457 64.478 1.00 13.74 A ATOM 123 CG2 THR A 18 15.072 14.866 65.228 1.00 14.06 A ATOM 124 C THR A 18 12.850 12.803 65.156 1.00 11.14 A ATOM 125 O THR A 18 12.000 12.597 66.023 1.00 11.01 A ATOM 126 N ILE A 19 13.810 11.931 64.860 1.00 10.75 A ATOM 127 CA ILE A 19 13.967 10.680 65.594 1.00 10.47 A ATOM 128 CB ILE A 19 14.722 9.634 64.757 1.00 10.60 A ATOM 129 CG2 ILE A 19 14.941 8.371 65.587 1.00 9.37 A ATOM 130 CG1 ILE A 19 13.924 9.327 63.483 1.00 10.89 A ATOM 131 CD1 ILE A 19 14.571 8.260 62.584 1.00 12.28 A ATOM 132 C ILE A 19 14.776 11.034 66.841 1.00 10.68 A ATOM 133 O ILE A 19 15.886 11.560 66.735 1.00 11.42 A ATOM 134 N LEU A 20 14.218 10.745 68.014 1.00 10.93 A ATOM 135 CA LEU A 20 14.850 11.093 69.287 1.00 11.54 A ATOM 136 CB LEU A 20 13.823 11.805 70.177 1.00 12.05 A ATOM 137 CG LEU A 20 13.140 13.028 69.555 1.00 12.25 A ATOM 138 CD1 LEU A 20 11.991 13.478 70.431 1.00 12.71 A ATOM 139 CD2 LEU A 20 14.156 14.157 69.371 1.00 13.13 A ATOM 140 C LEU A 20 15.474 9.943 70.072 1.00 11.49 A ATOM 141 O LEU A 20 16.197 10.177 71.044 1.00 12.18 A ATOM 142 N ALA A 21 15.194 8.711 69.659 1.00 10.73 A ATOM 143 CA ALA A 21 15.731 7.532 70.338 1.00 10.18 A ATOM 144 CB ALA A 21 15.087 7.387 71.720 1.00 10.22 A ATOM 145 C ALA A 21 15.456 6.286 69.501 1.00 10.69 A ATOM 146 O ALA A 21 14.472 6.242 68.757 1.00 10.07 A ATOM 147 N ILE A 22 16.329 5.286 69.622 1.00 10.11 A ATOM 148 CA ILE A 22 16.191 4.028 68.885 1.00 10.87 A ATOM 149 CB ILE A 22 17.101 3.990 67.624 1.00 11.25 A ATOM 150 CG2 ILE A 22 16.805 2.740 66.807 1.00 10.74 A ATOM 151 CG1 ILE A 22 16.889 5.242 66.765 1.00 11.30 A ATOM 152 CD1 ILE A 22 17.864 5.344 65.615 1.00 10.46 A ATOM 153 C ILE A 22 16.602 2.850 69.766 1.00 11.38 A ATOM 154 O ILE A 22 17.647 2.898 70.415 1.00 11.77 A ATOM 155 N GLY A 23 15.778 1.802 69.781 1.00 11.30 A ATOM 156 CA GLY A 23 16.072 0.607 70.560 1.00 11.51 A ATOM 157 C GLY A 23 15.733 −0.646 69.760 1.00 12.11 A ATOM 158 O GLY A 23 14.801 −0.614 68.952 1.00 11.93 A ATOM 159 N THR A 24 16.482 −1.734 69.961 1.00 11.78 A ATOM 160 CA THR A 24 16.244 −2.990 69.239 1.00 11.90 A ATOM 161 CB THR A 24 17.278 −3.209 68.094 1.00 12.22 A ATOM 162 OG1 THR A 24 18.587 −3.407 68.649 1.00 13.40 A ATOM 163 CG2 THR A 24 17.307 −2.010 67.160 1.00 12.77 A ATOM 164 C THR A 24 16.280 −4.234 70.140 1.00 11.99 A ATOM 165 O THR A 24 16.812 −4.199 71.258 1.00 12.20 A ATOM 166 N ALA A 25 15.713 −5.333 69.643 1.00 11.68 A ATOM 167 CA ALA A 25 15.682 −6.596 70.380 1.00 11.37 A ATOM 168 CB ALA A 25 14.534 −6.579 71.390 1.00 11.43 A ATOM 169 C ALA A 25 15.528 −7.799 69.439 1.00 12.04 A ATOM 170 O ALA A 25 14.978 −7.670 68.345 1.00 10.87 A ATOM 171 N ASN A 26 16.020 −8.964 69.868 1.00 12.29 A ATOM 172 CA ASN A 26 15.916 −10.194 69.074 1.00 12.75 A ATOM 173 CB ASN A 26 17.198 −10.467 68.259 1.00 13.20 A ATOM 174 CG ASN A 26 17.652 −9.276 67.425 1.00 13.62 A ATOM 175 OD1 ASN A 26 18.349 −8.385 67.919 1.00 13.50 A ATOM 176 ND2 ASN A 26 17.272 −9.265 66.145 1.00 11.58 A ATOM 177 C ASN A 26 15.689 −11.396 69.992 1.00 13.37 A ATOM 178 O ASN A 26 16.054 −11.366 71.173 1.00 13.18 A ATOM 179 N PRO A 27 15.084 −12.474 69.465 1.00 14.48 A ATOM 180 CD PRO A 27 14.417 −12.626 68.157 1.00 14.37 A ATOM 181 CA PRO A 27 14.856 −13.652 70.309 1.00 15.55 A ATOM 182 CB PRO A 27 14.166 −14.631 69.355 1.00 15.65 A ATOM 183 CG PRO A 27 13.383 −13.707 68.445 1.00 14.59 A ATOM 184 C PRO A 27 16.203 −14.176 70.820 1.00 16.73 A ATOM 185 O PRO A 27 17.239 −13.968 70.185 1.00 16.65 A ATOM 186 N ALA A 28 16.182 −14.861 71.958 1.00 18.08 A ATOM 187 CA ALA A 28 17.402 −15.387 72.565 1.00 19.92 A ATOM 188 CB ALA A 28 17.091 −15.886 73.983 1.00 20.22 A ATOM 189 C ALA A 28 18.122 −16.483 71.771 1.00 20.71 A ATOM 190 O ALA A 28 19.338 −16.634 71.882 1.00 22.24 A ATOM 191 N ASN A 29 17.384 −17.239 70.965 1.00 21.91 A ATOM 192 CA ASN A 29 17.969 −18.329 70.179 1.00 22.53 A ATOM 193 CB ASN A 29 16.853 −19.300 69.770 1.00 23.29 A ATOM 194 CG ASN A 29 17.360 −20.471 68.954 1.00 24.78 A ATOM 195 OD1 ASN A 29 18.351 −21.106 69.311 1.00 25.80 A ATOM 196 ND2 ASN A 29 16.669 −20.777 67.857 1.00 24.60 A ATOM 197 C ASN A 29 18.756 −17.870 68.940 1.00 22.49 A ATOM 198 O ASN A 29 18.163 −17.478 67.941 1.00 22.38 A ATOM 199 N CYS A 30 20.088 −17.930 69.013 1.00 22.40 A ATOM 200 CA CYS A 30 20.963 −17.534 67.901 1.00 23.15 A ATOM 201 CB CYS A 30 22.263 −16.912 68.436 1.00 23.31 A ATOM 202 SG CYS A 30 23.478 −16.418 67.155 1.00 25.62 A ATOM 203 C CYS A 30 21.297 −18.737 67.012 1.00 23.29 A ATOM 204 O CYS A 30 21.769 −19.768 67.496 1.00 23.46 A ATOM 205 N VAL A 31 21.068 −18.590 65.709 1.00 22.78 A ATOM 206 CA VAL A 31 21.307 −19.667 64.751 1.00 22.63 A ATOM 207 CB VAL A 31 20.012 −19.961 63.950 1.00 22.87 A ATOM 208 CG1 VAL A 31 20.196 −21.191 63.072 1.00 22.78 A ATOM 209 CG2 VAL A 31 18.840 −20.144 64.907 1.00 23.17 A ATOM 210 C VAL A 31 22.435 −19.359 63.757 1.00 22.49 A ATOM 211 O VAL A 31 22.312 −18.452 62.932 1.00 21.48 A ATOM 212 N GLU A 32 23.528 −20.121 63.832 1.00 22.05 A ATOM 213 CA GLU A 32 24.663 −19.925 62.925 1.00 22.03 A ATOM 214 CB GLU A 32 25.879 −20.715 63.414 1.00 23.60 A ATOM 215 CG GLU A 32 26.500 −20.173 64.690 1.00 25.06 A ATOM 216 CD GLU A 32 27.024 −18.765 64.517 1.00 26.01 A ATOM 217 OE1 GLU A 32 27.738 −18.520 63.521 1.00 27.39 A ATOM 218 OE2 GLU A 32 26.732 −17.904 65.375 1.00 26.48 A ATOM 219 C GLU A 32 24.310 −20.366 61.508 1.00 21.46 A ATOM 220 O GLU A 32 23.741 −21.435 61.311 1.00 20.95 A ATOM 221 N GLN A 33 24.672 −19.552 60.521 1.00 20.88 A ATOM 222 CA GLN A 33 24.360 −19.853 59.127 1.00 20.56 A ATOM 223 CB GLN A 33 24.497 −18.589 58.272 1.00 20.04 A ATOM 224 CG GLN A 33 23.983 −18.751 56.845 1.00 18.89 A ATOM 225 CD GLN A 33 22.468 −18.680 56.751 1.00 18.59 A ATOM 226 OE1 GLN A 33 21.751 −19.243 57.581 1.00 17.31 A ATOM 227 NE2 GLN A 33 21.972 −17.988 55.726 1.00 17.55 A ATOM 228 C GLN A 33 25.184 −20.974 58.488 1.00 20.69 A ATOM 229 O GLN A 33 24.650 −21.768 57.716 1.00 20.26 A ATOM 230 N SER A 34 26.475 −21.044 58.801 1.00 21.34 A ATOM 231 CA SER A 34 27.331 −22.068 58.201 1.00 22.30 A ATOM 232 CB SER A 34 28.770 −21.955 58.732 1.00 21.91 A ATOM 233 OG SER A 34 28.835 −22.155 60.128 1.00 22.81 A ATOM 234 C SER A 34 26.822 −23.497 58.383 1.00 22.37 A ATOM 235 O SER A 34 27.007 −24.340 57.503 1.00 23.51 A ATOM 236 N THR A 35 26.172 −23.772 59.507 1.00 22.43 A ATOM 237 CA THR A 35 25.659 −25.113 59.765 1.00 21.81 A ATOM 238 CB THR A 35 26.132 −25.621 61.136 1.00 22.18 A ATOM 239 OG1 THR A 35 25.700 −24.714 62.159 1.00 23.03 A ATOM 240 CG2 THR A 35 27.651 −25.725 61.165 1.00 22.82 A ATOM 241 C THR A 35 24.133 −25.229 59.708 1.00 21.18 A ATOM 242 O THR A 35 23.577 −26.273 60.056 1.00 21.01 A ATOM 243 N TYR A 36 23.452 −24.174 59.265 1.00 19.84 A ATOM 244 CA TYR A 36 21.991 −24.210 59.196 1.00 18.75 A ATOM 245 CB TYR A 36 21.429 −22.843 58.775 1.00 17.52 A ATOM 246 CG TYR A 36 19.928 −22.721 58.962 1.00 16.96 A ATOM 247 CD1 TYR A 36 19.346 −22.898 60.220 1.00 16.53 A ATOM 248 CE1 TYR A 36 17.964 −22.800 60.397 1.00 16.76 A ATOM 249 CD2 TYR A 36 19.088 −22.440 57.881 1.00 16.21 A ATOM 250 CE2 TYR A 36 17.705 −22.340 58.047 1.00 15.96 A ATOM 251 CZ TYR A 36 17.149 −22.522 59.305 1.00 16.90 A ATOM 252 OH TYR A 36 15.780 −22.438 59.472 1.00 16.69 A ATOM 253 C TYR A 36 21.465 −25.294 58.256 1.00 18.74 A ATOM 254 O TYR A 36 20.475 −25.955 58.566 1.00 19.06 A ATOM 255 N PRO A 37 22.111 −25.489 57.090 1.00 18.99 A ATOM 256 CD PRO A 37 23.208 −24.717 56.474 1.00 18.75 A ATOM 257 CA PRO A 37 21.627 −26.525 56.169 1.00 18.98 A ATOM 258 CB PRO A 37 22.706 −26.551 55.091 1.00 19.26 A ATOM 259 CG PRO A 37 23.097 −25.105 55.005 1.00 18.64 A ATOM 260 C PRO A 37 21.424 −27.887 56.838 1.00 19.27 A ATOM 261 O PRO A 37 20.387 −28.525 56.653 1.00 18.41 A ATOM 262 N ASP A 38 22.406 −28.331 57.617 1.00 19.51 A ATOM 263 CA ASP A 38 22.283 −29.618 58.303 1.00 20.18 A ATOM 264 CB ASP A 38 23.582 −29.976 59.040 1.00 20.94 A ATOM 265 CG ASP A 38 24.691 −30.417 58.097 1.00 22.36 A ATOM 266 OD1 ASP A 38 24.381 −31.017 57.043 1.00 22.82 A ATOM 267 OD2 ASP A 38 25.877 −30.186 58.417 1.00 23.40 A ATOM 268 C ASP A 38 21.125 −29.599 59.300 1.00 19.89 A ATOM 269 O ASP A 38 20.365 −30.565 59.407 1.00 19.55 A ATOM 270 N PHE A 39 20.991 −28.492 60.022 1.00 19.50 A ATOM 271 CA PHE A 39 19.934 −28.340 61.021 1.00 19.62 A ATOM 272 CB PHE A 39 20.163 −27.057 61.823 1.00 21.89 A ATOM 273 CG PHE A 39 19.139 −26.822 62.892 1.00 24.15 A ATOM 274 CD1 PHE A 39 19.106 −27.622 64.031 1.00 25.06 A ATOM 275 CD2 PHE A 39 18.193 −25.813 62.753 1.00 25.47 A ATOM 276 CE1 PHE A 39 18.145 −27.423 65.019 1.00 26.34 A ATOM 277 CE2 PHE A 39 17.221 −25.603 63.737 1.00 26.52 A ATOM 278 CZ PHE A 39 17.198 −26.410 64.871 1.00 27.00 A ATOM 279 C PHE A 39 18.535 −28.307 60.400 1.00 18.72 A ATOM 280 O PHE A 39 17.628 −29.011 60.852 1.00 18.17 A ATOM 281 N TYR A 40 18.365 −27.484 59.371 1.00 17.64 A ATOM 282 CA TYR A 40 17.080 −27.345 58.691 1.00 17.02 A ATOM 283 CB TYR A 40 17.177 −26.240 57.630 1.00 16.06 A ATOM 284 CG TYR A 40 15.923 −26.045 56.794 1.00 14.59 A ATOM 285 CD1 TYR A 40 14.742 −25.572 57.361 1.00 14.51 A ATOM 286 CE1 TYR A 40 13.595 −25.367 56.585 1.00 14.11 A ATOM 287 CD2 TYR A 40 15.933 −26.317 55.430 1.00 14.81 A ATOM 288 CE2 TYR A 40 14.799 −26.122 54.646 1.00 14.21 A ATOM 289 CZ TYR A 40 13.635 −25.645 55.227 1.00 14.27 A ATOM 290 OH TYR A 40 12.528 −25.435 54.440 1.00 13.60 A ATOM 291 C TYR A 40 16.591 −28.647 58.050 1.00 17.25 A ATOM 292 O TYR A 40 15.422 −29.004 58.178 1.00 17.01 A ATOM 293 N PHE A 41 17.471 −29.363 57.358 1.00 18.01 A ATOM 294 CA PHE A 41 17.044 −30.607 56.725 1.00 18.83 A ATOM 295 CB PHE A 41 18.051 −31.035 55.654 1.00 18.25 A ATOM 296 CG PHE A 41 17.815 −30.374 54.325 1.00 18.43 A ATOM 297 CD1 PHE A 41 18.015 −29.006 54.170 1.00 17.48 A ATOM 298 CD2 PHE A 41 17.312 −31.104 53.250 1.00 17.95 A ATOM 299 CE1 PHE A 41 17.713 −28.369 52.966 1.00 17.59 A ATOM 300 CE2 PHE A 41 17.006 −30.478 52.046 1.00 18.17 A ATOM 301 CZ PHE A 41 17.206 −29.104 51.904 1.00 18.05 A ATOM 302 C PHE A 41 16.766 −31.745 57.705 1.00 19.60 A ATOM 303 O PHE A 41 16.048 −32.690 57.377 1.00 19.06 A ATOM 304 N LYS A 42 17.314 −31.649 58.912 1.00 20.78 A ATOM 305 CA LYS A 42 17.079 −32.678 59.927 1.00 22.23 A ATOM 306 CB LYS A 42 18.174 −32.647 60.996 1.00 23.48 A ATOM 307 CG LYS A 42 17.972 −33.680 62.096 1.00 25.67 A ATOM 308 CD LYS A 42 18.923 −33.467 63.262 1.00 27.51 A ATOM 309 CE LYS A 42 18.621 −32.169 63.993 1.00 29.25 A ATOM 310 NZ LYS A 42 19.511 −31.974 65.173 1.00 30.49 A ATOM 311 C LYS A 42 15.724 −32.465 60.608 1.00 22.35 A ATOM 312 O LYS A 42 14.909 −33.386 60.697 1.00 22.15 A ATOM 313 N ILE A 43 15.485 −31.246 61.085 1.00 22.66 A ATOM 314 CA ILE A 43 14.233 −30.932 61.772 1.00 22.68 A ATOM 315 CB ILE A 43 14.269 −29.502 62.372 1.00 22.71 A ATOM 316 CG2 ILE A 43 14.054 −28.462 61.282 1.00 21.97 A ATOM 317 CG1 ILE A 43 13.190 −29.364 63.446 1.00 23.48 A ATOM 318 CD1 ILE A 43 13.366 −30.310 64.624 1.00 23.50 A ATOM 319 C ILE A 43 12.999 −31.082 60.874 1.00 22.84 A ATOM 320 O ILE A 43 11.891 −31.309 61.366 1.00 22.92 A ATOM 321 N THR A 44 13.184 −30.960 59.562 1.00 22.55 A ATOM 322 CA THR A 44 12.065 −31.104 58.637 1.00 22.54 A ATOM 323 CB THR A 44 12.152 −30.097 57.459 1.00 22.72 A ATOM 324 OG1 THR A 44 13.371 −30.303 56.730 1.00 22.37 A ATOM 325 CG2 THR A 44 12.098 −28.665 57.977 1.00 22.10 A ATOM 326 C THR A 44 12.014 −32.519 58.071 1.00 23.10 A ATOM 327 O THR A 44 11.202 −32.820 57.191 1.00 23.58 A ATOM 328 N ASN A 45 12.887 −33.383 58.584 1.00 23.35 A ATOM 329 CA ASN A 45 12.960 −34.775 58.147 1.00 23.44 A ATOM 330 CB ASN A 45 11.737 −35.544 58.664 1.00 24.41 A ATOM 331 CG ASN A 45 11.514 −35.346 60.161 1.00 25.94 A ATOM 332 OD1 ASN A 45 12.443 −35.452 60.959 1.00 26.60 A ATOM 333 ND2 ASN A 45 10.277 −35.062 60.544 1.00 26.55 A ATOM 334 C ASN A 45 13.051 −34.877 56.621 1.00 23.02 A ATOM 335 O ASN A 45 12.304 −35.623 55.990 1.00 22.54 A ATOM 336 N SER A 46 13.990 −34.133 56.041 1.00 22.98 A ATOM 337 CA SER A 46 14.178 −34.115 54.593 1.00 23.29 A ATOM 338 CB SER A 46 13.839 −32.723 54.056 1.00 23.17 A ATOM 339 OG SER A 46 12.593 −32.267 54.556 1.00 23.57 A ATOM 340 C SER A 46 15.606 −34.483 54.164 1.00 23.38 A ATOM 341 O SER A 46 16.051 −34.091 53.086 1.00 22.63 A ATOM 342 N GLU A 47 16.314 −35.241 54.995 1.00 23.79 A ATOM 343 CA GLU A 47 17.693 −35.618 54.687 1.00 24.63 A ATOM 344 CB GLU A 47 18.342 −36.266 55.912 1.00 25.51 A ATOM 345 CG GLU A 47 18.434 −35.310 57.089 1.00 28.07 A ATOM 346 CD GLU A 47 19.244 −35.856 58.236 1.00 29.80 A ATOM 347 OE1 GLU A 47 18.831 −36.878 58.824 1.00 31.27 A ATOM 348 OE2 GLU A 47 20.297 −35.260 58.550 1.00 30.37 A ATOM 349 C GLU A 47 17.878 −36.510 53.464 1.00 24.72 A ATOM 350 O GLU A 47 18.999 −36.670 52.974 1.00 24.73 A ATOM 351 N HIS A 48 16.792 −37.087 52.963 1.00 24.76 A ATOM 352 CA HIS A 48 16.893 −37.940 51.785 1.00 24.97 A ATOM 353 CB HIS A 48 15.765 −38.978 51.764 1.00 24.66 A ATOM 354 CG HIS A 48 14.401 −38.396 51.952 1.00 24.86 A ATOM 355 CD2 HIS A 48 13.382 −38.213 51.079 1.00 24.69 A ATOM 356 ND1 HIS A 48 13.956 −37.919 53.166 1.00 25.06 A ATOM 357 CE1 HIS A 48 12.721 −37.468 53.033 1.00 24.93 A ATOM 358 NE2 HIS A 48 12.350 −37.635 51.777 1.00 24.70 A ATOM 359 C HIS A 48 16.870 −37.111 50.502 1.00 25.02 A ATOM 360 O HIS A 48 17.084 −37.637 49.411 1.00 24.86 A ATOM 361 N LYS A 49 16.609 −35.814 50.634 1.00 25.23 A ATOM 362 CA LYS A 49 16.588 −34.927 49.472 1.00 25.72 A ATOM 363 CB LYS A 49 15.576 −33.800 49.680 1.00 26.92 A ATOM 364 CG LYS A 49 14.147 −34.284 49.886 1.00 28.26 A ATOM 365 CD LYS A 49 13.175 −33.119 49.924 1.00 30.09 A ATOM 366 CE LYS A 49 11.739 −33.597 50.099 1.00 31.30 A ATOM 367 NZ LYS A 49 10.776 −32.457 50.099 1.00 31.83 A ATOM 368 C LYS A 49 17.993 −34.356 49.298 1.00 25.62 A ATOM 369 O LYS A 49 18.215 −33.150 49.423 1.00 25.21 A ATOM 370 N THR A 50 18.936 −35.247 49.005 1.00 25.27 A ATOM 371 CA THR A 50 20.344 −34.901 48.840 1.00 25.11 A ATOM 372 CB THR A 50 21.147 −36.142 48.410 1.00 25.28 A ATOM 373 OG1 THR A 50 20.640 −36.633 47.164 1.00 25.79 A ATOM 374 CG2 THR A 50 21.018 −37.238 49.459 1.00 25.39 A ATOM 375 C THR A 50 20.662 −33.751 47.882 1.00 25.05 A ATOM 376 O THR A 50 21.462 −32.875 48.211 1.00 24.58 A ATOM 377 N GLU A 51 20.054 −33.758 46.700 1.00 24.67 A ATOM 378 CA GLU A 51 20.294 −32.703 45.721 1.00 24.81 A ATOM 379 CB GLU A 51 19.676 −33.083 44.374 1.00 25.94 A ATOM 380 CG GLU A 51 19.663 −31.964 43.338 1.00 27.31 A ATOM 381 CD GLU A 51 20.991 −31.243 43.233 1.00 28.46 A ATOM 382 OE1 GLU A 51 22.039 −31.924 43.231 1.00 29.16 A ATOM 383 OE2 GLU A 51 20.986 −29.994 43.145 1.00 28.42 A ATOM 384 C GLU A 51 19.729 −31.365 46.195 1.00 24.29 A ATOM 385 O GLU A 51 20.385 −30.328 46.083 1.00 23.82 A ATOM 386 N LEU A 52 18.511 −31.394 46.725 1.00 23.31 A ATOM 387 CA LEU A 52 17.874 −30.180 47.222 1.00 22.68 A ATOM 388 CB LEU A 52 16.477 −30.508 47.767 1.00 22.59 A ATOM 389 CG LEU A 52 15.576 −29.339 48.178 1.00 22.20 A ATOM 390 CD1 LEU A 52 15.415 −28.367 47.016 1.00 22.61 A ATOM 391 CD2 LEU A 52 14.221 −29.876 48.612 1.00 22.03 A ATOM 392 C LEU A 52 18.739 −29.559 48.321 1.00 22.60 A ATOM 393 O LEU A 52 18.904 −28.340 48.380 1.00 22.40 A ATOM 394 N LYS A 53 19.299 −30.401 49.185 1.00 22.30 A ATOM 395 CA LYS A 53 20.146 −29.916 50.268 1.00 22.67 A ATOM 396 CB LYS A 53 20.554 −31.067 51.193 1.00 22.70 A ATOM 397 CG LYS A 53 21.340 −30.614 52.422 1.00 23.68 A ATOM 398 CD LYS A 53 21.711 −31.786 53.316 1.00 24.89 A ATOM 399 CE LYS A 53 22.373 −31.312 54.597 1.00 25.28 A ATOM 400 NZ LYS A 53 22.726 −32.448 55.491 1.00 26.32 A ATOM 401 C LYS A 53 21.401 −29.225 49.734 1.00 22.70 A ATOM 402 O LYS A 53 21.884 −28.267 50.336 1.00 22.36 A ATOM 403 N GLU A 54 21.933 −29.716 48.615 1.00 23.17 A ATOM 404 CA GLU A 54 23.129 −29.112 48.025 1.00 23.50 A ATOM 405 CB GLU A 54 23.615 −29.912 46.807 1.00 24.90 A ATOM 406 CG GLU A 54 23.970 −31.367 47.092 1.00 27.49 A ATOM 407 CD GLU A 54 24.723 −32.028 45.943 1.00 28.58 A ATOM 408 OE1 GLU A 54 24.314 −31.860 44.773 1.00 29.73 A ATOM 409 OE2 GLU A 54 25.723 −32.724 46.214 1.00 29.34 A ATOM 410 C GLU A 54 22.793 −27.691 47.591 1.00 22.71 A ATOM 411 O GLU A 54 23.573 −26.762 47.814 1.00 22.66 A ATOM 412 N LYS A 55 21.629 −27.533 46.964 1.00 21.69 A ATOM 413 CA LYS A 55 21.178 −26.225 46.506 1.00 21.03 A ATOM 414 CB LYS A 55 19.819 −26.330 45.801 1.00 20.58 A ATOM 415 CG LYS A 55 19.849 −26.920 44.399 1.00 21.67 A ATOM 416 CD LYS A 55 18.472 −26.811 43.746 1.00 22.06 A ATOM 417 CE LYS A 55 18.490 −27.256 42.290 1.00 22.95 A ATOM 418 NZ LYS A 55 18.862 −28.692 42.156 1.00 23.21 A ATOM 419 C LYS A 55 21.049 −25.260 47.684 1.00 20.45 A ATOM 420 O LYS A 55 21.441 −24.097 47.588 1.00 19.89 A ATOM 421 N PHE A 56 20.498 −25.748 48.794 1.00 19.90 A ATOM 422 CA PHE A 56 20.309 −24.914 49.976 1.00 19.76 A ATOM 423 CB PHE A 56 19.436 −25.638 51.009 1.00 19.84 A ATOM 424 CG PHE A 56 18.945 −24.743 52.119 1.00 19.88 A ATOM 425 CD1 PHE A 56 18.160 −23.628 51.833 1.00 19.11 A ATOM 426 CD2 PHE A 56 19.283 −25.003 53.444 1.00 19.71 A ATOM 427 CE1 PHE A 56 17.718 −22.782 52.853 1.00 19.68 A ATOM 428 CE2 PHE A 56 18.848 −24.165 54.473 1.00 19.76 A ATOM 429 CZ PHE A 56 18.064 −23.052 54.177 1.00 19.57 A ATOM 430 C PHE A 56 21.648 −24.509 50.599 1.00 20.08 A ATOM 431 O PHE A 56 21.786 −23.399 51.114 1.00 19.29 A ATOM 432 N GLN A 57 22.633 −25.404 50.544 1.00 20.33 A ATOM 433 CA GLN A 57 23.957 −25.102 51.084 1.00 21.34 A ATOM 434 CB GLN A 57 24.883 −26.318 50.958 1.00 21.90 A ATOM 435 CG GLN A 57 26.264 −26.129 51.590 1.00 22.72 A ATOM 436 CD GLN A 57 26.206 −25.936 53.094 1.00 23.02 A ATOM 437 OE1 GLN A 57 25.666 −26.776 53.818 1.00 23.90 A ATOM 438 NE2 GLN A 57 26.766 −24.830 53.573 1.00 22.69 A ATOM 439 C GLN A 57 24.543 −23.924 50.300 1.00 21.43 A ATOM 440 O GLN A 57 25.161 −23.026 50.880 1.00 21.65 A ATOM 441 N ARG A 58 24.344 −23.933 48.982 1.00 21.69 A ATOM 442 CA ARG A 58 24.840 −22.857 48.128 1.00 22.25 A ATOM 443 CB ARG A 58 24.633 −23.184 46.645 1.00 23.45 A ATOM 444 CG ARG A 58 25.478 −24.334 46.108 1.00 27.13 A ATOM 445 CD ARG A 58 25.592 −24.237 44.587 1.00 28.97 A ATOM 446 NE ARG A 58 26.291 −25.374 43.994 1.00 31.10 A ATOM 447 CZ ARG A 58 25.779 −26.596 43.878 1.00 31.73 A ATOM 448 NH1 ARG A 58 24.551 −26.851 44.316 1.00 30.89 A ATOM 449 NH2 ARG A 58 26.495 −27.563 43.317 1.00 31.70 A ATOM 450 C ARG A 58 24.130 −21.544 48.451 1.00 21.39 A ATOM 451 O ARG A 58 24.758 −20.487 48.489 1.00 21.08 A ATOM 452 N MET A 59 22.820 −21.616 48.667 1.00 20.52 A ATOM 453 CA MET A 59 22.037 −20.433 49.004 1.00 20.06 A ATOM 454 CB MET A 59 20.560 −20.801 49.198 1.00 19.96 A ATOM 455 CG MET A 59 19.825 −21.168 47.908 1.00 20.74 A ATOM 456 SD MET A 59 18.084 −21.605 48.175 1.00 20.50 A ATOM 457 CE MET A 59 17.663 −22.339 46.587 1.00 21.29 A ATOM 458 C MET A 59 22.586 −19.807 50.285 1.00 20.21 A ATOM 459 O MET A 59 22.811 −18.595 50.348 1.00 19.35 A ATOM 460 N CYS A 60 22.814 −20.638 51.298 1.00 19.75 A ATOM 461 CA CYS A 60 23.336 −20.152 52.571 1.00 20.27 A ATOM 462 CB CYS A 60 23.254 −21.254 53.638 1.00 19.75 A ATOM 463 SG CYS A 60 21.564 −21.694 54.177 1.00 19.90 A ATOM 464 C CYS A 60 24.772 −19.627 52.468 1.00 20.80 A ATOM 465 O CYS A 60 25.109 −18.616 53.085 1.00 20.42 A ATOM 466 N ASP A 61 25.618 −20.301 51.689 1.00 21.26 A ATOM 467 CA ASP A 61 27.008 −19.865 51.542 1.00 22.02 A ATOM 468 CB ASP A 61 27.826 −20.878 50.729 1.00 22.21 A ATOM 469 CG ASP A 61 28.014 −22.201 51.445 1.00 23.21 A ATOM 470 OD1 ASP A 61 27.908 −22.240 52.692 1.00 21.87 A ATOM 471 OD2 ASP A 61 28.290 −23.203 50.747 1.00 23.65 A ATOM 472 C ASP A 61 27.161 −18.498 50.875 1.00 22.10 A ATOM 473 O ASP A 61 28.122 −17.778 51.145 1.00 22.14 A ATOM 474 N LYS A 62 26.224 −18.143 50.004 1.00 22.31 A ATOM 475 CA LYS A 62 26.307 −16.871 49.294 1.00 22.65 A ATOM 476 CB LYS A 62 26.114 −17.110 47.797 1.00 23.96 A ATOM 477 CG LYS A 62 27.022 −18.201 47.241 1.00 25.71 A ATOM 478 CD LYS A 62 27.053 −18.181 45.729 1.00 28.01 A ATOM 479 CE LYS A 62 27.778 −16.951 45.218 1.00 29.31 A ATOM 480 NZ LYS A 62 29.179 −16.906 45.723 1.00 30.60 A ATOM 481 C LYS A 62 25.331 −15.796 49.768 1.00 22.01 A ATOM 482 O LYS A 62 25.206 −14.746 49.135 1.00 21.84 A ATOM 483 N SER A 63 24.660 −16.052 50.886 1.00 20.99 A ATOM 484 CA SER A 63 23.688 −15.112 51.438 1.00 20.43 A ATOM 485 CB SER A 63 22.798 −15.830 52.452 1.00 19.65 A ATOM 486 OG SER A 63 23.572 −16.299 53.544 1.00 19.58 A ATOM 487 C SER A 63 24.326 −13.903 52.118 1.00 20.52 A ATOM 488 O SER A 63 23.685 −12.861 52.274 1.00 20.08 A ATOM 489 N MET A 64 25.584 −14.051 52.523 1.00 20.87 A ATOM 490 CA MET A 64 26.315 −12.990 53.212 1.00 21.59 A ATOM 491 CB MET A 64 26.284 −11.685 52.405 1.00 23.35 A ATOM 492 CG MET A 64 26.926 −11.785 51.024 1.00 25.55 A ATOM 493 SD MET A 64 28.605 −12.454 51.053 1.00 29.17 A ATOM 494 CE MET A 64 28.299 −14.085 50.424 1.00 28.30 A ATOM 495 C MET A 64 25.730 −12.762 54.606 1.00 21.04 A ATOM 496 O MET A 64 25.831 −11.671 55.175 1.00 20.22 A ATOM 497 N ILE A 65 25.114 −13.811 55.144 1.00 20.43 A ATOM 498 CA ILE A 65 24.523 −13.785 56.478 1.00 19.58 A ATOM 499 CB ILE A 65 23.059 −14.294 56.457 1.00 18.89 A ATOM 500 CG2 ILE A 65 22.542 −14.457 57.875 1.00 18.15 A ATOM 501 CG1 ILE A 65 22.176 −13.322 55.668 1.00 18.42 A ATOM 502 CD1 ILE A 65 20.726 −13.775 55.516 1.00 17.96 A ATOM 503 C ILE A 65 25.344 −14.718 57.362 1.00 19.92 A ATOM 504 O ILE A 65 25.572 −15.871 56.999 1.00 20.12 A ATOM 505 N LYS A 66 25.794 −14.225 58.513 1.00 19.96 A ATOM 506 CA LYS A 66 26.584 −15.047 59.426 1.00 20.16 A ATOM 507 CB LYS A 66 27.604 −14.186 60.175 1.00 21.74 A ATOM 508 CG LYS A 66 28.575 −13.467 59.257 1.00 24.36 A ATOM 509 CD LYS A 66 29.645 −12.710 60.029 1.00 25.33 A ATOM 510 CE LYS A 66 30.637 −13.655 60.689 1.00 26.98 A ATOM 511 NZ LYS A 66 31.829 −12.917 61.209 1.00 26.99 A ATOM 512 C LYS A 66 25.696 −15.782 60.431 1.00 19.49 A ATOM 513 O LYS A 66 25.986 −16.918 60.812 1.00 18.64 A ATOM 514 N ARG A 67 24.622 −15.126 60.861 1.00 18.51 A ATOM 515 CA ARG A 67 23.691 −15.726 61.810 1.00 18.88 A ATOM 516 CB ARG A 67 24.349 −15.877 63.187 1.00 20.52 A ATOM 517 CG ARG A 67 25.004 −14.622 63.746 1.00 23.68 A ATOM 518 CD ARG A 67 25.877 −14.994 64.946 1.00 26.21 A ATOM 519 NE ARG A 67 26.647 −13.871 65.476 1.00 28.84 A ATOM 520 CZ ARG A 67 27.641 −13.264 64.833 1.00 29.97 A ATOM 521 NH1 ARG A 67 27.999 −13.664 63.621 1.00 30.84 A ATOM 522 NH2 ARG A 67 28.286 −12.257 65.410 1.00 30.56 A ATOM 523 C ARG A 67 22.385 −14.950 61.939 1.00 17.34 A ATOM 524 O ARG A 67 22.300 −13.788 61.540 1.00 17.53 A ATOM 525 N ARG A 68 21.373 −15.612 62.494 1.00 15.84 A ATOM 526 CA ARG A 68 20.048 −15.030 62.690 1.00 15.12 A ATOM 527 CB ARG A 68 19.090 −15.512 61.595 1.00 15.02 A ATOM 528 CG ARG A 68 19.435 −15.049 60.182 1.00 15.37 A ATOM 529 CD ARG A 68 18.539 −15.737 59.159 1.00 15.36 A ATOM 530 NE ARG A 68 18.998 −17.087 58.835 1.00 15.15 A ATOM 531 CZ ARG A 68 18.294 −17.961 58.118 1.00 16.53 A ATOM 532 NH1 ARG A 68 17.092 −17.632 57.656 1.00 14.86 A ATOM 533 NH2 ARG A 68 18.797 −19.160 57.842 1.00 15.79 A ATOM 534 C ARG A 68 19.481 −15.459 64.047 1.00 15.54 A ATOM 535 O ARG A 68 19.968 −16.408 64.661 1.00 15.15 A ATOM 536 N TYR A 69 18.445 −14.762 64.503 1.00 14.96 A ATOM 537 CA TYR A 69 17.798 −15.088 65.770 1.00 15.18 A ATOM 538 CB TYR A 69 17.811 −13.869 66.701 1.00 15.19 A ATOM 539 CG TYR A 69 19.222 −13.407 67.003 1.00 15.86 A ATOM 540 CD1 TYR A 69 19.938 −12.641 66.081 1.00 15.86 A ATOM 541 CE1 TYR A 69 21.279 −12.307 66.304 1.00 16.29 A ATOM 542 CD2 TYR A 69 19.876 −13.821 68.163 1.00 16.01 A ATOM 543 CE2 TYR A 69 21.213 −13.498 68.394 1.00 16.51 A ATOM 544 CZ TYR A 69 21.909 −12.745 67.462 1.00 16.56 A ATOM 545 OH TYR A 69 23.243 −12.456 67.670 1.00 17.13 A ATOM 546 C TYR A 69 16.377 −15.533 65.459 1.00 15.75 A ATOM 547 O TYR A 69 15.668 −14.878 64.692 1.00 15.23 A ATOM 548 N MET A 70 15.965 −16.655 66.040 1.00 15.97 A ATOM 549 CA MET A 70 14.631 −17.191 65.775 1.00 17.00 A ATOM 550 CB MET A 70 14.731 −18.369 64.796 1.00 18.13 A ATOM 551 CG MET A 70 15.216 −18.019 63.389 1.00 20.30 A ATOM 552 SD MET A 70 15.414 −19.496 62.341 1.00 23.91 A ATOM 553 CE MET A 70 16.362 −18.809 60.972 1.00 22.14 A ATOM 554 C MET A 70 13.857 −17.654 67.007 1.00 16.77 A ATOM 555 O MET A 70 14.386 −18.385 67.844 1.00 17.33 A ATOM 556 N TYR A 71 12.598 −17.231 67.099 1.00 16.96 A ATOM 557 CA TYR A 71 11.713 −17.629 68.193 1.00 17.37 A ATOM 558 CB TYR A 71 10.377 −16.878 68.096 1.00 17.57 A ATOM 559 CG TYR A 71 9.219 −17.560 68.802 1.00 18.29 A ATOM 560 CD1 TYR A 71 9.065 −17.475 70.185 1.00 18.60 A ATOM 561 CE1 TYR A 71 8.012 −18.126 70.835 1.00 19.20 A ATOM 562 CD2 TYR A 71 8.291 −18.311 68.083 1.00 18.96 A ATOM 563 CE2 TYR A 71 7.238 −18.963 68.719 1.00 19.52 A ATOM 564 CZ TYR A 71 7.103 −18.868 70.093 1.00 19.82 A ATOM 565 OH TYR A 71 6.056 −19.511 70.718 1.00 19.82 A ATOM 566 C TYR A 71 11.462 −19.135 68.079 1.00 17.45 A ATOM 567 O TYR A 71 11.358 −19.842 69.085 1.00 16.85 A ATOM 568 N LEU A 72 11.348 −19.613 66.843 1.00 17.94 A ATOM 569 CA LEU A 72 11.124 −21.032 66.586 1.00 18.87 A ATOM 570 CB LEU A 72 10.858 −21.288 65.098 1.00 19.09 A ATOM 571 CG LEU A 72 9.483 −20.991 64.499 1.00 19.52 A ATOM 572 CD1 LEU A 72 9.514 −21.350 63.019 1.00 19.49 A ATOM 573 CD2 LEU A 72 8.404 −21.791 65.213 1.00 19.42 A ATOM 574 C LEU A 72 12.352 −21.831 66.997 1.00 18.91 A ATOM 575 O LEU A 72 13.458 −21.568 66.528 1.00 19.47 A ATOM 576 N THR A 73 12.152 −22.808 67.871 1.00 19.15 A ATOM 577 CA THR A 73 13.247 −23.651 68.336 1.00 19.69 A ATOM 578 CB THR A 73 13.379 −23.592 69.863 1.00 19.91 A ATOM 579 OG1 THR A 73 12.153 −24.037 70.457 1.00 20.02 A ATOM 580 CG2 THR A 73 13.679 −22.176 70.321 1.00 19.67 A ATOM 581 C THR A 73 12.955 −25.093 67.946 1.00 20.34 A ATOM 582 O THR A 73 11.850 −25.416 67.509 1.00 19.94 A ATOM 583 N GLU A 74 13.945 −25.963 68.101 1.00 20.84 A ATOM 584 CA GLU A 74 13.747 −27.364 67.775 1.00 21.72 A ATOM 585 CB GLU A 74 15.055 −28.140 67.970 1.00 22.75 A ATOM 586 CG GLU A 74 14.904 −29.649 67.901 1.00 24.21 A ATOM 587 CD GLU A 74 16.228 −30.359 67.729 1.00 25.53 A ATOM 588 OE1 GLU A 74 17.232 −29.907 68.322 1.00 25.87 A ATOM 589 OE2 GLU A 74 16.263 −31.378 67.003 1.00 26.84 A ATOM 590 C GLU A 74 12.629 −27.968 68.632 1.00 21.92 A ATOM 591 O GLU A 74 11.862 −28.803 68.153 1.00 21.27 A ATOM 592 N GLU A 75 12.520 −27.538 69.888 1.00 22.05 A ATOM 593 CA GLU A 75 11.481 −28.073 70.769 1.00 22.84 A ATOM 594 CB GLU A 75 11.667 −27.583 72.209 1.00 24.92 A ATOM 595 CG GLU A 75 13.096 −27.606 72.704 1.00 27.52 A ATOM 596 CD GLU A 75 13.837 −26.334 72.354 1.00 29.08 A ATOM 597 OE1 GLU A 75 13.446 −25.259 72.867 1.00 30.76 A ATOM 598 OE2 GLU A 75 14.803 −26.403 71.567 1.00 30.32 A ATOM 599 C GLU A 75 10.086 −27.682 70.296 1.00 22.09 A ATOM 600 O GLU A 75 9.157 −28.493 70.327 1.00 21.65 A ATOM 601 N ILE A 76 9.937 −26.432 69.869 1.00 21.20 A ATOM 602 CA ILE A 76 8.648 −25.953 69.388 1.00 20.72 A ATOM 603 CB ILE A 76 8.677 −24.424 69.138 1.00 20.85 A ATOM 604 CG2 ILE A 76 7.408 −23.981 68.404 1.00 20.95 A ATOM 605 CG1 ILE A 76 8.814 −23.689 70.476 1.00 21.17 A ATOM 606 CD1 ILE A 76 8.900 −22.178 70.356 1.00 21.73 A ATOM 607 C ILE A 76 8.288 −26.677 68.094 1.00 20.27 A ATOM 608 O ILE A 76 7.169 −27.165 67.939 1.00 19.16 A ATOM 609 N LEU A 77 9.243 −26.757 67.173 1.00 20.41 A ATOM 610 CA LEU A 77 8.992 −27.427 65.904 1.00 21.09 A ATOM 611 CB LEU A 77 10.233 −27.365 65.008 1.00 20.90 A ATOM 612 CG LEU A 77 10.516 −25.973 64.424 1.00 20.93 A ATOM 613 CD1 LEU A 77 11.852 −25.962 63.711 1.00 21.04 A ATOM 614 CD2 LEU A 77 9.395 −25.587 63.467 1.00 20.50 A ATOM 615 C LEU A 77 8.557 −28.872 66.114 1.00 21.87 A ATOM 616 O LEU A 77 7.678 −29.367 65.409 1.00 22.38 A ATOM 617 N LYS A 78 9.150 −29.546 67.095 1.00 22.54 A ATOM 618 CA LYS A 78 8.785 −30.933 67.354 1.00 23.21 A ATOM 619 CB LYS A 78 9.792 −31.577 68.320 1.00 24.36 A ATOM 620 CG LYS A 78 11.206 −31.602 67.746 1.00 26.62 A ATOM 621 CD LYS A 78 12.031 −32.799 68.203 1.00 28.49 A ATOM 622 CE LYS A 78 12.481 −32.672 69.644 1.00 29.78 A ATOM 623 NZ LYS A 78 13.422 −33.776 70.010 1.00 30.83 A ATOM 624 C LYS A 78 7.355 −31.090 67.871 1.00 22.73 A ATOM 625 O LYS A 78 6.767 −32.162 67.753 1.00 23.44 A ATOM 626 N GLU A 79 6.788 −30.017 68.417 1.00 22.50 A ATOM 627 CA GLU A 79 5.418 −30.042 68.940 1.00 22.20 A ATOM 628 CB GLU A 79 5.274 −29.037 70.094 1.00 24.23 A ATOM 629 CG GLU A 79 6.191 −29.276 71.295 1.00 27.11 A ATOM 630 CD GLU A 79 6.244 −28.080 72.247 1.00 29.29 A ATOM 631 OE1 GLU A 79 5.173 −27.543 72.598 1.00 31.41 A ATOM 632 OE2 GLU A 79 7.357 −27.678 72.655 1.00 30.28 A ATOM 633 C GLU A 79 4.380 −29.695 67.859 1.00 20.87 A ATOM 634 O GLU A 79 3.180 −29.910 68.046 1.00 20.47 A ATOM 635 N ASN A 80 4.843 −29.158 66.734 1.00 18.83 A ATOM 636 CA ASN A 80 3.946 −28.749 65.648 1.00 17.98 A ATOM 637 CB ASN A 80 4.013 −27.229 65.498 1.00 17.92 A ATOM 638 CG ASN A 80 3.591 −26.503 66.761 1.00 18.10 A ATOM 639 OD1 ASN A 80 2.407 −26.251 66.978 1.00 17.75 A ATOM 640 ND2 ASN A 80 4.562 −26.178 67.612 1.00 17.68 A ATOM 641 C ASN A 80 4.319 −29.421 64.328 1.00 16.94 A ATOM 642 O ASN A 80 4.901 −28.797 63.442 1.00 16.43 A ATOM 643 N PRO A 81 3.961 −30.703 64.172 1.00 16.48 A ATOM 644 CD PRO A 81 3.181 −31.528 65.108 1.00 16.60 A ATOM 645 CA PRO A 81 4.281 −31.448 62.949 1.00 16.06 A ATOM 646 CB PRO A 81 3.647 −32.826 63.200 1.00 16.19 A ATOM 647 CG PRO A 81 2.576 −32.556 64.195 1.00 17.80 A ATOM 648 C PRO A 81 3.895 −30.837 61.598 1.00 15.44 A ATOM 649 O PRO A 81 4.656 −30.956 60.635 1.00 14.88 A ATOM 650 N ASN A 82 2.740 −30.180 61.512 1.00 14.66 A ATOM 651 CA ASN A 82 2.334 −29.578 60.241 1.00 14.83 A ATOM 652 CB ASN A 82 0.833 −29.240 60.252 1.00 14.58 A ATOM 653 CG ASN A 82 −0.039 −30.447 59.932 1.00 15.49 A ATOM 654 OD1 ASN A 82 −1.277 −30.345 59.864 1.00 15.62 A ATOM 655 ND2 ASN A 82 0.598 −31.595 59.729 1.00 14.09 A ATOM 656 C ASN A 82 3.160 −28.337 59.877 1.00 14.64 A ATOM 657 O ASN A 82 3.217 −27.939 58.714 1.00 14.35 A ATOM 658 N VAL A 83 3.805 −27.728 60.866 1.00 14.89 A ATOM 659 CA VAL A 83 4.637 −26.556 60.596 1.00 15.18 A ATOM 660 CB VAL A 83 5.025 −25.821 61.910 1.00 14.86 A ATOM 661 CG1 VAL A 83 6.039 −24.718 61.621 1.00 15.10 A ATOM 662 CG2 VAL A 83 3.783 −25.221 62.552 1.00 14.94 A ATOM 663 C VAL A 83 5.909 −26.987 59.857 1.00 15.64 A ATOM 664 O VAL A 83 6.543 −26.183 59.162 1.00 15.69 A ATOM 665 N CYS A 84 6.270 −28.260 59.995 1.00 15.13 A ATOM 666 CA CYS A 84 7.465 −28.790 59.341 1.00 16.08 A ATOM 667 CB CYS A 84 8.022 −29.967 60.147 1.00 16.89 A ATOM 668 SG CYS A 84 8.593 −29.490 61.809 1.00 20.29 A ATOM 669 C CYS A 84 7.242 −29.216 57.889 1.00 15.77 A ATOM 670 O CYS A 84 8.199 −29.479 57.164 1.00 15.77 A ATOM 671 N GLU A 85 5.983 −29.294 57.470 1.00 15.87 A ATOM 672 CA GLU A 85 5.658 −29.675 56.098 1.00 16.07 A ATOM 673 CB GLU A 85 4.262 −30.308 56.032 1.00 16.42 A ATOM 674 CG GLU A 85 4.131 −31.593 56.834 1.00 16.57 A ATOM 675 CD GLU A 85 4.986 −32.721 56.280 1.00 17.93 A ATOM 676 OE1 GLU A 85 5.562 −33.478 57.087 1.00 17.45 A ATOM 677 OE2 GLU A 85 5.075 −32.860 55.041 1.00 18.39 A ATOM 678 C GLU A 85 5.699 −28.430 55.222 1.00 16.50 A ATOM 679 O GLU A 85 5.616 −27.316 55.727 1.00 15.38 A ATOM 680 N TYR A 86 5.830 −28.612 53.910 1.00 17.34 A ATOM 681 CA TYR A 86 5.874 −27.460 53.018 1.00 18.46 A ATOM 682 CB TYR A 86 6.224 −27.887 51.582 1.00 19.38 A ATOM 683 CG TYR A 86 6.095 −26.761 50.585 1.00 20.22 A ATOM 684 CD1 TYR A 86 6.856 −25.597 50.716 1.00 21.14 A ATOM 685 CE1 TYR A 86 6.676 −24.519 49.855 1.00 22.27 A ATOM 686 CD2 TYR A 86 5.155 −26.821 49.555 1.00 21.48 A ATOM 687 CE2 TYR A 86 4.967 −25.748 48.686 1.00 22.12 A ATOM 688 CZ TYR A 86 5.727 −24.600 48.845 1.00 22.64 A ATOM 689 OH TYR A 86 5.517 −23.521 48.020 1.00 23.89 A ATOM 690 C TYR A 86 4.544 −26.712 53.019 1.00 18.72 A ATOM 691 O TYR A 86 4.518 −25.482 53.102 1.00 18.89 A ATOM 692 N MET A 87 3.441 −27.449 52.943 1.00 18.63 A ATOM 693 CA MET A 87 2.128 −26.818 52.912 1.00 19.97 A ATOM 694 CB MET A 87 1.734 −26.542 51.463 1.00 22.09 A ATOM 695 CG MET A 87 0.665 −25.497 51.318 1.00 24.97 A ATOM 696 SD MET A 87 1.405 −23.880 51.450 1.00 30.11 A ATOM 697 CE MET A 87 1.541 −23.463 49.721 1.00 27.15 A ATOM 698 C MET A 87 1.020 −27.639 53.574 1.00 19.37 A ATOM 699 O MET A 87 0.199 −28.245 52.884 1.00 20.41 A ATOM 700 N ALA A 88 0.989 −27.654 54.903 1.00 18.05 A ATOM 701 CA ALA A 88 −0.033 −28.402 55.642 1.00 17.23 A ATOM 702 CB ALA A 88 0.624 −29.521 56.451 1.00 17.03 A ATOM 703 C ALA A 88 −0.797 −27.453 56.576 1.00 16.29 A ATOM 704 O ALA A 88 −0.274 −26.407 56.952 1.00 16.42 A ATOM 705 N PRO A 89 −2.043 −27.808 56.956 1.00 15.67 A ATOM 706 CD PRO A 89 −2.741 −29.042 56.551 1.00 15.28 A ATOM 707 CA PRO A 89 −2.894 −26.998 57.846 1.00 15.05 A ATOM 708 CB PRO A 89 −4.104 −27.900 58.083 1.00 15.61 A ATOM 709 CG PRO A 89 −4.184 −28.697 56.819 1.00 15.58 A ATOM 710 C PRO A 89 −2.178 −26.655 59.154 1.00 14.67 A ATOM 711 O PRO A 89 −1.999 −27.523 60.008 1.00 14.71 A ATOM 712 N SER A 90 −1.792 −25.391 59.321 1.00 13.74 A ATOM 713 CA SER A 90 −1.061 −24.990 60.526 1.00 13.11 A ATOM 714 CB SER A 90 0.427 −25.292 60.326 1.00 13.29 A ATOM 715 OG SER A 90 0.922 −24.652 59.149 1.00 13.45 A ATOM 716 C SER A 90 −1.219 −23.527 60.950 1.00 13.09 A ATOM 717 O SER A 90 −0.528 −23.066 61.866 1.00 12.71 A ATOM 718 N LEU A 91 −2.125 −22.792 60.309 1.00 12.11 A ATOM 719 CA LEU A 91 −2.308 −21.386 60.669 1.00 11.80 A ATOM 720 CB LEU A 91 −3.361 −20.725 59.770 1.00 11.33 A ATOM 721 CG LEU A 91 −3.691 −19.275 60.146 1.00 11.28 A ATOM 722 CD1 LEU A 91 −2.489 −18.391 59.860 1.00 10.89 A ATOM 723 CD2 LEU A 91 −4.913 −18.792 59.357 1.00 10.27 A ATOM 724 C LEU A 91 −2.697 −21.164 62.131 1.00 11.83 A ATOM 725 O LEU A 91 −2.109 −20.321 62.809 1.00 11.61 A ATOM 726 N ASP A 92 −3.680 −21.917 62.622 1.00 12.12 A ATOM 727 CA ASP A 92 −4.134 −21.745 64.001 1.00 12.34 A ATOM 728 CB ASP A 92 −5.233 −22.771 64.340 1.00 12.99 A ATOM 729 CG ASP A 92 −6.524 −22.550 63.536 1.00 14.23 A ATOM 730 OD1 ASP A 92 −6.606 −21.569 62.768 1.00 14.04 A ATOM 731 OD2 ASP A 92 −7.468 −23.362 63.677 1.00 15.03 A ATOM 732 C ASP A 92 −2.996 −21.823 65.022 1.00 12.28 A ATOM 733 O ASP A 92 −2.963 −21.045 65.980 1.00 12.39 A ATOM 734 N ALA A 93 −2.060 −22.747 64.820 1.00 11.80 A ATOM 735 CA ALA A 93 −0.931 −22.884 65.737 1.00 11.93 A ATOM 736 CB ALA A 93 −0.177 −24.187 65.462 1.00 12.38 A ATOM 737 C ALA A 93 0.010 −21.685 65.601 1.00 12.01 A ATOM 738 O ALA A 93 0.526 −21.175 66.599 1.00 11.34 A ATOM 739 N ARG A 94 0.234 −21.237 64.366 1.00 11.55 A ATOM 740 CA ARG A 94 1.102 −20.084 64.120 1.00 11.09 A ATOM 741 CB ARG A 94 1.325 −19.893 62.605 1.00 10.46 A ATOM 742 CG ARG A 94 2.047 −21.056 61.875 1.00 10.01 A ATOM 743 CD ARG A 94 1.938 −20.890 60.346 1.00 10.88 A ATOM 744 NE ARG A 94 2.397 −22.036 59.544 1.00 11.13 A ATOM 745 CZ ARG A 94 3.660 −22.262 59.184 1.00 12.04 A ATOM 746 NH1 ARG A 94 4.622 −21.427 59.553 1.00 11.41 A ATOM 747 NH2 ARG A 94 3.962 −23.309 58.420 1.00 10.17 A ATOM 748 C ARG A 94 0.484 −18.807 64.728 1.00 11.74 A ATOM 749 O ARG A 94 1.201 −17.938 65.236 1.00 12.18 A ATOM 750 N GLN A 95 −0.843 −18.699 64.692 1.00 11.95 A ATOM 751 CA GLN A 95 −1.524 −17.524 65.243 1.00 12.30 A ATOM 752 CB GLN A 95 −3.039 −17.590 64.973 1.00 12.64 A ATOM 753 CG GLN A 95 −3.438 −17.531 63.488 1.00 12.78 A ATOM 754 CD GLN A 95 −3.080 −16.212 62.812 1.00 13.00 A ATOM 755 OE1 GLN A 95 −1.934 −15.765 62.861 1.00 11.99 A ATOM 756 NE2 GLN A 95 −4.067 −15.587 62.170 1.00 12.04 A ATOM 757 C GLN A 95 −1.275 −17.390 66.745 1.00 12.26 A ATOM 758 O GLN A 95 −1.037 −16.287 67.243 1.00 11.48 A ATOM 759 N ALA A 96 −1.324 −18.511 67.463 1.00 12.75 A ATOM 760 CA ALA A 96 −1.099 −18.502 68.908 1.00 12.75 A ATOM 761 CB ALA A 96 −1.407 −19.883 69.503 1.00 12.71 A ATOM 762 C ALA A 96 0.331 −18.085 69.244 1.00 12.95 A ATOM 763 O ALA A 96 0.563 −17.420 70.260 1.00 13.08 A ATOM 764 N MET A 97 1.284 −18.462 68.389 1.00 12.73 A ATOM 765 CA MET A 97 2.691 −18.112 68.596 1.00 12.42 A ATOM 766 CB MET A 97 3.597 −18.849 67.596 1.00 12.18 A ATOM 767 CG MET A 97 3.612 −20.371 67.718 1.00 11.76 A ATOM 768 SD MET A 97 4.617 −21.149 66.408 1.00 13.63 A ATOM 769 CE MET A 97 4.109 −22.880 66.555 1.00 12.10 A ATOM 770 C MET A 97 2.899 −16.609 68.423 1.00 12.57 A ATOM 771 O MET A 97 3.570 −15.962 69.236 1.00 12.06 A ATOM 772 N LEU A 98 2.328 −16.062 67.354 1.00 11.79 A ATOM 773 CA LEU A 98 2.452 −14.634 67.063 1.00 12.16 A ATOM 774 CB LEU A 98 1.854 −14.324 65.684 1.00 11.36 A ATOM 775 CG LEU A 98 2.512 −15.031 64.496 1.00 12.62 A ATOM 776 CD1 LEU A 98 1.679 −14.830 63.227 1.00 12.76 A ATOM 777 CD2 LEU A 98 3.921 −14.487 64.305 1.00 12.17 A ATOM 778 C LEU A 98 1.763 −13.770 68.111 1.00 11.92 A ATOM 779 O LEU A 98 2.257 −12.695 68.460 1.00 12.04 A ATOM 780 N ALA A 99 0.621 −14.237 68.606 1.00 12.12 A ATOM 781 CA ALA A 99 −0.144 −13.492 69.602 1.00 12.56 A ATOM 782 CB ALA A 99 −1.389 −14.288 70.020 1.00 12.39 A ATOM 783 C ALA A 99 0.695 −13.155 70.827 1.00 13.30 A ATOM 784 O ALA A 99 0.474 −12.132 71.475 1.00 12.88 A ATOM 785 N MET A 100 1.660 −14.016 71.134 1.00 14.50 A ATOM 786 CA MET A 100 2.537 −13.818 72.285 1.00 15.61 A ATOM 787 CB MET A 100 2.832 −15.168 72.952 1.00 17.98 A ATOM 788 CG MET A 100 3.608 −15.105 74.281 1.00 21.83 A ATOM 789 SD MET A 100 5.365 −14.630 74.196 1.00 26.83 A ATOM 790 CE MET A 100 6.114 −16.169 73.669 1.00 24.50 A ATOM 791 C MET A 100 3.862 −13.135 71.932 1.00 15.20 A ATOM 792 O MET A 100 4.217 −12.113 72.520 1.00 15.12 A ATOM 793 N GLU A 101 4.577 −13.687 70.958 1.00 13.89 A ATOM 794 CA GLU A 101 5.890 −13.163 70.586 1.00 13.45 A ATOM 795 CB GLU A 101 6.616 −14.187 69.713 1.00 13.61 A ATOM 796 CG GLU A 101 8.094 −13.880 69.475 1.00 13.97 A ATOM 797 CD GLU A 101 8.942 −13.936 70.741 1.00 14.80 A ATOM 798 OE1 GLU A 101 8.422 −14.335 71.808 1.00 15.03 A ATOM 799 OE2 GLU A 101 10.143 −13.584 70.666 1.00 14.42 A ATOM 800 C GLU A 101 5.980 −11.778 69.933 1.00 13.03 A ATOM 801 O GLU A 101 6.860 −10.993 70.286 1.00 11.63 A ATOM 802 N VAL A 102 5.097 −11.469 68.985 1.00 12.32 A ATOM 803 CA VAL A 102 5.160 −10.161 68.340 1.00 12.06 A ATOM 804 CB VAL A 102 4.054 −10.002 67.271 1.00 12.10 A ATOM 805 CG1 VAL A 102 4.043 −8.579 66.730 1.00 12.24 A ATOM 806 CG2 VAL A 102 4.312 −10.982 66.120 1.00 12.82 A ATOM 807 C VAL A 102 5.071 −9.035 69.378 1.00 12.40 A ATOM 808 O VAL A 102 5.911 −8.135 69.388 1.00 12.03 A ATOM 809 N PRO A 103 4.061 −9.072 70.268 1.00 12.59 A ATOM 810 CD PRO A 103 2.862 −9.928 70.270 1.00 12.42 A ATOM 811 CA PRO A 103 3.942 −8.020 71.284 1.00 12.41 A ATOM 812 CB PRO A 103 2.585 −8.312 71.931 1.00 13.58 A ATOM 813 CG PRO A 103 1.819 −9.000 70.828 1.00 13.22 A ATOM 814 C PRO A 103 5.085 −8.056 72.312 1.00 12.46 A ATOM 815 O PRO A 103 5.570 −7.008 72.748 1.00 11.92 A ATOM 816 N ARG A 104 5.512 −9.256 72.705 1.00 12.35 A ATOM 817 CA ARG A 104 6.593 −9.376 73.691 1.00 12.83 A ATOM 818 CB ARG A 104 6.830 −10.841 74.073 1.00 13.38 A ATOM 819 CG ARG A 104 7.824 −11.005 75.233 1.00 14.51 A ATOM 820 CD ARG A 104 8.463 −12.393 75.252 1.00 15.96 A ATOM 821 NE ARG A 104 9.362 −12.594 74.116 1.00 17.99 A ATOM 822 CZ ARG A 104 10.561 −12.031 73.994 1.00 19.06 A ATOM 823 NH1 ARG A 104 11.025 −11.228 74.946 1.00 19.58 A ATOM 824 NH2 ARG A 104 11.295 −12.260 72.911 1.00 19.03 A ATOM 825 C ARG A 104 7.907 −8.789 73.179 1.00 12.54 A ATOM 826 O ARG A 104 8.559 −8.002 73.867 1.00 12.97 A ATOM 827 N LEU A 105 8.297 −9.190 71.972 1.00 12.55 A ATOM 828 CA LEU A 105 9.532 −8.722 71.356 1.00 12.96 A ATOM 829 CB LEU A 105 9.768 −9.491 70.047 1.00 13.70 A ATOM 830 CG LEU A 105 11.113 −9.417 69.327 1.00 15.14 A ATOM 831 CD1 LEU A 105 12.227 −9.949 70.231 1.00 14.66 A ATOM 832 CD2 LEU A 105 11.028 −10.247 68.034 1.00 14.82 A ATOM 833 C LEU A 105 9.454 −7.219 71.094 1.00 12.85 A ATOM 834 O LEU A 105 10.436 −6.494 71.271 1.00 12.86 A ATOM 835 N GLY A 106 8.278 −6.754 70.675 1.00 12.06 A ATOM 836 CA GLY A 106 8.086 −5.337 70.412 1.00 11.77 A ATOM 837 C GLY A 106 8.215 −4.504 71.675 1.00 11.78 A ATOM 838 O GLY A 106 8.767 −3.405 71.648 1.00 11.19 A ATOM 839 N LYS A 107 7.710 −5.025 72.790 1.00 11.65 A ATOM 840 CA LYS A 107 7.800 −4.312 74.060 1.00 12.93 A ATOM 841 CB LYS A 107 6.993 −5.029 75.145 1.00 14.06 A ATOM 842 CG LYS A 107 6.987 −4.280 76.465 1.00 15.87 A ATOM 843 CD LYS A 107 7.048 −5.223 77.649 1.00 17.85 A ATOM 844 CE LYS A 107 7.068 −4.444 78.954 1.00 19.08 A ATOM 845 NZ LYS A 107 7.304 −5.335 80.128 1.00 21.55 A ATOM 846 C LYS A 107 9.255 −4.203 74.520 1.00 13.01 A ATOM 847 O LYS A 107 9.664 −3.180 75.067 1.00 13.04 A ATOM 848 N GLU A 108 10.034 −5.260 74.302 1.00 13.42 A ATOM 849 CA GLU A 108 11.441 −5.264 74.702 1.00 13.99 A ATOM 850 CB GLU A 108 12.081 −6.618 74.360 1.00 15.13 A ATOM 851 CG GLU A 108 13.507 −6.782 74.851 1.00 16.71 A ATOM 852 CD GLU A 108 14.044 −8.195 74.660 1.00 17.86 A ATOM 853 OE1 GLU A 108 15.250 −8.408 74.910 1.00 18.93 A ATOM 854 OE2 GLU A 108 13.265 −9.088 74.267 1.00 16.99 A ATOM 855 C GLU A 108 12.208 −4.122 74.019 1.00 13.77 A ATOM 856 O GLU A 108 13.015 −3.433 74.651 1.00 13.37 A ATOM 857 N ALA A 109 11.954 −3.922 72.728 1.00 12.99 A ATOM 858 CA ALA A 109 12.618 −2.855 71.981 1.00 12.44 A ATOM 859 CB ALA A 109 12.370 −3.027 70.494 1.00 11.96 A ATOM 860 C ALA A 109 12.105 −1.491 72.440 1.00 12.31 A ATOM 861 O ALA A 109 12.881 −0.543 72.595 1.00 11.79 A ATOM 862 N ALA A 110 10.796 −1.400 72.657 1.00 11.92 A ATOM 863 CA ALA A 110 10.170 −0.154 73.093 1.00 12.92 A ATOM 864 CB ALA A 110 8.655 −0.335 73.173 1.00 12.53 A ATOM 865 C ALA A 110 10.712 0.332 74.440 1.00 13.13 A ATOM 866 O ALA A 110 10.938 1.528 74.632 1.00 13.01 A ATOM 867 N VAL A 111 10.923 −0.592 75.371 1.00 13.59 A ATOM 868 CA VAL A 111 11.442 −0.219 76.683 1.00 14.30 A ATOM 869 CB VAL A 111 11.512 −1.445 77.632 1.00 14.16 A ATOM 870 CG1 VAL A 111 12.249 −1.073 78.921 1.00 14.90 A ATOM 871 CG2 VAL A 111 10.102 −1.915 77.972 1.00 14.85 A ATOM 872 C VAL A 111 12.830 0.412 76.549 1.00 14.57 A ATOM 873 O VAL A 111 13.140 1.393 77.232 1.00 14.48 A ATOM 874 N LYS A 112 13.655 −0.140 75.660 1.00 14.33 A ATOM 875 CA LYS A 112 15.003 0.382 75.439 1.00 14.52 A ATOM 876 CB LYS A 112 15.803 −0.550 74.522 1.00 15.84 A ATOM 877 CG LYS A 112 16.113 −1.911 75.118 1.00 17.43 A ATOM 878 CD LYS A 112 16.934 −2.747 74.147 1.00 18.69 A ATOM 879 CE LYS A 112 17.182 −4.137 74.687 1.00 19.96 A ATOM 880 NZ LYS A 112 17.933 −4.976 73.708 1.00 20.59 A ATOM 881 C LYS A 112 14.973 1.783 74.829 1.00 14.19 A ATOM 882 O LYS A 112 15.771 2.645 75.198 1.00 13.66 A ATOM 883 N ALA A 113 14.054 2.008 73.894 1.00 13.82 A ATOM 884 CA ALA A 113 13.935 3.316 73.252 1.00 13.94 A ATOM 885 CB ALA A 113 12.985 3.227 72.039 1.00 13.86 A ATOM 886 C ALA A 113 13.443 4.384 74.235 1.00 13.81 A ATOM 887 O ALA A 113 13.923 5.519 74.228 1.00 13.80 A ATOM 888 N ILE A 114 12.492 4.014 75.085 1.00 13.62 A ATOM 889 CA ILE A 114 11.939 4.938 76.067 1.00 14.81 A ATOM 890 CB ILE A 114 10.690 4.325 76.751 1.00 14.96 A ATOM 891 CG2 ILE A 114 10.205 5.229 77.874 1.00 15.35 A ATOM 892 CG1 ILE A 114 9.592 4.106 75.702 1.00 15.11 A ATOM 893 CD1 ILE A 114 8.359 3.358 76.211 1.00 14.83 A ATOM 894 C ILE A 114 12.993 5.301 77.118 1.00 15.14 A ATOM 895 O ILE A 114 13.031 6.430 77.607 1.00 14.81 A ATOM 896 N LYS A 115 13.851 4.341 77.452 1.00 15.95 A ATOM 897 CA LYS A 115 14.915 4.572 78.427 1.00 17.10 A ATOM 898 CB LYS A 115 15.664 3.264 78.723 1.00 18.03 A ATOM 899 CG LYS A 115 16.793 3.422 79.732 1.00 20.46 A ATOM 900 CD LYS A 115 17.665 2.176 79.815 1.00 22.06 A ATOM 901 CE LYS A 115 18.867 2.413 80.730 1.00 24.19 A ATOM 902 NZ LYS A 115 19.768 1.230 80.814 1.00 24.53 A ATOM 903 C LYS A 115 15.896 5.615 77.882 1.00 16.58 A ATOM 904 O LYS A 115 16.293 6.536 78.596 1.00 16.08 A ATOM 905 N GLU A 116 16.282 5.470 76.615 1.00 15.74 A ATOM 906 CA GLU A 116 17.209 6.413 75.989 1.00 15.99 A ATOM 907 CB GLU A 116 17.559 5.973 74.563 1.00 15.39 A ATOM 908 CG GLU A 116 18.606 6.860 73.895 1.00 16.97 A ATOM 909 CD GLU A 116 18.736 6.634 72.392 1.00 17.20 A ATOM 910 OE1 GLU A 116 18.375 5.542 71.907 1.00 16.77 A ATOM 911 OE2 GLU A 116 19.219 7.553 71.694 1.00 17.90 A ATOM 912 C GLU A 116 16.576 7.807 75.935 1.00 16.26 A ATOM 913 O GLU A 116 17.223 8.811 76.250 1.00 15.55 A ATOM 914 N TRP A 117 15.312 7.853 75.520 1.00 16.06 A ATOM 915 CA TRP A 117 14.561 9.102 75.424 1.00 16.63 A ATOM 916 CB TRP A 117 13.113 8.792 75.026 1.00 15.45 A ATOM 917 CG TRP A 117 12.222 9.992 74.851 1.00 15.18 A ATOM 918 CD2 TRP A 117 10.815 10.061 75.130 1.00 14.59 A ATOM 919 CE2 TRP A 117 10.372 11.344 74.735 1.00 14.57 A ATOM 920 CE3 TRP A 117 9.885 9.162 75.672 1.00 14.93 A ATOM 921 CD1 TRP A 117 12.565 11.204 74.320 1.00 14.39 A ATOM 922 NE1 TRP A 117 11.459 12.019 74.246 1.00 14.28 A ATOM 923 CZ2 TRP A 117 9.038 11.752 74.864 1.00 14.45 A ATOM 924 CZ3 TRP A 117 8.555 9.569 75.801 1.00 14.58 A ATOM 925 CH2 TRP A 117 8.147 10.852 75.397 1.00 14.55 A ATOM 926 C TRP A 117 14.615 9.836 76.765 1.00 17.46 A ATOM 927 O TRP A 117 14.919 11.026 76.812 1.00 17.93 A ATOM 928 N GLY A 118 14.322 9.120 77.848 1.00 18.47 A ATOM 929 CA GLY A 118 14.375 9.713 79.175 1.00 19.45 A ATOM 930 C GLY A 118 13.121 10.377 79.724 1.00 20.29 A ATOM 931 O GLY A 118 13.110 10.800 80.883 1.00 20.22 A ATOM 932 N GLN A 119 12.066 10.469 78.918 1.00 20.22 A ATOM 933 CA GLN A 119 10.825 11.100 79.363 1.00 20.78 A ATOM 934 CB GLN A 119 10.282 12.014 78.257 1.00 21.39 A ATOM 935 CG GLN A 119 11.219 13.173 77.913 1.00 23.09 A ATOM 936 CD GLN A 119 11.655 13.958 79.146 1.00 23.77 A ATOM 937 OE1 GLN A 119 10.824 14.468 79.899 1.00 24.98 A ATOM 938 NE2 GLN A 119 12.962 14.050 79.357 1.00 24.40 A ATOM 939 C GLN A 119 9.763 10.079 79.782 1.00 20.88 A ATOM 940 O GLN A 119 9.859 8.903 79.443 1.00 20.86 A ATOM 941 N PRO A 120 8.733 10.524 80.525 1.00 21.16 A ATOM 942 CD PRO A 120 8.517 11.921 80.939 1.00 21.29 A ATOM 943 CA PRO A 120 7.641 9.667 81.008 1.00 21.57 A ATOM 944 CB PRO A 120 6.746 10.643 81.772 1.00 21.80 A ATOM 945 CG PRO A 120 7.677 11.753 82.165 1.00 22.42 A ATOM 946 C PRO A 120 6.877 8.983 79.873 1.00 21.27 A ATOM 947 O PRO A 120 6.608 9.607 78.851 1.00 21.61 A ATOM 948 N LYS A 121 6.519 7.714 80.056 1.00 21.35 A ATOM 949 CA LYS A 121 5.777 6.977 79.029 1.00 21.42 A ATOM 950 CB LYS A 121 5.623 5.501 79.421 1.00 22.56 A ATOM 951 CG LYS A 121 4.759 5.288 80.654 1.00 25.13 A ATOM 952 CD LYS A 121 4.399 3.822 80.900 1.00 26.18 A ATOM 953 CE LYS A 121 5.619 2.984 81.222 1.00 27.36 A ATOM 954 NZ LYS A 121 5.225 1.655 81.786 1.00 28.12 A ATOM 955 C LYS A 121 4.392 7.595 78.840 1.00 20.94 A ATOM 956 O LYS A 121 3.762 7.429 77.791 1.00 20.02 A ATOM 957 N SER A 122 3.928 8.309 79.863 1.00 19.98 A ATOM 958 CA SER A 122 2.621 8.956 79.836 1.00 19.81 A ATOM 959 CB SER A 122 2.252 9.457 81.236 1.00 20.86 A ATOM 960 OG SER A 122 3.131 10.488 81.656 1.00 20.86 A ATOM 961 C SER A 122 2.580 10.121 78.856 1.00 19.21 A ATOM 962 O SER A 122 1.508 10.633 78.533 1.00 19.72 A ATOM 963 N LYS A 123 3.748 10.540 78.380 1.00 18.76 A ATOM 964 CA LYS A 123 3.819 11.646 77.435 1.00 17.51 A ATOM 965 CB LYS A 123 5.069 12.486 77.715 1.00 19.70 A ATOM 966 CG LYS A 123 5.096 13.004 79.157 1.00 21.88 A ATOM 967 CD LYS A 123 6.289 13.894 79.465 1.00 24.26 A ATOM 968 CE LYS A 123 6.204 15.233 78.751 1.00 25.53 A ATOM 969 NZ LYS A 123 7.195 16.202 79.318 1.00 26.85 A ATOM 970 C LYS A 123 3.782 11.179 75.975 1.00 16.02 A ATOM 971 O LYS A 123 3.874 11.990 75.056 1.00 15.29 A ATOM 972 N ILE A 124 3.649 9.871 75.767 1.00 14.24 A ATOM 973 CA ILE A 124 3.551 9.326 74.413 1.00 13.14 A ATOM 974 CB ILE A 124 3.949 7.828 74.370 1.00 13.63 A ATOM 975 CG2 ILE A 124 3.612 7.235 73.000 1.00 13.42 A ATOM 976 CG1 ILE A 124 5.451 7.685 74.668 1.00 13.73 A ATOM 977 CD1 ILE A 124 5.932 6.250 74.850 1.00 14.46 A ATOM 978 C ILE A 124 2.084 9.503 74.016 1.00 12.41 A ATOM 979 O ILE A 124 1.184 9.010 74.695 1.00 12.34 A ATOM 980 N THR A 125 1.853 10.219 72.922 1.00 11.64 A ATOM 981 CA THR A 125 0.499 10.515 72.451 1.00 10.75 A ATOM 982 CB THR A 125 0.409 11.975 71.989 1.00 9.91 A ATOM 983 OG1 THR A 125 1.357 12.196 70.937 1.00 10.98 A ATOM 984 CG2 THR A 125 0.714 12.921 73.147 1.00 10.30 A ATOM 985 C THR A 125 −0.030 9.639 71.313 1.00 10.65 A ATOM 986 O THR A 125 −1.249 9.502 71.150 1.00 10.36 A ATOM 987 N HIS A 126 0.877 9.078 70.516 1.00 10.15 A ATOM 988 CA HIS A 126 0.494 8.223 69.389 1.00 9.76 A ATOM 989 CB HIS A 126 0.735 8.936 68.047 1.00 9.29 A ATOM 990 CG HIS A 126 −0.054 10.195 67.858 1.00 9.51 A ATOM 991 CD2 HIS A 126 −1.047 10.498 66.987 1.00 10.73 A ATOM 992 ND1 HIS A 126 0.185 11.346 68.580 1.00 9.94 A ATOM 993 CE1 HIS A 126 −0.624 12.303 68.159 1.00 10.59 A ATOM 994 NE2 HIS A 126 −1.381 11.815 67.193 1.00 10.64 A ATOM 995 C HIS A 126 1.329 6.935 69.390 1.00 9.52 A ATOM 996 O HIS A 126 2.463 6.926 69.870 1.00 9.39 A ATOM 997 N LEU A 127 0.770 5.865 68.826 1.00 8.68 A ATOM 998 CA LEU A 127 1.457 4.577 68.741 1.00 8.66 A ATOM 999 CB LEU A 127 0.943 3.615 69.820 1.00 8.64 A ATOM 1000 CG LEU A 127 1.448 2.167 69.722 1.00 9.47 A ATOM 1001 CD1 LEU A 127 2.954 2.119 69.949 1.00 9.18 A ATOM 1002 CD2 LEU A 127 0.728 1.298 70.748 1.00 9.28 A ATOM 1003 C LEU A 127 1.243 3.927 67.379 1.00 8.85 A ATOM 1004 O LEU A 127 0.107 3.737 66.956 1.00 7.92 A ATOM 1005 N ILE A 128 2.339 3.580 66.710 1.00 8.63 A ATOM 1006 CA ILE A 128 2.280 2.921 65.407 1.00 8.91 A ATOM 1007 CB ILE A 128 3.054 3.717 64.324 1.00 8.76 A ATOM 1008 CG2 ILE A 128 3.053 2.942 63.007 1.00 9.37 A ATOM 1009 CG1 ILE A 128 2.436 5.110 64.144 1.00 8.68 A ATOM 1010 CD1 ILE A 128 3.161 5.984 63.137 1.00 8.20 A ATOM 1011 C ILE A 128 2.950 1.551 65.541 1.00 9.26 A ATOM 1012 O ILE A 128 4.142 1.477 65.847 1.00 9.52 A ATOM 1013 N VAL A 129 2.195 0.475 65.329 1.00 9.33 A ATOM 1014 CA VAL A 129 2.768 −0.872 65.408 1.00 9.83 A ATOM 1015 CB VAL A 129 2.095 −1.728 66.500 1.00 9.91 A ATOM 1016 CG1 VAL A 129 2.655 −3.151 66.465 1.00 9.78 A ATOM 1017 CG2 VAL A 129 2.342 −1.099 67.873 1.00 8.95 A ATOM 1018 C VAL A 129 2.621 −1.571 64.063 1.00 10.19 A ATOM 1019 O VAL A 129 1.524 −1.638 63.504 1.00 10.94 A ATOM 1020 N CYS A 130 3.739 −2.089 63.561 1.00 10.12 A ATOM 1021 CA CYS A 130 3.803 −2.765 62.268 1.00 10.10 A ATOM 1022 CB CYS A 130 4.696 −1.946 61.328 1.00 10.57 A ATOM 1023 SG CYS A 130 5.174 −2.737 59.758 1.00 12.03 A ATOM 1024 C CYS A 130 4.343 −4.194 62.363 1.00 9.44 A ATOM 1025 O CYS A 130 5.309 −4.455 63.078 1.00 9.20 A ATOM 1026 N SER A 131 3.702 −5.109 61.641 1.00 8.71 A ATOM 1027 CA SER A 131 4.117 −6.516 61.579 1.00 9.13 A ATOM 1028 CB SER A 131 3.590 −7.297 62.788 1.00 9.14 A ATOM 1029 OG SER A 131 4.170 −8.592 62.834 1.00 8.81 A ATOM 1030 C SER A 131 3.535 −7.098 60.293 1.00 9.18 A ATOM 1031 O SER A 131 2.451 −6.699 59.878 1.00 9.08 A ATOM 1032 N THR A 132 4.246 −8.028 59.655 1.00 10.48 A ATOM 1033 CA THR A 132 3.754 −8.620 58.411 1.00 10.93 A ATOM 1034 CB THR A 132 4.689 −9.774 57.941 1.00 11.08 A ATOM 1035 OG1 THR A 132 5.988 −9.232 57.654 1.00 10.58 A ATOM 1036 CG2 THR A 132 4.150 −10.437 56.675 1.00 11.82 A ATOM 1037 C THR A 132 2.294 −9.089 58.544 1.00 11.41 A ATOM 1038 O THR A 132 1.505 −8.928 57.607 1.00 11.93 A ATOM 1039 N THR A 133 1.928 −9.647 59.701 1.00 11.44 A ATOM 1040 CA THR A 133 0.541 −10.075 59.960 1.00 11.06 A ATOM 1041 CB THR A 133 0.301 −11.586 59.681 1.00 12.44 A ATOM 1042 OG1 THR A 133 0.982 −12.371 60.675 1.00 12.81 A ATOM 1043 CG2 THR A 133 0.798 −11.975 58.292 1.00 12.09 A ATOM 1044 C THR A 133 0.171 −9.867 61.432 1.00 11.34 A ATOM 1045 O THR A 133 1.038 −9.591 62.262 1.00 10.26 A ATOM 1046 N THR A 134 −1.121 −9.972 61.741 1.00 10.39 A ATOM 1047 CA THR A 134 −1.599 −9.886 63.127 1.00 10.86 A ATOM 1048 CB THR A 134 −2.151 −8.478 63.490 1.00 10.72 A ATOM 1049 OG1 THR A 134 −2.068 −8.297 64.913 1.00 10.97 A ATOM 1050 CG2 THR A 134 −3.595 −8.310 63.049 1.00 9.79 A ATOM 1051 C THR A 134 −2.681 −10.973 63.214 1.00 10.76 A ATOM 1052 O THR A 134 −3.493 −11.124 62.307 1.00 10.88 A ATOM 1053 N PRO A 135 −2.696 −11.753 64.305 1.00 10.68 A ATOM 1054 CD PRO A 135 −1.766 −11.689 65.450 1.00 10.93 A ATOM 1055 CA PRO A 135 −3.665 −12.840 64.483 1.00 11.06 A ATOM 1056 CB PRO A 135 −2.969 −13.736 65.502 1.00 10.76 A ATOM 1057 CG PRO A 135 −2.338 −12.722 66.415 1.00 10.45 A ATOM 1058 C PRO A 135 −5.105 −12.568 64.890 1.00 11.42 A ATOM 1059 O PRO A 135 −5.999 −13.341 64.538 1.00 11.28 A ATOM 1060 N ASP A 136 −5.352 −11.481 65.608 1.00 11.37 A ATOM 1061 CA ASP A 136 −6.704 −11.235 66.091 1.00 12.18 A ATOM 1062 CB ASP A 136 −6.774 −11.593 67.587 1.00 13.43 A ATOM 1063 CG ASP A 136 −6.122 −12.935 67.916 1.00 14.45 A ATOM 1064 OD1 ASP A 136 −5.193 −12.973 68.762 1.00 13.87 A ATOM 1065 OD2 ASP A 136 −6.544 −13.955 67.343 1.00 14.97 A ATOM 1066 C ASP A 136 −7.199 −9.802 65.942 1.00 12.49 A ATOM 1067 O ASP A 136 −6.625 −8.983 65.225 1.00 12.60 A ATOM 1068 N LEU A 137 −8.310 −9.546 66.627 1.00 12.88 A ATOM 1069 CA LEU A 137 −8.924 −8.230 66.740 1.00 13.15 A ATOM 1070 CB LEU A 137 −10.244 −8.126 65.967 1.00 13.24 A ATOM 1071 CG LEU A 137 −10.145 −7.967 64.450 1.00 13.68 A ATOM 1072 CD1 LEU A 137 −10.283 −9.326 63.798 1.00 14.40 A ATOM 1073 CD2 LEU A 137 −11.235 −7.023 63.957 1.00 14.51 A ATOM 1074 C LEU A 137 −9.212 −8.202 68.231 1.00 13.21 A ATOM 1075 O LEU A 137 −9.906 −9.080 68.741 1.00 13.93 A ATOM 1076 N PRO A 138 −8.660 −7.225 68.963 1.00 13.99 A ATOM 1077 CD PRO A 138 −8.996 −7.174 70.396 1.00 14.42 A ATOM 1078 CA PRO A 138 −7.780 −6.107 68.602 1.00 13.83 A ATOM 1079 CB PRO A 138 −7.565 −5.401 69.941 1.00 14.52 A ATOM 1080 CG PRO A 138 −8.802 −5.728 70.705 1.00 14.81 A ATOM 1081 C PRO A 138 −6.444 −6.511 67.956 1.00 14.18 A ATOM 1082 O PRO A 138 −5.955 −7.621 68.166 1.00 13.48 A ATOM 1083 N GLY A 139 −5.872 −5.598 67.170 1.00 13.47 A ATOM 1084 CA GLY A 139 −4.596 −5.841 66.515 1.00 13.68 A ATOM 1085 C GLY A 139 −3.441 −5.742 67.504 1.00 13.10 A ATOM 1086 O GLY A 139 −3.664 −5.427 68.668 1.00 13.23 A ATOM 1087 N ALA A 140 −2.212 −5.995 67.056 1.00 12.38 A ATOM 1088 CA ALA A 140 −1.056 −5.938 67.961 1.00 12.40 A ATOM 1089 CB ALA A 140 0.216 −6.393 67.236 1.00 10.91 A ATOM 1090 C ALA A 140 −0.823 −4.568 68.611 1.00 12.51 A ATOM 1091 O ALA A 140 −0.152 −4.483 69.643 1.00 12.15 A ATOM 1092 N ASP A 141 −1.359 −3.499 68.024 1.00 12.33 A ATOM 1093 CA ASP A 141 −1.191 −2.173 68.622 1.00 12.63 A ATOM 1094 CB ASP A 141 −1.785 −1.081 67.724 1.00 13.06 A ATOM 1095 CG ASP A 141 −3.207 −1.384 67.287 1.00 13.39 A ATOM 1096 OD1 ASP A 141 −3.413 −2.385 66.564 1.00 13.50 A ATOM 1097 OD2 ASP A 141 −4.119 −0.618 67.661 1.00 13.61 A ATOM 1098 C ASP A 141 −1.856 −2.140 70.000 1.00 12.86 A ATOM 1099 O ASP A 141 −1.319 −1.562 70.948 1.00 12.35 A ATOM 1100 N TYR A 142 −3.022 −2.774 70.110 1.00 13.35 A ATOM 1101 CA TYR A 142 −3.747 −2.836 71.377 1.00 13.60 A ATOM 1102 CB TYR A 142 −5.090 −3.549 71.182 1.00 14.21 A ATOM 1103 CG TYR A 142 −5.781 −3.900 72.478 1.00 15.51 A ATOM 1104 CD1 TYR A 142 −6.503 −2.943 73.193 1.00 15.93 A ATOM 1105 CE1 TYR A 142 −7.110 −3.262 74.411 1.00 17.60 A ATOM 1106 CD2 TYR A 142 −5.680 −5.184 73.012 1.00 16.59 A ATOM 1107 CE2 TYR A 142 −6.275 −5.509 74.224 1.00 17.58 A ATOM 1108 CZ TYR A 142 −6.988 −4.549 74.917 1.00 18.62 A ATOM 1109 OH TYR A 142 −7.587 −4.890 76.112 1.00 20.44 A ATOM 1110 C TYR A 142 −2.932 −3.584 72.441 1.00 13.98 A ATOM 1111 O TYR A 142 −2.773 −3.109 73.572 1.00 13.20 A ATOM 1112 N GLN A 143 −2.420 −4.757 72.080 1.00 14.49 A ATOM 1113 CA GLN A 143 −1.635 −5.551 73.023 1.00 15.02 A ATOM 1114 CB GLN A 143 −1.239 −6.896 72.403 1.00 16.02 A ATOM 1115 CG GLN A 143 −2.406 −7.861 72.183 1.00 17.48 A ATOM 1116 CD GLN A 143 −3.193 −8.148 73.455 1.00 18.91 A ATOM 1117 OE1 GLN A 143 −2.621 −8.294 74.539 1.00 18.85 A ATOM 1118 NE2 GLN A 143 −4.515 −8.246 73.324 1.00 20.56 A ATOM 1119 C GLN A 143 −0.385 −4.824 73.518 1.00 15.31 A ATOM 1120 O GLN A 143 −0.047 −4.908 74.703 1.00 15.22 A ATOM 1121 N LEU A 144 0.303 −4.113 72.626 1.00 14.97 A ATOM 1122 CA LEU A 144 1.506 −3.385 73.032 1.00 15.35 A ATOM 1123 CB LEU A 144 2.189 −2.716 71.832 1.00 16.16 A ATOM 1124 CG LEU A 144 3.669 −3.050 71.600 1.00 17.50 A ATOM 1125 CD1 LEU A 144 4.321 −1.918 70.822 1.00 18.53 A ATOM 1126 CD2 LEU A 144 4.399 −3.242 72.926 1.00 18.13 A ATOM 1127 C LEU A 144 1.150 −2.317 74.061 1.00 15.11 A ATOM 1128 O LEU A 144 1.880 −2.110 75.030 1.00 14.55 A ATOM 1129 N THR A 145 0.030 −1.635 73.838 1.00 14.64 A ATOM 1130 CA THR A 145 −0.442 −0.599 74.752 1.00 15.04 A ATOM 1131 CB THR A 145 −1.769 0.018 74.258 1.00 15.52 A ATOM 1132 OG1 THR A 145 −1.544 0.707 73.023 1.00 15.30 A ATOM 1133 CG2 THR A 145 −2.325 0.993 75.288 1.00 15.63 A ATOM 1134 C THR A 145 −0.678 −1.215 76.130 1.00 15.20 A ATOM 1135 O THR A 145 −0.310 −0.640 77.156 1.00 14.90 A ATOM 1136 N LYS A 146 −1.296 −2.392 76.138 1.00 15.71 A ATOM 1137 CA LYS A 146 −1.587 −3.116 77.374 1.00 16.56 A ATOM 1138 CB LYS A 146 −2.469 −4.325 77.054 1.00 17.61 A ATOM 1139 CG LYS A 146 −2.785 −5.242 78.232 1.00 19.39 A ATOM 1140 CD LYS A 146 −3.567 −6.463 77.745 1.00 21.39 A ATOM 1141 CE LYS A 146 −3.488 −7.618 78.725 1.00 22.15 A ATOM 1142 NZ LYS A 146 −4.011 −8.877 78.116 1.00 23.90 A ATOM 1143 C LYS A 146 −0.302 −3.569 78.083 1.00 16.40 A ATOM 1144 O LYS A 146 −0.176 −3.421 79.302 1.00 16.41 A ATOM 1145 N LEU A 147 0.654 −4.102 77.322 1.00 16.28 A ATOM 1146 CA LEU A 147 1.912 −4.579 77.901 1.00 16.03 A ATOM 1147 CB LEU A 147 2.717 −5.387 76.872 1.00 16.79 A ATOM 1148 CG LEU A 147 2.089 −6.628 76.224 1.00 17.91 A ATOM 1149 CD1 LEU A 147 3.145 −7.359 75.409 1.00 18.58 A ATOM 1150 CD2 LEU A 147 1.520 −7.551 77.277 1.00 19.05 A ATOM 1151 C LEU A 147 2.789 −3.449 78.446 1.00 15.74 A ATOM 1152 O LEU A 147 3.477 −3.622 79.456 1.00 15.01 A ATOM 1153 N LEU A 148 2.765 −2.297 77.780 1.00 14.59 A ATOM 1154 CA LEU A 148 3.567 −1.149 78.202 1.00 14.85 A ATOM 1155 CB LEU A 148 3.913 −0.261 76.998 1.00 14.25 A ATOM 1156 CG LEU A 148 4.991 −0.710 76.017 1.00 14.59 A ATOM 1157 CD1 LEU A 148 4.989 0.201 74.790 1.00 14.37 A ATOM 1158 CD2 LEU A 148 6.349 −0.680 76.712 1.00 15.53 A ATOM 1159 C LEU A 148 2.877 −0.289 79.257 1.00 14.60 A ATOM 1160 O LEU A 148 3.535 0.459 79.981 1.00 14.89 A ATOM 1161 N GLY A 149 1.554 −0.381 79.336 1.00 14.31 A ATOM 1162 CA GLY A 149 0.822 0.426 80.295 1.00 14.76 A ATOM 1163 C GLY A 149 0.754 1.885 79.867 1.00 15.29 A ATOM 1164 O GLY A 149 0.838 2.792 80.696 1.00 15.01 A ATOM 1165 N LEU A 150 0.618 2.123 78.565 1.00 15.01 A ATOM 1166 CA LEU A 150 0.522 3.490 78.058 1.00 14.43 A ATOM 1167 CB LEU A 150 0.665 3.500 76.530 1.00 14.29 A ATOM 1168 CG LEU A 150 1.962 2.940 75.928 1.00 14.95 A ATOM 1169 CD1 LEU A 150 1.852 2.932 74.401 1.00 15.08 A ATOM 1170 CD2 LEU A 150 3.157 3.773 76.374 1.00 14.06 A ATOM 1171 C LEU A 150 −0.851 4.041 78.451 1.00 14.48 A ATOM 1172 O LEU A 150 −1.729 3.278 78.853 1.00 14.49 A ATOM 1173 N ARG A 151 −1.043 5.356 78.348 1.00 14.75 A ATOM 1174 CA ARG A 151 −2.343 5.942 78.686 1.00 15.18 A ATOM 1175 CB ARG A 151 −2.363 7.447 78.418 1.00 16.74 A ATOM 1176 CG ARG A 151 −1.317 8.281 79.141 1.00 20.10 A ATOM 1177 CD ARG A 151 −1.614 8.453 80.619 1.00 22.50 A ATOM 1178 NE ARG A 151 −1.242 7.285 81.409 1.00 25.48 A ATOM 1179 CZ ARG A 151 −0.889 7.345 82.690 1.00 26.63 A ATOM 1180 NH1 ARG A 151 −0.863 8.517 83.315 1.00 27.54 A ATOM 1181 NH2 ARG A 151 −0.554 6.240 83.345 1.00 27.39 A ATOM 1182 C ARG A 151 −3.376 5.285 77.767 1.00 14.81 A ATOM 1183 O ARG A 151 −3.086 5.017 76.597 1.00 14.19 A ATOM 1184 N PRO A 152 −4.594 5.026 78.276 1.00 14.13 A ATOM 1185 CD PRO A 152 −5.080 5.236 79.652 1.00 14.92 A ATOM 1186 CA PRO A 152 −5.626 4.397 77.440 1.00 13.82 A ATOM 1187 CB PRO A 152 −6.768 4.139 78.427 1.00 14.60 A ATOM 1188 CG PRO A 152 −6.581 5.212 79.469 1.00 15.28 A ATOM 1189 C PRO A 152 −6.063 5.243 76.244 1.00 13.54 A ATOM 1190 O PRO A 152 −6.637 4.718 75.285 1.00 13.02 A ATOM 1191 N TYR A 153 −5.782 6.543 76.296 1.00 12.81 A ATOM 1192 CA TYR A 153 −6.160 7.447 75.215 1.00 12.98 A ATOM 1193 CB TYR A 153 −6.697 8.760 75.799 1.00 13.85 A ATOM 1194 CG TYR A 153 −5.834 9.362 76.879 1.00 15.46 A ATOM 1195 CD1 TYR A 153 −4.728 10.150 76.559 1.00 15.67 A ATOM 1196 CE1 TYR A 153 −3.933 10.713 77.558 1.00 16.87 A ATOM 1197 CD2 TYR A 153 −6.124 9.145 78.228 1.00 15.87 A ATOM 1198 CE2 TYR A 153 −5.335 9.700 79.233 1.00 16.78 A ATOM 1199 CZ TYR A 153 −4.243 10.484 78.892 1.00 16.94 A ATOM 1200 OH TYR A 153 −3.466 11.045 79.887 1.00 18.20 A ATOM 1201 C TYR A 153 −5.046 7.714 74.198 1.00 12.40 A ATOM 1202 O TYR A 153 −5.072 8.707 73.471 1.00 11.41 A ATOM 1203 N VAL A 154 −4.061 6.822 74.157 1.00 11.87 A ATOM 1204 CA VAL A 154 −2.980 6.940 73.185 1.00 11.77 A ATOM 1205 CB VAL A 154 −1.853 5.908 73.489 1.00 11.94 A ATOM 1206 CG1 VAL A 154 −2.405 4.491 73.415 1.00 11.75 A ATOM 1207 CG2 VAL A 154 −0.689 6.092 72.525 1.00 11.07 A ATOM 1208 C VAL A 154 −3.648 6.625 71.837 1.00 11.61 A ATOM 1209 O VAL A 154 −4.427 5.677 71.746 1.00 11.48 A ATOM 1210 N LYS A 155 −3.372 7.434 70.815 1.00 11.04 A ATOM 1211 CA LYS A 155 −3.958 7.240 69.488 1.00 11.52 A ATOM 1212 CB LYS A 155 −4.021 8.579 68.744 1.00 12.00 A ATOM 1213 CG LYS A 155 −5.109 9.511 69.281 1.00 13.78 A ATOM 1214 CD LYS A 155 −5.049 10.889 68.638 1.00 14.84 A ATOM 1215 CE LYS A 155 −4.098 11.811 69.373 1.00 16.12 A ATOM 1216 NZ LYS A 155 −4.651 12.234 70.700 1.00 17.06 A ATOM 1217 C LYS A 155 −3.144 6.219 68.705 1.00 10.94 A ATOM 1218 O LYS A 155 −1.993 6.472 68.349 1.00 10.07 A ATOM 1219 N ARG A 156 −3.771 5.077 68.422 1.00 10.42 A ATOM 1220 CA ARG A 156 −3.118 3.956 67.748 1.00 10.30 A ATOM 1221 CB ARG A 156 −3.463 2.660 68.492 1.00 10.46 A ATOM 1222 CG ARG A 156 −3.114 2.635 69.984 1.00 12.15 A ATOM 1223 CD ARG A 156 −3.773 1.430 70.673 1.00 11.65 A ATOM 1224 NE ARG A 156 −5.153 1.718 71.061 1.00 13.59 A ATOM 1225 CZ ARG A 156 −6.222 1.026 70.670 1.00 13.73 A ATOM 1226 NH1 ARG A 156 −6.092 −0.017 69.860 1.00 13.14 A ATOM 1227 NH2 ARG A 156 −7.429 1.377 71.101 1.00 12.93 A ATOM 1228 C ARG A 156 −3.435 3.718 66.271 1.00 10.47 A ATOM 1229 O ARG A 156 −4.520 4.034 65.794 1.00 10.65 A ATOM 1230 N VAL A 157 −2.470 3.128 65.569 1.00 10.08 A ATOM 1231 CA VAL A 157 −2.629 2.742 64.166 1.00 10.38 A ATOM 1232 CB VAL A 157 −2.160 3.834 63.181 1.00 10.90 A ATOM 1233 CG1 VAL A 157 −0.714 4.156 63.410 1.00 13.08 A ATOM 1234 CG2 VAL A 157 −2.374 3.352 61.739 1.00 12.71 A ATOM 1235 C VAL A 157 −1.793 1.484 63.939 1.00 9.54 A ATOM 1236 O VAL A 157 −0.603 1.456 64.257 1.00 8.67 A ATOM 1237 N GLY A 158 −2.431 0.440 63.414 1.00 8.62 A ATOM 1238 CA GLY A 158 −1.725 −0.801 63.145 1.00 8.95 A ATOM 1239 C GLY A 158 −1.474 −0.920 61.655 1.00 9.11 A ATOM 1240 O GLY A 158 −2.377 −0.660 60.861 1.00 9.18 A ATOM 1241 N VAL A 159 −0.252 −1.297 61.280 1.00 8.82 A ATOM 1242 CA VAL A 159 0.139 −1.446 59.876 1.00 9.27 A ATOM 1243 CB VAL A 159 1.383 −0.578 59.566 1.00 10.03 A ATOM 1244 CG1 VAL A 159 1.821 −0.763 58.120 1.00 9.90 A ATOM 1245 CG2 VAL A 159 1.060 0.890 59.848 1.00 8.75 A ATOM 1246 C VAL A 159 0.449 −2.918 59.622 1.00 9.42 A ATOM 1247 O VAL A 159 1.541 −3.403 59.937 1.00 8.94 A ATOM 1248 N PHE A 160 −0.523 −3.620 59.048 1.00 9.07 A ATOM 1249 CA PHE A 160 −0.401 −5.049 58.793 1.00 9.95 A ATOM 1250 CB PHE A 160 −1.476 −5.787 59.607 1.00 9.65 A ATOM 1251 CG PHE A 160 −1.534 −5.354 61.057 1.00 10.47 A ATOM 1252 CD1 PHE A 160 −0.428 −5.519 61.889 1.00 10.51 A ATOM 1253 CD2 PHE A 160 −2.679 −4.757 61.577 1.00 10.31 A ATOM 1254 CE1 PHE A 160 −0.462 −5.091 63.226 1.00 10.88 A ATOM 1255 CE2 PHE A 160 −2.726 −4.325 62.913 1.00 11.26 A ATOM 1256 CZ PHE A 160 −1.618 −4.491 63.735 1.00 10.62 A ATOM 1257 C PHE A 160 −0.506 −5.439 57.320 1.00 10.38 A ATOM 1258 O PHE A 160 −1.192 −4.787 56.530 1.00 10.36 A ATOM 1259 N GLN A 161 0.179 −6.527 56.981 1.00 10.62 A ATOM 1260 CA GLN A 161 0.230 −7.076 55.634 1.00 11.79 A ATOM 1261 CB GLN A 161 −1.117 −7.743 55.272 1.00 11.33 A ATOM 1262 CG GLN A 161 −1.311 −9.055 56.058 1.00 12.18 A ATOM 1263 CD GLN A 161 −2.598 −9.818 55.754 1.00 12.20 A ATOM 1264 OE1 GLN A 161 −3.381 −10.113 56.662 1.00 11.95 A ATOM 1265 NE2 GLN A 161 −2.810 −10.161 54.487 1.00 12.09 A ATOM 1266 C GLN A 161 0.704 −6.102 54.554 1.00 12.04 A ATOM 1267 O GLN A 161 0.215 −6.114 53.421 1.00 13.06 A ATOM 1268 N HIS A 162 1.667 −5.256 54.922 1.00 11.82 A ATOM 1269 CA HIS A 162 2.279 −4.330 53.975 1.00 12.08 A ATOM 1270 CB HIS A 162 2.552 −2.962 54.619 1.00 11.69 A ATOM 1271 CG HIS A 162 1.307 −2.154 54.852 1.00 10.82 A ATOM 1272 CD2 HIS A 162 0.161 −2.456 55.507 1.00 9.91 A ATOM 1273 ND1 HIS A 162 1.142 −0.874 54.366 1.00 12.15 A ATOM 1274 CE1 HIS A 162 −0.051 −0.422 54.711 1.00 9.94 A ATOM 1275 NE2 HIS A 162 −0.667 −1.363 55.405 1.00 11.67 A ATOM 1276 C HIS A 162 3.575 −5.021 53.539 1.00 12.51 A ATOM 1277 O HIS A 162 3.854 −5.127 52.348 1.00 14.03 A ATOM 1278 N GLY A 163 4.361 −5.507 54.497 1.00 12.09 A ATOM 1279 CA GLY A 163 5.570 −6.229 54.130 1.00 12.81 A ATOM 1280 C GLY A 163 6.937 −5.602 54.325 1.00 12.93 A ATOM 1281 O GLY A 163 7.122 −4.713 55.159 1.00 13.11 A ATOM 1282 N CYS A 164 7.898 −6.079 53.533 1.00 12.87 A ATOM 1283 CA CYS A 164 9.285 −5.630 53.608 1.00 12.88 A ATOM 1284 CB CYS A 164 10.145 −6.435 52.621 1.00 14.32 A ATOM 1285 SG CYS A 164 10.567 −8.126 53.171 1.00 18.21 A ATOM 1286 C CYS A 164 9.565 −4.137 53.419 1.00 12.07 A ATOM 1287 O CYS A 164 10.611 −3.655 53.851 1.00 12.09 A ATOM 1288 N PHE A 165 8.656 −3.402 52.787 1.00 11.32 A ATOM 1289 CA PHE A 165 8.881 −1.970 52.579 1.00 11.97 A ATOM 1290 CB PHE A 165 8.268 −1.529 51.239 1.00 12.38 A ATOM 1291 CG PHE A 165 6.761 −1.608 51.194 1.00 12.73 A ATOM 1292 CD1 PHE A 165 5.977 −0.679 51.878 1.00 12.91 A ATOM 1293 CD2 PHE A 165 6.126 −2.624 50.487 1.00 12.52 A ATOM 1294 CE1 PHE A 165 4.582 −0.763 51.865 1.00 12.61 A ATOM 1295 CE2 PHE A 165 4.727 −2.719 50.466 1.00 12.91 A ATOM 1296 CZ PHE A 165 3.955 −1.785 51.160 1.00 12.54 A ATOM 1297 C PHE A 165 8.327 −1.090 53.711 1.00 11.55 A ATOM 1298 O PHE A 165 8.591 0.116 53.755 1.00 10.90 A ATOM 1299 N ALA A 166 7.597 −1.705 54.640 1.00 11.47 A ATOM 1300 CA ALA A 166 6.951 −0.987 55.742 1.00 10.36 A ATOM 1301 CB ALA A 166 6.055 −1.944 56.520 1.00 10.05 A ATOM 1302 C ALA A 166 7.832 −0.201 56.716 1.00 10.76 A ATOM 1303 O ALA A 166 7.311 0.568 57.541 1.00 10.61 A ATOM 1304 N GLY A 167 9.142 −0.404 56.660 1.00 10.33 A ATOM 1305 CA GLY A 167 10.025 0.363 57.525 1.00 10.23 A ATOM 1306 C GLY A 167 9.945 1.808 57.056 1.00 10.55 A ATOM 1307 O GLY A 167 10.031 2.757 57.844 1.00 9.84 A ATOM 1308 N GLY A 168 9.779 1.982 55.749 1.00 9.79 A ATOM 1309 CA GLY A 168 9.650 3.319 55.205 1.00 10.50 A ATOM 1310 C GLY A 168 8.246 3.849 55.466 1.00 9.99 A ATOM 1311 O GLY A 168 8.057 5.036 55.733 1.00 10.63 A ATOM 1312 N THR A 169 7.260 2.957 55.392 1.00 9.91 A ATOM 1313 CA THR A 169 5.853 3.307 55.615 1.00 8.80 A ATOM 1314 CB THR A 169 4.939 2.060 55.439 1.00 9.40 A ATOM 1315 OG1 THR A 169 5.186 1.457 54.163 1.00 10.04 A ATOM 1316 CG2 THR A 169 3.468 2.454 55.521 1.00 9.30 A ATOM 1317 C THR A 169 5.590 3.898 57.006 1.00 8.76 A ATOM 1318 O THR A 169 4.865 4.896 57.144 1.00 7.14 A ATOM 1319 N VAL A 170 6.157 3.288 58.046 1.00 7.94 A ATOM 1320 CA VAL A 170 5.925 3.804 59.391 1.00 7.96 A ATOM 1321 CB VAL A 170 6.391 2.818 60.492 1.00 8.12 A ATOM 1322 CG1 VAL A 170 5.595 1.516 60.377 1.00 8.51 A ATOM 1323 CG2 VAL A 170 7.894 2.571 60.387 1.00 8.83 A ATOM 1324 C VAL A 170 6.599 5.153 59.615 1.00 8.27 A ATOM 1325 O VAL A 170 6.121 5.958 60.411 1.00 8.24 A ATOM 1326 N LEU A 171 7.706 5.401 58.919 1.00 8.82 A ATOM 1327 CA LEU A 171 8.398 6.680 59.059 1.00 9.31 A ATOM 1328 CB LEU A 171 9.798 6.610 58.438 1.00 9.00 A ATOM 1329 CG LEU A 171 10.849 5.863 59.275 1.00 9.38 A ATOM 1330 CD1 LEU A 171 12.115 5.666 58.461 1.00 10.01 A ATOM 1331 CD2 LEU A 171 11.155 6.668 60.549 1.00 10.13 A ATOM 1332 C LEU A 171 7.559 7.756 58.371 1.00 9.34 A ATOM 1333 O LEU A 171 7.412 8.868 58.886 1.00 9.70 A ATOM 1334 N ARG A 172 7.006 7.411 57.208 1.00 9.62 A ATOM 1335 CA ARG A 172 6.155 8.319 56.435 1.00 9.46 A ATOM 1336 CB ARG A 172 5.757 7.647 55.106 1.00 10.16 A ATOM 1337 CG ARG A 172 4.732 8.408 54.269 1.00 10.70 A ATOM 1338 CD ARG A 172 4.768 7.971 52.792 1.00 10.81 A ATOM 1339 NE ARG A 172 4.534 6.538 52.581 1.00 10.35 A ATOM 1340 CZ ARG A 172 3.341 5.948 52.574 1.00 10.72 A ATOM 1341 NH1 ARG A 172 2.232 6.652 52.772 1.00 10.58 A ATOM 1342 NH2 ARG A 172 3.251 4.641 52.336 1.00 10.24 A ATOM 1343 C ARG A 172 4.906 8.703 57.246 1.00 9.67 A ATOM 1344 O ARG A 172 4.491 9.864 57.251 1.00 8.96 A ATOM 1345 N LEU A 173 4.315 7.735 57.943 1.00 9.66 A ATOM 1346 CA LEU A 173 3.135 8.015 58.759 1.00 9.61 A ATOM 1347 CB LEU A 173 2.469 6.714 59.221 1.00 10.65 A ATOM 1348 CG LEU A 173 1.700 5.893 58.180 1.00 10.70 A ATOM 1349 CD1 LEU A 173 1.374 4.522 58.764 1.00 10.48 A ATOM 1350 CD2 LEU A 173 0.422 6.630 57.766 1.00 10.97 A ATOM 1351 C LEU A 173 3.514 8.846 59.985 1.00 10.02 A ATOM 1352 O LEU A 173 2.838 9.819 60.314 1.00 8.14 A ATOM 1353 N ALA A 174 4.589 8.452 60.667 1.00 9.18 A ATOM 1354 CA ALA A 174 5.031 9.177 61.858 1.00 9.26 A ATOM 1355 CB ALA A 174 6.273 8.507 62.453 1.00 8.76 A ATOM 1356 C ALA A 174 5.331 10.640 61.533 1.00 9.47 A ATOM 1357 O ALA A 174 5.117 11.530 62.362 1.00 9.93 A ATOM 1358 N LYS A 175 5.833 10.889 60.330 1.00 9.17 A ATOM 1359 CA LYS A 175 6.160 12.252 59.925 1.00 9.55 A ATOM 1360 CB LYS A 175 6.749 12.262 58.509 1.00 9.91 A ATOM 1361 CG LYS A 175 7.144 13.652 58.009 1.00 10.71 A ATOM 1362 CD LYS A 175 7.661 13.602 56.573 1.00 11.77 A ATOM 1363 CE LYS A 175 8.152 14.967 56.104 1.00 11.36 A ATOM 1364 NZ LYS A 175 7.064 15.983 56.022 1.00 12.68 A ATOM 1365 C LYS A 175 4.932 13.167 59.986 1.00 9.54 A ATOM 1366 O LYS A 175 4.990 14.252 60.561 1.00 9.61 A ATOM 1367 N ASP A 176 3.816 12.733 59.409 1.00 9.94 A ATOM 1368 CA ASP A 176 2.611 13.563 59.437 1.00 10.35 A ATOM 1369 CB ASP A 176 1.577 13.062 58.422 1.00 10.89 A ATOM 1370 CG ASP A 176 1.986 13.336 56.984 1.00 11.89 A ATOM 1371 OD1 ASP A 176 2.750 14.301 56.755 1.00 12.55 A ATOM 1372 OD2 ASP A 176 1.526 12.600 56.084 1.00 12.25 A ATOM 1373 C ASP A 176 1.953 13.658 60.816 1.00 10.80 A ATOM 1374 O ASP A 176 1.484 14.729 61.206 1.00 11.51 A ATOM 1375 N LEU A 177 1.913 12.558 61.563 1.00 10.38 A ATOM 1376 CA LEU A 177 1.278 12.595 62.882 1.00 10.56 A ATOM 1377 CB LEU A 177 1.206 11.190 63.502 1.00 11.79 A ATOM 1378 CG LEU A 177 0.639 9.991 62.725 1.00 14.19 A ATOM 1379 CD1 LEU A 177 0.109 8.979 63.738 1.00 13.55 A ATOM 1380 CD2 LEU A 177 −0.469 10.405 61.769 1.00 13.39 A ATOM 1381 C LEU A 177 2.012 13.535 63.845 1.00 10.13 A ATOM 1382 O LEU A 177 1.381 14.256 64.613 1.00 10.07 A ATOM 1383 N ALA A 178 3.343 13.532 63.798 1.00 9.17 A ATOM 1384 CA ALA A 178 4.132 14.387 64.684 1.00 9.84 A ATOM 1385 CB ALA A 178 5.565 13.867 64.768 1.00 9.65 A ATOM 1386 C ALA A 178 4.144 15.860 64.261 1.00 9.88 A ATOM 1387 O ALA A 178 4.064 16.756 65.108 1.00 10.05 A ATOM 1388 N GLU A 179 4.243 16.111 62.958 1.00 9.81 A ATOM 1389 CA GLU A 179 4.286 17.479 62.447 1.00 10.22 A ATOM 1390 CB GLU A 179 4.834 17.488 61.005 1.00 10.39 A ATOM 1391 CG GLU A 179 6.363 17.310 60.920 1.00 12.08 A ATOM 1392 CD GLU A 179 6.887 17.099 59.495 1.00 12.59 A ATOM 1393 OE1 GLU A 179 6.109 17.252 58.527 1.00 13.52 A ATOM 1394 OE2 GLU A 179 8.090 16.781 59.344 1.00 11.85 A ATOM 1395 C GLU A 179 2.954 18.241 62.507 1.00 10.38 A ATOM 1396 O GLU A 179 2.953 19.465 62.644 1.00 10.28 A ATOM 1397 N ASN A 180 1.828 17.534 62.426 1.00 10.18 A ATOM 1398 CA ASN A 180 0.522 18.204 62.453 1.00 10.49 A ATOM 1399 CB ASN A 180 −0.468 17.472 61.534 1.00 10.37 A ATOM 1400 CG ASN A 180 −1.703 18.304 61.229 1.00 10.46 A ATOM 1401 OD1 ASN A 180 −1.591 19.448 60.787 1.00 11.09 A ATOM 1402 ND2 ASN A 180 −2.888 17.733 61.457 1.00 10.21 A ATOM 1403 C ASN A 180 −0.121 18.362 63.834 1.00 10.50 A ATOM 1404 O ASN A 180 −1.202 18.945 63.944 1.00 10.62 A ATOM 1405 N ASN A 181 0.535 17.860 64.880 1.00 10.99 A ATOM 1406 CA ASN A 181 −0.016 17.927 66.238 1.00 11.61 A ATOM 1407 CB ASN A 181 −0.564 16.549 66.625 1.00 10.99 A ATOM 1408 CG ASN A 181 −1.740 16.127 65.759 1.00 11.32 A ATOM 1409 OD1 ASN A 181 −2.859 16.615 65.934 1.00 10.59 A ATOM 1410 ND2 ASN A 181 −1.489 15.227 64.808 1.00 9.52 A ATOM 1411 C ASN A 181 0.998 18.401 67.292 1.00 11.97 A ATOM 1412 O ASN A 181 1.937 17.679 67.643 1.00 12.00 A ATOM 1413 N LYS A 182 0.795 19.614 67.798 1.00 12.75 A ATOM 1414 CA LYS A 182 1.696 20.206 68.789 1.00 13.47 A ATOM 1415 CB LYS A 182 1.196 21.599 69.184 1.00 14.26 A ATOM 1416 CG LYS A 182 2.079 22.332 70.192 1.00 15.00 A ATOM 1417 CD LYS A 182 1.552 23.747 70.417 1.00 16.14 A ATOM 1418 CE LYS A 182 2.521 24.601 71.221 1.00 16.60 A ATOM 1419 NZ LYS A 182 1.974 25.979 71.402 1.00 18.49 A ATOM 1420 C LYS A 182 1.856 19.357 70.044 1.00 13.44 A ATOM 1421 O LYS A 182 0.872 18.987 70.684 1.00 13.52 A ATOM 1422 N GLY A 183 3.105 19.060 70.391 1.00 13.68 A ATOM 1423 CA GLY A 183 3.383 18.262 71.574 1.00 13.42 A ATOM 1424 C GLY A 183 3.351 16.758 71.360 1.00 12.95 A ATOM 1425 O GLY A 183 3.689 15.993 72.259 1.00 13.54 A ATOM 1426 N ALA A 184 2.963 16.320 70.169 1.00 13.05 A ATOM 1427 CA ALA A 184 2.875 14.891 69.893 1.00 11.73 A ATOM 1428 CB ALA A 184 2.194 14.659 68.537 1.00 11.31 A ATOM 1429 C ALA A 184 4.218 14.167 69.930 1.00 11.28 A ATOM 1430 O ALA A 184 5.223 14.664 69.426 1.00 11.97 A ATOM 1431 N ARG A 185 4.216 12.990 70.547 1.00 10.77 A ATOM 1432 CA ARG A 185 5.402 12.145 70.650 1.00 10.15 A ATOM 1433 CB ARG A 185 5.943 12.158 72.085 1.00 10.47 A ATOM 1434 CG ARG A 185 6.661 13.478 72.457 1.00 10.37 A ATOM 1435 CD ARG A 185 7.966 13.635 71.667 1.00 11.21 A ATOM 1436 NE ARG A 185 8.724 14.859 71.958 1.00 11.36 A ATOM 1437 CZ ARG A 185 8.514 16.039 71.375 1.00 11.90 A ATOM 1438 NH1 ARG A 185 7.557 16.180 70.462 1.00 11.35 A ATOM 1439 NH2 ARG A 185 9.287 17.078 71.676 1.00 12.08 A ATOM 1440 C ARG A 185 4.937 10.754 70.219 1.00 9.96 A ATOM 1441 O ARG A 185 4.102 10.121 70.878 1.00 8.97 A ATOM 1442 N VAL A 186 5.477 10.297 69.093 1.00 9.29 A ATOM 1443 CA VAL A 186 5.083 9.024 68.499 1.00 9.31 A ATOM 1444 CB VAL A 186 4.918 9.190 66.966 1.00 9.15 A ATOM 1445 CG1 VAL A 186 4.292 7.933 66.360 1.00 9.74 A ATOM 1446 CG2 VAL A 186 4.063 10.423 66.659 1.00 9.08 A ATOM 1447 C VAL A 186 6.026 7.852 68.742 1.00 9.11 A ATOM 1448 O VAL A 186 7.213 7.930 68.423 1.00 8.24 A ATOM 1449 N LEU A 187 5.496 6.774 69.325 1.00 9.01 A ATOM 1450 CA LEU A 187 6.293 5.570 69.547 1.00 8.10 A ATOM 1451 CB LEU A 187 5.856 4.829 70.819 1.00 8.38 A ATOM 1452 CG LEU A 187 6.458 3.432 71.043 1.00 7.36 A ATOM 1453 CD1 LEU A 187 7.982 3.520 71.124 1.00 7.26 A ATOM 1454 CD2 LEU A 187 5.901 2.821 72.327 1.00 6.64 A ATOM 1455 C LEU A 187 6.011 4.703 68.319 1.00 8.64 A ATOM 1456 O LEU A 187 4.852 4.408 68.021 1.00 8.42 A ATOM 1457 N VAL A 188 7.069 4.320 67.610 1.00 8.34 A ATOM 1458 CA VAL A 188 6.954 3.497 66.406 1.00 8.95 A ATOM 1459 CB VAL A 188 7.675 4.163 65.208 1.00 8.81 A ATOM 1460 CG1 VAL A 188 7.505 3.307 63.952 1.00 9.57 A ATOM 1461 CG2 VAL A 188 7.127 5.563 64.983 1.00 8.73 A ATOM 1462 C VAL A 188 7.603 2.144 66.665 1.00 9.22 A ATOM 1463 O VAL A 188 8.750 2.089 67.109 1.00 9.45 A ATOM 1464 N VAL A 189 6.876 1.059 66.389 1.00 9.29 A ATOM 1465 CA VAL A 189 7.403 −0.286 66.609 1.00 9.54 A ATOM 1466 CB VAL A 189 6.771 −0.938 67.876 1.00 9.93 A ATOM 1467 CG1 VAL A 189 7.359 −2.339 68.101 1.00 10.83 A ATOM 1468 CG2 VAL A 189 7.006 −0.060 69.103 1.00 10.08 A ATOM 1469 C VAL A 189 7.180 −1.250 65.437 1.00 9.89 A ATOM 1470 O VAL A 189 6.044 −1.446 64.985 1.00 9.62 A ATOM 1471 N CYS A 190 8.267 −1.838 64.944 1.00 10.01 A ATOM 1472 CA CYS A 190 8.194 −2.838 63.875 1.00 10.09 A ATOM 1473 CB CYS A 190 9.120 −2.495 62.703 1.00 11.33 A ATOM 1474 SG CYS A 190 8.653 −1.059 61.716 1.00 12.55 A ATOM 1475 C CYS A 190 8.680 −4.130 64.530 1.00 10.56 A ATOM 1476 O CYS A 190 9.794 −4.182 65.062 1.00 9.40 A ATOM 1477 N SER A 191 7.847 −5.165 64.498 1.00 10.19 A ATOM 1478 CA SER A 191 8.193 −6.448 65.106 1.00 10.68 A ATOM 1479 CB SER A 191 7.402 −6.629 66.405 1.00 10.50 A ATOM 1480 OG SER A 191 7.696 −7.867 67.016 1.00 10.11 A ATOM 1481 C SER A 191 7.863 −7.573 64.137 1.00 10.91 A ATOM 1482 O SER A 191 6.706 −7.740 63.750 1.00 10.99 A ATOM 1483 N GLU A 192 8.876 −8.351 63.760 1.00 11.05 A ATOM 1484 CA GLU A 192 8.699 −9.442 62.800 1.00 10.62 A ATOM 1485 CB GLU A 192 9.462 −9.107 61.512 1.00 10.66 A ATOM 1486 CG GLU A 192 9.135 −7.721 60.914 1.00 10.64 A ATOM 1487 CD GLU A 192 7.802 −7.684 60.166 1.00 10.87 A ATOM 1488 OE1 GLU A 192 7.109 −8.719 60.125 1.00 11.53 A ATOM 1489 OE2 GLU A 192 7.446 −6.618 59.618 1.00 10.92 A ATOM 1490 C GLU A 192 9.170 −10.796 63.347 1.00 10.89 A ATOM 1491 O GLU A 192 10.285 −10.917 63.847 1.00 9.91 A ATOM 1492 N VAL A 193 8.316 −11.811 63.221 1.00 11.07 A ATOM 1493 CA VAL A 193 8.602 −13.162 63.711 1.00 11.62 A ATOM 1494 CB VAL A 193 7.725 −13.468 64.953 1.00 11.44 A ATOM 1495 CG1 VAL A 193 7.933 −14.908 65.420 1.00 11.03 A ATOM 1496 CG2 VAL A 193 8.074 −12.489 66.077 1.00 11.56 A ATOM 1497 C VAL A 193 8.328 −14.197 62.614 1.00 12.46 A ATOM 1498 O VAL A 193 7.192 −14.331 62.151 1.00 12.86 A ATOM 1499 N THR A 194 9.366 −14.933 62.216 1.00 12.81 A ATOM 1500 CA THR A 194 9.260 −15.931 61.148 1.00 12.86 A ATOM 1501 CB THR A 194 10.664 −16.424 60.702 1.00 13.15 A ATOM 1502 OG1 THR A 194 11.370 −16.975 61.822 1.00 12.89 A ATOM 1503 CG2 THR A 194 11.472 −15.264 60.112 1.00 13.13 A ATOM 1504 C THR A 194 8.381 −17.160 61.395 1.00 13.30 A ATOM 1505 O THR A 194 8.258 −18.017 60.519 1.00 12.89 A ATOM 1506 N ALA A 195 7.775 −17.256 62.571 1.00 13.76 A ATOM 1507 CA ALA A 195 6.897 −18.384 62.872 1.00 14.53 A ATOM 1508 CB ALA A 195 6.322 −18.242 64.278 1.00 15.45 A ATOM 1509 C ALA A 195 5.758 −18.440 61.855 1.00 14.54 A ATOM 1510 O ALA A 195 5.173 −19.498 61.612 1.00 14.97 A ATOM 1511 N VAL A 196 5.445 −17.296 61.260 1.00 14.30 A ATOM 1512 CA VAL A 196 4.363 −17.231 60.289 1.00 14.81 A ATOM 1513 CB VAL A 196 3.774 −15.792 60.215 1.00 14.74 A ATOM 1514 CG1 VAL A 196 4.742 −14.859 59.494 1.00 15.82 A ATOM 1515 CG2 VAL A 196 2.412 −15.816 59.525 1.00 15.91 A ATOM 1516 C VAL A 196 4.770 −17.696 58.884 1.00 14.53 A ATOM 1517 O VAL A 196 3.914 −18.082 58.088 1.00 14.83 A ATOM 1518 N THR A 197 6.069 −17.694 58.589 1.00 14.33 A ATOM 1519 CA THR A 197 6.542 −18.097 57.263 1.00 14.12 A ATOM 1520 CB THR A 197 7.393 −16.975 56.603 1.00 14.84 A ATOM 1521 OG1 THR A 197 8.492 −16.640 57.460 1.00 14.20 A ATOM 1522 CG2 THR A 197 6.548 −15.736 56.346 1.00 14.92 A ATOM 1523 C THR A 197 7.361 −19.392 57.184 1.00 13.95 A ATOM 1524 O THR A 197 7.515 −19.951 56.099 1.00 14.12 A ATOM 1525 N PHE A 198 7.891 −19.868 58.309 1.00 13.34 A ATOM 1526 CA PHE A 198 8.705 −21.089 58.295 1.00 13.23 A ATOM 1527 CB PHE A 198 9.239 −21.393 59.706 1.00 12.64 A ATOM 1528 CG PHE A 198 10.107 −22.633 59.782 1.00 12.39 A ATOM 1529 CD1 PHE A 198 9.538 −23.904 59.752 1.00 12.24 A ATOM 1530 CD2 PHE A 198 11.495 −22.524 59.849 1.00 12.72 A ATOM 1531 CE1 PHE A 198 10.336 −25.054 59.783 1.00 12.32 A ATOM 1532 CE2 PHE A 198 12.306 −23.668 59.880 1.00 12.12 A ATOM 1533 CZ PHE A 198 11.720 −24.936 59.846 1.00 12.30 A ATOM 1534 C PHE A 198 7.958 −22.310 57.764 1.00 13.09 A ATOM 1535 O PHE A 198 6.816 −22.572 58.152 1.00 12.80 A ATOM 1536 N ARG A 199 8.609 −23.060 56.877 1.00 13.29 A ATOM 1537 CA ARG A 199 8.012 −24.275 56.323 1.00 13.07 A ATOM 1538 CB ARG A 199 6.925 −23.922 55.293 1.00 13.33 A ATOM 1539 CG ARG A 199 7.405 −23.140 54.078 1.00 12.99 A ATOM 1540 CD ARG A 199 6.224 −22.551 53.305 1.00 13.81 A ATOM 1541 NE ARG A 199 5.473 −21.575 54.101 1.00 13.90 A ATOM 1542 CZ ARG A 199 4.324 −21.820 54.734 1.00 13.37 A ATOM 1543 NH1 ARG A 199 3.757 −23.020 54.682 1.00 12.59 A ATOM 1544 NH2 ARG A 199 3.735 −20.854 55.424 1.00 12.86 A ATOM 1545 C ARG A 199 9.076 −25.183 55.702 1.00 13.44 A ATOM 1546 O ARG A 199 10.198 −24.749 55.446 1.00 12.86 A ATOM 1547 N GLY A 200 8.717 −26.447 55.479 1.00 14.16 A ATOM 1548 CA GLY A 200 9.647 −27.412 54.908 1.00 14.89 A ATOM 1549 C GLY A 200 10.055 −27.114 53.476 1.00 15.67 A ATOM 1550 O GLY A 200 9.433 −26.282 52.820 1.00 15.33 A ATOM 1551 N PRO A 201 11.101 −27.789 52.962 1.00 16.65 A ATOM 1552 CD PRO A 201 11.997 −28.662 53.747 1.00 16.48 A ATOM 1553 CA PRO A 201 11.616 −27.610 51.600 1.00 17.08 A ATOM 1554 CB PRO A 201 13.059 −28.084 51.724 1.00 16.70 A ATOM 1555 CG PRO A 201 12.923 −29.231 52.681 1.00 17.23 A ATOM 1556 C PRO A 201 10.861 −28.372 50.514 1.00 18.19 A ATOM 1557 O PRO A 201 10.369 −29.475 50.748 1.00 18.52 A ATOM 1558 N SER A 202 10.788 −27.777 49.325 1.00 19.20 A ATOM 1559 CA SER A 202 10.112 −28.381 48.171 1.00 20.83 A ATOM 1560 CB SER A 202 8.714 −27.777 48.003 1.00 20.75 A ATOM 1561 OG SER A 202 8.080 −28.273 46.833 1.00 22.13 A ATOM 1562 C SER A 202 10.939 −28.131 46.906 1.00 21.36 A ATOM 1563 O SER A 202 11.276 −26.988 46.601 1.00 21.26 A ATOM 1564 N ASP A 203 11.259 −29.188 46.162 1.00 22.79 A ATOM 1565 CA ASP A 203 12.071 −29.018 44.958 1.00 24.44 A ATOM 1566 CB ASP A 203 12.717 −30.349 44.543 1.00 25.63 A ATOM 1567 CG ASP A 203 11.705 −31.429 44.235 1.00 27.41 A ATOM 1568 OD1 ASP A 203 12.134 −32.575 43.975 1.00 29.04 A ATOM 1569 OD2 ASP A 203 10.490 −31.143 44.249 1.00 28.72 A ATOM 1570 C ASP A 203 11.345 −28.383 43.774 1.00 24.57 A ATOM 1571 O ASP A 203 11.938 −28.183 42.714 1.00 25.13 A ATOM 1572 N THR A 204 10.070 −28.055 43.952 1.00 24.84 A ATOM 1573 CA THR A 204 9.307 −27.406 42.892 1.00 25.35 A ATOM 1574 CB THR A 204 7.995 −28.171 42.574 1.00 25.57 A ATOM 1575 OG1 THR A 204 7.270 −28.430 43.784 1.00 26.36 A ATOM 1576 CG2 THR A 204 8.309 −29.491 41.878 1.00 25.89 A ATOM 1577 C THR A 204 8.980 −25.962 43.290 1.00 25.30 A ATOM 1578 O THR A 204 8.263 −25.253 42.579 1.00 24.92 A ATOM 1579 N HIS A 205 9.520 −25.533 44.429 1.00 25.03 A ATOM 1580 CA HIS A 205 9.308 −24.175 44.924 1.00 25.38 A ATOM 1581 CB HIS A 205 8.244 −24.166 46.026 1.00 26.03 A ATOM 1582 CG HIS A 205 6.916 −24.699 45.585 1.00 26.52 A ATOM 1583 CD2 HIS A 205 5.865 −24.087 44.989 1.00 27.09 A ATOM 1584 ND1 HIS A 205 6.571 −26.029 45.698 1.00 26.88 A ATOM 1585 CE1 HIS A 205 5.366 −26.214 45.189 1.00 26.94 A ATOM 1586 NE2 HIS A 205 4.915 −25.051 44.751 1.00 27.31 A ATOM 1587 C HIS A 205 10.609 −23.584 45.461 1.00 25.22 A ATOM 1588 O HIS A 205 10.719 −23.267 46.643 1.00 25.50 A ATOM 1589 N LEU A 206 11.591 −23.425 44.579 1.00 24.95 A ATOM 1590 CA LEU A 206 12.892 −22.890 44.963 1.00 24.94 A ATOM 1591 CB LEU A 206 13.863 −22.992 43.781 1.00 24.92 A ATOM 1592 CG LEU A 206 14.102 −24.420 43.264 1.00 25.37 A ATOM 1593 CD1 LEU A 206 15.120 −24.397 42.129 1.00 25.23 A ATOM 1594 CD2 LEU A 206 14.591 −25.313 44.404 1.00 24.70 A ATOM 1595 C LEU A 206 12.850 −21.455 45.495 1.00 25.23 A ATOM 1596 O LEU A 206 13.729 −21.047 46.257 1.00 24.95 A ATOM 1597 N ASP A 207 11.832 −20.690 45.104 1.00 25.29 A ATOM 1598 CA ASP A 207 11.709 −19.317 45.583 1.00 25.66 A ATOM 1599 CB ASP A 207 10.656 −18.548 44.775 1.00 27.12 A ATOM 1600 CG ASP A 207 9.299 −19.231 44.768 1.00 28.64 A ATOM 1601 OD1 ASP A 207 8.347 −18.634 44.222 1.00 29.73 A ATOM 1602 OD2 ASP A 207 9.178 −20.360 45.294 1.00 29.96 A ATOM 1603 C ASP A 207 11.341 −19.309 47.065 1.00 25.27 A ATOM 1604 O ASP A 207 11.753 −18.426 47.817 1.00 25.41 A ATOM 1605 N SER A 208 10.567 −20.301 47.486 1.00 24.29 A ATOM 1606 CA SER A 208 10.173 −20.399 48.881 1.00 23.76 A ATOM 1607 CB SER A 208 9.090 −21.473 49.048 1.00 24.07 A ATOM 1608 OG SER A 208 8.686 −21.592 50.400 1.00 25.22 A ATOM 1609 C SER A 208 11.409 −20.761 49.704 1.00 22.63 A ATOM 1610 O SER A 208 11.607 −20.258 50.809 1.00 22.30 A ATOM 1611 N LEU A 209 12.251 −21.620 49.138 1.00 21.70 A ATOM 1612 CA LEU A 209 13.464 −22.075 49.802 1.00 20.71 A ATOM 1613 CB LEU A 209 14.136 −23.165 48.957 1.00 20.77 A ATOM 1614 CG LEU A 209 15.193 −24.039 49.629 1.00 20.98 A ATOM 1615 CD1 LEU A 209 14.554 −24.802 50.786 1.00 20.75 A ATOM 1616 CD2 LEU A 209 15.786 −25.009 48.608 1.00 20.81 A ATOM 1617 C LEU A 209 14.461 −20.950 50.078 1.00 20.48 A ATOM 1618 O LEU A 209 15.090 −20.924 51.139 1.00 20.50 A ATOM 1619 N VAL A 210 14.621 −20.029 49.131 1.00 19.42 A ATOM 1620 CA VAL A 210 15.560 −18.929 49.329 1.00 19.15 A ATOM 1621 CB VAL A 210 15.658 −18.009 48.080 1.00 19.36 A ATOM 1622 CG1 VAL A 210 14.353 −17.264 47.857 1.00 20.36 A ATOM 1623 CG2 VAL A 210 16.806 −17.025 48.251 1.00 20.35 A ATOM 1624 C VAL A 210 15.123 −18.119 50.545 1.00 18.35 A ATOM 1625 O VAL A 210 15.954 −17.608 51.289 1.00 18.00 A ATOM 1626 N GLY A 211 13.812 −18.016 50.742 1.00 17.76 A ATOM 1627 CA GLY A 211 13.288 −17.295 51.888 1.00 17.42 A ATOM 1628 C GLY A 211 13.710 −17.941 53.202 1.00 16.84 A ATOM 1629 O GLY A 211 13.903 −17.249 54.201 1.00 17.07 A ATOM 1630 N GLN A 212 13.855 −19.265 53.207 1.00 16.19 A ATOM 1631 CA GLN A 212 14.267 −19.979 54.415 1.00 16.19 A ATOM 1632 CB GLN A 212 14.053 −21.491 54.250 1.00 16.68 A ATOM 1633 CG GLN A 212 12.614 −21.917 53.927 1.00 18.07 A ATOM 1634 CD GLN A 212 11.600 −21.436 54.954 1.00 18.95 A ATOM 1635 OE1 GLN A 212 11.761 −21.657 56.152 1.00 19.82 A ATOM 1636 NE2 GLN A 212 10.547 −20.779 54.485 1.00 19.27 A ATOM 1637 C GLN A 212 15.741 −19.702 54.741 1.00 15.86 A ATOM 1638 O GLN A 212 16.191 −19.908 55.869 1.00 15.74 A ATOM 1639 N ALA A 213 16.492 −19.231 53.751 1.00 15.43 A ATOM 1640 CA ALA A 213 17.904 −18.922 53.953 1.00 15.06 A ATOM 1641 CB ALA A 213 18.686 −19.225 52.674 1.00 15.32 A ATOM 1642 C ALA A 213 18.137 −17.463 54.365 1.00 14.68 A ATOM 1643 O ALA A 213 19.204 −17.117 54.886 1.00 14.33 A ATOM 1644 N LEU A 214 17.135 −16.616 54.154 1.00 14.29 A ATOM 1645 CA LEU A 214 17.275 −15.192 54.455 1.00 14.48 A ATOM 1646 CB LEU A 214 16.924 −14.378 53.205 1.00 14.91 A ATOM 1647 CG LEU A 214 17.668 −14.670 51.901 1.00 15.41 A ATOM 1648 CD1 LEU A 214 17.042 −13.844 50.774 1.00 16.41 A ATOM 1649 CD2 LEU A 214 19.146 −14.341 52.058 1.00 16.05 A ATOM 1650 C LEU A 214 16.520 −14.576 55.640 1.00 14.29 A ATOM 1651 O LEU A 214 17.082 −13.739 56.351 1.00 14.63 A ATOM 1652 N PHE A 215 15.264 −14.965 55.844 1.00 13.93 A ATOM 1653 CA PHE A 215 14.440 −14.377 56.907 1.00 13.96 A ATOM 1654 CB PHE A 215 12.961 −14.752 56.718 1.00 15.54 A ATOM 1655 CG PHE A 215 12.433 −14.517 55.324 1.00 17.87 A ATOM 1656 CD1 PHE A 215 12.952 −13.507 54.519 1.00 18.86 A ATOM 1657 CD2 PHE A 215 11.395 −15.302 54.826 1.00 18.79 A ATOM 1658 CE1 PHE A 215 12.445 −13.283 53.234 1.00 19.31 A ATOM 1659 CE2 PHE A 215 10.882 −15.086 53.547 1.00 19.39 A ATOM 1660 CZ PHE A 215 11.409 −14.074 52.750 1.00 19.43 A ATOM 1661 C PHE A 215 14.826 −14.689 58.349 1.00 13.33 A ATOM 1662 O PHE A 215 15.054 −15.847 58.704 1.00 12.97 A ATOM 1663 N GLY A 216 14.859 −13.637 59.170 1.00 12.63 A ATOM 1664 CA GLY A 216 15.195 −13.751 60.585 1.00 12.55 A ATOM 1665 C GLY A 216 14.239 −12.912 61.429 1.00 12.18 A ATOM 1666 O GLY A 216 13.452 −12.136 60.873 1.00 11.45 A ATOM 1667 N ASP A 217 14.313 −13.050 62.757 1.00 11.54 A ATOM 1668 CA ASP A 217 13.430 −12.325 63.687 1.00 11.59 A ATOM 1669 CB ASP A 217 12.952 −13.267 64.798 1.00 11.47 A ATOM 1670 CG ASP A 217 12.188 −14.469 64.275 1.00 12.37 A ATOM 1671 OD1 ASP A 217 12.114 −14.667 63.043 1.00 12.95 A ATOM 1672 OD2 ASP A 217 11.665 −15.227 65.112 1.00 13.04 A ATOM 1673 C ASP A 217 14.046 −11.089 64.362 1.00 11.79 A ATOM 1674 O ASP A 217 15.253 −11.040 64.619 1.00 11.06 A ATOM 1675 N GLY A 218 13.196 −10.109 64.681 1.00 11.39 A ATOM 1676 CA GLY A 218 13.666 −8.899 65.338 1.00 10.97 A ATOM 1677 C GLY A 218 12.637 −7.786 65.469 1.00 11.12 A ATOM 1678 O GLY A 218 11.619 −7.780 64.774 1.00 11.86 A ATOM 1679 N ALA A 219 12.894 −6.850 66.379 1.00 10.90 A ATOM 1680 CA ALA A 219 12.010 −5.702 66.587 1.00 10.79 A ATOM 1681 CB ALA A 219 11.083 −5.943 67.792 1.00 10.28 A ATOM 1682 C ALA A 219 12.848 −4.439 66.811 1.00 10.65 A ATOM 1683 O ALA A 219 13.940 −4.496 67.388 1.00 10.66 A ATOM 1684 N ALA A 220 12.333 −3.309 66.337 1.00 9.85 A ATOM 1685 CA ALA A 220 13.002 −2.019 66.486 1.00 10.37 A ATOM 1686 CB ALA A 220 13.677 −1.616 65.172 1.00 9.86 A ATOM 1687 C ALA A 220 11.959 −0.979 66.887 1.00 10.57 A ATOM 1688 O ALA A 220 10.824 −1.007 66.399 1.00 10.66 A ATOM 1689 N ALA A 221 12.339 −0.068 67.781 1.00 9.94 A ATOM 1690 CA ALA A 221 11.419 0.963 68.246 1.00 10.32 A ATOM 1691 CB ALA A 221 10.959 0.653 69.680 1.00 10.35 A ATOM 1692 C ALA A 221 12.045 2.352 68.192 1.00 10.54 A ATOM 1693 O ALA A 221 13.237 2.518 68.475 1.00 9.74 A ATOM 1694 N LEU A 222 11.223 3.341 67.840 1.00 10.56 A ATOM 1695 CA LEU A 222 11.664 4.731 67.735 1.00 11.43 A ATOM 1696 CB LEU A 222 11.676 5.180 66.269 1.00 12.57 A ATOM 1697 CG LEU A 222 12.161 4.265 65.151 1.00 13.60 A ATOM 1698 CD1 LEU A 222 11.614 4.787 63.819 1.00 13.87 A ATOM 1699 CD2 LEU A 222 13.681 4.204 65.138 1.00 12.89 A ATOM 1700 C LEU A 222 10.704 5.672 68.459 1.00 11.56 A ATOM 1701 O LEU A 222 9.532 5.341 68.669 1.00 12.07 A ATOM 1702 N ILE A 223 11.216 6.838 68.848 1.00 11.46 A ATOM 1703 CA ILE A 223 10.393 7.887 69.447 1.00 11.36 A ATOM 1704 CB ILE A 223 10.904 8.370 70.829 1.00 11.65 A ATOM 1705 CG2 ILE A 223 10.178 9.655 71.223 1.00 10.99 A ATOM 1706 CG1 ILE A 223 10.687 7.289 71.893 1.00 11.08 A ATOM 1707 CD1 ILE A 223 9.227 6.989 72.214 1.00 12.35 A ATOM 1708 C ILE A 223 10.588 9.011 68.435 1.00 11.23 A ATOM 1709 O ILE A 223 11.726 9.402 68.149 1.00 11.56 A ATOM 1710 N VAL A 224 9.486 9.509 67.879 1.00 10.50 A ATOM 1711 CA VAL A 224 9.522 10.570 66.876 1.00 10.56 A ATOM 1712 CB VAL A 224 8.947 10.078 65.519 1.00 9.92 A ATOM 1713 CG1 VAL A 224 8.933 11.223 64.499 1.00 9.91 A ATOM 1714 CG2 VAL A 224 9.770 8.915 64.999 1.00 9.84 A ATOM 1715 C VAL A 224 8.705 11.782 67.310 1.00 10.99 A ATOM 1716 O VAL A 224 7.578 11.644 67.789 1.00 10.91 A ATOM 1717 N GLY A 225 9.276 12.970 67.135 1.00 11.59 A ATOM 1718 CA GLY A 225 8.567 14.181 67.499 1.00 11.11 A ATOM 1719 C GLY A 225 9.126 15.444 66.874 1.00 11.82 A ATOM 1720 O GLY A 225 10.297 15.500 66.488 1.00 10.35 A ATOM 1721 N SER A 226 8.273 16.457 66.761 1.00 12.29 A ATOM 1722 CA SER A 226 8.676 17.755 66.230 1.00 13.04 A ATOM 1723 CB SER A 226 7.557 18.364 65.376 1.00 13.32 A ATOM 1724 OG SER A 226 7.422 17.697 64.133 1.00 14.87 A ATOM 1725 C SER A 226 8.940 18.661 67.437 1.00 13.71 A ATOM 1726 O SER A 226 8.429 18.406 68.533 1.00 13.89 A ATOM 1727 N ASP A 227 9.746 19.701 67.240 1.00 13.96 A ATOM 1728 CA ASP A 227 10.056 20.659 68.304 1.00 14.97 A ATOM 1729 CB ASP A 227 8.775 21.400 68.711 1.00 15.35 A ATOM 1730 OG ASP A 227 7.974 21.886 67.512 1.00 15.96 A ATOM 1731 OD1 ASP A 227 8.588 22.393 66.551 1.00 16.70 A ATOM 1732 OD2 ASP A 227 6.729 21.766 67.536 1.00 17.02 A ATOM 1733 C ASP A 227 10.705 20.040 69.549 1.00 15.00 A ATOM 1734 O ASP A 227 10.144 20.093 70.646 1.00 14.00 A ATOM 1735 N PRO A 228 11.906 19.458 69.398 1.00 15.76 A ATOM 1736 CD PRO A 228 12.704 19.370 68.165 1.00 16.05 A ATOM 1737 CA PRO A 228 12.614 18.832 70.524 1.00 16.49 A ATOM 1738 CB PRO A 228 13.862 18.230 69.868 1.00 16.50 A ATOM 1739 CG PRO A 228 13.500 18.124 68.405 1.00 17.67 A ATOM 1740 C PRO A 228 12.996 19.845 71.605 1.00 16.81 A ATOM 1741 O PRO A 228 13.345 20.982 71.296 1.00 16.80 A ATOM 1742 N VAL A 229 12.936 19.432 72.868 1.00 17.75 A ATOM 1743 CA VAL A 229 13.307 20.311 73.972 1.00 18.66 A ATOM 1744 CB VAL A 229 12.759 19.777 75.319 1.00 18.87 A ATOM 1745 CG1 VAL A 229 13.106 20.735 76.442 1.00 18.50 A ATOM 1746 CG2 VAL A 229 11.252 19.587 75.231 1.00 19.24 A ATOM 1747 C VAL A 229 14.842 20.357 74.024 1.00 19.25 A ATOM 1748 O VAL A 229 15.490 19.361 74.338 1.00 19.01 A ATOM 1749 N PRO A 230 15.440 21.516 73.703 1.00 19.93 A ATOM 1750 CD PRO A 230 14.785 22.779 73.322 1.00 20.33 A ATOM 1751 CA PRO A 230 16.898 21.673 73.713 1.00 20.52 A ATOM 1752 CB PRO A 230 17.082 23.173 73.500 1.00 20.70 A ATOM 1753 CG PRO A 230 15.912 23.527 72.641 1.00 20.85 A ATOM 1754 C PRO A 230 17.585 21.188 74.986 1.00 21.15 A ATOM 1755 O PRO A 230 17.133 21.471 76.092 1.00 20.91 A ATOM 1756 N GLU A 231 18.677 20.450 74.807 1.00 21.72 A ATOM 1757 CA GLU A 231 19.474 19.921 75.914 1.00 22.87 A ATOM 1758 CB GLU A 231 19.977 21.072 76.790 1.00 24.06 A ATOM 1759 CG GLU A 231 20.632 22.204 76.014 1.00 26.41 A ATOM 1760 CD GLU A 231 21.929 21.795 75.342 1.00 28.22 A ATOM 1761 OE1 GLU A 231 22.428 22.575 74.502 1.00 29.91 A ATOM 1762 OE2 GLU A 231 22.458 20.705 75.654 1.00 29.36 A ATOM 1763 C GLU A 231 18.778 18.879 76.792 1.00 22.51 A ATOM 1764 O GLU A 231 19.405 18.321 77.693 1.00 23.39 A ATOM 1765 N ILE A 232 17.492 18.626 76.548 1.00 21.33 A ATOM 1766 CA ILE A 232 16.744 17.622 77.314 1.00 20.10 A ATOM 1767 CB ILE A 232 15.372 18.165 77.808 1.00 20.35 A ATOM 1768 CG2 ILE A 232 14.505 17.021 78.323 1.00 20.81 A ATOM 1769 CG1 ILE A 232 15.588 19.189 78.927 1.00 20.76 A ATOM 1770 CD1 ILE A 232 16.381 18.652 80.107 1.00 20.81 A ATOM 1771 C ILE A 232 16.511 16.406 76.418 1.00 19.24 A ATOM 1772 O ILE A 232 16.779 15.270 76.808 1.00 18.76 A ATOM 1773 N GLU A 233 15.998 16.654 75.218 1.00 18.19 A ATOM 1774 CA GLU A 233 15.773 15.588 74.248 1.00 17.68 A ATOM 1775 CB GLU A 233 14.435 15.796 73.516 1.00 16.61 A ATOM 1776 CG GLU A 233 13.225 15.614 74.442 1.00 15.77 A ATOM 1777 CD GLU A 233 11.878 15.811 73.763 1.00 15.66 A ATOM 1778 OE1 GLU A 233 11.663 16.888 73.164 1.00 14.98 A ATOM 1779 OE2 GLU A 233 11.024 14.894 73.846 1.00 13.88 A ATOM 1780 C GLU A 233 16.969 15.696 73.304 1.00 18.08 A ATOM 1781 O GLU A 233 17.581 16.763 73.202 1.00 18.12 A ATOM 1782 N LYS A 234 17.316 14.606 72.626 1.00 18.13 A ATOM 1783 CA LYS A 234 18.479 14.620 71.743 1.00 18.28 A ATOM 1784 CB LYS A 234 19.609 13.818 72.391 1.00 19.97 A ATOM 1785 CG LYS A 234 20.833 13.658 71.517 1.00 22.36 A ATOM 1786 CD LYS A 234 21.912 12.864 72.228 1.00 24.07 A ATOM 1787 CE LYS A 234 23.161 12.748 71.377 1.00 24.43 A ATOM 1788 NZ LYS A 234 24.241 12.063 72.132 1.00 26.13 A ATOM 1789 C LYS A 234 18.226 14.088 70.332 1.00 17.50 A ATOM 1790 O LYS A 234 18.151 12.879 70.117 1.00 17.33 A ATOM 1791 N PRO A 235 18.103 14.995 69.349 1.00 16.44 A ATOM 1792 CD PRO A 235 18.018 16.454 69.532 1.00 16.79 A ATOM 1793 CA PRO A 235 17.861 14.628 67.948 1.00 15.90 A ATOM 1794 CB PRO A 235 17.822 15.983 67.244 1.00 16.17 A ATOM 1795 CG PRO A 235 17.250 16.890 68.297 1.00 17.19 A ATOM 1796 C PRO A 235 18.948 13.719 67.365 1.00 15.14 A ATOM 1797 O PRO A 235 20.133 13.916 67.642 1.00 15.33 A ATOM 1798 N ILE A 236 18.540 12.739 66.559 1.00 13.84 A ATOM 1799 CA ILE A 236 19.475 11.815 65.914 1.00 13.10 A ATOM 1800 CB ILE A 236 19.117 10.335 66.217 1.00 12.82 A ATOM 1801 CG2 ILE A 236 20.170 9.416 65.618 1.00 13.36 A ATOM 1802 CG1 ILE A 236 19.028 10.104 67.727 1.00 12.98 A ATOM 1803 CD1 ILE A 236 18.623 8.689 68.107 1.00 13.32 A ATOM 1804 C ILE A 236 19.454 12.029 64.389 1.00 12.89 A ATOM 1805 O ILE A 236 20.503 12.188 63.760 1.00 12.73 A ATOM 1806 N PHE A 237 18.254 12.019 63.808 1.00 12.93 A ATOM 1807 CA PHE A 237 18.052 12.233 62.372 1.00 13.23 A ATOM 1808 CB PHE A 237 17.878 10.894 61.631 1.00 13.29 A ATOM 1809 CG PHE A 237 19.118 10.037 61.594 1.00 13.07 A ATOM 1810 CD1 PHE A 237 20.214 10.398 60.812 1.00 13.37 A ATOM 1811 CD2 PHE A 237 19.183 8.860 62.334 1.00 13.32 A ATOM 1812 CE1 PHE A 237 21.359 9.594 60.769 1.00 13.12 A ATOM 1813 CE2 PHE A 237 20.321 8.050 62.300 1.00 13.01 A ATOM 1814 CZ PHE A 237 21.411 8.418 61.515 1.00 13.20 A ATOM 1815 C PHE A 237 16.769 13.057 62.185 1.00 13.74 A ATOM 1816 O PHE A 237 15.818 12.909 62.953 1.00 14.05 A ATOM 1817 N GLU A 238 16.744 13.917 61.170 1.00 14.11 A ATOM 1818 CA GLU A 238 15.558 14.728 60.873 1.00 14.73 A ATOM 1819 CB GLU A 238 15.917 16.213 60.718 1.00 15.82 A ATOM 1820 CG GLU A 238 16.429 16.918 61.958 1.00 18.71 A ATOM 1821 CD GLU A 238 16.434 18.438 61.794 1.00 21.33 A ATOM 1822 OE1 GLU A 238 17.008 18.939 60.803 1.00 22.01 A ATOM 1823 OE2 GLU A 238 15.856 19.135 62.657 1.00 22.77 A ATOM 1824 C GLU A 238 14.963 14.251 59.548 1.00 14.20 A ATOM 1825 O GLU A 238 15.707 13.948 58.614 1.00 13.90 A ATOM 1826 N MET A 239 13.638 14.180 59.456 1.00 13.86 A ATOM 1827 CA MET A 239 13.008 13.766 58.205 1.00 14.51 A ATOM 1828 CB MET A 239 11.702 13.006 58.468 1.00 15.35 A ATOM 1829 CG MET A 239 11.940 11.583 58.970 1.00 17.08 A ATOM 1830 SD MET A 239 10.448 10.564 59.044 1.00 19.48 A ATOM 1831 CE MET A 239 9.981 10.786 60.745 1.00 18.17 A ATOM 1832 C MET A 239 12.757 15.011 57.363 1.00 14.60 A ATOM 1833 O MET A 239 12.329 16.047 57.884 1.00 13.98 A ATOM 1834 N VAL A 240 13.041 14.905 56.067 1.00 14.28 A ATOM 1835 CA VAL A 240 12.893 16.025 55.141 1.00 15.20 A ATOM 1836 CB VAL A 240 14.224 16.271 54.375 1.00 15.56 A ATOM 1837 CG1 VAL A 240 14.091 17.470 53.452 1.00 15.90 A ATOM 1838 CG2 VAL A 240 15.366 16.479 55.363 1.00 16.93 A ATOM 1839 C VAL A 240 11.784 15.875 54.096 1.00 15.14 A ATOM 1840 O VAL A 240 11.009 16.803 53.865 1.00 14.78 A ATOM 1841 N TRP A 241 11.715 14.706 53.466 1.00 15.48 A ATOM 1842 CA TRP A 241 10.740 14.462 52.405 1.00 15.48 A ATOM 1843 CB TRP A 241 11.309 15.035 51.104 1.00 17.25 A ATOM 1844 CG TRP A 241 10.446 14.908 49.891 1.00 18.55 A ATOM 1845 CD2 TRP A 241 10.627 13.993 48.802 1.00 19.60 A ATOM 1846 CE2 TRP A 241 9.618 14.267 47.851 1.00 20.24 A ATOM 1847 CE3 TRP A 241 11.544 12.968 48.536 1.00 19.96 A ATOM 1848 CD1 TRP A 241 9.363 15.674 49.571 1.00 19.19 A ATOM 1849 NE1 TRP A 241 8.860 15.296 48.345 1.00 20.36 A ATOM 1850 CZ2 TRP A 241 9.503 13.554 46.652 1.00 20.07 A ATOM 1851 CZ3 TRP A 241 11.428 12.259 47.344 1.00 20.26 A ATOM 1852 CH2 TRP A 241 10.414 12.559 46.417 1.00 20.45 A ATOM 1853 C TRP A 241 10.500 12.958 52.252 1.00 15.29 A ATOM 1854 O TRP A 241 11.399 12.162 52.516 1.00 15.20 A ATOM 1855 N THR A 242 9.297 12.570 51.827 1.00 14.37 A ATOM 1856 CA THR A 242 8.984 11.149 51.636 1.00 13.75 A ATOM 1857 CB THR A 242 8.150 10.563 52.815 1.00 14.23 A ATOM 1858 OG1 THR A 242 6.860 11.188 52.853 1.00 15.91 A ATOM 1859 CG2 THR A 242 8.863 10.780 54.144 1.00 13.74 A ATOM 1860 C THR A 242 8.207 10.878 50.350 1.00 13.35 A ATOM 1661 O THR A 242 7.526 11.757 49.820 1.00 13.22 A ATOM 1862 N ALA A 243 8.310 9.648 49.856 1.00 12.74 A ATOM 1863 CA ALA A 243 7.607 9.244 48.646 1.00 12.52 A ATOM 1864 CB ALA A 243 8.379 9.702 47.410 1.00 12.73 A ATOM 1865 C ALA A 243 7.422 7.726 48.611 1.00 12.56 A ATOM 1866 O ALA A 243 8.142 6.988 49.285 1.00 12.38 A ATOM 1867 N GLN A 244 6.430 7.276 47.848 1.00 12.33 A ATOM 1868 CA GLN A 244 6.158 5.850 47.681 1.00 13.23 A ATOM 1869 CB GLN A 244 5.005 5.372 48.581 1.00 13.07 A ATOM 1870 CG GLN A 244 4.761 3.860 48.475 1.00 12.26 A ATOM 1871 CD GLN A 244 3.457 3.383 49.114 1.00 12.34 A ATOM 1872 OE1 GLN A 244 2.378 3.893 48.811 1.00 12.05 A ATOM 1873 NE2 GLN A 244 3.556 2.379 49.989 1.00 10.52 A ATOM 1874 C GLN A 244 5.753 5.660 46.225 1.00 13.65 A ATOM 1875 O GLN A 244 4.996 6.466 45.681 1.00 13.54 A ATOM 1876 N THR A 245 6.260 4.611 45.588 1.00 14.00 A ATOM 1877 CA THR A 245 5.903 4.361 44.200 1.00 14.97 A ATOM 1878 CB THR A 245 6.862 5.104 43.240 1.00 15.16 A ATOM 1879 OG1 THR A 245 6.295 5.121 41.922 1.00 16.09 A ATOM 1880 CG2 THR A 245 8.222 4.418 43.201 1.00 16.31 A ATOM 1881 C THR A 245 5.908 2.872 43.875 1.00 15.50 A ATOM 1882 O THR A 245 6.472 2.069 44.616 1.00 15.47 A ATOM 1883 N ILE A 246 5.257 2.516 42.770 1.00 16.25 A ATOM 1884 CA ILE A 246 5.174 1.136 42.309 1.00 16.49 A ATOM 1885 CB ILE A 246 3.698 0.719 42.056 1.00 16.23 A ATOM 1886 CG2 ILE A 246 3.636 −0.679 41.456 1.00 15.84 A ATOM 1887 CG1 ILE A 246 2.915 0.748 43.376 1.00 15.94 A ATOM 1888 CD1 ILE A 246 1.417 0.555 43.212 1.00 15.61 A ATOM 1889 C ILE A 246 5.960 1.046 41.001 1.00 18.27 A ATOM 1890 O ILE A 246 5.689 1.790 40.058 1.00 17.51 A ATOM 1891 N ALA A 247 6.937 0.145 40.956 1.00 19.38 A ATOM 1892 CA ALA A 247 7.770 −0.025 39.768 1.00 21.64 A ATOM 1893 CB ALA A 247 8.938 −0.960 40.080 1.00 21.46 A ATOM 1894 C ALA A 247 6.971 −0.566 38.584 1.00 23.14 A ATOM 1895 O ALA A 247 6.131 −1.451 38.743 1.00 23.05 A ATOM 1896 N PRO A 248 7.223 −0.033 37.378 1.00 24.93 A ATOM 1897 CD PRO A 248 8.193 1.027 37.042 1.00 25.33 A ATOM 1898 CA PRO A 248 6.510 −0.488 36.183 1.00 26.41 A ATOM 1899 CB PRO A 248 6.983 0.490 35.107 1.00 26.16 A ATOM 1900 CG PRO A 248 8.370 0.834 35.554 1.00 26.28 A ATOM 1901 C PRO A 248 6.835 −1.945 35.847 1.00 28.02 A ATOM 1902 O PRO A 248 7.964 −2.401 36.040 1.00 28.21 A ATOM 1903 N ASP A 249 5.832 −2.667 35.354 1.00 29.84 A ATOM 1904 CA ASP A 249 5.982 −4.077 34.997 1.00 31.50 A ATOM 1905 CB ASP A 249 6.744 −4.214 33.680 1.00 32.96 A ATOM 1906 CG ASP A 249 5.969 −3.663 32.506 1.00 34.22 A ATOM 1907 OD1 ASP A 249 4.816 −4.104 32.299 1.00 35.29 A ATOM 1908 OD2 ASP A 249 6.512 −2.794 31.792 1.00 35.24 A ATOM 1909 C ASP A 249 6.691 −4.878 36.077 1.00 31.86 A ATOM 1910 O ASP A 249 7.796 −5.379 35.867 1.00 32.42 A ATOM 1911 N SER A 250 6.049 −5.004 37.232 1.00 31.79 A ATOM 1912 CA SER A 250 6.629 −5.747 38.338 1.00 31.71 A ATOM 1913 CB SER A 250 7.363 −4.793 39.281 1.00 31.24 A ATOM 1914 OG SER A 250 6.458 −3.890 39.883 1.00 30.46 A ATOM 1915 C SER A 250 5.556 −6.506 39.111 1.00 31.85 A ATOM 1916 O SER A 250 5.839 −7.133 40.129 1.00 31.15 A ATOM 1917 N GLU A 251 4.321 −6.441 38.624 1.00 32.41 A ATOM 1918 CA GLU A 251 3.219 −7.135 39.275 1.00 32.93 A ATOM 1919 CB GLU A 251 1.915 −6.885 38.510 1.00 34.41 A ATOM 1920 CG GLU A 251 0.667 −7.443 39.186 1.00 36.20 A ATOM 1921 CD GLU A 251 −0.612 −7.063 38.459 1.00 37.28 A ATOM 1922 OE1 GLU A 251 −1.705 −7.458 38.925 1.00 37.89 A ATOM 1923 OE2 GLU A 251 −0.525 −6.368 37.421 1.00 38.05 A ATOM 1924 C GLU A 251 3.542 −8.625 39.301 1.00 32.68 A ATOM 1925 O GLU A 251 3.762 −9.240 38.254 1.00 32.66 A ATOM 1926 N GLY A 252 3.595 −9.196 40.501 1.00 32.04 A ATOM 1927 CA GLY A 252 3.901 −10.609 40.637 1.00 30.95 A ATOM 1928 C GLY A 252 5.326 −10.861 41.093 1.00 30.57 A ATOM 1929 O GLY A 252 5.672 −11.974 41.488 1.00 30.50 A ATOM 1930 N ALA A 253 6.159 −9.827 41.045 1.00 29.95 A ATOM 1931 CA ALA A 253 7.553 −9.955 41.454 1.00 29.30 A ATOM 1932 CB ALA A 253 8.253 −8.608 41.344 1.00 29.04 A ATOM 1933 C ALA A 253 7.670 −10.494 42.876 1.00 29.10 A ATOM 1934 O ALA A 253 8.502 −11.358 43.153 1.00 28.97 A ATOM 1935 N ILE A 254 6.833 −9.977 43.772 1.00 29.05 A ATOM 1936 CA ILE A 254 6.827 −10.404 45.169 1.00 28.75 A ATOM 1937 CB ILE A 254 7.611 −9.424 46.070 1.00 28.87 A ATOM 1938 CG2 ILE A 254 7.593 −9.922 47.511 1.00 29.14 A ATOM 1939 CG1 ILE A 254 9.055 −9.287 45.584 1.00 29.03 A ATOM 1940 CD1 ILE A 254 9.901 −10.528 45.803 1.00 30.14 A ATOM 1941 C ILE A 254 5.387 −10.447 45.670 1.00 28.64 A ATOM 1942 O ILE A 254 4.730 −9.411 45.773 1.00 28.64 A ATOM 1943 N ASP A 255 4.895 −11.639 45.989 1.00 28.26 A ATOM 1944 CA ASP A 255 3.525 −11.762 46.471 1.00 27.70 A ATOM 1945 CB ASP A 255 2.598 −12.163 45.322 1.00 29.83 A ATOM 1946 CG ASP A 255 2.660 −13.643 45.016 1.00 32.19 A ATOM 1947 OD1 ASP A 255 2.153 −14.443 45.835 1.00 33.88 A ATOM 1948 OD2 ASP A 255 3.222 −14.012 43.964 1.00 33.72 A ATOM 1949 C ASP A 255 3.401 −12.778 47.600 1.00 26.17 A ATOM 1950 O ASP A 255 4.086 −13.803 47.612 1.00 26.56 A ATOM 1951 N GLY A 256 2.519 −12.483 48.548 1.00 23.34 A ATOM 1952 CA GLY A 256 2.304 −13.379 49.664 1.00 20.65 A ATOM 1953 C GLY A 256 0.831 −13.708 49.807 1.00 18.54 A ATOM 1954 O GLY A 256 −0.030 −12.931 49.389 1.00 17.67 A ATOM 1955 N HIS A 257 0.537 −14.862 50.395 1.00 17.10 A ATOM 1956 CA HIS A 257 −0.844 −15.289 50.586 1.00 16.09 A ATOM 1957 CB HIS A 257 −1.205 −16.374 49.567 1.00 17.01 A ATOM 1958 CG HIS A 257 −0.976 −15.973 48.141 1.00 17.98 A ATOM 1959 CD2 HIS A 257 −0.126 −16.458 47.204 1.00 18.47 A ATOM 1960 ND1 HIS A 257 −1.680 −14.957 47.529 1.00 18.29 A ATOM 1961 CE1 HIS A 257 −1.275 −14.836 46.276 1.00 18.53 A ATOM 1962 NE2 HIS A 257 −0.332 −15.734 46.054 1.00 18.65 A ATOM 1963 C HIS A 257 −1.034 −15.842 51.997 1.00 15.08 A ATOM 1964 O HIS A 257 −0.328 −16.771 52.400 1.00 14.51 A ATOM 1965 N LEU A 258 −1.981 −15.274 52.744 1.00 13.67 A ATOM 1966 CA LEU A 258 −2.269 −15.735 54.104 1.00 12.94 A ATOM 1967 CB LEU A 258 −2.743 −14.565 54.973 1.00 13.79 A ATOM 1968 CG LEU A 258 −2.864 −14.775 56.490 1.00 14.04 A ATOM 1969 CD1 LEU A 258 −3.994 −15.736 56.802 1.00 15.09 A ATOM 1970 CD2 LEU A 258 −1.542 −15.300 57.035 1.00 13.98 A ATOM 1971 C LEU A 258 −3.369 −16.789 53.972 1.00 12.65 A ATOM 1972 O LEU A 258 −4.527 −16.464 53.684 1.00 11.92 A ATOM 1973 N ARG A 259 −2.998 −18.047 54.185 1.00 11.51 A ATOM 1974 CA ARG A 259 −3.927 −19.162 54.033 1.00 12.09 A ATOM 1975 CB ARG A 259 −3.614 −19.896 52.723 1.00 12.33 A ATOM 1976 CG ARG A 259 −3.690 −19.023 51.473 1.00 12.60 A ATOM 1977 CD ARG A 259 −5.127 −18.640 51.129 1.00 13.20 A ATOM 1978 NE ARG A 259 −5.220 −17.892 49.874 1.00 13.86 A ATOM 1979 CZ ARG A 259 −5.066 −16.575 49.767 1.00 14.56 A ATOM 1980 NH1 ARG A 259 −4.814 −15.846 50.843 1.00 13.37 A ATOM 1981 NH2 ARG A 259 −5.163 −15.987 48.580 1.00 14.20 A ATOM 1982 C ARG A 259 −3.892 −20.155 55.194 1.00 12.02 A ATOM 1983 O ARG A 259 −3.224 −19.925 56.208 1.00 11.93 A ATOM 1984 N GLU A 260 −4.608 −21.266 55.032 1.00 12.07 A ATOM 1985 CA GLU A 260 −4.677 −22.293 56.067 1.00 11.81 A ATOM 1986 CB GLU A 260 −5.658 −23.401 55.638 1.00 12.66 A ATOM 1987 CG GLU A 260 −7.136 −22.962 55.733 1.00 12.50 A ATOM 1988 CD GLU A 260 −8.119 −23.909 55.037 1.00 13.49 A ATOM 1989 OE1 GLU A 260 −8.009 −25.138 55.209 1.00 13.25 A ATOM 1990 OE2 GLU A 260 −9.020 −23.414 54.323 1.00 13.98 A ATOM 1991 C GLU A 260 −3.314 −22.877 56.433 1.00 12.29 A ATOM 1992 O GLU A 260 −3.138 −23.412 57.531 1.00 12.18 A ATOM 1993 N ALA A 261 −2.344 −22.760 55.530 1.00 12.23 A ATOM 1994 CA ALA A 261 −1.006 −23.282 55.789 1.00 12.39 A ATOM 1995 CB ALA A 261 −0.454 −23.962 54.531 1.00 13.04 A ATOM 1996 C ALA A 261 −0.047 −22.180 56.255 1.00 12.98 A ATOM 1997 O ALA A 261 1.165 −22.383 56.308 1.00 12.59 A ATOM 1998 N GLY A 262 −0.591 −21.016 56.596 1.00 13.18 A ATOM 1999 CA GLY A 262 0.249 −19.916 57.033 1.00 13.93 A ATOM 2000 C GLY A 262 0.495 −18.934 55.902 1.00 14.52 A ATOM 2001 O GLY A 262 −0.305 −18.850 54.965 1.00 14.28 A ATOM 2002 N LEU A 263 1.598 −18.193 55.981 1.00 15.26 A ATOM 2003 CA LEU A 263 1.944 −17.210 54.954 1.00 16.05 A ATOM 2004 CB LEU A 263 2.466 −15.924 55.609 1.00 15.77 A ATOM 2005 CG LEU A 263 2.933 −14.826 54.646 1.00 15.80 A ATOM 2006 CD1 LEU A 263 1.737 −14.294 53.861 1.00 16.55 A ATOM 2007 CD2 LEU A 263 3.604 −13.700 55.424 1.00 15.82 A ATOM 2008 C LEU A 263 2.997 −17.737 53.976 1.00 17.41 A ATOM 2009 O LEU A 263 4.087 −18.131 54.388 1.00 15.70 A ATOM 2010 N THR A 264 2.669 −17.745 52.683 1.00 19.51 A ATOM 2011 CA THR A 264 3.604 −18.203 51.652 1.00 22.55 A ATOM 2012 CB THR A 264 3.032 −19.396 50.841 1.00 22.62 A ATOM 2013 OG1 THR A 264 1.814 −19.005 50.193 1.00 22.53 A ATOM 2014 CG2 THR A 264 2.758 −20.578 51.759 1.00 22.97 A ATOM 2015 C THR A 264 3.930 −17.061 50.684 1.00 25.08 A ATOM 2016 O THR A 264 3.152 −16.116 50.553 1.00 24.86 A ATOM 2017 N PHE A 265 5.080 −17.150 50.014 1.00 27.68 A ATOM 2018 CA PHE A 265 5.520 −16.124 49.059 1.00 30.90 A ATOM 2019 CB PHE A 265 6.761 −15.399 49.590 1.00 31.48 A ATOM 2020 CG PHE A 265 6.458 −14.282 50.550 1.00 31.83 A ATOM 2021 CD1 PHE A 265 5.800 −13.133 50.116 1.00 32.13 A ATOM 2022 CD2 PHE A 265 6.851 −14.364 51.882 1.00 31.97 A ATOM 2023 CE1 PHE A 265 5.541 −12.080 50.997 1.00 31.84 A ATOM 2024 CE2 PHE A 265 6.595 −13.316 52.770 1.00 32.16 A ATOM 2025 CZ PHE A 265 5.941 −12.174 52.325 1.00 31.81 A ATOM 2026 C PHE A 265 5.844 −16.701 47.679 1.00 33.06 A ATOM 2027 O PHE A 265 6.356 −17.817 47.572 1.00 33.32 A ATOM 2028 N HIS A 266 5.552 −15.931 46.630 1.00 35.28 A ATOM 2029 CA HIS A 266 5.803 −16.354 45.249 1.00 37.58 A ATOM 2030 CB HIS A 266 4.495 −16.800 44.589 1.00 38.61 A ATOM 2031 CG HIS A 266 3.760 −17.857 45.355 1.00 40.09 A ATOM 2032 CD2 HIS A 266 3.407 −19.120 45.018 1.00 40.75 A ATOM 2033 ND1 HIS A 266 3.288 −17.657 46.635 1.00 40.98 A ATOM 2034 CE1 HIS A 266 2.674 −18.750 47.053 1.00 41.00 A ATOM 2035 NE2 HIS A 266 2.732 −19.653 46.090 1.00 41.36 A ATOM 2036 C HIS A 266 6.427 −15.224 44.421 1.00 38.52 A ATOM 2037 O HIS A 266 5.931 −14.096 44.426 1.00 38.95 A ATOM 2038 N LEU A 267 7.503 −15.533 43.699 1.00 39.31 A ATOM 2039 CA LEU A 267 8.197 −14.531 42.889 1.00 39.61 A ATOM 2040 CB LEU A 267 9.705 −14.576 43.174 1.00 39.95 A ATOM 2041 CG LEU A 267 10.194 −14.308 44.603 1.00 40.58 A ATOM 2042 CD1 LEU A 267 9.725 −15.410 45.541 1.00 40.74 A ATOM 2043 CD2 LEU A 267 11.711 −14.243 44.608 1.00 40.64 A ATOM 2044 C LEU A 267 7.975 −14.660 41.381 1.00 39.65 A ATOM 2045 O LEU A 267 7.598 −15.719 40.878 1.00 39.80 A ATOM 2046 N ALA A 268 8.217 −13.562 40.670 1.00 39.52 A ATOM 2047 CA ALA A 268 8.069 −13.510 39.218 1.00 39.27 A ATOM 2048 CB ALA A 268 6.646 −13.114 38.846 1.00 39.26 A ATOM 2049 C ALA A 268 9.062 −12.486 38.673 1.00 39.03 A ATOM 2050 O ALA A 268 8.990 −11.303 39.004 1.00 39.11 A ATOM 2051 N GLY A 269 9.988 −12.942 37.837 1.00 38.84 A ATOM 2052 CA GLY A 269 10.985 −12.040 37.288 1.00 38.15 A ATOM 2053 C GLY A 269 12.158 −11.931 38.247 1.00 37.50 A ATOM 2054 O GLY A 269 12.241 −12.699 39.206 1.00 37.96 A ATOM 2055 N ALA A 270 13.058 −10.983 38.003 1.00 36.27 A ATOM 2056 CA ALA A 270 14.223 −10.808 38.865 1.00 34.83 A ATOM 2057 CB ALA A 270 15.486 −10.771 38.019 1.00 35.40 A ATOM 2058 C ALA A 270 14.130 −9.547 39.724 1.00 33.76 A ATOM 2059 O ALA A 270 14.279 −8.431 39.224 1.00 33.47 A ATOM 2060 N VAL A 271 13.892 −9.737 41.019 1.00 32.23 A ATOM 2061 CA VAL A 271 13.773 −8.626 41.961 1.00 31.04 A ATOM 2062 CB VAL A 271 13.521 −9.145 43.402 1.00 31.01 A ATOM 2063 CG1 VAL A 271 13.626 −8.003 44.404 1.00 30.77 A ATOM 2064 CG2 VAL A 271 12.151 −9.783 43.484 1.00 31.12 A ATOM 2065 C VAL A 271 14.989 −7.697 41.972 1.00 29.97 A ATOM 2066 O VAL A 271 14.841 −6.479 41.883 1.00 30.03 A ATOM 2067 N PRO A 272 16.206 −8.256 42.086 1.00 29.22 A ATOM 2068 CD PRO A 272 16.559 −9.677 42.254 1.00 28.94 A ATOM 2069 CA PRO A 272 17.410 −7.417 42.104 1.00 28.46 A ATOM 2070 CB PRO A 272 18.542 −8.442 42.131 1.00 28.41 A ATOM 2071 CG PRO A 272 17.932 −9.590 42.878 1.00 28.73 A ATOM 2072 C PRO A 272 17.509 −6.479 40.897 1.00 27.94 A ATOM 2073 O PRO A 272 17.907 −5.323 41.032 1.00 27.50 A ATOM 2074 N ASP A 273 17.147 −6.986 39.722 1.00 27.25 A ATOM 2075 CA ASP A 273 17.193 −6.196 38.496 1.00 26.96 A ATOM 2076 CB ASP A 273 16.970 −7.099 37.281 1.00 27.99 A ATOM 2077 CG ASP A 273 18.228 −7.831 36.859 1.00 29.35 A ATOM 2078 OD1 ASP A 273 18.956 −8.347 37.734 1.00 30.19 A ATOM 2079 OD2 ASP A 273 18.488 −7.899 35.642 1.00 31.21 A ATOM 2080 C ASP A 273 16.164 −5.070 38.494 1.00 26.29 A ATOM 2081 O ASP A 273 16.457 −3.951 38.082 1.00 25.72 A ATOM 2082 N ILE A 274 14.954 −5.368 38.952 1.00 26.11 A ATOM 2083 CA ILE A 274 13.899 −4.363 38.990 1.00 25.68 A ATOM 2084 CB ILE A 274 12.561 −4.987 39.440 1.00 25.78 A ATOM 2085 CG2 ILE A 274 11.480 −3.915 39.498 1.00 25.49 A ATOM 2086 CG1 ILE A 274 12.169 −6.103 38.465 1.00 26.11 A ATOM 2087 CD1 ILE A 274 10.946 −6.901 38.866 1.00 26.62 A ATOM 2088 C ILE A 274 14.281 −3.215 39.925 1.00 25.55 A ATOM 2089 O ILE A 274 14.087 −2.045 39.594 1.00 24.97 A ATOM 2090 N VAL A 275 14.838 −3.550 41.086 1.00 25.89 A ATOM 2091 CA VAL A 275 15.249 −2.530 42.048 1.00 26.31 A ATOM 2092 CB VAL A 275 15.736 −3.164 43.380 1.00 26.56 A ATOM 2093 CG1 VAL A 275 16.295 −2.087 44.301 1.00 26.70 A ATOM 2094 CG2 VAL A 275 14.586 −3.886 44.068 1.00 26.15 A ATOM 2095 C VAL A 275 16.371 −1.657 41.482 1.00 26.97 A ATOM 2096 O VAL A 275 16.257 −0.433 41.458 1.00 27.12 A ATOM 2097 N SER A 276 17.442 −2.289 41.006 1.00 27.37 A ATOM 2098 CA SER A 276 18.587 −1.559 40.465 1.00 28.02 A ATOM 2099 CB SER A 276 19.741 −2.526 40.173 1.00 28.39 A ATOM 2100 OG SER A 276 19.374 −3.502 39.214 1.00 28.82 A ATOM 2101 C SER A 276 18.286 −0.729 39.218 1.00 28.31 A ATOM 2102 O SER A 276 18.977 0.254 38.947 1.00 28.51 A ATOM 2103 N LYS A 277 17.265 −1.116 38.461 1.00 28.38 A ATOM 2104 CA LYS A 277 16.901 −0.379 37.255 1.00 28.77 A ATOM 2105 CB LYS A 277 16.196 −1.298 36.255 1.00 30.10 A ATOM 2106 CG LYS A 277 17.077 −2.408 35.702 1.00 32.06 A ATOM 2107 CD LYS A 277 16.333 −3.237 34.667 1.00 33.51 A ATOM 2108 CE LYS A 277 17.151 −4.443 34.229 1.00 34.41 A ATOM 2109 NZ LYS A 277 18.471 −4.060 33.652 1.00 34.50 A ATOM 2110 C LYS A 277 15.998 0.814 37.556 1.00 28.23 A ATOM 2111 O LYS A 277 15.910 1.745 36.756 1.00 28.03 A ATOM 2112 N ASN A 278 15.339 0.784 38.712 1.00 27.01 A ATOM 2113 CA ASN A 278 14.427 1.853 39.115 1.00 26.27 A ATOM 2114 CB ASN A 278 13.103 1.253 39.591 1.00 26.13 A ATOM 2115 CG ASN A 278 12.247 0.739 38.447 1.00 26.09 A ATOM 2116 OD1 ASN A 278 11.588 1.516 37.752 1.00 26.66 A ATOM 2117 ND2 ASN A 278 12.261 −0.572 38.240 1.00 25.15 A ATOM 2118 C ASN A 278 14.989 2.735 40.221 1.00 26.25 A ATOM 2119 O ASN A 278 14.376 3.738 40.591 1.00 26.18 A ATOM 2120 N ILE A 279 16.155 2.370 40.743 1.00 25.52 A ATOM 2121 CA ILE A 279 16.762 3.123 41.830 1.00 25.04 A ATOM 2122 CB ILE A 279 17.921 2.327 42.474 1.00 25.04 A ATOM 2123 CG2 ILE A 279 19.131 2.299 41.548 1.00 25.43 A ATOM 2124 CG1 ILE A 279 18.284 2.951 43.820 1.00 24.74 A ATOM 2125 CD1 ILE A 279 17.153 2.907 44.818 1.00 24.79 A ATOM 2126 C ILE A 279 17.265 4.513 41.446 1.00 24.99 A ATOM 2127 O ILE A 279 17.085 5.468 42.204 1.00 24.98 A ATOM 2128 N THR A 280 17.887 4.636 40.276 1.00 24.16 A ATOM 2129 CA THR A 280 18.406 5.927 39.846 1.00 23.97 A ATOM 2130 CB THR A 280 19.122 5.831 38.480 1.00 23.59 A ATOM 2131 OG1 THR A 280 20.213 4.907 38.573 1.00 23.27 A ATOM 2132 CG2 THR A 280 19.661 7.195 38.069 1.00 23.09 A ATOM 2133 C THR A 280 17.309 6.978 39.745 1.00 24.11 A ATOM 2134 O THR A 280 17.489 8.109 40.197 1.00 23.96 A ATOM 2135 N LYS A 281 16.172 6.608 39.161 1.00 24.39 A ATOM 2136 CA LYS A 281 15.069 7.550 39.010 1.00 24.90 A ATOM 2137 CB LYS A 281 13.962 6.949 38.140 1.00 26.58 A ATOM 2138 CG LYS A 281 13.414 5.626 38.631 1.00 28.54 A ATOM 2139 CD LYS A 281 12.272 5.129 37.750 1.00 30.15 A ATOM 2140 CE LYS A 281 11.047 6.036 37.837 1.00 31.02 A ATOM 2141 NZ LYS A 281 11.308 7.427 37.359 1.00 32.08 A ATOM 2142 C LYS A 281 14.501 7.990 40.353 1.00 24.09 A ATOM 2143 O LYS A 281 14.058 9.128 40.502 1.00 24.02 A ATOM 2144 N ALA A 282 14.509 7.092 41.331 1.00 23.31 A ATOM 2145 CA ALA A 282 14.004 7.434 42.658 1.00 22.44 A ATOM 2146 CB ALA A 282 13.877 6.176 43.517 1.00 22.10 A ATOM 2147 C ALA A 282 14.967 8.432 43.309 1.00 22.14 A ATOM 2148 O ALA A 282 14.544 9.360 43.999 1.00 21.76 A ATOM 2149 N LEU A 283 16.264 8.240 43.074 1.00 21.91 A ATOM 2150 CA LEU A 283 17.298 9.119 43.627 1.00 22.25 A ATOM 2151 CB LEU A 283 18.681 8.487 43.466 1.00 21.95 A ATOM 2152 CG LEU A 283 19.137 7.434 44.471 1.00 21.65 A ATOM 2153 CD1 LEU A 283 20.407 6.781 43.954 1.00 21.52 A ATOM 2154 CD2 LEU A 283 19.372 8.078 45.837 1.00 20.87 A ATOM 2155 C LEU A 283 17.324 10.498 42.977 1.00 22.77 A ATOM 2156 O LEU A 283 17.448 11.513 43.667 1.00 22.46 A ATOM 2157 N VAL A 284 17.235 10.535 41.651 1.00 23.26 A ATOM 2158 CA VAL A 284 17.258 11.810 40.942 1.00 24.56 A ATOM 2159 CB VAL A 284 17.197 11.617 39.402 1.00 24.60 A ATOM 2160 CG1 VAL A 284 18.434 10.888 38.922 1.00 24.22 A ATOM 2161 CG2 VAL A 284 15.948 10.847 39.018 1.00 25.47 A ATOM 2162 C VAL A 284 16.099 12.696 41.371 1.00 25.10 A ATOM 2163 O VAL A 284 16.268 13.896 41.576 1.00 26.07 A ATOM 2164 N GLU A 285 14.924 12.097 41.520 1.00 25.93 A ATOM 2165 CA GLU A 285 13.732 12.832 41.915 1.00 26.80 A ATOM 2166 CB GLU A 285 12.500 11.947 41.715 1.00 28.36 A ATOM 2167 CG GLU A 285 11.241 12.450 42.384 1.00 31.15 A ATOM 2168 CD GLU A 285 10.001 11.815 41.809 1.00 32.58 A ATOM 2169 OE1 GLU A 285 10.025 10.588 41.569 1.00 34.38 A ATOM 2170 OE2 GLU A 285 9.000 12.538 41.599 1.00 34.22 A ATOM 2171 C GLU A 285 13.788 13.347 43.351 1.00 26.74 A ATOM 2172 O GLU A 285 13.174 14.363 43.676 1.00 26.52 A ATOM 2173 N ALA A 286 14.534 12.655 44.205 1.00 26.28 A ATOM 2174 CA ALA A 286 14.651 13.057 45.602 1.00 26.53 A ATOM 2175 CB ALA A 286 14.821 11.821 46.477 1.00 25.97 A ATOM 2176 C ALA A 286 15.797 14.035 45.864 1.00 26.80 A ATOM 2177 O ALA A 286 15.683 14.921 46.713 1.00 26.76 A ATOM 2178 N PHE A 287 16.894 13.884 45.127 1.00 27.08 A ATOM 2179 CA PHE A 287 18.062 14.733 45.329 1.00 27.56 A ATOM 2180 CB PHE A 287 19.294 13.848 45.536 1.00 26.16 A ATOM 2181 CG PHE A 287 19.300 13.142 46.860 1.00 25.16 A ATOM 2182 CD1 PHE A 287 19.599 13.837 48.027 1.00 24.31 A ATOM 2183 CD2 PHE A 287 18.941 11.802 46.952 1.00 24.68 A ATOM 2184 CE1 PHE A 287 19.538 13.210 49.270 1.00 24.57 A ATOM 2185 CE2 PHE A 287 18.876 11.164 48.191 1.00 24.72 A ATOM 2186 CZ PHE A 287 19.174 11.872 49.353 1.00 24.05 A ATOM 2187 C PHE A 287 18.354 15.805 44.282 1.00 29.00 A ATOM 2188 O PHE A 287 19.231 16.646 44.487 1.00 28.79 A ATOM 2189 N GLU A 288 17.636 15.781 43.164 1.00 30.59 A ATOM 2190 CA GLU A 288 17.845 16.801 42.138 1.00 32.44 A ATOM 2191 CB GLU A 288 16.899 16.581 40.954 1.00 33.45 A ATOM 2192 CG GLU A 288 17.114 17.546 39.799 1.00 35.64 A ATOM 2193 CD GLU A 288 16.158 17.296 38.646 1.00 36.73 A ATOM 2194 OE1 GLU A 288 14.950 17.577 38.796 1.00 37.57 A ATOM 2195 OE2 GLU A 288 16.616 16.808 37.592 1.00 37.77 A ATOM 2196 C GLU A 288 17.588 18.176 42.761 1.00 32.65 A ATOM 2197 O GLU A 288 18.391 19.095 42.608 1.00 33.11 A ATOM 2198 N PRO A 289 16.463 18.329 43.482 1.00 33.05 A ATOM 2199 CD PRO A 289 15.364 17.358 43.650 1.00 33.26 A ATOM 2200 CA PRO A 289 16.121 19.602 44.125 1.00 33.05 A ATOM 2201 CB PRO A 289 14.818 19.279 44.851 1.00 33.14 A ATOM 2202 CG PRO A 289 14.192 18.256 43.966 1.00 33.18 A ATOM 2203 C PRO A 289 17.196 20.118 45.083 1.00 33.10 A ATOM 2204 O PRO A 289 17.298 21.324 45.315 1.00 33.32 A ATOM 2205 N LEU A 290 17.988 19.206 45.641 1.00 32.89 A ATOM 2206 CA LEU A 290 19.047 19.580 46.577 1.00 32.40 A ATOM 2207 CB LEU A 290 19.289 18.457 47.596 1.00 32.52 A ATOM 2208 CG LEU A 290 18.136 18.060 48.524 1.00 32.73 A ATOM 2209 CD1 LEU A 290 18.595 16.961 49.469 1.00 32.65 A ATOM 2210 CD2 LEU A 290 17.672 19.267 49.313 1.00 32.85 A ATOM 2211 C LEU A 290 20.351 19.887 45.852 1.00 32.01 A ATOM 2212 O LEU A 290 21.323 20.330 46.468 1.00 31.92 A ATOM 2213 N GLY A 291 20.369 19.640 44.545 1.00 31.46 A ATOM 2214 CA GLY A 291 21.559 19.898 43.753 1.00 30.99 A ATOM 2215 C GLY A 291 22.663 18.874 43.948 1.00 30.50 A ATOM 2216 O GLY A 291 23.839 19.169 43.726 1.00 30.55 A ATOM 2217 N ILE A 292 22.290 17.665 44.355 1.00 29.69 A ATOM 2218 CA ILE A 292 23.261 16.601 44.583 1.00 29.08 A ATOM 2219 CB ILE A 292 23.031 15.937 45.953 1.00 29.06 A ATOM 2220 CG2 ILE A 292 23.989 14.764 46.135 1.00 28.81 A ATOM 2221 CG1 ILE A 292 23.224 16.973 47.066 1.00 28.76 A ATOM 2222 CD1 ILE A 292 22.920 16.455 48.454 1.00 28.39 A ATOM 2223 C ILE A 292 23.189 15.530 43.499 1.00 28.90 A ATOM 2224 O ILE A 292 22.140 14.926 43.282 1.00 28.79 A ATOM 2225 N SER A 293 24.312 15.302 42.821 1.00 28.59 A ATOM 2226 CA SER A 293 24.381 14.304 41.756 1.00 28.30 A ATOM 2227 CB SER A 293 24.792 14.969 40.440 1.00 28.20 A ATOM 2228 OG SER A 293 26.091 15.529 40.548 1.00 28.70 A ATOM 2229 C SER A 293 25.373 13.188 42.087 1.00 27.62 A ATOM 2230 O SER A 293 25.332 12.119 41.485 1.00 27.89 A ATOM 2231 N ASP A 294 26.265 13.446 43.039 1.00 27.00 A ATOM 2232 CA ASP A 294 27.266 12.463 43.450 1.00 26.30 A ATOM 2233 CB ASP A 294 28.587 13.173 43.769 1.00 27.80 A ATOM 2234 CG ASP A 294 29.621 12.246 44.379 1.00 28.79 A ATOM 2235 OD1 ASP A 294 29.606 11.037 44.063 1.00 28.85 A ATOM 2236 OD2 ASP A 294 30.459 12.735 45.168 1.00 30.27 A ATOM 2237 C ASP A 294 26.770 11.676 44.667 1.00 25.13 A ATOM 2238 O ASP A 294 26.850 12.151 45.797 1.00 24.51 A ATOM 2239 N TYR A 295 26.276 10.465 44.424 1.00 23.98 A ATOM 2240 CA TYR A 295 25.727 9.628 45.487 1.00 22.92 A ATOM 2241 CB TYR A 295 24.901 8.504 44.861 1.00 23.20 A ATOM 2242 CG TYR A 295 23.850 9.050 43.922 1.00 23.56 A ATOM 2243 CD1 TYR A 295 22.910 9.985 44.366 1.00 24.31 A ATOM 2244 CE1 TYR A 295 21.984 10.552 43.491 1.00 24.25 A ATOM 2245 CD2 TYR A 295 23.833 8.690 42.573 1.00 24.63 A ATOM 2246 CE2 TYR A 295 22.911 9.251 41.688 1.00 24.54 A ATOM 2247 CZ TYR A 295 21.992 10.182 42.153 1.00 24.93 A ATOM 2248 OH TYR A 295 21.095 10.752 41.279 1.00 24.87 A ATOM 2249 C TYR A 295 26.723 9.088 46.514 1.00 22.33 A ATOM 2250 O TYR A 295 26.338 8.392 47.455 1.00 21.89 A ATOM 2251 N ASN A 296 28.001 9.407 46.339 1.00 21.23 A ATOM 2252 CA ASN A 296 29.011 8.999 47.306 1.00 20.36 A ATOM 2253 CB ASN A 296 30.383 8.844 46.641 1.00 21.14 A ATOM 2254 CG ASN A 296 30.596 7.460 46.052 1.00 20.97 A ATOM 2255 OD1 ASN A 296 30.624 6.464 46.776 1.00 21.95 A ATOM 2256 ND2 ASN A 296 30.749 7.392 44.735 1.00 20.64 A ATOM 2257 C ASN A 296 29.073 10.104 48.359 1.00 19.68 A ATOM 2258 O ASN A 296 29.722 9.959 49.395 1.00 19.26 A ATOM 2259 N SER A 297 28.373 11.206 48.089 1.00 19.05 A ATOM 2260 CA SER A 297 28.354 12.345 49.003 1.00 18.66 A ATOM 2261 CB SER A 297 28.379 13.659 48.209 1.00 18.96 A ATOM 2262 OG SER A 297 27.200 13.833 47.438 1.00 20.75 A ATOM 2263 C SER A 297 27.196 12.379 50.006 1.00 18.07 A ATOM 2264 O SER A 297 26.998 13.387 50.687 1.00 17.98 A ATOM 2265 N ILE A 298 26.435 11.292 50.101 1.00 17.31 A ATOM 2266 CA ILE A 298 25.312 11.216 51.046 1.00 16.71 A ATOM 2267 CB ILE A 298 23.949 11.279 50.305 1.00 16.38 A ATOM 2268 CG2 ILE A 298 23.849 12.575 49.504 1.00 16.94 A ATOM 2269 CG1 ILE A 298 23.797 10.070 49.375 1.00 16.73 A ATOM 2270 CD1 ILE A 298 22.459 10.005 48.652 1.00 16.32 A ATOM 2271 C ILE A 298 25.392 9.891 51.814 1.00 16.04 A ATOM 2272 O ILE A 298 26.006 8.943 51.317 1.00 16.33 A ATOM 2273 N PHE A 299 24.810 9.819 53.018 1.00 15.01 A ATOM 2274 CA PHE A 299 24.843 8.556 53.759 1.00 14.11 A ATOM 2275 CB PHE A 299 24.851 8.754 55.292 1.00 13.75 A ATOM 2276 CG PHE A 299 23.689 9.547 55.850 1.00 12.78 A ATOM 2277 CD1 PHE A 299 23.713 10.939 55.852 1.00 12.57 A ATOM 2278 CD2 PHE A 299 22.616 8.897 56.455 1.00 12.47 A ATOM 2279 CE1 PHE A 299 22.687 11.674 56.458 1.00 12.78 A ATOM 2280 CE2 PHE A 299 21.583 9.620 57.064 1.00 12.49 A ATOM 2281 CZ PHE A 299 21.620 11.012 57.066 1.00 12.45 A ATOM 2282 C PHE A 299 23.698 7.645 53.311 1.00 14.17 A ATOM 2283 O PHE A 299 22.620 8.119 52.932 1.00 14.13 A ATOM 2284 N TRP A 300 23.953 6.338 53.347 1.00 13.43 A ATOM 2285 CA TRP A 300 23.012 5.330 52.863 1.00 13.55 A ATOM 2286 CB TRP A 300 23.689 4.499 51.756 1.00 13.64 A ATOM 2287 CG TRP A 300 23.741 5.128 50.398 1.00 14.19 A ATOM 2288 CD2 TRP A 300 22.917 4.794 49.275 1.00 14.07 A ATOM 2289 CE2 TRP A 300 23.295 5.642 48.212 1.00 14.33 A ATOM 2290 CE3 TRP A 300 21.888 3.861 49.067 1.00 14.36 A ATOM 2291 CD1 TRP A 300 24.568 6.134 49.981 1.00 14.12 A ATOM 2292 NE1 TRP A 300 24.305 6.447 48.669 1.00 14.30 A ATOM 2293 CZ2 TRP A 300 22.683 5.585 46.953 1.00 14.52 A ATOM 2294 CZ3 TRP A 300 21.278 3.805 47.813 1.00 14.75 A ATOM 2295 CH2 TRP A 300 21.679 4.665 46.774 1.00 14.61 A ATOM 2296 C TRP A 300 22.394 4.327 53.840 1.00 12.97 A ATOM 2297 O TRP A 300 23.067 3.808 54.733 1.00 13.38 A ATOM 2298 N ILE A 301 21.109 4.050 53.631 1.00 12.82 A ATOM 2299 CA ILE A 301 20.370 3.041 54.389 1.00 12.85 A ATOM 2300 CB ILE A 301 19.465 3.629 55.510 1.00 12.55 A ATOM 2301 CG2 ILE A 301 18.614 2.508 56.122 1.00 12.29 A ATOM 2302 CG1 ILE A 301 20.311 4.266 56.620 1.00 12.45 A ATOM 2303 CD1 ILE A 301 20.591 5.741 56.412 1.00 11.84 A ATOM 2304 C ILE A 301 19.471 2.341 53.356 1.00 13.12 A ATOM 2305 O ILE A 301 18.549 2.951 52.806 1.00 13.40 A ATOM 2306 N ALA A 302 19.754 1.072 53.073 1.00 13.05 A ATOM 2307 CA ALA A 302 18.965 0.321 52.093 1.00 13.27 A ATOM 2308 CB ALA A 302 19.806 0.064 50.836 1.00 13.42 A ATOM 2309 C ALA A 302 18.462 −1.006 52.658 1.00 13.08 A ATOM 2310 O ALA A 302 19.217 −1.741 53.295 1.00 13.86 A ATOM 2311 N HIS A 303 17.188 −1.313 52.425 1.00 12.38 A ATOM 2312 CA HIS A 303 16.613 −2.566 52.905 1.00 12.20 A ATOM 2313 CB HIS A 303 15.131 −2.673 52.516 1.00 11.11 A ATOM 2314 CG HIS A 303 14.535 −4.016 52.809 1.00 10.71 A ATOM 2315 CD2 HIS A 303 14.074 −4.986 51.983 1.00 10.88 A ATOM 2316 ND1 HIS A 303 14.422 −4.518 54.088 1.00 11.15 A ATOM 2317 CE1 HIS A 303 13.918 −5.739 54.039 1.00 10.53 A ATOM 2318 NE2 HIS A 303 13.699 −6.047 52.773 1.00 10.34 A ATOM 2319 C HIS A 303 17.390 −3.732 52.295 1.00 12.67 A ATOM 2320 O HIS A 303 17.415 −3.901 51.076 1.00 12.89 A ATOM 2321 N PRO A 304 18.033 −4.558 53.137 1.00 13.61 A ATOM 2322 CD PRO A 304 18.161 −4.439 54.602 1.00 14.16 A ATOM 2323 CA PRO A 304 18.808 −5.698 52.638 1.00 14.34 A ATOM 2324 CB PRO A 304 19.786 −5.950 53.774 1.00 14.36 A ATOM 2325 CG PRO A 304 18.916 −5.711 54.973 1.00 14.60 A ATOM 2326 C PRO A 304 17.956 −6.929 52.324 1.00 14.55 A ATOM 2327 O PRO A 304 18.096 −7.965 52.972 1.00 15.04 A ATOM 2328 N GLY A 305 17.077 −6.809 51.331 1.00 14.61 A ATOM 2329 CA GLY A 305 16.224 −7.925 50.966 1.00 14.76 A ATOM 2330 C GLY A 305 17.055 −9.156 50.666 1.00 15.27 A ATOM 2331 O GLY A 305 16.671 −10.275 51.006 1.00 15.14 A ATOM 2332 N GLY A 306 18.199 −8.938 50.027 1.00 15.34 A ATOM 2333 CA GLY A 306 19.102 −10.025 49.678 1.00 16.49 A ATOM 2334 C GLY A 306 20.457 −9.455 49.307 1.00 16.93 A ATOM 2335 O GLY A 306 20.564 −8.249 49.082 1.00 17.30 A ATOM 2336 N PRO A 307 21.515 −10.278 49.228 1.00 17.46 A ATOM 2337 CD PRO A 307 21.579 −11.730 49.472 1.00 18.01 A ATOM 2338 CA PRO A 307 22.836 −9.748 48.874 1.00 18.03 A ATOM 2339 CB PRO A 307 23.761 −10.938 49.126 1.00 18.12 A ATOM 2340 CG PRO A 307 22.891 −12.109 48.814 1.00 18.51 A ATOM 2341 C PRO A 307 22.949 −9.212 47.444 1.00 18.05 A ATOM 2342 O PRO A 307 23.710 −8.272 47.184 1.00 17.85 A ATOM 2343 N ALA A 308 22.191 −9.803 46.524 1.00 17.71 A ATOM 2344 CA ALA A 308 22.224 −9.383 45.126 1.00 18.01 A ATOM 2345 CB ALA A 308 21.413 −10.347 44.269 1.00 18.21 A ATOM 2346 C ALA A 308 21.715 −7.956 44.926 1.00 18.23 A ATOM 2347 O ALA A 308 22.236 −7.219 44.085 1.00 18.16 A ATOM 2348 N ILE A 309 20.691 −7.569 45.681 1.00 17.84 A ATOM 2349 CA ILE A 309 20.155 −6.217 45.561 1.00 17.99 A ATOM 2350 CB ILE A 309 18.928 −6.011 46.480 1.00 18.26 A ATOM 2351 CG2 ILE A 309 18.527 −4.541 46.488 1.00 18.23 A ATOM 2352 CG1 ILE A 309 17.771 −6.893 45.999 1.00 18.73 A ATOM 2353 CD1 ILE A 309 16.508 −6.785 46.833 1.00 19.58 A ATOM 2354 C ILE A 309 21.238 −5.204 45.925 1.00 17.80 A ATOM 2355 O ILE A 309 21.412 −4.191 45.243 1.00 17.95 A ATOM 2356 N LEU A 310 21.978 −5.488 46.992 1.00 17.66 A ATOM 2357 CA LEU A 310 23.051 −4.600 47.428 1.00 17.75 A ATOM 2358 CB LEU A 310 23.611 −5.070 48.774 1.00 17.50 A ATOM 2359 CG LEU A 310 22.609 −5.217 49.926 1.00 17.03 A ATOM 2360 CD1 LEU A 310 23.348 −5.610 51.199 1.00 16.69 A ATOM 2361 CD2 LEU A 310 21.863 −3.908 50.138 1.00 17.12 A ATOM 2362 C LEU A 310 24.182 −4.513 46.392 1.00 18.34 A ATOM 2363 O LEU A 310 24.685 −3.422 46.102 1.00 17.54 A ATOM 2364 N ASP A 311 24.578 −5.655 45.832 1.00 18.40 A ATOM 2365 CA ASP A 311 25.645 −5.673 44.829 1.00 19.39 A ATOM 2366 CB ASP A 311 25.973 −7.107 44.384 1.00 19.51 A ATOM 2367 CG ASP A 311 26.604 −7.945 45.483 1.00 20.61 A ATOM 2368 OD1 ASP A 311 27.210 −7.374 46.416 1.00 20.57 A ATOM 2369 OD2 ASP A 311 26.509 −9.189 45.395 1.00 21.12 A ATOM 2370 C ASP A 311 25.273 −4.860 43.588 1.00 19.57 A ATOM 2371 O ASP A 311 26.079 −4.072 43.090 1.00 19.38 A ATOM 2372 N GLN A 312 24.057 −5.059 43.086 1.00 20.06 A ATOM 2373 CA GLN A 312 23.604 −4.351 41.890 1.00 20.92 A ATOM 2374 CB GLN A 312 22.336 −5.011 41.331 1.00 21.67 A ATOM 2375 CG GLN A 312 22.644 −6.263 40.511 1.00 22.92 A ATOM 2376 CD GLN A 312 21.408 −6.980 40.001 1.00 23.83 A ATOM 2377 OE1 GLN A 312 20.503 −6.365 39.435 1.00 24.46 A ATOM 2378 NE2 GLN A 312 21.372 −8.297 40.187 1.00 24.27 A ATOM 2379 C GLN A 312 23.389 −2.856 42.106 1.00 21.43 A ATOM 2380 O GLN A 312 23.610 −2.054 41.193 1.00 21.12 A ATOM 2381 N VAL A 313 22.964 −2.472 43.304 1.00 21.36 A ATOM 2382 CA VAL A 313 22.772 −1.056 43.593 1.00 22.26 A ATOM 2383 CB VAL A 313 22.064 −0.847 44.958 1.00 21.61 A ATOM 2384 CG1 VAL A 313 22.126 0.618 45.368 1.00 21.70 A ATOM 2385 CG2 VAL A 313 20.610 −1.280 44.856 1.00 21.27 A ATOM 2386 C VAL A 313 24.152 −0.399 43.620 1.00 22.76 A ATOM 2387 O VAL A 313 24.365 0.652 43.016 1.00 22.83 A ATOM 2388 N GLU A 314 25.090 −1.044 44.306 1.00 23.89 A ATOM 2389 CA GLU A 314 26.452 −0.539 44.423 1.00 24.82 A ATOM 2390 CB GLU A 314 27.285 −1.490 45.290 1.00 26.33 A ATOM 2391 CG GLU A 314 28.633 −0.930 45.720 1.00 28.97 A ATOM 2392 CD GLU A 314 29.345 −1.809 46.737 1.00 30.11 A ATOM 2393 OE1 GLU A 314 28.730 −2.158 47.768 1.00 30.61 A ATOM 2394 OE2 GLU A 314 30.528 −2.141 46.511 1.00 31.99 A ATOM 2395 C GLU A 314 27.107 −0.370 43.046 1.00 25.07 A ATOM 2396 O GLU A 314 27.788 0.627 42.790 1.00 24.35 A ATOM 2397 N GLN A 315 26.893 −1.339 42.162 1.00 24.83 A ATOM 2398 CA GLN A 315 27.472 −1.280 40.823 1.00 25.91 A ATOM 2399 CB GLN A 315 27.421 −2.664 40.165 1.00 26.90 A ATOM 2400 CG GLN A 315 28.328 −3.678 40.846 1.00 29.10 A ATOM 2401 CD GLN A 315 28.375 −5.012 40.128 1.00 31.04 A ATOM 2402 OE1 GLN A 315 28.733 −5.083 38.949 1.00 32.27 A ATOM 2403 NE2 GLN A 315 28.019 −6.083 40.838 1.00 31.39 A ATOM 2404 C GLN A 315 26.787 −0.250 39.928 1.00 25.61 A ATOM 2405 O GLN A 315 27.448 0.453 39.166 1.00 25.64 A ATOM 2406 N LYS A 316 25.464 −0.161 40.030 1.00 25.14 A ATOM 2407 CA LYS A 316 24.683 0.781 39.232 1.00 25.04 A ATOM 2408 CB LYS A 316 23.187 0.591 39.524 1.00 26.09 A ATOM 2409 CG LYS A 316 22.251 1.622 38.882 1.00 26.89 A ATOM 2410 CD LYS A 316 21.711 1.164 37.528 1.00 27.90 A ATOM 2411 CE LYS A 316 22.772 1.182 36.447 1.00 28.93 A ATOM 2412 NZ LYS A 316 22.266 0.658 35.140 1.00 27.99 A ATOM 2413 C LYS A 316 25.069 2.238 39.489 1.00 24.49 A ATOM 2414 O LYS A 316 25.110 3.046 38.561 1.00 24.40 A ATOM 2415 N LEU A 317 25.361 2.571 40.744 1.00 23.79 A ATOM 2416 CA LEU A 317 25.712 3.941 41.112 1.00 23.24 A ATOM 2417 CB LEU A 317 24.917 4.344 42.356 1.00 23.11 A ATOM 2418 CG LEU A 317 23.407 4.110 42.247 1.00 22.79 A ATOM 2419 CD1 LEU A 317 22.780 4.131 43.631 1.00 22.84 A ATOM 2420 CD2 LEU A 317 22.786 5.164 41.335 1.00 22.52 A ATOM 2421 C LEU A 317 27.204 4.175 41.361 1.00 23.10 A ATOM 2422 O LEU A 317 27.602 5.265 41.773 1.00 23.32 A ATOM 2423 N ALA A 318 28.021 3.156 41.115 1.00 22.49 A ATOM 2424 CA ALA A 318 29.466 3.253 41.314 1.00 22.25 A ATOM 2425 CB ALA A 318 30.080 4.152 40.238 1.00 22.73 A ATOM 2426 C ALA A 318 29.823 3.781 42.705 1.00 22.10 A ATOM 2427 O ALA A 318 30.592 4.735 42.837 1.00 21.67 A ATOM 2428 N LEU A 319 29.271 3.148 43.738 1.00 21.00 A ATOM 2429 CA LEU A 319 29.519 3.546 45.122 1.00 20.63 A ATOM 2430 CB LEU A 319 28.350 3.104 46.010 1.00 20.00 A ATOM 2431 CG LEU A 319 26.936 3.586 45.666 1.00 19.28 A ATOM 2432 CD1 LEU A 319 25.935 2.999 46.661 1.00 19.38 A ATOM 2433 CD2 LEU A 319 26.888 5.099 45.699 1.00 18.96 A ATOM 2434 C LEU A 319 30.808 2.944 45.688 1.00 21.45 A ATOM 2435 O LEU A 319 31.163 1.814 45.366 1.00 20.80 A ATOM 2436 N LYS A 320 31.498 3.699 46.541 1.00 21.99 A ATOM 2437 CA LYS A 320 32.717 3.203 47.173 1.00 23.22 A ATOM 2438 CB LYS A 320 33.413 4.315 47.966 1.00 24.04 A ATOM 2439 CG LYS A 320 33.695 5.585 47.170 1.00 26.42 A ATOM 2440 CD LYS A 320 34.439 6.616 48.014 1.00 27.32 A ATOM 2441 CE LYS A 320 34.260 8.023 47.455 1.00 28.64 A ATOM 2442 NZ LYS A 320 34.606 8.111 46.002 1.00 29.29 A ATOM 2443 C LYS A 320 32.283 2.086 48.128 1.00 23.17 A ATOM 2444 O LYS A 320 31.162 2.097 48.634 1.00 23.14 A ATOM 2445 N PRO A 321 33.167 1.114 48.392 1.00 23.18 A ATOM 2446 CD PRO A 321 34.535 0.975 47.858 1.00 23.17 A ATOM 2447 CA PRO A 321 32.842 −0.001 49.291 1.00 23.00 A ATOM 2448 CB PRO A 321 34.174 −0.738 49.416 1.00 23.25 A ATOM 2449 CG PRO A 321 34.812 −0.495 48.077 1.00 23.67 A ATOM 2450 C PRO A 321 32.280 0.405 50.655 1.00 22.40 A ATOM 2451 O PRO A 321 31.373 −0.239 51.182 1.00 21.92 A ATOM 2452 N GLU A 322 32.813 1.482 51.214 1.00 22.04 A ATOM 2453 CA GLU A 322 32.391 1.954 52.528 1.00 21.71 A ATOM 2454 CB GLU A 322 33.316 3.088 52.988 1.00 23.36 A ATOM 2455 CG GLU A 322 34.795 2.845 52.720 1.00 26.98 A ATOM 2456 CD GLU A 322 35.132 2.879 51.241 1.00 28.13 A ATOM 2457 OE1 GLU A 322 34.883 3.918 50.596 1.00 30.06 A ATOM 2458 OE2 GLU A 322 35.640 1.867 50.720 1.00 30.37 A ATOM 2459 C GLU A 322 30.934 2.429 52.631 1.00 20.23 A ATOM 2460 O GLU A 322 30.368 2.439 53.720 1.00 19.87 A ATOM 2461 N LYS A 323 30.326 2.821 51.515 1.00 19.09 A ATOM 2462 CA LYS A 323 28.946 3.314 51.555 1.00 18.24 A ATOM 2463 CB LYS A 323 28.468 3.697 50.148 1.00 17.68 A ATOM 2464 CG LYS A 323 29.359 4.719 49.423 1.00 17.88 A ATOM 2465 CD LYS A 323 29.670 5.951 50.275 1.00 18.08 A ATOM 2466 CE LYS A 323 28.407 6.688 50.708 1.00 17.75 A ATOM 2467 NZ LYS A 323 28.711 7.892 51.538 1.00 18.08 A ATOM 2468 C LYS A 323 27.949 2.330 52.186 1.00 18.18 A ATOM 2469 O LYS A 323 27.091 2.727 52.980 1.00 17.44 A ATOM 2470 N MET A 324 28.072 1.050 51.843 1.00 17.79 A ATOM 2471 CA MET A 324 27.168 0.022 52.362 1.00 17.73 A ATOM 2472 CB MET A 324 26.926 −1.049 51.290 1.00 17.86 A ATOM 2473 CG MET A 324 26.067 −0.601 50.116 1.00 18.32 A ATOM 2474 SD MET A 324 24.323 −0.405 50.580 1.00 19.61 A ATOM 2475 CE MET A 324 23.587 0.034 48.988 1.00 18.17 A ATOM 2476 C MET A 324 27.619 −0.658 53.657 1.00 17.26 A ATOM 2477 O MET A 324 27.054 −1.685 54.044 1.00 17.39 A ATOM 2478 N ASN A 325 28.620 −0.099 54.332 1.00 17.04 A ATOM 2479 CA ASN A 325 29.105 −0.689 55.578 1.00 16.26 A ATOM 2480 CB ASN A 325 30.138 0.227 56.249 1.00 16.89 A ATOM 2481 CG ASN A 325 31.544 0.043 55.694 1.00 17.31 A ATOM 2482 OD1 ASN A 325 31.792 −0.825 54.856 1.00 17.48 A ATOM 2483 ND2 ASN A 325 32.475 0.865 56.170 1.00 16.86 A ATOM 2484 C ASN A 325 27.996 −1.000 56.592 1.00 15.84 A ATOM 2485 O ASN A 325 27.873 −2.134 57.061 1.00 15.57 A ATOM 2486 N ALA A 326 27.194 0.006 56.931 1.00 14.81 A ATOM 2487 CA ALA A 326 26.127 −0.162 57.918 1.00 14.14 A ATOM 2488 CB ALA A 326 25.499 1.199 58.243 1.00 14.41 A ATOM 2489 C ALA A 326 25.043 −1.152 57.501 1.00 14.35 A ATOM 2490 O ALA A 326 24.589 −1.967 58.313 1.00 14.78 A ATOM 2491 N THR A 327 24.635 −1.079 56.241 1.00 13.41 A ATOM 2492 CA THR A 327 23.605 −1.962 55.713 1.00 13.87 A ATOM 2493 CB THR A 327 23.242 −1.569 54.259 1.00 13.38 A ATOM 2494 OG1 THR A 327 22.655 −0.256 54.253 1.00 13.83 A ATOM 2495 CG2 THR A 327 22.253 −2.570 53.657 1.00 13.68 A ATOM 2496 C THR A 327 24.072 −3.421 55.753 1.00 14.01 A ATOM 2497 O THR A 327 23.371 −4.288 56.279 1.00 13.75 A ATOM 2498 N ARG A 328 25.259 −3.682 55.211 1.00 14.33 A ATOM 2499 CA ARG A 328 25.814 −5.040 55.182 1.00 14.77 A ATOM 2500 CB ARG A 328 27.082 −5.080 54.316 1.00 15.22 A ATOM 2501 CG ARG A 328 26.835 −4.886 52.812 1.00 16.37 A ATOM 2502 CD ARG A 328 28.148 −4.913 52.021 1.00 18.14 A ATOM 2503 NE ARG A 328 27.969 −4.631 50.597 1.00 19.53 A ATOM 2504 CZ ARG A 328 27.457 −5.483 49.715 1.00 20.66 A ATOM 2505 NH1 ARG A 328 27.064 −6.689 50.102 1.00 22.08 A ATOM 2506 NH2 ARG A 328 27.345 −5.136 48.439 1.00 21.33 A ATOM 2507 C ARG A 328 26.116 −5.620 56.573 1.00 15.06 A ATOM 2508 O ARG A 328 26.114 −6.836 56.748 1.00 15.82 A ATOM 2509 N GLU A 329 26.381 −4.762 57.555 1.00 14.77 A ATOM 2510 CA GLU A 329 26.651 −5.229 58.918 1.00 14.81 A ATOM 2511 CB GLU A 329 27.125 −4.067 59.799 1.00 15.33 A ATOM 2512 CG GLU A 329 27.244 −4.379 61.293 1.00 17.33 A ATOM 2513 CD GLU A 329 28.431 −5.268 61.645 1.00 18.89 A ATOM 2514 OE1 GLU A 329 29.282 −5.523 60.764 1.00 18.54 A ATOM 2515 OE2 GLU A 329 28.519 −5.702 62.818 1.00 20.32 A ATOM 2516 C GLU A 329 25.378 −5.840 59.509 1.00 14.36 A ATOM 2517 O GLU A 329 25.425 −6.885 60.163 1.00 13.91 A ATOM 2518 N VAL A 330 24.243 −5.185 59.278 1.00 13.59 A ATOM 2519 CA VAL A 330 22.965 −5.676 59.785 1.00 14.02 A ATOM 2520 CB VAL A 330 21.856 −4.604 59.629 1.00 13.99 A ATOM 2521 CG1 VAL A 330 20.484 −5.196 59.968 1.00 13.58 A ATOM 2522 CG2 VAL A 330 22.157 −3.425 60.556 1.00 14.00 A ATOM 2523 C VAL A 330 22.549 −6.968 59.077 1.00 14.02 A ATOM 2524 O VAL A 330 22.062 −7.899 59.721 1.00 13.94 A ATOM 2525 N LEU A 331 22.738 −7.029 57.759 1.00 13.64 A ATOM 2526 CA LEU A 331 22.399 −8.237 57.005 1.00 13.71 A ATOM 2527 CB LEU A 331 22.655 −8.037 55.502 1.00 14.19 A ATOM 2528 CG LEU A 331 22.547 −9.303 54.637 1.00 13.98 A ATOM 2529 CD1 LEU A 331 21.135 −9.876 54.726 1.00 13.96 A ATOM 2530 CD2 LEU A 331 22.894 −8.988 53.189 1.00 14.69 A ATOM 2531 C LEU A 331 23.262 −9.397 57.501 1.00 14.26 A ATOM 2532 O LEU A 331 22.792 −10.527 57.647 1.00 13.37 A ATOM 2533 N SER A 332 24.531 −9.099 57.760 1.00 15.11 A ATOM 2534 CA SER A 332 25.485 −10.097 58.225 1.00 16.35 A ATOM 2535 CB SER A 332 26.903 −9.509 58.174 1.00 17.12 A ATOM 2536 OG SER A 332 27.870 −10.444 58.619 1.00 19.44 A ATOM 2537 C SER A 332 25.180 −10.602 59.638 1.00 16.20 A ATOM 2538 O SER A 332 25.254 −11.799 59.902 1.00 16.47 A ATOM 2539 N GLU A 333 24.821 −9.689 60.536 1.00 15.96 A ATOM 2540 CA GLU A 333 24.537 −10.040 61.929 1.00 15.99 A ATOM 2541 CB GLU A 333 24.922 −8.872 62.848 1.00 17.32 A ATOM 2542 CG GLU A 333 26.411 −8.541 62.897 1.00 20.64 A ATOM 2543 CD GLU A 333 27.242 −9.659 63.496 1.00 22.34 A ATOM 2544 OE1 GLU A 333 26.931 −10.096 64.625 1.00 23.49 A ATOM 2545 OE2 GLU A 333 28.211 −10.096 62.843 1.00 23.53 A ATOM 2546 C GLU A 333 23.105 −10.454 62.279 1.00 14.90 A ATOM 2547 O GLU A 333 22.887 −11.062 63.328 1.00 14.01 A ATOM 2548 N TYR A 334 22.135 −10.144 61.421 1.00 13.81 A ATOM 2549 CA TYR A 334 20.735 −10.455 61.740 1.00 13.26 A ATOM 2550 CB TYR A 334 20.031 −9.174 62.216 1.00 13.56 A ATOM 2551 CG TYR A 334 20.683 −8.494 63.398 1.00 14.44 A ATOM 2552 CD1 TYR A 334 20.558 −9.018 64.686 1.00 15.41 A ATOM 2553 CE1 TYR A 334 21.191 −8.413 65.774 1.00 16.14 A ATOM 2554 CD2 TYR A 334 21.455 −7.342 63.225 1.00 14.72 A ATOM 2555 CE2 TYR A 334 22.088 −6.729 64.303 1.00 15.69 A ATOM 2556 CZ TYR A 334 21.954 −7.270 65.572 1.00 16.75 A ATOM 2557 OH TYR A 334 22.584 −6.668 66.639 1.00 17.76 A ATOM 2558 C TYR A 334 19.878 −11.071 60.631 1.00 12.57 A ATOM 2559 O TYR A 334 18.802 −11.600 60.907 1.00 12.41 A ATOM 2560 N GLY A 335 20.333 −10.993 59.387 1.00 12.22 A ATOM 2561 CA GLY A 335 19.537 −11.522 58.287 1.00 11.80 A ATOM 2562 C GLY A 335 18.447 −10.524 57.912 1.00 11.96 A ATOM 2563 O GLY A 335 18.430 −9.404 58.429 1.00 11.44 A ATOM 2564 N ASN A 336 17.535 −10.928 57.028 1.00 11.66 A ATOM 2565 CA ASN A 336 16.433 −10.071 56.577 1.00 11.70 A ATOM 2566 CB ASN A 336 15.957 −10.540 55.189 1.00 11.42 A ATOM 2567 CG ASN A 336 14.806 −9.710 54.638 1.00 12.51 A ATOM 2568 OD1 ASN A 336 14.090 −9.039 55.382 1.00 13.12 A ATOM 2569 ND2 ASN A 336 14.610 −9.770 53.318 1.00 12.55 A ATOM 2570 C ASN A 336 15.272 −10.144 57.573 1.00 11.85 A ATOM 2571 O ASN A 336 14.529 −11.132 57.589 1.00 11.61 A ATOM 2572 N MET A 337 15.125 −9.103 58.396 1.00 11.75 A ATOM 2573 CA MET A 337 14.066 −9.023 59.406 1.00 11.30 A ATOM 2574 CB MET A 337 14.616 −8.402 60.702 1.00 11.74 A ATOM 2575 CG MET A 337 15.776 −9.162 61.347 1.00 11.23 A ATOM 2576 SD MET A 337 16.500 −8.267 62.775 1.00 12.05 A ATOM 2577 CE MET A 337 17.454 −7.023 61.918 1.00 10.68 A ATOM 2578 C MET A 337 12.872 −8.185 58.912 1.00 11.73 A ATOM 2579 O MET A 337 12.185 −7.521 59.705 1.00 11.01 A ATOM 2580 N SER A 338 12.636 −8.220 57.606 1.00 10.58 A ATOM 2581 CA SER A 338 11.540 −7.480 56.987 1.00 11.13 A ATOM 2582 CB SER A 338 10.194 −8.129 57.344 1.00 11.47 A ATOM 2583 OG SER A 338 9.133 −7.611 56.541 1.00 11.75 A ATOM 2584 C SER A 338 11.539 −5.995 57.365 1.00 10.94 A ATOM 2585 O SER A 338 12.580 −5.341 57.318 1.00 10.10 A ATOM 2586 N SER A 339 10.380 −5.466 57.753 1.00 10.98 A ATOM 2587 CA SER A 339 10.266 −4.044 58.084 1.00 10.99 A ATOM 2588 CB SER A 339 8.838 −3.709 58.543 1.00 11.08 A ATOM 2589 OG SER A 339 8.561 −4.237 59.829 1.00 10.91 A ATOM 2590 C SER A 339 11.259 −3.494 59.107 1.00 10.72 A ATOM 2591 O SER A 339 11.591 −2.311 59.059 1.00 10.36 A ATOM 2592 N ALA A 340 11.743 −4.338 60.015 1.00 10.25 A ATOM 2593 CA ALA A 340 12.678 −3.877 61.048 1.00 10.47 A ATOM 2594 CB ALA A 340 12.734 −4.900 62.192 1.00 10.31 A ATOM 2595 C ALA A 340 14.102 −3.553 60.584 1.00 10.95 A ATOM 2596 O ALA A 340 14.793 −2.763 61.230 1.00 10.69 A ATOM 2597 N CYS A 341 14.542 −4.153 59.480 1.00 11.51 A ATOM 2598 CA CYS A 341 15.907 −3.939 58.978 1.00 12.12 A ATOM 2599 CB CYS A 341 16.080 −4.551 57.582 1.00 13.41 A ATOM 2600 SG CYS A 341 16.004 −6.345 57.497 1.00 15.80 A ATOM 2601 C CYS A 341 16.407 −2.501 58.911 1.00 11.76 A ATOM 2602 O CYS A 341 17.434 −2.167 59.511 1.00 11.11 A ATOM 2603 N VAL A 342 15.704 −1.653 58.165 1.00 11.06 A ATOM 2604 CA VAL A 342 16.152 −0.274 58.010 1.00 11.17 A ATOM 2605 CB VAL A 342 15.254 0.506 57.021 1.00 10.53 A ATOM 2606 CG1 VAL A 342 15.371 −0.118 55.637 1.00 10.75 A ATOM 2607 CG2 VAL A 342 13.812 0.501 57.493 1.00 10.96 A ATOM 2608 C VAL A 342 16.266 0.487 59.321 1.00 10.94 A ATOM 2609 O VAL A 342 17.048 1.436 59.423 1.00 11.24 A ATOM 2610 N LEU A 343 15.501 0.073 60.328 1.00 10.28 A ATOM 2611 CA LEU A 343 15.576 0.736 61.623 1.00 9.58 A ATOM 2612 CB LEU A 343 14.298 0.479 62.435 1.00 9.47 A ATOM 2613 CG LEU A 343 13.005 0.940 61.735 1.00 9.16 A ATOM 2614 CD1 LEU A 343 11.828 0.841 62.708 1.00 9.75 A ATOM 2615 CD2 LEU A 343 13.160 2.381 61.236 1.00 10.29 A ATOM 2616 C LEU A 343 16.832 0.261 62.374 1.00 9.66 A ATOM 2617 O LEU A 343 17.470 1.051 63.073 1.00 9.55 A ATOM 2618 N PHE A 344 17.197 −1.014 62.223 1.00 10.11 A ATOM 2619 CA PHE A 344 18.417 −1.525 62.858 1.00 10.35 A ATOM 2620 CB PHE A 344 18.593 −3.040 62.626 1.00 10.60 A ATOM 2621 CG PHE A 344 17.946 −3.924 63.674 1.00 11.60 A ATOM 2622 CD1 PHE A 344 16.560 −4.063 63.743 1.00 11.33 A ATOM 2623 CD2 PHE A 344 18.737 −4.673 64.551 1.00 12.06 A ATOM 2624 CE1 PHE A 344 15.970 −4.939 64.664 1.00 12.07 A ATOM 2625 CE2 PHE A 344 18.162 −5.551 65.477 1.00 12.12 A ATOM 2626 CZ PHE A 344 16.773 −5.686 65.533 1.00 12.33 A ATOM 2627 C PHE A 344 19.605 −0.804 62.204 1.00 10.33 A ATOM 2628 O PHE A 344 20.588 −0.460 62.870 1.00 9.78 A ATOM 2629 N ILE A 345 19.514 −0.574 60.895 1.00 9.91 A ATOM 2630 CA ILE A 345 20.598 0.092 60.168 1.00 10.19 A ATOM 2631 CB ILE A 345 20.360 0.029 58.632 1.00 9.96 A ATOM 2632 CG2 ILE A 345 21.463 0.791 57.893 1.00 9.91 A ATOM 2633 CG1 ILE A 345 20.345 −1.438 58.180 1.00 10.15 A ATOM 2634 CD1 ILE A 345 19.967 −1.653 56.722 1.00 9.55 A ATOM 2635 C ILE A 345 20.798 1.539 60.624 1.00 10.60 A ATOM 2636 O ILE A 345 21.938 2.006 60.728 1.00 11.29 A ATOM 2637 N LEU A 346 19.706 2.254 60.889 1.00 10.89 A ATOM 2638 CA LEU A 346 19.809 3.633 61.375 1.00 11.20 A ATOM 2639 CB LEU A 346 18.414 4.251 61.580 1.00 10.69 A ATOM 2640 CG LEU A 346 17.624 4.627 60.321 1.00 10.61 A ATOM 2641 CD1 LEU A 346 16.187 4.996 60.695 1.00 11.25 A ATOM 2642 CD2 LEU A 346 18.313 5.790 59.617 1.00 11.23 A ATOM 2643 C LEU A 346 20.561 3.627 62.707 1.00 11.84 A ATOM 2644 O LEU A 346 21.406 4.492 62.965 1.00 12.64 A ATOM 2645 N ASP A 347 20.258 2.644 63.550 1.00 12.06 A ATOM 2646 CA ASP A 347 20.908 2.537 64.857 1.00 13.39 A ATOM 2647 CB ASP A 347 20.217 1.450 65.690 1.00 13.78 A ATOM 2648 CG ASP A 347 20.591 1.508 67.163 1.00 15.67 A ATOM 2649 OD1 ASP A 347 20.710 2.629 67.706 1.00 14.75 A ATOM 2650 OD2 ASP A 347 20.746 0.432 67.783 1.00 15.69 A ATOM 2651 C ASP A 347 22.408 2.245 64.710 1.00 13.67 A ATOM 2652 O ASP A 347 23.239 2.873 65.367 1.00 13.64 A ATOM 2653 N GLU A 348 22.751 1.301 63.838 1.00 14.56 A ATOM 2654 CA GLU A 348 24.147 0.938 63.592 1.00 15.36 A ATOM 2655 CB GLU A 348 24.215 −0.210 62.579 1.00 16.27 A ATOM 2656 CG GLU A 348 25.617 −0.592 62.092 1.00 17.76 A ATOM 2657 CD GLU A 348 26.541 −1.082 63.200 1.00 18.78 A ATOM 2658 OE1 GLU A 348 26.047 −1.562 64.242 1.00 19.58 A ATOM 2659 OE2 GLU A 348 27.773 −1.002 63.019 1.00 19.89 A ATOM 2660 C GLU A 348 24.946 2.134 63.071 1.00 15.06 A ATOM 2661 O GLU A 348 26.049 2.405 63.541 1.00 14.81 A ATOM 2662 N MET A 349 24.388 2.853 62.104 1.00 14.78 A ATOM 2663 CA MET A 349 25.079 4.008 61.540 1.00 15.19 A ATOM 2664 CB MET A 349 24.265 4.625 60.401 1.00 15.22 A ATOM 2665 CG MET A 349 24.931 5.857 59.811 1.00 17.23 A ATOM 2666 SD MET A 349 24.032 6.538 58.421 1.00 18.52 A ATOM 2667 CE MET A 349 24.320 5.238 57.186 1.00 16.39 A ATOM 2668 C MET A 349 25.390 5.100 62.563 1.00 14.73 A ATOM 2669 O MET A 349 26.503 5.624 62.599 1.00 14.30 A ATOM 2670 N ARG A 350 24.409 5.453 63.384 1.00 14.34 A ATOM 2671 CA ARG A 350 24.615 6.498 64.379 1.00 15.08 A ATOM 2672 CB ARG A 350 23.272 6.950 64.962 1.00 14.45 A ATOM 2673 CG ARG A 350 22.518 5.897 65.756 1.00 14.44 A ATOM 2674 CD ARG A 350 22.510 6.236 67.247 1.00 14.54 A ATOM 2675 NE ARG A 350 21.567 5.396 67.984 1.00 14.41 A ATOM 2676 CZ ARG A 350 21.013 5.735 69.144 1.00 14.88 A ATOM 2677 NH1 ARG A 350 21.308 6.902 69.701 1.00 14.87 A ATOM 2678 NH2 ARG A 350 20.159 4.912 69.745 1.00 14.52 A ATOM 2679 C ARG A 350 25.571 6.066 65.492 1.00 15.83 A ATOM 2680 O ARG A 350 26.360 6.873 65.987 1.00 15.01 A ATOM 2681 N LYS A 351 25.514 4.795 65.880 1.00 16.14 A ATOM 2682 CA LYS A 351 26.411 4.305 66.921 1.00 17.27 A ATOM 2683 CB LYS A 351 25.988 2.909 67.382 1.00 18.64 A ATOM 2684 CG LYS A 351 24.844 2.916 68.386 1.00 20.60 A ATOM 2685 CD LYS A 351 24.438 1.494 68.767 1.00 22.37 A ATOM 2686 CE LYS A 351 23.636 1.480 70.061 1.00 23.69 A ATOM 2687 NZ LYS A 351 22.393 2.293 69.986 1.00 24.80 A ATOM 2688 C LYS A 351 27.860 4.286 66.430 1.00 17.14 A ATOM 2689 O LYS A 351 28.771 4.696 67.152 1.00 16.83 A ATOM 2690 N LYS A 352 28.073 3.817 65.203 1.00 16.98 A ATOM 2691 CA LYS A 352 29.419 3.767 64.627 1.00 17.64 A ATOM 2692 CB LYS A 352 29.416 2.966 63.323 1.00 18.76 A ATOM 2693 CG LYS A 352 29.490 1.470 63.526 1.00 21.91 A ATOM 2694 CD LYS A 352 30.857 1.068 64.077 1.00 23.41 A ATOM 2695 CE LYS A 352 30.896 −0.405 64.432 1.00 24.84 A ATOM 2696 NZ LYS A 352 29.886 −0.731 65.483 1.00 26.79 A ATOM 2697 C LYS A 352 29.995 5.156 64.363 1.00 17.19 A ATOM 2698 O LYS A 352 31.204 5.369 64.500 1.00 16.04 A ATOM 2699 N SER A 353 29.138 6.094 63.970 1.00 16.74 A ATOM 2700 CA SER A 353 29.583 7.460 63.710 1.00 17.39 A ATOM 2701 CB SER A 353 28.435 8.297 63.138 1.00 17.32 A ATOM 2702 OG SER A 353 28.067 7.843 61.848 1.00 16.97 A ATOM 2703 C SER A 353 30.073 8.088 65.012 1.00 18.27 A ATOM 2704 O SER A 353 31.043 8.850 65.025 1.00 18.81 A ATOM 2705 N THR A 354 29.391 7.768 66.106 1.00 18.39 A ATOM 2706 CA THR A 354 29.749 8.290 67.420 1.00 19.76 A ATOM 2707 CB THR A 354 28.618 8.011 68.435 1.00 20.00 A ATOM 2708 OG1 THR A 354 27.443 8.729 68.043 1.00 20.37 A ATOM 2709 CG2 THR A 354 29.027 8.435 69.839 1.00 20.74 A ATOM 2710 C THR A 354 31.036 7.618 67.899 1.00 20.00 A ATOM 2711 O THR A 354 31.959 8.272 68.399 1.00 19.48 A ATOM 2712 N GLN A 355 31.080 6.303 67.730 1.00 20.15 A ATOM 2713 CA GLN A 355 32.222 5.493 68.128 1.00 21.65 A ATOM 2714 CB GLN A 355 31.913 4.019 67.837 1.00 22.91 A ATOM 2715 CG GLN A 355 33.095 3.066 67.958 1.00 25.78 A ATOM 2716 CD GLN A 355 32.778 1.685 67.405 1.00 27.34 A ATOM 2717 OE1 GLN A 355 31.862 1.009 67.874 1.00 29.12 A ATOM 2718 NE2 GLN A 355 33.532 1.264 66.398 1.00 28.38 A ATOM 2719 C GLN A 355 33.530 5.889 67.432 1.00 21.31 A ATOM 2720 O GLN A 355 34.562 6.071 68.086 1.00 21.87 A ATOM 2721 N ASN A 356 33.488 6.027 66.111 1.00 20.41 A ATOM 2722 CA ASN A 356 34.692 6.352 65.356 1.00 20.53 A ATOM 2723 CB ASN A 356 34.655 5.657 63.992 1.00 21.37 A ATOM 2724 CG ASN A 356 34.710 4.143 64.116 1.00 22.05 A ATOM 2725 OD1 ASN A 356 35.340 3.608 65.029 1.00 22.39 A ATOM 2726 ND2 ASN A 356 34.060 3.447 63.193 1.00 23.15 A ATOM 2727 C ASN A 356 35.027 7.829 65.182 1.00 19.88 A ATOM 2728 O ASN A 356 35.927 8.179 64.413 1.00 19.58 A ATOM 2729 N GLY A 357 34.301 8.687 65.894 1.00 19.15 A ATOM 2730 CA GLY A 357 34.563 10.117 65.848 1.00 18.39 A ATOM 2731 C GLY A 357 34.155 10.930 64.634 1.00 18.00 A ATOM 2732 O GLY A 357 34.839 11.896 64.289 1.00 17.19 A ATOM 2733 N LEU A 358 33.056 10.564 63.982 1.00 17.83 A ATOM 2734 CA LEU A 358 32.599 11.325 62.819 1.00 18.37 A ATOM 2735 CB LEU A 358 31.641 10.487 61.960 1.00 18.29 A ATOM 2736 CG LEU A 358 32.261 9.431 61.033 1.00 18.70 A ATOM 2737 CD1 LEU A 358 33.183 10.113 60.032 1.00 18.64 A ATOM 2738 CD2 LEU A 358 33.028 8.392 61.841 1.00 18.14 A ATOM 2739 C LEU A 358 31.905 12.589 63.329 1.00 18.28 A ATOM 2740 O LEU A 358 31.430 12.621 64.465 1.00 19.60 A ATOM 2741 N LYS A 359 31.847 13.625 62.497 1.00 18.13 A ATOM 2742 CA LYS A 359 31.245 14.894 62.902 1.00 18.17 A ATOM 2743 CB LYS A 359 31.862 16.033 62.085 1.00 19.78 A ATOM 2744 CG LYS A 359 33.378 16.146 62.242 1.00 22.00 A ATOM 2745 CD LYS A 359 33.773 16.502 63.672 1.00 24.21 A ATOM 2746 CE LYS A 359 33.331 17.915 64.027 1.00 26.14 A ATOM 2747 NZ LYS A 359 33.637 18.270 65.443 1.00 27.55 A ATOM 2748 C LYS A 359 29.713 14.990 62.861 1.00 17.59 A ATOM 2749 O LYS A 359 29.147 15.972 63.337 1.00 17.60 A ATOM 2750 N THR A 360 29.046 13.992 62.286 1.00 16.40 A ATOM 2751 CA THR A 360 27.577 13.975 62.247 1.00 15.45 A ATOM 2752 CB THR A 360 26.992 14.499 60.911 1.00 15.82 A ATOM 2753 OG1 THR A 360 27.231 13.539 59.877 1.00 15.65 A ATOM 2754 CG2 THR A 360 27.613 15.840 60.524 1.00 16.52 A ATOM 2755 C THR A 360 27.116 12.532 62.413 1.00 14.68 A ATOM 2756 O THR A 360 27.897 11.598 62.215 1.00 14.27 A ATOM 2757 N THR A 361 25.852 12.348 62.777 1.00 13.61 A ATOM 2758 CA THR A 361 25.307 11.008 62.965 1.00 13.33 A ATOM 2759 CB THR A 361 23.919 11.066 63.629 1.00 13.09 A ATOM 2760 OG1 THR A 361 23.093 11.988 62.915 1.00 12.47 A ATOM 2761 CG2 THR A 361 24.043 11.529 65.081 1.00 13.05 A ATOM 2762 C THR A 361 25.194 10.256 61.645 1.00 13.18 A ATOM 2763 O THR A 361 24.936 9.050 61.633 1.00 13.52 A ATOM 2764 N GLY A 362 25.394 10.973 60.542 1.00 13.05 A ATOM 2765 CA GLY A 362 25.325 10.368 59.222 1.00 13.54 A ATOM 2766 C GLY A 362 26.693 10.220 58.572 1.00 13.80 A ATOM 2767 O GLY A 362 26.921 10.676 57.447 1.00 13.72 A ATOM 2768 N GLU A 363 27.606 9.578 59.292 1.00 14.30 A ATOM 2769 CA GLU A 363 28.969 9.342 58.823 1.00 14.87 A ATOM 2770 CB GLU A 363 28.951 8.326 57.672 1.00 15.38 A ATOM 2771 CG GLU A 363 28.092 7.101 58.010 1.00 16.94 A ATOM 2772 CD GLU A 363 28.216 5.954 57.023 1.00 17.95 A ATOM 2773 OE1 GLU A 363 28.357 6.202 55.808 1.00 18.60 A ATOM 2774 OE2 GLU A 363 28.144 4.789 57.472 1.00 19.19 A ATOM 2775 C GLU A 363 29.682 10.634 58.414 1.00 15.17 A ATOM 2776 O GLU A 363 30.481 10.655 57.475 1.00 14.88 A ATOM 2777 N GLY A 364 29.388 11.711 59.136 1.00 15.36 A ATOM 2778 CA GLY A 364 30.023 12.986 58.851 1.00 16.19 A ATOM 2779 C GLY A 364 29.429 13.764 57.693 1.00 16.44 A ATOM 2780 O GLY A 364 29.856 14.884 57.418 1.00 16.69 A ATOM 2781 N LEU A 365 28.445 13.184 57.012 1.00 16.46 A ATOM 2782 CA LEU A 365 27.813 13.853 55.880 1.00 16.91 A ATOM 2783 CB LEU A 365 27.494 12.831 54.786 1.00 16.94 A ATOM 2784 CG LEU A 365 28.696 11.997 54.320 1.00 17.07 A ATOM 2785 CD1 LEU A 365 28.228 10.876 53.405 1.00 17.97 A ATOM 2786 CD2 LEU A 365 29.703 12.889 53.610 1.00 16.75 A ATOM 2787 C LEU A 365 26.544 14.587 56.323 1.00 16.99 A ATOM 2788 O LEU A 365 26.039 14.354 57.421 1.00 17.16 A ATOM 2789 N GLU A 366 26.034 15.469 55.467 1.00 16.87 A ATOM 2790 CA GLU A 366 24.838 16.252 55.787 1.00 17.25 A ATOM 2791 CB GLU A 366 24.941 17.644 55.144 1.00 19.11 A ATOM 2792 CG GLU A 366 23.629 18.432 55.109 1.00 21.19 A ATOM 2793 CD GLU A 366 23.828 19.896 54.758 1.00 22.96 A ATOM 2794 OE1 GLU A 366 24.687 20.198 53.905 1.00 23.65 A ATOM 2795 OE2 GLU A 366 23.111 20.748 55.328 1.00 24.80 A ATOM 2796 C GLU A 366 23.499 15.611 55.410 1.00 16.91 A ATOM 2797 O GLU A 366 22.589 15.540 56.244 1.00 16.56 A ATOM 2798 N TRP A 367 23.374 15.153 54.168 1.00 15.76 A ATOM 2799 CA TRP A 367 22.127 14.535 53.703 1.00 15.43 A ATOM 2800 CB TRP A 367 21.699 15.136 52.358 1.00 15.92 A ATOM 2801 CG TRP A 367 21.584 16.640 52.362 1.00 17.29 A ATOM 2802 CD2 TRP A 367 20.521 17.420 52.924 1.00 17.28 A ATOM 2803 CE2 TRP A 367 20.843 18.781 52.714 1.00 17.73 A ATOM 2804 CE3 TRP A 367 19.327 17.101 53.587 1.00 17.91 A ATOM 2805 CD1 TRP A 367 22.483 17.535 51.848 1.00 17.11 A ATOM 2806 NE1 TRP A 367 22.043 18.823 52.054 1.00 17.26 A ATOM 2807 CZ2 TRP A 367 20.014 19.823 53.142 1.00 18.10 A ATOM 2808 CZ3 TRP A 367 18.500 18.139 54.014 1.00 17.80 A ATOM 2809 CH2 TRP A 367 18.849 19.483 53.789 1.00 18.48 A ATOM 2810 C TRP A 367 22.243 13.021 53.551 1.00 14.85 A ATOM 2811 O TRP A 367 23.335 12.493 53.340 1.00 14.03 A ATOM 2812 N GLY A 368 21.105 12.333 53.643 1.00 13.90 A ATOM 2813 CA GLY A 368 21.093 10.883 53.510 1.00 13.64 A ATOM 2814 C GLY A 368 19.786 10.357 52.939 1.00 12.46 A ATOM 2815 O GLY A 368 18.826 11.110 52.773 1.00 13.28 A ATOM 2816 N VAL A 369 19.739 9.064 52.633 1.00 12.00 A ATOM 2817 CA VAL A 369 18.530 8.470 52.077 1.00 11.30 A ATOM 2818 CB VAL A 369 18.634 8.356 50.533 1.00 11.23 A ATOM 2819 CG1 VAL A 369 19.762 7.405 50.155 1.00 10.95 A ATOM 2820 CG2 VAL A 369 17.316 7.871 49.952 1.00 11.34 A ATOM 2821 C VAL A 369 18.265 7.083 52.656 1.00 11.73 A ATOM 2822 O VAL A 369 19.198 6.334 52.936 1.00 11.94 A ATOM 2823 N LEU A 370 16.989 6.759 52.848 1.00 11.77 A ATOM 2824 CA LEU A 370 16.580 5.456 53.371 1.00 11.76 A ATOM 2825 CB LEU A 370 15.911 5.606 54.749 1.00 11.28 A ATOM 2826 CG LEU A 370 15.397 4.333 55.445 1.00 11.66 A ATOM 2827 CD1 LEU A 370 15.368 4.547 56.960 1.00 11.65 A ATOM 2828 CD2 LEU A 370 14.015 3.962 54.918 1.00 12.29 A ATOM 2829 C LEU A 370 15.595 4.857 52.376 1.00 11.86 A ATOM 2830 O LEU A 370 14.646 5.527 51.971 1.00 11.90 A ATOM 2831 N PHE A 371 15.828 3.604 51.984 1.00 11.79 A ATOM 2832 CA PHE A 371 14.968 2.912 51.027 1.00 11.80 A ATOM 2833 CB PHE A 371 15.755 2.528 49.761 1.00 12.26 A ATOM 2834 CG PHE A 371 16.049 3.680 48.835 1.00 13.18 A ATOM 2835 CD1 PHE A 371 15.017 4.364 48.199 1.00 13.53 A ATOM 2836 CD2 PHE A 371 17.364 4.053 48.569 1.00 13.39 A ATOM 2837 CE1 PHE A 371 15.291 5.401 47.309 1.00 14.13 A ATOM 2838 CE2 PHE A 371 17.650 5.090 47.680 1.00 14.61 A ATOM 2839 CZ PHE A 371 16.612 5.765 47.049 1.00 14.39 A ATOM 2840 C PHE A 371 14.350 1.633 51.580 1.00 11.83 A ATOM 2841 O PHE A 371 15.024 0.837 52.242 1.00 11.89 A ATOM 2842 N GLY A 372 13.069 1.442 51.278 1.00 11.66 A ATOM 2843 CA GLY A 372 12.357 0.238 51.677 1.00 11.23 A ATOM 2844 C GLY A 372 11.875 −0.413 50.386 1.00 12.03 A ATOM 2845 O GLY A 372 11.381 0.290 49.504 1.00 11.11 A ATOM 2846 N PHE A 373 12.034 −1.732 50.254 1.00 12.31 A ATOM 2847 CA PHE A 373 11.604 −2.446 49.043 1.00 12.91 A ATOM 2848 CB PHE A 373 12.815 −3.026 48.281 1.00 13.68 A ATOM 2849 CG PHE A 373 13.966 −2.063 48.107 1.00 14.91 A ATOM 2850 CD1 PHE A 373 13.784 −0.832 47.485 1.00 15.93 A ATOM 2851 CD2 PHE A 373 15.245 −2.406 48.547 1.00 15.06 A ATOM 2852 CE1 PHE A 373 14.859 0.046 47.303 1.00 16.22 A ATOM 2853 CE2 PHE A 373 16.327 −1.538 48.372 1.00 15.66 A ATOM 2854 CZ PHE A 373 16.133 −0.309 47.749 1.00 15.82 A ATOM 2855 C PHE A 373 10.698 −3.609 49.450 1.00 12.82 A ATOM 2856 O PHE A 373 10.962 −4.269 50.455 1.00 11.69 A ATOM 2857 N GLY A 374 9.650 −3.879 48.672 1.00 13.46 A ATOM 2858 CA GLY A 374 8.756 −4.979 49.019 1.00 14.44 A ATOM 2859 C GLY A 374 7.629 −5.288 48.041 1.00 15.41 A ATOM 2860 O GLY A 374 7.630 −4.787 46.916 1.00 15.04 A ATOM 2861 N PRO A 375 6.639 −6.108 48.457 1.00 16.00 A ATOM 2862 CD PRO A 375 6.560 −6.647 49.828 1.00 16.19 A ATOM 2863 CA PRO A 375 5.467 −6.538 47.680 1.00 16.73 A ATOM 2864 CB PRO A 375 4.529 −7.081 48.751 1.00 16.44 A ATOM 2865 CG PRO A 375 5.475 −7.711 49.703 1.00 16.06 A ATOM 2866 C PRO A 375 4.799 −5.474 46.820 1.00 18.46 A ATOM 2867 O PRO A 375 4.691 −4.298 47.206 1.00 17.70 A ATOM 2868 N GLY A 376 4.319 −5.915 45.660 1.00 20.24 A ATOM 2869 CA GLY A 376 3.682 −5.010 44.731 1.00 21.94 A ATOM 2870 C GLY A 376 4.800 −4.070 44.412 1.00 23.04 A ATOM 2871 O GLY A 376 4.606 −2.851 44.335 1.00 24.98 A ATOM 2872 N LEU A 377 5.977 −4.666 44.214 1.00 22.83 A ATOM 2873 CA LEU A 377 7.203 −3.935 43.963 1.00 20.77 A ATOM 2874 CB LEU A 377 7.742 −4.194 42.562 1.00 22.54 A ATOM 2875 CG LEU A 377 8.891 −5.198 42.724 1.00 23.55 A ATOM 2876 CD1 LEU A 377 9.542 −5.485 41.399 1.00 24.83 A ATOM 2877 CD2 LEU A 377 9.919 −4.634 43.709 1.00 23.91 A ATOM 2878 C LEU A 377 7.042 −2.465 44.240 1.00 19.02 A ATOM 2879 O LEU A 377 6.897 −1.629 43.344 1.00 17.12 A ATOM 2880 N THR A 378 7.057 −2.194 45.537 1.00 16.80 A ATOM 2881 CA THR A 378 6.910 −0.873 46.096 1.00 14.86 A ATOM 2882 CB THR A 378 5.954 −0.918 47.319 1.00 14.08 A ATOM 2883 OG1 THR A 378 4.660 −1.385 46.905 1.00 15.17 A ATOM 2884 CG2 THR A 378 5.825 0.455 47.954 1.00 13.38 A ATOM 2885 C THR A 378 8.279 −0.393 46.565 1.00 14.33 A ATOM 2886 O THR A 378 9.075 −1.172 47.104 1.00 13.55 A ATOM 2887 N ILE A 379 8.553 0.885 46.339 1.00 13.27 A ATOM 2888 CA ILE A 379 9.803 1.500 46.772 1.00 12.71 A ATOM 2889 CB ILE A 379 10.649 2.010 45.570 1.00 13.23 A ATOM 2890 CG2 ILE A 379 11.892 2.740 46.078 1.00 13.06 A ATOM 2891 CG1 ILE A 379 11.066 0.837 44.678 1.00 14.08 A ATOM 2892 CD1 ILE A 379 11.854 1.247 43.439 1.00 15.36 A ATOM 2893 C ILE A 379 9.425 2.703 47.633 1.00 12.32 A ATOM 2894 O ILE A 379 8.763 3.615 47.151 1.00 12.02 A ATOM 2895 N GLU A 380 9.804 2.682 48.911 1.00 11.67 A ATOM 2896 CA GLU A 380 9.532 3.803 49.808 1.00 11.50 A ATOM 2897 CB GLU A 380 9.123 3.317 51.212 1.00 11.02 A ATOM 2898 CG GLU A 380 7.764 2.601 51.299 1.00 11.78 A ATOM 2899 CD GLU A 380 6.607 3.522 51.695 1.00 11.77 A ATOM 2900 OE1 GLU A 380 6.819 4.747 51.805 1.00 11.99 A ATOM 2901 OE2 GLU A 380 5.479 3.019 51.897 1.00 11.77 A ATOM 2902 C GLU A 380 10.848 4.576 49.907 1.00 11.95 A ATOM 2903 O GLU A 380 11.912 3.971 50.076 1.00 11.95 A ATOM 2904 N THR A 381 10.773 5.900 49.783 1.00 12.03 A ATOM 2905 CA THR A 381 11.951 6.763 49.867 1.00 12.38 A ATOM 2906 CB THR A 381 12.186 7.570 48.552 1.00 13.41 A ATOM 2907 OG1 THR A 381 12.202 6.690 47.422 1.00 14.31 A ATOM 2908 CG2 THR A 381 13.522 8.311 48.613 1.00 13.86 A ATOM 2909 C THR A 381 11.777 7.791 50.987 1.00 12.43 A ATOM 2910 O THR A 381 10.747 8.466 51.062 1.00 12.02 A ATOM 2911 N VAL A 382 12.778 7.900 51.860 1.00 12.62 A ATOM 2912 CA VAL A 382 12.754 8.882 52.942 1.00 13.01 A ATOM 2913 CB VAL A 382 12.626 8.229 54.346 1.00 12.57 A ATOM 2914 CG1 VAL A 382 12.612 9.321 55.414 1.00 12.79 A ATOM 2915 CG2 VAL A 382 11.362 7.380 54.433 1.00 12.77 A ATOM 2916 C VAL A 382 14.062 9.678 52.933 1.00 13.29 A ATOM 2917 O VAL A 382 15.140 9.109 53.128 1.00 13.54 A ATOM 2918 N VAL A 383 13.977 10.984 52.692 1.00 13.17 A ATOM 2919 CA VAL A 383 15.178 11.819 52.698 1.00 13.33 A ATOM 2920 CB VAL A 383 15.024 13.063 51.793 1.00 13.72 A ATOM 2921 CG1 VAL A 383 16.291 13.928 51.870 1.00 13.77 A ATOM 2922 CG2 VAL A 383 14.782 12.628 50.356 1.00 14.43 A ATOM 2923 C VAL A 383 15.438 12.264 54.136 1.00 12.88 A ATOM 2924 O VAL A 383 14.522 12.687 54.845 1.00 12.31 A ATOM 2925 N LEU A 384 16.694 12.168 54.559 1.00 13.47 A ATOM 2926 CA LEU A 384 17.083 12.520 55.922 1.00 13.63 A ATOM 2927 CB LEU A 384 17.542 11.257 56.662 1.00 13.93 A ATOM 2928 CG LEU A 384 16.574 10.078 56.767 1.00 12.86 A ATOM 2929 CD1 LEU A 384 17.339 8.831 57.206 1.00 12.88 A ATOM 2930 CD2 LEU A 384 15.465 10.406 57.752 1.00 12.99 A ATOM 2931 C LEU A 384 18.214 13.543 55.988 1.00 14.36 A ATOM 2932 O LEU A 384 18.951 13.734 55.022 1.00 14.08 A ATOM 2933 N ARG A 385 18.330 14.199 57.140 1.00 14.44 A ATOM 2934 CA ARG A 385 19.402 15.163 57.400 1.00 15.65 A ATOM 2935 CB ARG A 385 18.858 16.594 57.540 1.00 16.91 A ATOM 2936 CG ARG A 385 19.954 17.674 57.630 1.00 19.02 A ATOM 2937 CD ARG A 385 19.381 19.100 57.574 1.00 20.86 A ATOM 2938 NE ARG A 385 20.430 20.114 57.422 1.00 23.18 A ATOM 2939 CZ ARG A 385 21.158 20.611 58.419 1.00 24.39 A ATOM 2940 NH1 ARG A 385 20.960 20.202 59.663 1.00 25.40 A ATOM 2941 NH2 ARG A 385 22.096 21.518 58.171 1.00 25.36 A ATOM 2942 C ARG A 385 20.001 14.701 58.731 1.00 15.04 A ATOM 2943 O ARG A 385 19.268 14.342 59.653 1.00 14.72 A ATOM 2944 N SER A 386 21.326 14.683 58.823 1.00 14.39 A ATOM 2945 CA SER A 386 21.992 14.242 60.043 1.00 14.75 A ATOM 2946 CB SER A 386 23.422 13.803 59.732 1.00 14.25 A ATOM 2947 OG SER A 386 24.170 14.898 59.235 1.00 14.91 A ATOM 2948 C SER A 386 22.030 15.347 61.093 1.00 14.95 A ATOM 2949 O SER A 386 21.565 16.465 60.855 1.00 14.63 A ATOM 2950 N VAL A 387 22.592 15.014 62.252 1.00 15.31 A ATOM 2951 CA VAL A 387 22.734 15.943 63.369 1.00 16.50 A ATOM 2952 CB VAL A 387 21.947 15.452 64.606 1.00 16.07 A ATOM 2953 CG1 VAL A 387 22.214 16.364 65.796 1.00 15.48 A ATOM 2954 CG2 VAL A 387 20.457 15.408 64.287 1.00 15.50 A ATOM 2955 C VAL A 387 24.218 16.025 63.735 1.00 18.05 A ATOM 2956 O VAL A 387 24.912 15.006 63.750 1.00 17.63 A ATOM 2957 N ALA A 388 24.693 17.233 64.030 1.00 19.63 A ATOM 2958 CA ALA A 388 26.095 17.455 64.389 1.00 22.13 A ATOM 2959 CB ALA A 388 26.325 18.931 64.711 1.00 22.23 A ATOM 2960 C ALA A 388 26.548 16.588 65.560 1.00 23.82 A ATOM 2961 O ALA A 388 25.890 16.540 66.601 1.00 24.03 A ATOM 2962 N ILE A 389 27.689 15.926 65.366 1.00 25.95 A ATOM 2963 CA ILE A 389 28.306 15.023 66.338 1.00 27.95 A ATOM 2964 CB ILE A 389 28.605 15.734 67.679 1.00 28.69 A ATOM 2965 CG2 ILE A 389 28.958 14.707 68.752 1.00 29.02 A ATOM 2966 CG1 ILE A 389 29.788 16.693 67.512 1.00 28.93 A ATOM 2967 CD1 ILE A 389 29.524 17.871 66.590 1.00 29.88 A ATOM 2968 C ILE A 389 27.470 13.775 66.607 1.00 28.74 A ATOM 2969 OT1 ILE A 389 27.939 12.668 66.256 1.00 28.79 A ATOM 2970 OT2 ILE A 389 26.354 13.915 67.157 1.00 29.65 A

[0270]

1 64 1 389 PRT Medicago sativa 1 Met Val Ser Val Ser Glu Ile Arg Lys Ala Gln Arg Ala Glu Gly Pro 1 5 10 15 Ala Thr Ile Leu Ala Ile Gly Thr Ala Asn Pro Ala Asn Cys Val Glu 20 25 30 Gln Ser Thr Tyr Pro Asp Phe Tyr Phe Lys Ile Thr Asn Ser Glu His 35 40 45 Lys Thr Glu Leu Lys Glu Lys Phe Gln Arg Met Cys Asp Lys Ser Met 50 55 60 Ile Lys Arg Arg Tyr Met Tyr Leu Thr Glu Glu Ile Leu Lys Glu Asn 65 70 75 80 Pro Asn Val Cys Glu Tyr Met Ala Pro Ser Leu Asp Ala Arg Gln Asp 85 90 95 Met Val Val Val Glu Val Pro Arg Leu Gly Lys Glu Ala Ala Val Lys 100 105 110 Ala Ile Lys Glu Trp Gly Gln Pro Lys Ser Lys Ile Thr His Leu Ile 115 120 125 Val Cys Thr Thr Ser Gly Val Asp Met Pro Gly Ala Asp Tyr Gln Leu 130 135 140 Thr Lys Leu Leu Gly Leu Arg Pro Tyr Val Lys Arg Tyr Met Met Tyr 145 150 155 160 Gln Gln Gly Cys Phe Ala Gly Gly Thr Val Leu Arg Leu Ala Lys Asp 165 170 175 Leu Ala Glu Asn Asn Lys Gly Ala Arg Val Leu Val Val Cys Ser Glu 180 185 190 Val Thr Ala Val Thr Phe Arg Gly Pro Ser Asp Thr His Leu Asp Ser 195 200 205 Leu Val Gly Gln Ala Leu Phe Gly Asp Gly Ala Ala Ala Leu Ile Val 210 215 220 Gly Ser Asp Pro Val Pro Glu Ile Glu Lys Pro Ile Phe Glu Met Val 225 230 235 240 Trp Thr Ala Gln Thr Ile Ala Pro Asp Ser Glu Gly Ala Ile Asp Gly 245 250 255 His Leu Arg Glu Ala Gly Leu Thr Phe His Leu Leu Lys Asp Val Pro 260 265 270 Gly Ile Val Ser Lys Asn Ile Thr Lys Ala Leu Val Glu Ala Phe Glu 275 280 285 Pro Leu Gly Ile Ser Asp Tyr Asn Ser Ile Phe Trp Ile Ala His Pro 290 295 300 Gly Gly Pro Ala Ile Leu Asp Gln Val Glu Gln Lys Leu Ala Leu Lys 305 310 315 320 Pro Glu Lys Met Asn Ala Thr Arg Glu Val Leu Ser Glu Tyr Gly Asn 325 330 335 Met Ser Ser Ala Cys Val Leu Phe Ile Leu Asp Glu Met Arg Lys Lys 340 345 350 Ser Thr Gln Asn Gly Leu Lys Thr Thr Gly Glu Gly Leu Glu Trp Gly 355 360 365 Val Leu Phe Gly Phe Gly Pro Gly Leu Thr Ile Glu Thr Val Val Leu 370 375 380 Arg Ser Val Ala Ile 385 2 24 PRT Medicago sativa 2 Ser Glu Gly Ala Ile Asp Gly His Leu Arg Glu Ala Gly Leu Thr Phe 1 5 10 15 His Leu Leu Lys Asp Val Pro Gly 20 3 24 PRT Hordeum vulgare 3 Ser Glu Gly Ala Ile Asp Gly His Leu Thr Glu Ala Gly Leu Thr Ile 1 5 10 15 His Leu Leu Lys Asp Val Pro Gly 20 4 24 PRT Ruta graveolens 4 Ser Asp Gly Ala Ile Glu Gly His Ile Arg Glu Glu Gly Leu Thr Val 1 5 10 15 His Leu Lys Lys Asp Val Pro Ala 20 5 24 PRT Arachis hypogaea 5 Ser His Gly Ala Ile Gly Gly Leu Leu Arg Glu Val Gly Leu Thr Phe 1 5 10 15 Tyr Leu Asn Lys Ser Val Pro Asp 20 6 24 PRT Pinus sp. 6 Ser Asp Gly Ala Ile Ser Gly Lys Leu Arg Glu Val Gly Leu Thr Phe 1 5 10 15 Gln Leu Lys Gly Ala Val Pro Asp 20 7 24 PRT Phalaenopsis sp. 7 Ser Ala Gly Ala Ile Gly Gly His Val Ser Glu Gly Gly Leu Leu Ala 1 5 10 15 Thr Leu His Arg Asp Val Pro Gln 20 8 393 PRT Pinus sylvestris 8 Met Gly Gly Val Asp Phe Glu Gly Phe Arg Lys Leu Gln Arg Ala Asp 1 5 10 15 Gly Phe Ala Ser Ile Leu Ala Ile Gly Thr Ala Asn Pro Pro Asn Ala 20 25 30 Val Asp Gln Ser Thr Tyr Pro Asp Phe Tyr Phe Arg Ile Thr Gly Asn 35 40 45 Glu His Asn Thr Glu Leu Lys Asp Lys Phe Lys Arg Ile Cys Glu Arg 50 55 60 Ser Ala Ile Lys Gln Arg Tyr Met Tyr Leu Thr Glu Glu Ile Leu Lys 65 70 75 80 Lys Asn Pro Asp Val Cys Ala Phe Val Glu Val Pro Ser Leu Asp Ala 85 90 95 Arg Gln Ala Met Leu Ala Met Glu Val Pro Arg Leu Ala Lys Glu Ala 100 105 110 Ala Glu Lys Ala Ile Gln Glu Trp Gly Gln Ser Lys Ser Gly Ile Thr 115 120 125 His Leu Ile Phe Cys Ser Thr Thr Thr Pro Asp Leu Pro Gly Ala Asp 130 135 140 Phe Glu Val Ala Lys Leu Leu Gly Leu His Pro Ser Val Lys Arg Val 145 150 155 160 Gly Val Phe Gln His Gly Cys Phe Ala Gly Gly Thr Val Leu Arg Met 165 170 175 Ala Lys Asp Leu Ala Glu Asn Asn Arg Gly Ala Arg Val Leu Val Ile 180 185 190 Cys Ser Glu Thr Thr Ala Val Thr Phe Arg Gly Pro Ser Glu Thr His 195 200 205 Leu Asp Ser Leu Val Gly Gln Ala Leu Phe Gly Asp Gly Ala Ser Ala 210 215 220 Leu Ile Val Gly Ala Asp Pro Ile Pro Gln Val Glu Lys Ala Cys Phe 225 230 235 240 Glu Ile Val Trp Thr Ala Gln Thr Val Val Pro Asn Ser Glu Gly Ala 245 250 255 Ile Gly Gly Lys Val Arg Glu Val Gly Leu Thr Phe Gln Leu Lys Gly 260 265 270 Ala Val Pro Asp Leu Ile Ser Ala Asn Ile Glu Asn Cys Met Val Glu 275 280 285 Ala Phe Ser Gln Phe Lys Ile Ser Asp Trp Asn Lys Leu Phe Trp Val 290 295 300 Val His Pro Gly Gly Arg Ala Ile Leu Asp Arg Val Glu Ala Lys Leu 305 310 315 320 Asn Leu Asp Pro Thr Lys Leu Ile Pro Thr Arg His Val Met Ser Glu 325 330 335 Tyr Gly Asn Met Ser Ser Ala Cys Val His Phe Ile Leu Asp Gln Thr 340 345 350 Arg Lys Ala Ser Leu Gln Asn Gly Cys Ser Thr Thr Gly Glu Gly Leu 355 360 365 Glu Met Gly Val Leu Phe Gly Phe Gly Pro Gly Leu Thr Ile Glu Thr 370 375 380 Val Val Leu Lys Ser Val Pro Ile Gln 385 390 9 396 PRT Pinus sylvestris 9 Met Ala Ala Gly Met Met Lys Asp Leu Glu Ala Phe Arg Lys Ala Gln 1 5 10 15 Arg Ala Asp Gly Pro Ala Thr Ile Leu Ala Ile Gly Thr Ala Thr Pro 20 25 30 Pro Asn Ala Val Asp Gln Ser Ser Tyr Pro Asp Tyr Tyr Phe Lys Ile 35 40 45 Thr Asn Ser Glu His Met Thr Glu Leu Lys Glu Lys Phe Arg Arg Met 50 55 60 Cys Asp Lys Ser Ala Ile Lys Lys Arg Tyr Met Tyr Leu Thr Glu Glu 65 70 75 80 Ile Leu Lys Glu Asn Pro Lys Val Cys Glu Tyr Met Ala Pro Ser Leu 85 90 95 Asp Ala Arg Gln Asp Met Val Val Val Glu Val Pro Arg Leu Gly Lys 100 105 110 Glu Ala Ala Ala Lys Ala Ile Lys Glu Trp Gly Gln Pro Lys Ser Lys 115 120 125 Ile Thr His Val Ile Phe Cys Thr Thr Ser Gly Val Asp Met Pro Gly 130 135 140 Ala Asp Tyr Gln Leu Thr Lys Leu Leu Gly Leu Arg Pro Ser Val Lys 145 150 155 160 Arg Val Met Met Tyr Gln Gln Gly Cys Phe Ala Gly Gly Thr Val Leu 165 170 175 Arg Val Ala Lys Asp Leu Ala Glu Asn Asn Arg Gly Ala Arg Val Leu 180 185 190 Val Val Cys Ser Glu Ile Thr Ala Val Thr Phe Arg Gly Pro Ser Asp 195 200 205 Thr His Leu Asp Ser Met Val Gly Gln Ala Leu Phe Gly Asp Gly Ala 210 215 220 Ala Ala Leu Ile Val Gly Ala Asp Pro Val Pro Glu Val Glu Lys Pro 225 230 235 240 Cys Phe Glu Leu Met Trp Thr Ala Gln Thr Ile Leu Pro Asp Ser Asp 245 250 255 Gly Ala Ile Asp Gly His Leu Arg Glu Val Gly Leu Thr Phe His Leu 260 265 270 Leu Lys Asp Val Pro Gly Leu Ile Ser Lys Asn Ile Glu Lys Ser Leu 275 280 285 Val Glu Ala Phe Gln Gln Phe Gly Ile Ser Asp Trp Asn Gln Leu Phe 290 295 300 Trp Ile Ala His Pro Gly Gly Pro Ala Ile Leu Asp Gln Val Glu Ala 305 310 315 320 Lys Leu Asn Leu Asp Pro Lys Lys Leu Ser Ala Thr Arg Gln Val Leu 325 330 335 Ser Asp Tyr Gly Asn Met Ser Ser Ala Cys Val His Phe Ile Leu Asp 340 345 350 Glu Met Arg Lys Ser Ser Lys Glu Lys Gly Cys Ser Thr Thr Gly Glu 355 360 365 Gly Leu Asp Val Gly Val Leu Phe Gly Phe Gly Pro Gly Leu Thr Val 370 375 380 Glu Thr Val Val Leu Lys Ser Val Pro Leu Leu Asp 385 390 395 10 389 PRT Medicago sativa 10 Met Val Ser Val Ser Glu Ile Arg Lys Ala Gln Arg Ala Glu Gly Pro 1 5 10 15 Ala Thr Ile Leu Ala Ile Gly Thr Ala Asn Pro Ala Asn Cys Val Glu 20 25 30 Gln Ser Thr Tyr Pro Asp Phe Tyr Phe Lys Ile Thr Asn Ser Glu His 35 40 45 Lys Thr Glu Leu Lys Glu Lys Phe Gln Arg Met Cys Asp Lys Ser Met 50 55 60 Ile Lys Arg Arg Tyr Met Tyr Leu Thr Glu Glu Ile Leu Lys Glu Asn 65 70 75 80 Pro Asn Val Cys Glu Tyr Met Ala Pro Ser Leu Asp Ala Arg Gln Asp 85 90 95 Met Val Val Val Glu Val Pro Arg Leu Gly Lys Glu Ala Ala Val Lys 100 105 110 Ala Ile Lys Glu Trp Gly Gln Pro Lys Ser Lys Ile Thr His Leu Ile 115 120 125 Val Cys Thr Thr Ser Gly Val Asp Met Pro Gly Ala Asp Tyr Gln Leu 130 135 140 Thr Lys Leu Leu Gly Leu Arg Pro Tyr Val Lys Arg Tyr Met Met Tyr 145 150 155 160 Gln Gln Gly Cys Phe Ala Gly Gly Thr Val Leu Arg Leu Ala Lys Asp 165 170 175 Leu Ala Glu Asn Asn Lys Gly Ala Arg Val Leu Val Val Cys Ser Glu 180 185 190 Val Thr Ala Val Thr Phe Arg Gly Pro Ser Asp Thr His Leu Asp Ser 195 200 205 Leu Val Gly Gln Ala Leu Phe Gly Asp Gly Ala Ala Ala Leu Ile Val 210 215 220 Gly Ser Asp Pro Val Pro Glu Ile Glu Lys Pro Ile Phe Glu Met Val 225 230 235 240 Trp Thr Ala Gln Thr Ile Ala Pro Asp Ser Glu Gly Ala Ile Asp Gly 245 250 255 His Leu Arg Glu Ala Gly Leu Thr Phe His Leu Leu Lys Asp Val Pro 260 265 270 Gly Ile Val Ser Lys Asn Ile Thr Lys Ala Leu Val Glu Ala Phe Glu 275 280 285 Pro Leu Gly Ile Ser Asp Tyr Asn Ser Ile Phe Trp Ile Ala His Pro 290 295 300 Gly Gly Pro Ala Ile Leu Asp Gln Val Glu Gln Lys Leu Ala Leu Lys 305 310 315 320 Pro Glu Lys Met Asn Ala Thr Arg Glu Val Leu Ser Glu Tyr Gly Asn 325 330 335 Met Ser Ser Ala Cys Val Leu Phe Ile Leu Asp Glu Met Arg Lys Lys 340 345 350 Ser Thr Gln Asn Gly Leu Lys Thr Thr Gly Glu Gly Leu Glu Trp Gly 355 360 365 Val Leu Phe Gly Phe Gly Pro Gly Leu Thr Ile Glu Thr Val Val Leu 370 375 380 Arg Ser Val Ala Ile 385 11 11 PRT Pinus sylvestris 11 Arg Gln Ala Met Leu Ala Met Glu Val Pro Arg 1 5 10 12 12 PRT Pinus sylvestris 12 Phe Cys Ser Thr Thr Thr Pro Asp Leu Pro Gly Ala 1 5 10 13 11 PRT Pinus sylvestris 13 Val Lys Arg Val Gly Val Phe Gln His Gly Cys 1 5 10 14 27 PRT Pinus sylvestris 14 Gly Ala Ile Gly Gly Lys Val Arg Glu Val Gly Leu Thr Phe Gln Leu 1 5 10 15 Lys Gly Ala Val Pro Asp Leu Ile Ser Ala Asn 20 25 15 11 PRT Pinus sp. 15 Arg Gln Ala Met Leu Ala Ala Glu Val Pro Arg 1 5 10 16 12 PRT Pinus sp. 16 Phe Cys Thr Thr Thr Thr Pro Asp Leu Pro Gly Ala 1 5 10 17 11 PRT Pinus sp. 17 Val Lys Arg Val Gly Val Phe Gln His Gly Cys 1 5 10 18 27 PRT Pinus sp. 18 Gly Ala Ile Ser Gly Lys Leu Arg Glu Val Gly Leu Thr Phe Gln Leu 1 5 10 15 Lys Gly Ala Val Pro Asp Leu Ile Ser Thr Asn 20 25 19 11 PRT Pinus strobus 19 Arg Gln Ala Met Leu Ala Val Glu Val Pro Arg 1 5 10 20 12 PRT Pinus strobus 20 Phe Cys Thr Thr Thr Thr Pro Asp Leu Pro Gly Ala 1 5 10 21 11 PRT Pinus strobus 21 Val Lys Arg Val Gly Val Phe Gln His Gly Cys 1 5 10 22 27 PRT Pinus strobus 22 Gly Ala Ile Ser Gly Lys Leu Arg Glu Val Gly Leu Thr Phe Gln Leu 1 5 10 15 Lys Gly Ala Val Pro Asp Leu Ile Ser Thr Asn 20 25 23 11 PRT Vitis vinifera 23 Arg Gln Glu Ile Ile Thr Ala Glu Val Pro Lys 1 5 10 24 12 PRT Vitis vinifera 24 Phe Cys Thr Thr Ser Gly Val Glu Met Pro Gly Ala 1 5 10 25 11 PRT Vitis vinifera 25 Val Arg Arg Val Met Leu Asp Gln Gln Gly Cys 1 5 10 26 27 PRT Vitis vinifera 26 Gly Ala Ile Ala Gly Asn Leu Arg Glu Val Gly Leu Thr Phe His Leu 1 5 10 15 Trp Pro Asn Val Pro Thr Leu Ile Ser Glu Asn 20 25 27 11 PRT Arachis hypogaea 27 Arg Glu Asp Met Met Ile Arg Glu Val Pro Arg 1 5 10 28 12 PRT Arachis hypogaea 28 Phe Cys Thr Thr Ser Gly Val Ala Leu Pro Gly Val 1 5 10 29 11 PRT Arachis hypogaea 29 Val Lys Arg Tyr Met Met Tyr His Gln Gly Cys 1 5 10 30 27 PRT Arachis hypogaea 30 Gly Ala Ile Gly Gly Leu Leu Arg Glu Val Gly Leu Thr Phe Tyr Leu 1 5 10 15 Asn Lys Ser Val Pro Asp Ile Ile Ser Gln Asn 20 25 31 11 PRT Pinus sylvestris 31 Arg Gln Asp Met Val Val Val Glu Val Pro Arg 1 5 10 32 12 PRT Pinus sylvestris 32 Phe Cys Thr Thr Ser Gly Val Asp Met Pro Gly Ala 1 5 10 33 11 PRT Pinus sylvestris 33 Val Lys Arg Val Met Met Tyr Gln Gln Gly Cys 1 5 10 34 27 PRT Pinus sylvestris 34 Gly Ala Ile Asp Gly His Leu Arg Glu Val Gly Leu Thr Phe His Leu 1 5 10 15 Leu Lys Asp Val Pro Gly Leu Ile Ser Lys Asn 20 25 35 11 PRT Medicago sativa 35 Arg Gln Asp Met Val Val Val Glu Val Pro Arg 1 5 10 36 12 PRT Medicago sativa 36 Val Cys Thr Thr Ser Gly Val Asp Met Pro Gly Ala 1 5 10 37 11 PRT Medicago sativa 37 Val Lys Arg Tyr Met Met Tyr Gln Gln Gly Cys 1 5 10 38 27 PRT Medicago sativa 38 Gly Ala Ile Asp Gly His Leu Arg Glu Ala Gly Leu Thr Phe His Leu 1 5 10 15 Leu Lys Asp Val Pro Gly Ile Val Ser Lys Asn 20 25 39 11 PRT Solanum tuberosum 39 Arg Gln Asp Ile Val Val Val Glu Val Pro Lys 1 5 10 40 12 PRT Solanum tuberosum 40 Phe Cys Thr Thr Ser Gly Val Asp Met Pro Gly Ala 1 5 10 41 11 PRT Solanum tuberosum 41 Val Lys Arg Leu Met Met Tyr Gln Gln Gly Cys 1 5 10 42 27 PRT Solanum tuberosum 42 Gly Ala Ile Asp Gly His Leu Arg Glu Val Gly Leu Thr Phe His Leu 1 5 10 15 Leu Lys Asp Val Pro Gly Leu Ile Ser Lys Asn 20 25 43 11 PRT Ipomoea purpurea 43 Arg Gln Asp Ile Leu Val Ser Glu Val Pro Lys 1 5 10 44 12 PRT Ipomoea purpurea 44 Phe Cys Thr Thr Ser Gly Val Asp Met Pro Gly Ala 1 5 10 45 11 PRT Ipomoea purpurea 45 Val Lys Arg Leu Met Met Tyr Gln Gln Gly Cys 1 5 10 46 27 PRT Ipomoea purpurea 46 Ser Tyr Leu Lys Leu Gln Leu Arg Glu Met Gly Leu Thr Phe His Cys 1 5 10 15 Ser Lys Ala Val Pro Ser Leu Ile Thr Gln Asn 20 25 47 11 PRT Gerbera hybrida 47 Arg Gln Asp Leu Val Val Thr Gly Val Pro Met 1 5 10 48 12 PRT Gerbera hybrida 48 Phe Cys Thr Thr Ala Gly Val Asp Met Pro Gly Ala 1 5 10 49 11 PRT Gerbera hybrida 49 Val Lys Arg Tyr Met Leu Tyr Gln Gln Gly Cys 1 5 10 50 27 PRT Gerbera hybrida 50 Lys Ala Val Lys Leu His Leu Arg Glu Gly Gly Leu Thr Phe Gln Leu 1 5 10 15 His Arg Asp Val Pro Leu Met Val Ala Lys Asn 20 25 51 7 PRT Pinus sp. 51 Ser Thr Thr Thr Pro Asp Leu 1 5 52 7 PRT Pinus sp. 52 Ser Thr Thr Thr Pro Asp Leu 1 5 53 7 PRT Pinus sp. 53 Thr Thr Thr Thr Pro Asp Leu 1 5 54 7 PRT Vitis sp. 54 Thr Thr Ser Gly Val Glu Met 1 5 55 7 PRT Arachis hypogaea 55 Thr Thr Ser Gly Val Ala Leu 1 5 56 7 PRT Pinus sp. 56 Thr Thr Ser Gly Val Asp Met 1 5 57 7 PRT Medicago sativa 57 Thr Thr Ser Gly Val Asp Met 1 5 58 5 PRT Pinus sp. 58 His Leu Leu Lys Asp 1 5 59 5 PRT Pinus sp. 59 Gln Leu Lys Gly Ala 1 5 60 5 PRT Pinus sp. 60 Gln Leu Lys Gly Ala 1 5 61 5 PRT Vitis sp. 61 His Leu Trp Pro Asn 1 5 62 5 PRT Arachis hypogaea 62 Tyr Leu Asn Lys Ser 1 5 63 5 PRT Pinus sp. 63 His Leu Leu Lys Asp 1 5 64 5 PRT Medicago sativa 64 His Leu Leu Lys Asp 1 5 

That which is claimed is:
 1. A method of producing a mutant polyketide synthase comprising: (a) comparing a crystal structure of a wild type polyketide synthase with a crystal structure of a second polyketide synthase; (b) substituting one or more amino acids of the wild type polyketide synthase with the amino acid residues at homologous positions in the second polyketide synthase; and (c) producing said mutant polyketide synthase.
 2. The method of claim 1, wherein the wild type polyketide synthase comprises at least fourteen active site α-carbons having the structural coordinates of Table
 1. 3. The method of claim 2, wherein said one or more amino acids to be substituted are selected from the group consisting of positions 96, 98, 99, 100, 131, 133, 134, 135, 137, 157, 158, 159, 160, 165, 255, 257, 258, 266, 268, 269, 270 and
 273. 4. The method of claim 3, wherein one or more substitutions are selected from the group consisting of D96A, V98L, V99A, V100M, T131S, S133T, G134T, V135P, M137L, Y157V, M158G, M159V, Y160F, Q165H, D255G, H257K, L258V, H266Q, L268K, K269G, D270A and G273D.
 5. The method of claim 3, wherein said one or more amino acids comprise substitutions at positions 98, 131, 133, 134, 135 and
 137. 6. The method of claim 5, wherein the substitutions comprise V98L, T131S, S133T, G134T, V135P, and M137L.
 7. The method of claim 5, wherein said one or more amino acids further comprise substitutions at positions 96, 99 and
 100. 8. The method of claim 6, wherein the substitutions further comprise D96A, V99A and V100M.
 9. The method of claim 5, wherein said one or more amino acids further comprise substitutions at positions 158 and
 160. 10. The method of claim 6, wherein the substitutions further comprise M158G and Y160F.
 11. The method of claim 7, wherein said one or more amino acids further comprise substitutions at positions 158, 160 and
 269. 12. The method of claim 8, wherein the substitutions further comprise M158G, Y160F and K269G.
 13. The method of claim 9, wherein said one or more amino acids further comprise substitutions at positions 157, 159 and
 165. 14. The method of claim 10, wherein the substitutions further comprise Y157V, M159V and Q165H.
 15. The method of claim 11, wherein said one or more amino acids further comprise substitutions at positions 157, 159, 165, 268, 270 and
 273. 16. The method of claim 12, wherein the substitutions further comprise Y157V, M159V, Q165H, L268K, D270A and G273D.
 17. The method of claim 15, wherein said one or more amino acids further comprise substitutions at positions 255, 257, 258 and
 266. 18. The method of claim 16, wherein the substitutions further comprise D255G, H257K, L258V and H266Q.
 19. The method of claim 1, wherein said wild type polyketide synthase is a chalcone synthase.
 20. The method of claim 1, wherein said second polyketide synthase is a stilbene synthase.
 21. The method of claim 1, wherein said wild type polyketide synthase is a chalcone synthase and wherein said second polyketide synthase is a stilbene synthase.
 22. The method of claim 1, wherein said mutant polyketide synthase is produced in vitro.
 23. The method of claim 1, wherein said mutant polyketide synthase is produced in vivo.
 24. The method of claim 23, wherein said mutant polyketide synthase is produced in a plant.
 25. A method of producing a mutant polyketide synthase, said method comprising: expressing a mutant polyketide synthase created by substituting one or more amino acids of a wild type polyketide synthase with the amino acid residues at homologous positions of a second polyketide synthase, wherein said amino acid residues are selected by comparing a crystal structure of the wild type polyketide synthase with a crystal structure of the second polyketide synthase.
 26. A method of producing a mutant polyketide synthase, said method comprising: synthesizing a mutant polyketide synthase created by substituting one or more amino acids of a wild type polyketide synthase with the amino acid residues at homologous positions of a second polyketide synthase, wherein said amino acid residues are selected by comparing a crystal structure of the wild type polyketide synthase with a crystal structure of the second polyketide synthase.
 27. An isolated polyketide synthase comprising SEQ ID NO:1, wherein one or more amino acid residues are modified at one or more positions selected from the group consisting of positions 96, 98, 99, 100, 131, 133, 134, 135, 137, 157, 158, 159, 160, 165, 255, 257, 258, 266, 268, 269, 270 and
 273. 28. The synthase according to claim 27, wherein said modifications are selected from the group consisting of D96A, V98L, V99A, V100M, T131S, S133T, G134T, V135P, M137L, Y157V, M158G, M159V, Y160F, Q165H, D255G, H257K, L258V, H266Q, L268K, K269G, D270A and G273D.
 29. The synthase according to claim 27, wherein said one or more amino acids comprise modifications at positions 98, 131, 133, 134, 135 and
 137. 30. The synthase according to claim 29, wherein the modifications comprise V98L, T131S, S133T, G134T, V135P, and M137L.
 31. The synthase according to claim 29, wherein said one or more amino acids further comprise modifications at positions 96, 99 and
 100. 32. The synthase according to claim 30, wherein the modifications further comprise D96A, V99A and V100M.
 33. The synthase according to claim 29, wherein said one or more amino acids further comprise modifications at positions 158 and
 160. 34. The synthase according to claim 30, wherein the modifications further comprise M158G and Y160F.
 35. The synthase according to claim 31, wherein said one or more amino acids further comprise modifications at positions 158, 160 and
 269. 36. The synthase according to claim 32, wherein the modifications further comprise M158G, Y160F and K269G.
 37. The synthase according to claim 33, wherein said one or more amino acids further comprise modifications at positions 157, 159 and
 165. 38. The synthase according to claim 34, wherein the modifications further comprise Y157V, M159V and Q165H.
 39. The synthase according to claim 35, wherein said one or more amino acids further comprise modifications at positions 157, 159, 165, 268, 270 and
 273. 40. The synthase according to claim 36, wherein the modifications further comprise Y157V, M159V, Q165H, L268K, D270A and G273D.
 41. The synthase according to claim 39, wherein said one or more amino acids further comprise modifications at positions 255, 257, 258 and
 266. 42. The synthase according to claim 40, wherein the modifications further comprise D255G, H257K, L258V and H266Q.
 43. A crystalline form of the synthase of claim
 27. 44. A crystalline form of the synthase of claim
 28. 45. A nucleic acid encoding the synthase of claim
 27. 46. A nucleic acid encoding the synthase of claim
 28. 47. A method of altering the substrate specificity of a polyketide synthase comprising: (a) comparing a crystal structure of a wild type polyketide synthase with a crystal structure of a second polyketide synthase; and (b) substituting one or more amino acids in the active site of the wild type polyketide synthase with the amino acid residues at homologous positions in the second polyketide synthase.
 48. The method of claim 47, wherein the wild type polyketide synthase comprises at least fourteen active site α-carbons having the structural coordinates of Table
 1. 49. The method of claim 48, wherein the said one or more amino acids to be substituted are selected from the group consisting of positions 132, 133, 137, 161, 194, 197, 211, 216, 254, 256, 263, 265, 267 and
 338. 50. A method of altering the activity of a polyketide synthase comprising: (a) comparing a crystal structure of a wild type polyketide synthase with a crystal structure of a second polyketide synthase; and (b) substituting one or more amino acids of the wild type polyketide synthase with the amino acid residues at homologous positions in the second polyketide synthase.
 51. The method of claim 50, wherein the wild type polyketide synthase comprises at least fourteen active site or-carbons having the structural coordinates of Table
 1. 52. The method of claim 51, wherein said one or more amino acids to be substituted are selected from the group consisting of positions 96, 98, 99, 100, 131, 133, 134, 135, 137, 157, 158, 159, 160, 165, 255, 257, 258, 266, 268, 269, 270 and
 273. 53. The method of claim 52, wherein one or more substitutions are selected from the group consisting of D96A, V98L, V99A, V100M, T131S, S 133T, G134T, V135P, M137L, Y157V, M158G, M159V, Y160F, Q165H, D255G, H257K, L258V, H266Q, L268K, K269G, D270A and G273D.
 54. The method of claim 50, wherein said wild type polyketide synthase is a chalcone synthase.
 55. The method of claim 50, wherein said second polyketide synthase is a stilbene synthase.
 56. The method of claim 50, wherein said wild type polyketide synthase is a chalcone synthase and wherein said second polyketide synthase is a stilbene synthase.
 57. The method of claim 50, wherein the altered activity results in the formation of the product of the second polyketide synthase instead of the product of the wild type polyketide synthase.
 58. The method of claim 50, wherein the altered activity results in the formation of both the product of the second polyketide synthase and the product of the wild type polyketide synthase.
 59. The method of claim 56, wherein the altered activity results in the formation of resveratrol instead of chalcone.
 60. The method of claim 56, wherein the altered activity results in the formation of both resveratrol and chalcone.
 61. A method for altering the polyketide content of a plant by introducing the nucleic acid of claim
 45. 62. A method for altering the polyketide content of a plant by introducing the nucleic acid of claim
 46. 63. The method of claim 61, wherein said polyketide is resveratrol.
 64. The method of claim 62, wherein said polyketide is resveratrol.
 65. A computer program on a computer readable medium, said computer program comprising instructions to cause a computer to: (a) define two different polyketide synthases or fragments thereof based on two sets of atomic coordinates derived from crystals of said two different polyketide synthases; and (b) compare the structure of said two different polyketide synthases.
 66. The computer program of claim 65, wherein at least one set of atomic coordinates are as set forth in PDB Accession No. 1BI5, PDB Accession No. 1D6F, PDB AccessionNo.1D6I, PDB Accession No.1D6H, PDB AccessionNo.1BQ6, PDB Accession No.1CML, PDB Accession No.1CHW, PDB AccessionNo.1CGK, PDB Accession No. 1CGZ, PDB Accession No. 1EE0, Table 1, Appendix A, Appendix B, Appendix C, or portions thereof. 